| 1. |
- Blom, Kristin, et al.
(författare)
-
Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition
- 2019
-
Ingår i: BMC Research Notes. - : Springer Nature. - 1756-0500. ; 12:1
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity by inducing a M2 to M1 phenotype switch in monocyte/macrophage models. In the present study we investigated the potential role of protein kinases in mediating this effect.Results: MBZ potently binds and inhibits Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) with a Kd and an IC50 of 7 and 360 nM, respectively. The specific DYRK1B inhibitor AZ191 did not mimic the cytokine release profile of MBZ in untreated THP-1 monocytes. However, in THP-1 cells differentiated into macrophages, AZ191 strongly induced a pro-inflammatory cytokine release pattern similar to MBZ and LPS/IFNγ. Furthermore, like MBZ, AZ191 increased the expression of the M1 marker CD80 and decreased the M2 marker CD163 in THP-1 macrophages. In this model, AZ191 also increased phospho-ERK activity although to a lesser extent compared to MBZ. Taken together, the results demonstrate that DYRK1B inhibition could, at least partly, recapitulate immune responses induced by MBZ. Hence, DYRK1B inhibition induced by MBZ may be part of the mechanism of action to switch M2 to M1 macrophages.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Eklund Wimelius, Malin, 1972-, et al.
(författare)
-
"They think of us as part of the problem instead of part of the solution" : Swedish civil society and faith based organizations in resilience building and prevention of radicalization and violent Islamist extremism
- 2020
-
Ingår i: Journal for Deradicalization. - : German Institute on Radicalization and De-Radicalization Studies (GIRDS). - 2363-9849. ; :22, s. 122-154
-
Tidskriftsartikel (refereegranskat)abstract
- Radicalization and violent extremism are pressing issues on the Swedish political agenda. The local level has been identified as pivotal when it comes to preventive work and local public actors are encouraged to cooperate with civil society in efforts to promote local resilience. However, the Swedish debate on the role of civil society organizations (CSOs) and faith based organizations (FBOs) in resilience building and prevention is heated. Based on 14 interviews with representatives for secular, Christian and Muslim CSOs and FBOs, we have explored and analysed how they perceive their role in resilience building and preventive work. We have asked how they interpret local resilience against radicalization and violent extremism and what they think is needed in order to promote it. Findings are mirrored against a recent literature review on local resilience. In the interviews, there is a strong emphasis on work to strengthen social support networks, enhance community resources and build collective identity. In relation to the literature review, there are significant similarities with how resilience is defined and said to be promoted.
|
|
| 5. |
- Eklund Wimelius, Malin, 1972-, et al.
(författare)
-
What is local resilience against radicalization and how can it be promoted? : a multidisciplinary literature review
- 2023
-
Ingår i: Studies in Conflict and Terrorism. - : Routledge. - 1057-610X .- 1521-0731. ; 46:7, s. 1108-1125
-
Tidskriftsartikel (refereegranskat)abstract
- In this research note, we present results from a review of research on local resilience in relation to radicalization in public health, social work, crisis management, and community policing using terrorism studies as a point of departure. In order to identify agreements between literatures, we focus on how local resilience is understood, how it is said to be promoted, and how this knowledge could be synthesized. We show that resilience by and large is understood as both a process and a capacity underpinned by cooperation, social networks, and community resources and that an initial mapping of existing strengths and resources is pivotal for local resilience-building.
|
|
| 6. |
- Eriksson, Malin, 1969-, et al.
(författare)
-
Ensamkommande ungdomars placering vid SiS särskilda ungdomshem : Placeringsmotiv, problembild och insatser
- 2021
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Under år 2017 var nästan 33 procent av samtliga pojkar placerade på SiS, ensamkommande ungdomar. För SiS innebär gruppen ensamkommande ungdomar nya utmaningar genom språkbarriärer och komplex problematik.Syftet med rapporten är att bidra till ökad kunskap om på vilka grunder ensamkommande ungdomar placeras på SiS, hur placeringsinsatsen organiseras och om insatserna under placeringen skiljer sig jämfört med insatserna för andra placerade ungdomar. Rapporten fokuserar på följande forskningsfrågor: Vilka motiv ligger till grund för ensamkommande ungdomars placering på SiS? Vilka problem avser en SiS-placering lösa? Finns det skillnader mellan hur olika aktörer uppfattar motiv och problem vid SiS-placering? Vilka insatser genomförs under placeringstiden och hur uppfattas dessa? Skiljer sig användningen av särskilda befogenheter i hanteringen av ensamkommande ungdomar jämfört med andra placerade ungdomar?Svaren på forskningsfrågorna baseras på intervjuer med SiS-personal, socialsekreterare och ensamkommande ungdomar placerade vid SiS, avidentifierade journaler samt data ur klient- och institutionsadministrativa system (KIA).Resultaten visar att två övergripande och delvis motstridiga bilder framträder vad gäller motiv för placering av ensamkommande ungdomar på SiS. Å ena sidan finns uppfattningen att ensamkommande ungdomar har en komplex problematik vilket motiverar placering på SiS. Å andra sidan uppfattas en del av de ensamkommande på SiS som felplacerade eller placerade på för vaga grunder. De insatser som ges under placeringen handlar till stor del om att ge struktur, fasta ramar och upprätta en vardag, vilket SiS har goda förutsättningar att lyckas med inom ramen för den strukturerade tvångsvårdsmiljö som erbjuds. Insatser som avser att hjälpa ensamkommande ungdomar att ”uppnå drogfrihet” eller ”komma ifrån en kriminell livsstil” har dock sämre förutsättningar att lyckas inom SiS, då dessa insatser utformas med det svenska språket och ”svenska bärande samhällsnormer” som grund. När det gäller användandet av särskilda befogenheter, visar resultaten att dessa används i lägre utsträckning för ensamkommande jämfört med andra ungdomar.
|
|
| 7. |
- Eriksson, Malin, et al.
(författare)
-
I stand on my own two feet but need someone who really cares : Social networks and social capital among unaccompanied minors for becoming established in Swedish society
- 2019
-
Ingår i: The Journal of Refugee Studies. - : Oxford University Press. - 0951-6328 .- 1471-6925. ; 32:3, s. 372-396
-
Tidskriftsartikel (refereegranskat)abstract
- Settling in a new host country as an unaccompanied minor holds a lot of challenges such as adaptation of new social norms, learning a new language and understanding a new culture. Social networks may foster good conditions for settlement in the host community but little is known about the availability, quality and significance of social networks for unaccompanied minors (UM) in Sweden. The aim of this qualitative grounded-theory situational study was to explore experiences of social networks among UM and the significance of those networks for becoming established in Sweden, based on data from in-depth interviews with 11 young persons. Unaccompanied young persons were broadly found to be involved in three different kinds of networks: professional carers, like-ethnic friends and ‘Swedes’ in general. Networks with professionals (i.e. linking social capital) were perceived as both a secure base and a source of rejection, and could either facilitate or obstruct the establishment. Supporting networks with like-ethnic friends (bonding social capital) proved to be the most available and important resource for becoming established, while access to networks with Swedes (bridging social capital) was in general low but still perceived as important for becoming established, not least for reducing language and cultural barriers.
|
|
| 8. |
- Eriksson, Malin, et al.
