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| 39. |
- Aine, Mattias, et al.
(författare)
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Biological determinants of bladder cancer gene expression subtypes.
- 2015
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Molecular stratification of tumors by gene expression profiling has been applied to a large number of human malignancies and holds great promise for personalized treatment. Comprehensive classification schemes for urothelial carcinoma have been proposed by three separate groups but have not previously been evaluated simultaneously in independent data. Here we map the interrelations between the proposed molecular subtypes onto the intrinsic structure of a rich independent dataset and show that subtype stratification within each scheme can be explained in terms of a set of common underlying biological processes. We highlight novel biological and genomic drivers of urothelial carcinoma molecular subtypes and show that tumors carrying genomic aberrations characteristic of distinct molecular pathways converge on a common top level phenotype corresponding to the two major molecular subtypes of non-muscle invasive disease.
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| 40. |
- Aine, Mattias, et al.
(författare)
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Integrative epigenomic analysis of differential DNA methylation in urothelial carcinoma.
- 2015
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Ingår i: Genome Medicine. - : Springer Science and Business Media LLC. - 1756-994X. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- Urothelial carcinoma of the bladder (UC) is a common malignancy. Although extensive transcriptome analysis has provided insights into the gene expression patterns of this tumor type, the mechanistic underpinnings of differential methylation remain poorly understood. Multi-level genomic data may be used to profile the regulatory potential and landscape of differential methylation in cancer and gain understanding of the processes underlying epigenetic and phenotypic characteristics of tumors.
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| 41. |
- Aine, Mattias, et al.
(författare)
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On Molecular Classification of Bladder Cancer: Out of One, Many.
- 2015
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Ingår i: European Urology. - : Elsevier BV. - 1873-7560 .- 0302-2838. ; 68:6, s. 921-923
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Tidskriftsartikel (refereegranskat)abstract
- Comparative analysis showed that bladder cancer classification systems identify overlapping subtypes but at different levels. Muscle-invasive bladder cancer shows remarkable heterogeneity, and six subtypes were identified that differ in transcriptional networks, marker profiles, and expression of actionable targets.
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| 42. |
- Bernhardsson, Christian, et al.
(författare)
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Environmental radiation baseline around the Belarusian nuclear power plant – assessments in Belarus and Lithuania
- 2023
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Ingår i: Medical Physics in the Baltic States : Proceedings of the 16<sup>th</sup> International Conference on Medical Physics - Proceedings of the 16<sup>th</sup> International Conference on Medical Physics. - 1822-5721. ; , s. 121-125
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Konferensbidrag (refereegranskat)abstract
- Prior to the operation of the first Belarussian nuclear power plant (BelNPP), the baseline of the radiation environment was determined within a radius of about 30 km from BelNPP. This independent assessment was carried out during two expeditions in 2019. In 2022, a similar survey was carried out (during the initialoperation of BelNPP) on the Lithuanian side of the boarder. Here we present the overall project and some general results of the baseline assessments.
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| 43. |
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| 44. |
- Damberg, Mattias, et al.
(författare)
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Investigation of transcription factor AP-2 beta genotype in women with premenstrual dysphoric disorder.