(författare)
-
Utvärdering av insatser för ensamkommande barn och ungdomar i Umeå 2012-2013 : slutrapport
- 2014
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I denna slutrapport redovisas en utvärdering av hur mottagningssystemet och samhällets insatser för ensamkommande barn och ungdomar har utformats och fungerat i Umeå kommun under perioden 2012-2013. Rapporten har utvecklats inom ramen för forskningsprojektet ”Hur fungerar samhällets insatser för ensamkommande flyktingungdomar?” och handlar om flyktingungdomars introduktion och etablering i det svenska samhället.En av slutsatserna är att det saknas en tydlig politisk styrning och vägledning av mottagandet av ensamkommande i Umeå och att aktörerna i hög grad själva har fått tolka sina uppdrag och samordna insatserna. En annan slutsats är att samhällets insatser har bidragit till att stödja, stärka och förbereda ungdomarna på att leva i Sverige och till att socialisera dem till vad som förväntas och krävs för att anpassa sig i det svenska samhället, men det finns stora utmaningar när det gäller ungdomarnas fortsatta integration i samhället.I rapporten presenteras också rekommendationer för hur mottagandet kan utvecklas. Bland annat rekommenderas att de olika aktörernas uppdrag förtydligas och att en mer utvecklad målsättning och vägledning för Umeå kommuns mottagande av ensamkommande arbetas fram. Aktörerna bör också utveckla och pröva nya sätt att främja ungdomarnas integration i samhället som bättre tillvaratar resurser i civilsamhället.Forskningsprojektet har utvecklats och genomförts av en tvärvetenskaplig forskargrupp vid Umeå universitet i samverkan med Umeå kommun och KFUM i Umeå. Projektet har medfinansierats av Europeiska Flyktingfonden.
|
|
| 9. |
|
|
| 10. |
- Ghazinour, Mehdi, 1967-, et al.
(författare)
-
Are the problems and motives clear enough? : A study on the placement of unaccompanied asylum-seeking minors at compulsory care institutions in Sweden
- 2021
-
Ingår i: The Journal of Refugee Studies. - : Oxford University Press. - 0951-6328 .- 1471-6925. ; 34:2, s. 1675-1694
-
Tidskriftsartikel (refereegranskat)abstract
- The Swedish National Board of Institutional Care (SNBIC) is an independent governmental agency that provides compulsory care for minors with psychosocial problems, criminal behavior, and substance abuse. During recent years, a noticeable number of the youth placed at compulsory care institutions have been asylum-seeking minors who have arrived in Sweden without parents or guardians. This steady increase in placements has raised questions and concerns among the involved actors regarding the motives and needs underlying these placements. This qualitative study investigates the main motives that lead unaccompanied asylum-seeking minors to be placed at SNBIC residential homes and the problems that are to be solved during their placement, according to social workers and SNBIC staff. The study is based on 28 in-depth interviews with social workers and SNBIC staff. Findings indicate clear disagreement between social workers and SNBIC staff with regard to the motives for placing unaccompanied minors at SNBIC homes. Although the social workers and SNBIC staff explain that most of the unaccompanied youth placed at SNBIC homes have some form of criminal behavior or substance abuse, SNBIC staff believe, in some cases, the problem is not sufficiently serious to warrant compulsory care. As these disagreements and misunderstandings between the actors have an impact on their collaboration and, consequently, the situation of the unaccompanied minors, all attempts to reach a consensus on the leading causes for placement and the problems that need to be solved with SNBIC placement would increase security for both the young people and the relevant staff.
|
|
| 11. |
- Ghazinour, Mehdi, 1967-, et al.
(författare)
-
Ensamkommande barns placering vid SiS särskilda ungdomshem : Vilka placeras, hur mår de och vilka insatser får de?
- 2019
-
Ingår i: Socialmedicinsk Tidskrift. - Stockholm : Socialmedicinsk tidskrift. - 0037-833X. ; 96:1, s. 22-37
-
Tidskriftsartikel (refereegranskat)abstract
- Antalet asylsökande barn har globalt ökat dramatiskt de senaste åren och Sverige har under flera år mottagit ensamkommande ungdomar. Deras behov har tillgodosetts genom samarbete mellan ett stort antal aktörer. De senaste åren har antalet ensamkommande ungdomar som placerats för tvångsvård vid SiS särskilda ungdomshem ökat. Syftet med denna artikel är att beskriva vad som kännetecknar ensamkommande ungdomar som placeras på SiS särskilda ungdomshem, beträffande bakgrund, asylstatus, hälsa och tillgång till sociala nätverk samt att beskriva de insatser som genomförs vid placering av ensamkommande ungdomar på SiS. Resultaten baseras på en genom-gång av avidentifierade journaler från 25 ensamkommande ungdomar som varit placerade på SiS under 2015, och visar att gruppen som sådan består av en majoritet pojkar, flertalet har traumatiska upplevelser i sitt förflutna, en majoritet har en dokumenterad psykisk ohälsa, tillgången till sociala nätverk i Sverige är begränsad och flertalet saknar uppehållstillstånd i Sverige.
|
|
| 12. |
- Hanberger, Anders, 1953-, et al.
(författare)
-
Local Service-Delivery Networks for Unaccompanied Children in Sweden : evaluating Their Effectiveness
- 2016
-
Ingår i: Journal of social service research. - : Routledge. - 0148-8376 .- 1540-7314. ; 42:5, s. 675-688
-
Tidskriftsartikel (refereegranskat)abstract
- This article defines the effectiveness of local service-delivery networks for unaccompanied and separated children (UASC) and develops criteria for evaluating the effectiveness of such networks in Sweden. It also explores factors and conditions that enhance network performance and suggests that cultural and multicultural competences are required for such networks to be effective. Twentyone evaluation criteria are developed for enhancing network performance generated from research into UASC, network governance theory, and the authors’ own evaluation of the reception of UASC in a Swedish municipality. The evaluation and this article are based on 32 interviews with social workers, legal guardians, care-home staff, teachers and school personnel, a questionnaire, and 11 interviews with UASC. The article reanalyzes data from the authors’ evaluation study finalized in 2014 and applies the criteria tentatively on this reception system. Experiences and findings include the importance of taking into account client needs and involvement in services when evaluating the effectiveness of service-delivery networks. The criteria can productively inform policy and practice when actors deliberate on how to assess and improve local reception-system and servicedelivery-network performance in different contexts.
|
|
| 13. |
|
|
| 14. |
- Klevstig, Martina, et al.
(författare)
-
Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia
- 2019
-
Ingår i: Journal of Molecular and Cellular Cardiology. - : Elsevier BV. - 0022-2828 .- 1095-8584. ; 137, s. 1-8
-
Tidskriftsartikel (refereegranskat)abstract
- Aims: The microsomal triglyceride transport protein (MTTP) is critical for assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins and is most abundant in the liver and intestine. Surprisingly, MTTP is also expressed in the heart. Here we tested the functional relevance of cardiac MTTP expression. Materials and methods: We combined clinical studies, advanced expression analysis of human heart biopsies and analyses in genetically modified mice lacking cardiac expression of the MTTP-A isoform of MTTP. Results: Our results indicate that lower cardiac MTTP expression in humans is associated with structural and perfusion abnormalities in patients with ischemic heart disease. MTTP-A deficiency in mice heart does not affect total MTTP expression, activity or lipid concentration in the heart. Despite this, MTTP-A deficient mice displayed impaired cardiac function after a myocardial infarction. Expression analysis of MTTP indicates that MTTP expression is linked to cardiac function and responses in the heart. Conclusions: Our results indicate that MTTP may play an important role for the heart function in conjunction to ischemic events.
|
|
| 15. |
- Li Zweifel, Ulla, et al.
(författare)
-
God havsmiljö 2020 : Marin strategi för Nordsjön och Östersjön Del 2: God miljöstatus och miljökvalitetsnormer
- 2012
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Havsmiljöförordningens övergripande mål är att upprätthålla eller uppnå en god miljöstatus i de svenska förvaltningsområdena Nordsjön och Östersjön till år 2020. En av uppgifterna i den första förvaltningsperioden är att bestämma vad som kännetecknar god miljöstatus i respektive förvaltningsområde samt att ta fram miljökvalitetsnormer. God miljöstatus baseras på ett ramverk av så kallade deskriptorer som anges i havsmiljödirektivet, det vill säga det EU-direktiv som i Sverige genomförs genom havsmiljöförordningen. Deskriptorerna beskriver god miljöstatus på en övergripande nivå för 11 temaområden. Till varje deskriptor hör en rad kriterier som anger vad som ska ingå i en bedömning av miljöstatus. I Sverige har god miljöstatus formulerats för samtliga 29 kriterier som ska beaktas enligt direktivet. Dessa kvalitativa beskrivningar anger vad som kännetecknar god miljöstatus i Nordsjön och Östersjön. För att praktiskt bedöma om god miljöstatus har uppnåtts föreslås 37 nationella indikatorer. En uppsättning av indikatorer omfattar miljöns tillstånd och avspeglar ekosystemets komponenter i form av nyckelarter, samhällen, och livsmiljöer. En utgångspunkt vid val av indikatorer för miljöns tillstånd har varit koppling till de belastningar som i den inledande bedömningen av miljötillståndet i Nordsjön och Östersjön bedömts ha stor negativ påverkan på ekosystemet. En annan uppsättning indikatorer berör påverkan och belastning på miljön i form av tillförsel av näringsämnen och farliga ämnen, samt biologisk och fysisk störning av miljön. Tillsammans utgör indikatorerna ett verktyg för att följa utvecklingen av miljötillståndet och effekter av åtgärder i havsmiljön. Vid val av indikatorer har arbetet delvis utgått från existerande miljöövervakning och redan utvecklade indikatorer. Med denna utgångspunkt uppfylls en rad av havsmiljödirektivets krav, bland annat en god uppföljning av effekter av tillförsel av näringsämnen. Funktionella indikatorer, det vill säga indikatorer som utvärderats och för vilka god miljöstatus har definierats, saknas dock för tio av havsmiljödirektivets 29 kriterier. För uppföljning av biologisk mångfald saknas bland annat miljöövervakning och metoder för att bedöma livsmiljöers tillstånd. För att kunna bedöma fysiska skador på havsbotten saknas en övergripande sammanställning av information om aktiviteter som påverkar havsbottnar samt metodik för att bedöma effekterna. Det saknas också utvecklade indikatorer för det kriterium som berör uppföljning av storleks- och åldersstruktur hos fiskar. Brist på kunskap gör också att inga förslag på svenska indikatorer kan ges för effekter på levande organismer från marint avfall, undervattensbuller, och främmande arter samt att endast ett begränsat antal indikatorer tagits fram som speglar effekter av farliga ämnen. De indikatorer som fastställs i juli 2012 utgör således inte en slutlig lista för att följa upp havsmiljödirektivet. Bristerna kommer att beaktas i det fortsatta genomförandet av havsmiljöförordningen där nästa steg är att anpassa miljöövervakningsprogrammen till uppföljning av miljötillståndet med valda indikatorer senast år 2014 samt att ta fram åtgärdsprogram till år 2015. God miljöstatus ska uppnås genom tillämpning av miljökvalitetsnormer det vill säga rättsligt bindande regler som avspeglar den lägsta godtagbara miljökvaliteten i Nordsjön och Östersjön. För att nå god miljöstatus har elva svenska miljökvalitetsnormer formulerats. Dessa miljökvalitetsnormer omfattar belastning i form av näringsämnen, farliga ämnen, främmande arter, uttag av arter, fysisk påverkan på havsbottnar och avfall i havsmiljön. Målsättningen har varit att utforma miljökvalitetsnormer som motsvarar alla de belastningar som i den inledande bedömningen har identifierats ha en stor påverkan på miljön.
|
|
| 16. |
- Näsman, Mattias, 1989-, et al.
(författare)
-
A promised land? : First summary of the research program
- 2023
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This document lays out the background for the research program “A promised land? Drivers, challenges and opportunities related to the (green) industrialization of Northern Sweden,” (nr. M22-0029) awarded by the Swedish Riksbankens Jubileumsfond’s in 2022. The document summarizes work in progress and may therefore be updated and republished in different versions according to the requirements of the program. This interdisciplinary program aims to understand the economic, social, and political challenges and opportunities of the ongoing industrial transformation in northern Sweden. A key element of the program is to identify drivers, obstacles, and preconditions in a historical, present, and forward-looking process-perspective.
|
|
| 17. |
- Strandh, Veronica, 1982-, et al.
(författare)
-
Allmänhetens kännedom om våldsbejakandeextremism och om kommunernas arbete
- 2018
-
Ingår i: Mänsklig säkerhet.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Kommunernas roll i det förebyggande arbetet mot våldsbejakande extremism framhålls ofta som central. Kraven och förväntningarna på kommunerna har ökat och många har idag inte bara lokala samordnare mot våldsbejakande extremism, utan också egna handlingsplaner. Kunskap och forskning om hur kommunerna arbetar har dessutom vuxit. Hur allmänheten ser på kommunernas arbete och på våldsbejakande extremism som fenomen vet vi emellertid mindre om. I den här artikeln redovisas en delmängd från en nationell enkätundersökning som ingår i ett forskningsprojekt vid Umeå universitet om radikalisering och lokal motståndskraft. Resultat från enkätundersökningen visar bland annat att våldsbejakande extremism oroar allmänheten men att få vet till vem man på lokal nivå skall vända sig med frågor som rör detta och att förtroendet för kommunernas arbete är relativt lågt.
|
|
| 18. |
|
|
| 19. |
- Wimelius, Malin E., 1972-, et al.
(författare)
-
Swedish reception of unaccompanied refugee children : promoting integration?
- 2017
-
Ingår i: Journal of International Migration and Integration. - : Springer. - 1488-3473 .- 1874-6365. ; 18:1, s. 143-157
-
Tidskriftsartikel (refereegranskat)abstract
- In this article we describe and analyse the Swedish reception of unaccompanied refugee children and efforts to promote their integration into Swedish society. We identify the actors involved in the reception and promotion of the children's integration and investigate their efforts through the lens of social ecological systems theory. We show that reception is fraught with challenges that concern lack of interconnections between actors; lack of an articulated political vision of integration and absence of systematic evaluations and long-term follow-ups of how the reception effects integration.
|
|
| 20. |
- Abzhandadze, Tamar, 1980, et al.
(författare)
-
Transforming self-reported outcomes from a stroke register to the modified Rankin Scale: a cross-sectional, explorative study
- 2020
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
-
Tidskriftsartikel (refereegranskat)abstract
- The aim was to create an algorithm to transform self-reported outcomes from a stroke register to the modified Rankin Scale (mRS). Two stroke registers were used: the Vaststroke, a local register in Gothenburg, Sweden, and the Riksstroke, a Swedish national register. The reference variable, mRS (from Vaststroke), was mapped with seven self-reported questions from Riksstroke. The transformation algorithm was created as a result of manual mapping performed by healthcare professionals. A supervised machine learning method-decision tree-was used to further evaluate the transformation algorithm. Of 1145 patients, 54% were male, the mean age was 71 y. The mRS grades 0, 1 and 2 could not be distinguished as a result of manual mapping or by using the decision tree analysis. Thus, these grades were merged. With manual mapping, 78% of the patients were correctly classified, and the level of agreement was almost perfect, weighted Kappa (K-w) was 0.81. With the decision tree, 80% of the patients were correctly classified, and substantial agreement was achieved, K-w=0.67. The self-reported outcomes from a stroke register can be transformed to the mRS. A mRS algorithm based on manual mapping might be useful for researchers using self-reported questionnaire data.
|
|
| 21. |
- Ahlborg, Mikael G., et al.