- 2005
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Ingår i: Neuroscience letters. - : Elsevier BV. - 0304-3940. ; 377:1, s. 49-52
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Tidskriftsartikel (refereegranskat)abstract
- It has repeatedly been shown that the serotonergic system is involved in the symptomatology of premenstrual dysphoric disorder (PMDD). Women with PMDD are reported to differ from symptom-free controls with regard to serotonin-related biological markers. Evidence from family and twin studies suggests a genetic contribution to the aetiology of PMDD. The expression of human transcription factor AP-2beta in neural crest cell lineages and neuroectodermal cells suggests that this protein may be of importance for functional characteristics of neurons by regulating the expression of target genes. Within the monoaminergic systems, several genes have binding sites for AP-2beta in regulatory regions, suggesting an involvement of AP-2beta in these systems. The gene encoding AP-2beta is located on chromosome 6p12-p21.1 and includes a polymorphic region consisting of a variable number of [CAAA] repeats located in the second intron. We have earlier shown that AP-2beta genotype is associated with serotonergic phenotypes and that brainstem levels of AP-2beta correlate positively to serotonin metabolism in rat frontal cortex. The aim of this study was to investigate the relationship between PMDD and transcription factor AP-2beta genotype. The participants included 176 women with PMDD and 91 healthy controls. Genotyping was performed by polymerase chain reactions. We did not observe any differences in AP-2beta genotype frequencies between PMDD subjects and controls. Our results suggest that AP-2beta genotype is not a risk factor for PMDD. To our knowledge, this is the first study investigating transcription factor AP-2beta genotype in women with PMDD. Hence, these results should be considered preliminary until replicated.
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| 45. |
- Eriksson, Daniel, et al.
(författare)
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Analysis and optimization with the Kullback-Leibler divergence for misfire detection using estimated torque
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Engine misfire detection is an important part of the On-Board Diagnostics (OBDII) legislations to reduce exhaust emissions and avoid damage to the catalytic converters. The flywheel angular velocity signal is analyzed, investigating how to use the signal in order to best detect misfires. An algorithm for engine misfire detection is proposed based on the flywheel angular velocity signal. The flywheel signal is used to estimate the torque at the flywheel and a test quantity is designed by weighting and thresholding the samples of estimated torque related to one combustion. During the development process, the Kullback-Leibler divergence is used to analyze the ability to detect a misfire given a test quantity and how the misfire detectability performance varies depending on, e.g., load and speed. The Kullback-Leibler divergence is also used for parameter optimization to maximize the difference between misfire data and fault-free data. Evaluation shows that the proposed misfire detection algorithm is able to have a low probability of false alarms while having a low probability of missed detections.
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| 46. |
- Eriksson, Daniel, 1984-, et al.
(författare)
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Flywheel angular velocity model for misfire and driveline disturbance simulation
- 2013
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Ingår i: Proceedings of the 7th IFAC Symposium on Advances in Automotive Control, The International Federation of Automatic Control. - : Elsevier. ; , s. 570-575
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Konferensbidrag (refereegranskat)abstract
- A flywheel angular velocity model for misfire and disturbance simulation is presented. Applications of the model are, for example, initial parameter calibration and robustness analysis of misfire detection algorithms. An analytical cylinder pressure model is used to model cylinder torque and a multi-body model with torsional flexibilities is used to model crankshaft and driveline oscillations. Misfires, cylinder variations, changes in auxiliary load, and flywheel manufacturing errors can be injected in the model and the resulting speed variations can be simulated. A qualitative validation of the model shows that simulated angular velocity captures the amplitude and oscillatory behavior of measurement data and the effects of different phenomena, such as misfire and flywheel manufacturing errors.
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| 47. |
- Eriksson, Mattias, et al.