(författare)
-
SoCap YMH - youth mental health, social capital and help-seeking : a study protocol
- 2024
-
Ingår i: Frontiers in Public Health. - : Frontiers Media S.A.. - 2296-2565. ; 12
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The increase in adolescents reporting mental health problems presents a major public health challenge. The complex association between mental health and social capital motivates further investigation of social capital as a crucial aspect in shaping adolescents' help-seeking knowledge, attitudes, and behaviours.Aim: This protocol presents a project that aims to investigate social capital in relation to help-seeking and mental health in close collaboration with adolescents and key stakeholders in the school setting, in the southern part of Sweden.Methods: A mixed-method design with three interconnected work packages (WP) will be undertaken with an emphasis on co-production where adolescents are involved throughout the process. WP1 is a development and validation of two questionnaire instruments for assessing social capital and help-seeking in adolescence. WP2 is a longitudinal quantitative study involving 1,500 adolescents from two regions representing rural and suburban/urban settings. Adolescents aged 15 will be asked to complete questionnaires concerning social capital, mental health, and help-seeking in a baseline and one-year follow-up, allowing for investigation of the role of social capital for help-seeking. WP3 is designed to elucidate experiences and knowledge of adolescents and key stakeholders via collaborative World Café workshops. These will be held along the project to evolve the generated knowledge and maximize it's applicability during and after the project is finalized.Conclusion: The results are expected to further the understanding of the relationship between adolescents' social capital, mental health, and help-seeking, to contribute to a deeper understanding of the mechanisms behind the paradoxical help-seeking patterns among adolescents today and to narrow the gap between research and practice to produce sustainable and efficient strategies, which may facilitate help-seeking and improve the mental health of adolescents within existing organizational structures.
|
|
| 22. |
- Ahlborg, Mikael, 1985-
(författare)
-
Social capital and inequalities in mental health among young adolescents in Sweden
- 2022
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this thesis was to explore social capital and inequalities in mental health among young adolescents in Sweden. This is a compilation thesis comprising four studies. Studies I and II are quantitative studies of crosssectional data from the Swedish Health Behaviour in School-aged Children survey. The aim of Study I was to investigate socioeconomic inequalities in health using both a subjective and an objective measure of socioeconomic status among Swedish adolescents. The findings showed that subjective socioeconomic status robustly and independently predicted mental health problems, poor life satisfaction and poor general health perception. The association between objective socioeconomic status and mental health was weakened, and even reversed, when subjective socioeconomic status was accounted for in regression models. A Latent Profile Analysis was applied in Study II with the aim of identifying distinct profiles of family, school and peer social capital in a nationally representative sample of adolescents and to explore health outcomes in those profiles. The findings showed that five distinct profiles best represented the data for 11 and 15-year olds, while a four-profile model was optimal for 13-year olds. Significant inequalities were identified between profiles when these were examined in terms of mental health problems and life satisfaction. The design of Study III was a qualitative semi-structured interview study. The aim was to explore social capital from the perspective of adolescents in relation to mental health. Adolescents spoke of having access to a safe space, feeling connected to others and predictability as important aspects of social relationships and networks in relation to mental health. The aim of Study IV was to identify and evaluate the design and psychometric properties of instruments for assessing social capital specifically developed and validated for self-reporting among adolescents (10-19 years). The design was a systematic review, in which 20 instruments were identified. The results revealed a lack of instruments that covered both the multidimensionality of social capital and contextual relevance in relation to adolescents. The conclusion from this thesis is that social capital may be useful for identifying vulnerable individuals and for differentiating between the natural imbalance of adolescence and what may lead to serious illness. Longitudinal research and refinement of the operationalization of the concept are, however, needed to enhance the understanding of these findings.
|
|
| 23. |
|
|
| 24. |
- Ahlinder, Jon, et al.
(författare)
-
Upstream land use with microbial downstream consequences : iron and humic substances link to Legionella spp
- 2024
-
Ingår i: Water Research. - : Elsevier. - 0043-1354 .- 1879-2448. ; 256
-
Tidskriftsartikel (refereegranskat)abstract
- Intensified land use can disturb water quality, potentially increasing the abundance of bacterial pathogens, threatening public access to clean water. This threat involves both direct contamination of faecal bacteria as well as indirect factors, such as disturbed water chemistry and microbiota, which can lead to contamination. While direct contamination has been well described, the impact of indirect factors is less explored, despite the potential of severe downstream consequences on water supply. To assess direct and indirect downstream effects of buildings, farms, pastures and fields on potential water sources, we studied five Swedish lakes and their inflows. We analysed a total of 160 samples in a gradient of anthropogenic activity spanning four time points, including faecal and water-quality indicators. Through species distribution modelling, Random Forest and network analysis using 16S rRNA amplicon sequencing data, our findings highlight that land use indirectly impacts lakes via inflows. Land use impacted approximately one third of inflow microbiota taxa, in turn impacting ∌20–50 % of lake taxa. Indirect effects via inflows were also suggested by causal links between e.g. water colour and lake bacterial taxa, where this influenced the abundance of several freshwater bacteria, such as Polynucleobacter and Limnohabitans. However, it was not possible to identify direct effects on the lakes based on analysis of physiochemical- or microbial parameters. To avoid potential downstream consequences on water supply, it is thus important to consider possible indirect effects from upstream land use and inflows, even when no direct effects can be observed on lakes. Legionella (a genus containing bacterial pathogens) illustrated potential consequences, since the genus was particularly abundant in inflows and was shown to increase by the presence of pastures, fields, and farms. The approach presented here could be used to assess the suitability of lakes as alternative raw water sources or help to mitigate contaminations in important water catchments. Continued broad investigations of stressors on the microbial network can identify indirect effects, avoid enrichment of pathogens, and help secure water accessibility.
|
|
| 25. |
|
|
| 26. |
- Al Musawi, Ahmed, et al.
(författare)
-
Intervention for a correct medication list and medication use in older adults : a non-randomised feasibility study among inpatients and residents during care transitions
- 2024
-
Ingår i: International Journal of Clinical Pharmacy. - : Springer. - 2210-7703 .- 2210-7711.
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundMedication discrepancies in care transitions and medication non-adherence are problematic. Few interventions consider the entire process, from the hospital to the patient's medication use at home.AimIn preparation for randomised controlled trials (RCTs), this study aimed (1) to investigate the feasibility of recruitment and retention of patients, and data collection to reduce medication discrepancies at discharge and improve medication adherence, and (2) to explore the outcomes of the interventions.MethodParticipants were recruited from a hospital and a residential area. Hospital patients participated in a pharmacist-led intervention to establish a correct medication list upon discharge and a follow-up interview two weeks post-discharge. All participants received a person-centred adherence intervention for three to six months. Discrepancies in the medication lists, the Beliefs about Medicines Questionnaire (BMQ-S), and the Medication Adherence Report Scale (MARS-5) were assessed.ResultsOf 87 asked to participate, 35 were included, and 12 completed the study. Identifying discrepancies, discussing discrepancies with physicians, and performing follow-up interviews were possible. Conducting the adherence intervention was also possible using individual health plans for medication use. Among the seven hospital patients, 24 discrepancies were found. Discharging physicians agreed that all discrepancies were errors, but only ten were corrected in the discharge information. Ten participants decreased their total BMQ-S concern scores, and seven increased their total MARS-5 scores.ConclusionBased on this study, conducting the two RCTs separately may increase the inclusion rate. Data collection was feasible. Both interventions were feasible in many aspects but need to be optimised in upcoming RCTs.
|
|
| 27. |
- Albertsson, Anna-Karin, et al.
(författare)
-
PLUS Borås : Om professionsutveckling och dokumentation
- 2009
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- PLUS betyder Projekt för Läsutveckling, Utvärdering och Samverkan. Det handlar om lässtimulerande arbete bland barn från nyfödd upp till 16 år och omfattar alltså alla barn- och skolbibliotekarier i Borås. Folkbiblioteken i Borås består av Stadsbiblioteket och nio kommundelsbibliotek. I kommundelarna är skol- och folkbiblioteken samorganiserade eller i nära samverkan. Samtliga högstadieskolor och flera låg- och mellanstadieskolor har fackutbildade bibliotekarier. Alla folkbiblioteksenheter har barnbibliotekarietjänster. Stadsbiblioteket ansvarar för att barnbibliotekarier och skolbibliotekarier träffas regelbundet i sina respektive nätverk. Läsfrämjande arbete bedrivs på alla bibliotek, drygt trettio personer arbetar med det på varsitt håll. Det finns mycket kunskap och gedigen erfarenhet men tid för reflektion och bollande med idéer för inspiration och metodikutveckling är mycket begränsad. Idéer till projektets innehåll baseras i strävan att knyta alla bibliotekarier som arbetar med språk- och läsutvecklingen till en gemensam bas och därmed skapa förutsättningar för ett utvecklingsarbete i hela kommunen.
|
|
| 28. |
- Aldi, Silvia, et al.
(författare)
-
Dual roles of heparanase in human carotid plaque calcification
- 2019
-
Ingår i: Atherosclerosis. - : ELSEVIER IRELAND LTD. - 0021-9150 .- 1879-1484. ; 283, s. 127-136
-
Tidskriftsartikel (refereegranskat)abstract
- Background and aims: Calcification is a hallmark of advanced atherosclerosis and an active process akin to bone remodeling. Heparanase (HPSE) is an endo-beta-glucuronidase, which cleaves glycosaminoglycan chains of heparan sulfate proteoglycans. The role of HPSE is controversial in osteogenesis and bone remodeling while it is unexplored in vascular calcification. Previously, we reported upregulation of HPSE in human carotid endarterectomies from symptomatic patients and showed correlation of HPSE expression with markers of inflammation and increased thrombogenicity. The present aim is to investigate HPSE expression in relation to genes associated with osteogenesis and osteolysis and the effect of elevated HPSE expression on calcification and osteolysis in vitro.Methods: Transcriptomic and immunohistochemical analyses were performed using the Biobank of Karolinska Endarterectomies (BiKE). In vitro calcification and osteolysis were analysed in human carotid smooth muscle cells overexpressing HPSE and bone marrow-derived osteoclasts from HPSE-transgenic mice respectively.Results: HPSE expression correlated primarily with genes coupled to osteoclast differentiation and function in human carotid atheromas. HPSE was expressed in osteoclast-like cells in atherosclerotic lesions, and HPSE-transgenic bone marrow-derived osteoclasts displayed a higher osteolytic activity compared to wild-type cells. Contrarily, human carotid SMCs with an elevated HPSE expression demonstrated markedly increased mineralization upon osteogenic differentiation.Conclusions: We suggest that HPSE may have dual functions in vascular calcification, depending on the stage of the disease and presence of inflammatory cells. While HPSE plausibly enhances mineralization and osteogenic differentiation of vascular smooth muscle cells, it is associated with inflammation-induced osteoclast differentiation and activity in advanced atherosclerotic plaques.
|
|
| 29. |
- Alexanderson, Camilla, 1978, et al.
(författare)
-
Early postnatal oestradiol exposure causes insulin resistance and signs of inflammation in circulation and skeletal muscle.
- 2009
-
Ingår i: The Journal of endocrinology. - 1479-6805. ; 201:1, s. 49-58
-
Tidskriftsartikel (refereegranskat)abstract
- Early postnatal events can predispose to metabolic and endocrine disease in adulthood. In this study, we evaluated the programming effects of a single early postnatal oestradiol injection on insulin sensitivity in adult female rats. We also assessed the expression of genes involved in inflammation and glucose metabolism in skeletal muscle and adipose tissue and analysed circulating inflammation markers as possible mediators of insulin resistance. Neonatal oestradiol exposure reduced insulin sensitivity and increased plasma levels of monocyte chemoattractant protein-1 (MCP-1) and soluble intercellular adhesion molecule-1. In skeletal muscle, oestradiol increased the expression of genes encoding complement component 3 (C3), Mcp-1, retinol binding protein-4 (Rbp4) and transforming growth factor beta1 (Tgfbeta1). C3 and MCP-1 are both related to insulin resistance, and C3, MCP-1 and TGFbeta1 are also involved in inflammation. Expression of genes encoding glucose transporter-4 (Glut 4), carnitine-palmitoyl transferase 1b (Cpt1b), peroxisome proliferator-activated receptor delta (Ppard) and uncoupling protein 3 (Ucp3), which are connected to glucose uptake, lipid oxidation, and energy uncoupling, was down regulated. Expression of several inflammatory genes in skeletal muscle correlated negatively with whole-body insulin sensitivity. In s.c. inguinal adipose tissue, expression of Tgfbeta1, Ppard and C3 was decreased, while expression of Rbp4 and Cpt1b was increased. Inguinal adipose tissue weight was increased but adipocyte size was unaltered, suggesting an increased number of adipocytes. We suggest that early neonatal oestrogen exposure may reduce insulin sensitivity by inducing chronic, low-grade systemic and skeletal muscle inflammation and disturbances of glucose and lipid metabolism in skeletal muscle in adulthood.
|
|
| 30. |
- Alexanderson, Camilla, 1978, et al.
(författare)
-
Postnatal testosterone exposure results in insulin resistance, enlarged mesenteric adipocytes, and an atherogenic lipid profile in adult female rats: comparisons with estradiol and dihydrotestosterone.
- 2007
-
Ingår i: Endocrinology. - : The Endocrine Society. - 0013-7227 .- 1945-7170. ; 148:11, s. 5369-76
-
Tidskriftsartikel (refereegranskat)abstract
- Postnatal events contribute to features of the metabolic syndrome in adulthood. In this study, postnatally administered testosterone reduced insulin sensitivity and increased the mesenteric fat depot, the size of mesenteric adipocytes, serum levels of total cholesterol, low-density lipoprotein cholesterol, and triglycerides, and the atherogenic index in adult female rats. To assess the involvement of estrogen and androgen receptors in these programming effects, we compared testosterone-exposed rats to rats exposed to estradiol or dihydrotestosterone (DHT). Estradiol-treated rats had lower insulin sensitivity than testosterone-treated rats and, like those rats, had enlarged mesenteric adipocytes and increased triglyceride levels. DHT also reduced insulin sensitivity but did not mimic the other metabolic effects of testosterone. All treated rats were probably anovulatory, but only those treated with testosterone had reduced testosterone levels. This study confirms our previous finding that postnatal administration of testosterone reduces insulin sensitivity in adult female rats and shows that this effect is accompanied by unfavorable changes in mesenteric fat tissue and in serum lipid levels. The findings in the estradiol and DHT groups suggest that estrogen receptors exert stronger metabolic programming effects than androgen receptors. Thus, insults such as sex hormone exposure in early life may have long-lasting effects, thereby creating a predisposition to disturbances in insulin sensitivity, adipose tissue, and lipid profile in adulthood.
|
|
| 31. |
- Almby, Kristina E., et al.
(författare)
-
Effects of Gastric Bypass Surgery on the Brain : Simultaneous Assessment of Glucose Uptake, Blood Flow, Neural Activity, and Cognitive Function During Normo- and Hypoglycemia
- 2021
-
Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 70:6, s. 1265-1277
-
Tidskriftsartikel (refereegranskat)abstract
- While Roux-en-Y gastric bypass (RYGB) surgery in obese individuals typically improves glycemic control and prevents diabetes, it also frequently causes asymptomatic hypoglycemia. Previous work showed attenuated counterregulatory responses following RYGB. The underlying mechanisms as well as the clinical consequences are unclear. In this study, 11 subjects without diabetes with severe obesity were investigated pre- and post-RYGB during hyperinsulinemic normo-hypoglycemic clamps. Assessments were made of hormones, cognitive function, cerebral blood flow by arterial spin labeling, brain glucose metabolism by F-18-fluorodeoxyglucose (FDG) positron emission tomography, and activation of brain networks by functional MRI. Post- versus presurgery, we found a general increase of cerebral blood flow but a decrease of total brain FDG uptake during normoglycemia. During hypoglycemia, there was a marked increase in total brain FDG uptake, and this was similar for post- and presurgery, whereas hypothalamic FDG uptake was reduced during hypoglycemia. During hypoglycemia, attenuated responses of counterregulatory hormones and improvements in cognitive function were seen postsurgery. In early hypoglycemia, there was increased activation post- versus presurgery of neural networks in brain regions implicated in glucose regulation, such as the thalamus and hypothalamus. The results suggest adaptive responses of the brain that contribute to lowering of glycemia following RYGB, and the underlying mechanisms should be further elucidated.
|
|
| 32. |
- Ander, Magnus, et al.