(författare)
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Quantification of food waste in public catering services : A case study from a Swedish municipality
- 2017
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Ingår i: Waste Management. - : Elsevier BV. - 0956-053X .- 1879-2456. ; 61, s. 415-422
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Tidskriftsartikel (refereegranskat)abstract
- Food waste is a major problem that must be reduced in order to achieve a sustainable food supply chain. Since food waste valorisation measures, like energy recovery, have limited possibilities to fully recover the resources invested in food production, there is a need to prevent food waste. Prevention is most important at the end of the value chain, where the largest number of sub-processes have already taken place and occur in vain if the food is not used for its intended purpose, i.e. consumption. Catering facilities and households are at the very end of the food supply chain, and in Sweden the public catering sector serves a large number of meals through municipal organisations, including schools, preschools and elderly care homes. Since the first step in waste reduction is to establish a baseline measurement in order to identify problems, this study sought to quantify food waste in schools, preschools and elderly care homes in one municipality in Sweden. The quantification was conducted during three months, spread out over three semesters, and was performed in all 30 public kitchen units in the municipality of Sala. The kitchen staff used kitchen scales to quantify the mass of wasted and served food divided into serving waste (with sub-categories), plate waste and other food waste. The food waste level was quantified as 75 g of food waste per portion served, or 23% of the mass of food served. However, there was great variation between kitchens, with the waste level ranging from 33 g waste per portion served (13%) to 131 g waste per portion served (34%). Wasted food consisted of 64% serving waste, 33% plate waste and 3% other food waste. Preschools had a lower waste level than schools, possibly due to preschool carers eating together with the children. Kitchens that received warm food prepared in another kitchen (satellite kitchens) had a 42% higher waste level than kitchens preparing all food themselves (production units), possibly due to the latter having higher flexibility in cooking the right amount of food and being able to chill and save surplus food. The large variation between kitchens indicates that they have different causes of food waste, but also different opportunities to reduce it. Detailed waste quantification for each kitchen can therefore be the first step in the process of waste reduction.
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| 48. |
- Eriksson, Mattias, et al.
(författare)
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Quantities and quantification methodologies of food waste in Swedish hospitals
- 2020
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Ingår i: Sustainability. - : MDPI AG. - 2071-1050. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- To move towards a sustainable food system, we cannot continue to waste substantial amounts of the food produced. This is especially true for later stages in the food supply chain, where most sub-processes consume resources in vain when food is wasted. Hospitals are located at the end of the food supply chain and the sector has high levels of food waste. This study investigated food waste quantification practices in Swedish hospitals, examined whether a questionnaire is an appropriate methodology for such mapping, and compiled data for the sector in order to determine the amount of food waste and its composition. A questionnaire was sent to all 21 regional authorities, formerly known as county councils, responsible for hospitals in Sweden. The questionnaire responses were supplemented with food waste records from three regions that organize the catering in a total of 20 hospitals. The results showed that it is common practice in most hospitals to quantify food waste, with quantification focusing on lunch and dinner in relation to the number of guests served. It was also clear that waste quantification practices have been established for years, and in the majority of the hospitals studied. The data revealed that, in comparison with other sectors, food waste was still high, 111 g guest(-1) meal(-1), consisting of 42% plate waste, 36% serving waste, and 22% kitchen waste. However, there was great variation between hospitals, which, in combination with well-established, standardized waste quantification routines, meaning that this sector has strong potential to spread best practices and improve overall performance in reducing food waste generation.
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| 49. |
- Eriksson, Mattias, et al.
(författare)
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The tree structure : A general framework for food waste quantification in food services
- 2018
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Ingår i: Resources, Conservation and Recycling. - : Elsevier BV. - 0921-3449 .- 1879-0658. ; 130, s. 140-151
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Tidskriftsartikel (refereegranskat)abstract
- Food waste in the food services industry has been identified as an important unsustainability hotspot, but standardised methods for food waste quantification are lacking. Existing studies on waste quantity assessments have several limitations, such as short and infrequent quantifications times, large methodological variations ranging from physical measurements to visual observations, and lack of comparability across catering unit types. Since lack of comparable waste figures can lead to error-prone analysis, a general framework is needed for waste quantification in food services. This paper presents one such framework that allows data comparisons when overlapping observations are included. The framework was tested in six case studies in professional (public and private) catering units in Sweden. Data were collected from different schools, elderly care homes and hotels and fitted into the framework. The results from these case studies indicate that the framework enables catering units to focus waste quantification on their individual problem areas. It also provides the possibility to extend waste quantification over time without any loss of generalisability. A graphical representation of the framework fits the traditional tree structure and was found to act as a suitable foundation for food waste quantification in food services by structuring collected data. In order to fully utilise the potential of the tree structure, it should be supplemented with precise definitions to create a catering food waste quantification standard.
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| 50. |
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