(författare)
-
Elchockvapen som hjälpmedel vid polisiära ingripanden : En vetenskaplig utvärdering av Polismyndighetens försöksverksamhet med elchockvapen 2018-2019
- 2020
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- BAKGRUND: Ur ett internationellt perspektiv har det, inom polisen, under de senaste åren skett en ökning i användandet av mindre dödliga vapen. Dessa vapen används för att ta kontroll över potentiellt farliga och icke samarbetsvilliga personer. Ett vanligt förekommande mindre dödligt vapen är elchockvapen (ECV). Elchockvapen har fram till 2018 inte använts i Sverige, men Polismyndigheten har under åren 2018–2019 genomfört en försöksverksamhet med ECV.SYFTE: Syftet med undersökningen var att utvärdera Polismyndighetens försöksverksamhet med ECV, samt att undersöka vilken legitimitet polisens användning av ECV har bland allmänheten.METOD: Både kvantitativa och kvalitativa data samlades in för att utvärdera försöket med ECV. Mätningar före, under, och i slutet av försöksverksamheten genomfördes med hjälp av en enkät. Enkäten besvarades av två grupper av poliser; en grupp som ingick i försöksverksamheten med ECV samt en kontrollgrupp poliser som inte ingick i försöksverksamheten. För att fördjupa förståelsen för enkätresultaten genomfördes djupintervjuer och fokusgruppsintervjuer med poliser som hade erfarenhet av ECV under försöksverksamheten. För att undersöka legitimitetsaspekter utifrån ett medborgarperspektiv genomfördes fokusgrupper med deltagare från allmänheten. Data från Polisens arbetsskadesystem LISA inhämtades för att undersöka ECV:s inverkan på skador hos poliserna.RESULTAT: Enkätresultaten visade inga skillnader mellan delaktiga och kontrollgrupp när det gäller upplevelse av stressfulla situationer. Upplevelsen av trygghet vid ingripanden med hög grad av motstånd eller när polisen blir fysisk angripen har dock ökat för de poliser som deltagit i ECVförsöket, jämfört med kontrollgruppen. Intervjuresultaten åskådliggör också att tillgången till ECV bidrar till att minska upplevelsen av stress i våldsamma situationer genom att ECV ökar tryggheten i sådana situationer. Intervjuresultaten påvisar även att tillgången till ECV gör att man slipper använda andra potentiellt skadligare våldshjälpmedel såsom fysiska metoder och skjutvapen. Enkätresultatet visar ingen skillnad mellan de som ingick i försöksverksamheten och kontrollgruppen när det gäller att utsättas för hot, våld eller motstånd, eller att polis eller motpart blir skadade. Resultaten från intervjuer och fokusgrupper synliggör att poliserna upplever att ECV fyller en viktig funktion. Poliserna ser enbart fördelar med ECV och vissa menar att det är det bästa verktyg som de har fått. ECV upplevs kunna rädda liv, minska skador på polis och motpart, samt förbättra arbetsmiljön för poliser. Intervjuer och fokusgrupper pekar på att deltagarna upplever att ECV har en deeskalerande inverkan, vilket både kan minska våldsanvändningen, och förebygga våld mot polisen. Enkät och intervjuresultaten indikerar att ECV bidrar till en minskad användning av andra hjälpmedel såsom batong och pepparspray, vilka ofta ger mer skador på både motpart och polis. Deltagarna från allmänheten har uppfattningen att ECV är ett effektivt och bra verktyg för polisen, men lyfter vikten av att det finns en lyhördhet gällande vilka situationer som den används i och mot vem.SLUTSATSER: Utifrån våra enkätresultat är det svårt att dra några säkra slutsatser kring hur användandet av ECV inverkar på skador hos poliser och motpart. Erfarenheterna bland de delaktiga är dock att risken för våld och skador minskar markant, vilket är en viktig indikator. Tillgången till ECV kan öka trygghet och minska stress i ingripandesituationer där kraftigt motstånd och våld förekommer. ECV kan även minska användandet av pepparspray och batong, och det finns indikationer på att ECV har använts istället för skjutvapen. ECV kan underlätta val av hjälpmedel vid ingripanden med hög grad av hot och våld och kan ha en deeskalerande inverkan. Polisens användande av våldshjälpmedel, inklusive ECV, upplevs berättigat av informanterna från allmänheten.
|
|
| 33. |
- Andersen, Malin, 1977-, et al.
(författare)
-
Alternative promoter usage of the membrane glycoprotein CD36
- 2006
-
Ingår i: BMC Molecular Biology. - : Springer Science and Business Media LLC. - 1471-2199. ; 7, s. 8-
-
Tidskriftsartikel (refereegranskat)abstract
- Background: CD36 is a membrane glycoprotein involved in a variety of cellular processes such as lipid transport, immune regulation, hemostasis, adhesion, angiogenesis and atherosclerosis. It is expressed in many tissues and cell types, with a tissue specific expression pattern that is a result of a complex regulation for which the molecular mechanisms are not yet fully understood. There are several alternative mRNA isoforms described for the gene. We have investigated the expression patterns of five alternative first exons of the CD36 gene in several human tissues and cell types, to better understand the molecular details behind its regulation.Results: We have identified one novel alternative first exon of the CD36 gene, and confirmed the expression of four previously known alternative first exons of the gene. The alternative transcripts are all expressed in more than one human tissue and their expression patterns vary highly in skeletal muscle, heart, liver, adipose tissue, placenta, spinal cord, cerebrum and monocytes. All alternative first exons are upregulated in THP-1 macrophages in response to oxidized low density lipoproteins. The alternative promoters lack TATA-boxes and CpG islands. The upstream region of exon 1b contains several features common for house keeping gene and monocyte specific gene promoters.Conclusion: Tissue-specific expression patterns of the alternative first exons of CD36 suggest that the alternative first exons of the gene are regulated individually and tissue specifically. At the same time, the fact that all first exons are upregulated in THP-1 macrophages in response to oxidized low density lipoproteins may suggest that the alternative first exons are coregulated in this cell type and environmental condition. The molecular mechanisms regulating CD36 thus appear to be unusually complex, which might reflect the multifunctional role of the gene in different tissues and cellular conditions.
|
|
| 34. |
- Andersen, Malin, 1977-, et al.
(författare)
-
In silico detection of sequence variations modifying transcriptional regulation
- 2008
-
Ingår i: PloS Computational Biology. - : Public Library of Science (PLoS). - 1553-734X .- 1553-7358. ; 4:1, s. e5-
-
Tidskriftsartikel (refereegranskat)abstract
- Identification of functional genetic variation associated with increased susceptibility to complex diseases can elucidate genes and underlying biochemical mechanisms linked to disease onset and progression. For genes linked to genetic diseases, most identified causal mutations alter an encoded protein sequence. Technological advances for measuring RNA abundance suggest that a significant number of undiscovered causal mutations may alter the regulation of gene transcription. However, it remains a challenge to separate causal genetic variations from linked neutral variations. Here we present an in silico driven approach to identify possible genetic variation in regulatory sequences. The approach combines phylogenetic footprinting and transcription factor binding site prediction to identify variation in candidate cis-regulatory elements. The bioinformatics approach has been tested on a set of SNPs that are reported to have a regulatory function, as well as background SNPs. In the absence of additional information about an analyzed gene, the poor specificity of binding site prediction is prohibitive to its application. However, when additional data is available that can give guidance on which transcription factor is involved in the regulation of the gene, the in silico binding site prediction improves the selection of candidate regulatory polymorphisms for further analyses. The bioinformatics software generated for the analysis has been implemented as a Web-based application system entitled RAVEN ( regulatory analysis of variation in enhancers). The RAVEN system is available at http://www.cisreg.ca for all researchers interested in the detection and characterization of regulatory sequence variation.
|
|
| 35. |
|
|
| 36. |
|
|
| 37. |
|
|
| 38. |
|
|
| 39. |
- Andersson, Håkan S., 1967-, et al.
(författare)
-
The toxicity of ribbon worms: alpha-nemertides or tetrodotoxin, or both?
- 2016
-
Ingår i: Planta Medica. - : Georg Thieme Verlag KG. - 0032-0943 .- 1439-0221. ; 82:Supplement 1
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The marine ribbon worms (nemerteans) are predators which capture their prey by everting a proboscis carrying a mixture of toxins which brings on rapid paralysis [1]. Moreover, ribbon worms have a thick layer of epidermal mucus of similar constitution. Tetrodotoxin (TTX) has been identified as one of these toxins [2]. The extreme toxicity of TTX (lethal by ingestion of 0.5-2 mg) is due to its ability to block voltage-gated sodium channels. Although several bacterial species (among these Vibrio sp.) have been linked to its synthesis, the biogenic origin and biosynthesis is unclear. One hypothesis is that TTX production occurs in a symbiotic relationship with its host, in this case the ribbon worm [3]. We have made significant effort to identify TTX in a setup for production through the cultivation of Vibrio alginolyticus in nutrient broth infused with mucus from the ribbon worm Lineus longissimus. Toxicity was demonstrated by fraction injections into shore crabs, but no TTX was found, and it could be shown conclusively that toxicity was unrelated to TTX and the Vibrio culture itself, and rather a constituent of the ribbon worm mucus [4]. The following studies led us to the discovery of a new class of peptides, the alpha-nemertides, in the mucus of the ribbon worms, which could be directly linked to the toxic effects. A literature review of the available evidence for TTX in ribbon worms show that the evidence in most cases are indirect, although notable exceptions exist. This points to the necessity to further investigate the presence and roles of TTX and alpha-nemertides in ribbon worms.
|
|
| 40. |
- Andersson, Malin, et al.
(författare)
-
How to measure renal artery stenosis - a retrospective comparison of morphological measurement approaches in relation to hemodynamic significance
- 2015
-
Ingår i: BMC Medical Imaging. - : BioMed Central. - 1471-2342. ; 15
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Although it is well known that renal artery stenosis may cause renovascular hypertension, it is unclear how the degree of stenosis should best be measured in morphological images. The aim of this study was to determine which morphological measures from Computed Tomography Angiography (CTA) and Magnetic Resonance Angiography (MRA) are best in predicting whether a renal artery stenosis is hemodynamically significant or not. Methods: Forty-seven patients with hypertension and a clinical suspicion of renovascular hypertension were examined with CTA, MRA, captopril-enhanced renography (CER) and captopril test (Ctest). CTA and MRA images of the renal arteries were analyzed by two readers using interactive vessel segmentation software. The measures included minimum diameter, minimum area, diameter reduction and area reduction. In addition, two radiologists visually judged the diameter reduction without automated segmentation. The results were then compared using limits of agreement and intra-class correlation, and correlated with the results from CER combined with Ctest (which were used as standard of reference) using receiver operating characteristics (ROC) analysis. Results: A total of 68 kidneys had all three investigations (CTA, MRA and CER + Ctest), where 11 kidneys (16.2 %) got a positive result on the CER + Ctest. The greatest area under ROC curve (AUROC) was found for the area reduction on MRA, with a value of 0.91 (95 % confidence interval 0.82-0.99), excluding accessory renal arteries. As comparison, the AUROC for the radiologists' visual assessments on CTA and MRA were 0.90 (0.82-0.98) and 0.91 (0.83-0.99) respectively. None of the differences were statistically significant. Conclusions: No significant differences were found between the morphological measures in their ability to predict hemodynamically significant stenosis, but a tendency of MRA having higher AUROC than CTA. There was no significant difference between measurements made by the radiologists and measurements made with fuzzy connectedness segmentation. Further studies are required to definitely identify the optimal measurement approach.
|
|
| 41. |
- Andersson, Peter, et al.
(författare)
-
Implementation and evaluation of Illness Management and Recovery (IMR) in mandated forensic psychiatric care-Study protocol for a multicenter cluster randomized trial
- 2022
-
Ingår i: Contemporary Clinical Trials Communications. - : Elsevier. - 2451-8654. ; 27
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: Forensic mental health care is hampered by lack of evidence-based treatments. The Swedish forensic mental health population consists of patients suffering from severe illnesses such as schizophrenia and bipolar disorders, similar to populations in international studies. Illness Management and Recovery (IMR) is an intervention for patients with serious mental illness, based on psychoeducational, cognitive-behavioral and motivational components. The purpose is to strengthen participants' illness management skills and recovery.Objective: To test effectiveness of IMR within forensic mental health by comparing it to treatment as usual.Method: This is a cluster-randomized controlled trial. Patients in forensic mental health inpatient units are randomized to an active (IMR) or a control condition (treatment as usual). Clustering of patients is based on ward-units where inpatients are admitted. Patients in the active condition receive two group and one individual IMR sessions per week. The treatment phase is estimated to last nine months. Outcomes include illness related disability, illness management skills, sense of recovery, hope, mental health and security related problems. Outcomes are measured at baseline, four months into treatment, at treatment completion and at three months follow-up. Staff experiences of implementing IMR will be explored by a self-report measure and semi-structured interview based on Normalization Process Theory.Ethics and dissemination: The study is approved by the Swedish Ethical Review Authority (Registration No. 2020-02046). Participation will be voluntary based on written informed consent. Results will be disseminated through peer-reviewed articles and conferences. The study is registered in the US registry of clinical trials (NCT04695132).
|
|
| 42. |
- Andersson-Watz, Anna, 1980-, et al.
(författare)
-
Introducing Mechanically Assisted Cough for Patients with Progressive Neurological Disease : Patient-Physical Therapist Interaction and Physical Therapist Perspective
- 2024
-
Ingår i: Physical Therapy. - : Oxford University Press. - 0031-9023 .- 1538-6724.
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The goal of this study was to explore patient-physical therapist interaction and the physical therapist's experience of the introductory session for mechanical insufflation-exsufflation (MI-E) device treatment for patients with progressive neurological disease.METHODS: Qualitative content analysis of participant-observation of interaction between patients and physical therapists during 9 MI-E introduction sessions in different clinical care settings and 10 follow-up interviews with 6 physical therapists.RESULTS: The introduction of MI-E emerged as a process of instilling a sense of security in the patient. The process can be described in 4 steps: (1) gain understanding by being responsive to the person's whole life-situation; (2) share knowledge and expectations in a respectful and permissive way; (3) introduce the device in a gentle and reciprocal interactivity; and (4) adapt to home-use in an inclusive dialogue with the patient and their significant others. Physical therapists described a need for assurance to instill a sense of security in the patient, implying a need for confidence, competent peers, guiding yet flexible routines, and emotional support.CONCLUSION: Physical therapists have a need to foster assurance in employing a person-centered approach to make a patient feel secure in the process of introducing MI-E treatment. Multiple modes of professional knowledge were used together with action-based and relational-based ethics to facilitate a person-centered care approach. This seems to be a promising approach for providing good care when introducing MI-E to patients. Further research is needed to explore this from the patient's perspective.IMPACT: This study added to the body of knowledge regarding MI-E treatment in relation to patients. This has direct implication, particularly for inexperienced physical therapists, for informed care for the patient during introduction. Our study also supports that person-centered care should be implemented at all levels of health care to make it possible for physical therapists to practice person-centered care.
|
|
| 43. |
|
|
| 44. |
|
|
| 45. |
- Andre, Malin, et al.
(författare)
-
Behandling av patienter med hud- och mjukdelsinfektioner. Resultat av STRAMAs diagnos- och receptundersokning bland allmanlakare
- 2006
-
Ingår i: Läkartidningen. - 0023-7205. ; 103:42, s. 3165-3167
-
Tidskriftsartikel (refereegranskat)abstract
- n one week of November 2000 and 2002, a diagnosis-antibiotic prescribing study was performed in general practice in 5 counties in Sweden. In total 11 515 patients were registered with a diagnosis of an infectious disease. Skin- and soft tissue infections were responsible for 10% of the visits and 13% of the antibioitc prescriptions. Older people (> 65 years) had more skin- and soft tissue infections in comparison to younger people. A high percentage of the patients received antibiotics.
|
|
| 46. |
- André, Malin, 1949-, et al.
(författare)
-
Diagnosis-prescribing surveys in 2000, 2002 and 2005 in Swedish general practice : Consultations, diagnosis, diagnostics and treatment choices
- 2008
-
Ingår i: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 40:8, s. 648-654
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this study is to present diagnostic patterns, diagnostics used and antibiotic treatment in relation to guidelines in 3 repeated diagnosis-prescription studies conducted simultaneously in general practice in 5 Swedish counties, during 1 week in November 2000, 2002 and 2005. General practitioners (GPs) at the participating health centres were asked to complete a form for all patients with symptoms of an infectious disease. During the studied periods a total of 15,371 consultations was registered. Consultations with GPs diagnosed as respiratory tract infection (RTI), especially consultations for sore throat, decreased considerably between y 2000 and 2005. The percentage of patients allocated an RTI diagnosis and prescribed an antibiotic declined significantly from 54% to 49% and the decline was most pronounced among children. Penicillin V remained the dominant antibiotic prescribed throughout the study periods. For lower urinary tract infections there was a significant change in choice of prescribed antibiotics with an increase for pivmecillinam and nitrofurantoin and a decrease for trimethoprim, in accordance with recommendations. The results indicate a quite close adherence to current guidelines, with changes in the pattern of consultations as well as in the management of infectious diseases in general practice in Sweden.
|
|
| 47. |
- André, Malin, 1949-, et al.
(författare)
-
The management of infections in children in general practice in Sweden. : a repeated 1-week diagnosis-prescribing study in 5 counties in 2000 and 2002.
- 2005
-
Ingår i: The Journal of Infectious Diseases. - : Informa UK Limited. - 0022-1899 .- 0036-5548 .- 1651-1980. ; 37:11-12, s. 863-869
-
Tidskriftsartikel (refereegranskat)abstract
- A diagnosis-prescribing study was performed in 5 Swedish counties during 1 week in November in 2000 and repeated in 2002. The aim of the present study was to analyse data for children 0-15y of age who consulted a general practitioner with symptoms of an infection. During the 2 weeks studied, 4049 children were consulted. Respiratory tract infections (RTI) were the predominant diagnoses, above all among the youngest children, while the proportion of urinary tract infections and skin infections increased with increasing age. Between the y 2000 and 2002, the proportion of children allocated the diagnosis streptococcal tonsillitis and pneumonia decreased (p<0.01 and p<0.001, respectively) while the proportion of common cold increased (p<0.001). Antibiotic prescribing decreased from 55% to 48% (p<0.001) for respiratory infections between the years studied. The only significant changes in type of antibiotics prescribed were the increase of isoxazolylpenicillins (p<0.001) used for skin infection and the decrease of macrolides (p=0.001). A diagnostic test was used in more than half of the consultations. Of children allocated a RTI diagnosis, 36% were prescribed antibiotics when a C-reactive protein test was performed compared to 58% in those not tested. Further studies are needed in general practice to determine the optimal use of near-patient tests in children with RTI.
|
|
| 48. |
- André, Malin, et al.
(författare)
-
The Use of CRP Tests in Patients with Respiratory Tract Infections in Primary Care in Sweden Can Be Questioned
- 2004
-
Ingår i: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 36:3, s. 192-197
-
Tidskriftsartikel (refereegranskat)abstract
- A diagnosis-antibiotic prescribing study was performed in 5 counties in Sweden during 1 week in November in 2000 and 2002 respectively. As a part of the study, the use and results of C-reactive protein (CRP) tests in relation to duration of symptoms and antibiotic prescribing in 6778 patients assigned a diagnosis of respiratory tract infections were analysed. In almost half (42%) of the patients, a CRP test was performed. The majority of CRP tests (69%) were performed in patients assigned diagnosis upper respiratory tract infection, where the test is not recommended. Overall, there was a minor decrease in antibiotic prescribing when CRP was used (41%), in comparison to 44% of the patients where no CRP was performed (p<0.01). Patients assigned diagnoses implying a bacterial aetiology were prescribed antibiotics irrespective of result of CRP or length of symptoms before consultation. For patients assigned viral diagnoses, antibiotic prescribing increased with increasing duration of symptoms and increasing value of CRP. The use of CRP decreased antibiotic prescribing in patients assigned to viral diagnoses and with longstanding symptoms (p<0.001). However, 59% of the patients assigned viral diagnoses with CRP≥25 received antibiotics, which seems to indicate a misinterpretation of CRP and a non-optimal use of antibiotics.
|
|
| 49. |
- André, Malin, et al.
(författare)
-
Upper respiratory tract infections in general practice: diagnosis, antibiotic prescribing, duration of symptoms and use of diagnostic tests
- 2002
-
Ingår i: Scandinavian Journal of Infectious Diseases. - : Taylor & Francis. - 2374-4235 .- 0036-5548 .- 1651-1980. ; 34, s. 880-
-
Tidskriftsartikel (refereegranskat)abstract
- A diagnosis/antibiotic prescribing study was performed in 5 counties in Sweden for 1 week in November 2000. As part of this study, the characteristics and clinical management of patients with upper respiratory tract infections (n = 2899) in primary care were analyzed. Almost half of the patients were aged < 15 y and one-fifth of the patients consulted out of hours. Of all patients seeking primary care for upper respiratory tract infections, 56.0% were prescribed an antibiotic. Almost all patients who were given the diagnoses streptococcal tonsillitis, acute otitis media or acute sinusitis were prescribed antibiotics, compared to 10% of patients with common cold or acute pharyngitis. The most frequently prescribed antibiotic was penicillin V (79.2%) and this was even more pronounced out of hours, when the diagnoses otitis media and streptococcal tonsillitis were more frequently used. In patients with common cold and acute pharyngitis, the percentage who received antibiotics increased with increasing length of symptoms and increasing CRP levels. In patients with acute pharyngitis or streptococcal tonsillitis, antibiotics were prescribed less frequently provided streptococcal tests were performed. The management of patients with upper respiratory tract infections in general practice seems to be in good agreement with current Swedish guidelines. However, the study indicates some areas for improvement. The diagnosis of acute sinusitis seems to have been overestimated and used only to justify antibiotic treatment.
|
|
| 50. |
- Asplund, Lillemor, et al.
(författare)
-
Screening av Tetrabrombisfenol A
- 2004
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Tetrabrombisfenol A (TBBPA), CAS nr 79-94-7, är ett flamskyddsmedel med stor användning. Till största delen används det som reaktivt flamskyddsmedel, dvs. TBBPA binds in kemiskt i polymera material. Allt binds dock inte in utan en mindre del kan läcka ut från den flamskyddade produkten (Sellström och Jansson, 1995). En viss användning av TBBPA som additivt flamskyddsmedel förekommer också (KemI, 2000). TBBPA är det flamskyddsmedel som omsätts mest i Sverige, 2001 omsattes 203 ton vilket kan jämföras med 58 ton för hexabromcyklododekan (HBCD). Användningen av HBCD ökade medan användningen av TBBPA minskade enligt KEMI (KemI, 2003, 4/03 ). TBBPA används främst vid tillverkning av flamskyddad epoxy- och polykarbonatplast men även i omättad polyester (WHO/IPCS, 1995). Epoxyplast som flamskyddats med TBBPA används huvudsakligen i kretskort. TBBPA används också i plastinkapslingar av elektroniska komponenter, i kåpor och i höljen till elektrisk utrustning.
|
|
