| 1. |
|
|
| 2. |
- Aggarwal, R, et al.
(författare)
-
2016 American College of Rheumatology/European League Against Rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative
- 2017
-
Ingår i: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 76:5, s. 792-801
-
Tidskriftsartikel (refereegranskat)abstract
- To develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). Expert surveys, logistic regression, and conjoint analysis were used to develop 287 definitions using core set measures. Myositis experts rated greater improvement among multiple pairwise scenarios in conjoint analysis surveys, where different levels of improvement in 2 core set measures were presented. The PAPRIKA (Potentially All Pairwise Rankings of All Possible Alternatives) method determined the relative weights of core set measures and conjoint analysis definitions. The performance characteristics of the definitions were evaluated on patient profiles using expert consensus (gold standard) and were validated using data from a clinical trial. The nominal group technique was used to reach consensus. Consensus was reached for a conjoint analysis-based continuous model using absolute per cent change in core set measures (physician, patient, and extramuscular global activity, muscle strength, Health Assessment Questionnaire, and muscle enzyme levels). A total improvement score (range 0–100), determined by summing scores for each core set measure, was based on improvement in and relative weight of each core set measure. Thresholds for minimal, moderate, and major improvement were ≥20, ≥40, and ≥60 points in the total improvement score. The same criteria were chosen for juvenile DM, with different improvement thresholds. Sensitivity and specificity in DM/PM patient cohorts were 85% and 92%, 90% and 96%, and 92% and 98% for minimal, moderate, and major improvement, respectively. Definitions were validated in the clinical trial analysis for differentiating the physician rating of improvement (p<0.001). The response criteria for adult DM/PM consisted of the conjoint analysis model based on absolute per cent change in 6 core set measures, with thresholds for minimal, moderate, and major improvement.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Ruiz, J. A., et al.
(författare)
-
Autoionisation of superexcited states in N-2 to the N2+B state
- 2003
-
Ingår i: Chemical Physics Letters. - : Elsevier BV. - 0009-2614 .- 1873-4448. ; 372:02-jan, s. 139-146
-
Tidskriftsartikel (refereegranskat)abstract
- Vibrationally resolved N-2(+) (B-X) (1-2) and (0-1) emission bands were recorded after photoexcitation of N-2 in the 20-46 eV energy range. The branching ratio between these transitions reveals strong non-Franck-Condon effects. Ab initio calculations using a configuration interaction method based on Kohn-Sham orbitals indicate that the autoionisation of certain superexcited states is responsible for some structures present in the branching ratio curve.
|
|
| 6. |
- Ruiz, J. M., et al.
(författare)
-
Selective excitation of the np sigma(1)Sigma(+)(u) and np pi(1)Pi(u) to E,F (1)Sigma(+)(g) emission systems in molecular hydrogen using synchrotron radiation
- 2004
-
Ingår i: Chemical Physics Letters. - : Elsevier BV. - 0009-2614 .- 1873-4448. ; 388:03-jan, s. 31-35
-
Tidskriftsartikel (refereegranskat)abstract
- The npsigma(1)Sigma(u)(+) and nppi(1)Pi(u) states in H-2 have been selectively excited using monoenergetic synchrotron light in the range 14.4-15.5 eV and the subsequent emission was observed using a grating spectrometer. In total 22 well separated bands of the npsigma(1)Sigma(u)(divided by) and nppi(1)Pi(u) to E,F (1)Sigma(g)(divided by) systems (n = 3-7) were observed and rotationally analysed. The intensities of the P and R branches relative to the Q branch vary strongly in the nppi to EF bands confirming the existence of predissociations of a large number of nppi(1)Pi(divided by) levels. Energy levels of the E,F (1) Sigma(g)(divided by) state (v(EF) = 0, 1, 3, 6-10) are obtained which confirm earlier determinations from other H-2 experiments.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Kukk, E., et al.
(författare)
-
Dissociation of deuteromethane following carbon 1s core ionization
- 2002
-
Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 66:1
-
Tidskriftsartikel (refereegranskat)abstract
- Energy-resolved electron-ion coincidence spectra of the deuteromethane molecule were measured following ionization by narrow-band synchrotron radiation. The ion mass spectra were recorded in coincidence with the outer and inner valence photoelectrons and with the normal Auger electrons from the decay of the carbon 1s core hole. Complementary noncoincidence ion mass spectra were measured below and above the C 1s threshold. The fragmentation patterns of the singly and doubly ionized deuteromethane under different ionization conditions are examined. Carbon core ionization is shown to open new photodissociation pathways not available in the valence ionization photon energy regime. With the aid of ab initio quantum chemistry calculations, a two-step model of the dissociation following core ionization is proposed, showing a good agreement with the experimental findings.
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
- Alvarez Ruiz, Jesus, et al.
(författare)
-
Synchrotron radiation induced fluorescence spectroscopy of SF6
- 2005
-
Ingår i: Journal of Physics B. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 38, s. 387-
-
Tidskriftsartikel (refereegranskat)abstract
- The fluorescence of gaseous SF6 was investigated after excitation with 25-80eV synchrotron radiation photons. The total UV-Vis-near IR fluorescence yield was recorded and interpreted in terms of inner valence excitations/ionizations and double excitations in SF6. Dispersed fluorescence measurements in the 400-1000 nm spectral range reveal excited S, S+, F and F+ fragments as solely responsible for the emission. The fluorescence intensity of some of the observed atomic transitions was monitored as a function of the excitation energy. Single, double and triple excitations as well as direct ionizations and shake-ups are proposed as the triggering processes responsible for the creation of the emitting fragments.
|
|
| 15. |
- Erman, P., et al.
(författare)
-
Non Franck-Condon effects in photoionization of molecular oxygen
- 2000
-
Ingår i: Physica scripta. T. - 0281-1847. ; 62:4, s. 294-300
-
Tidskriftsartikel (refereegranskat)abstract
- We present a theoretical and experimental analysis of non Franck-Condon effects in photoionization to the b (4)Sigma(g)(-), state of O-2(+). Experimentally, by dispersing the synchrotron radiation induced O-2(+) b (4)Sigma(g)(-) a (IIu)-I-4 fluorescence we derive the b (4)Sigma(g)(-), State vibrational branching ratios in the excitation energy range 21-34 eV. The vibrational branching ratios reveal features in the region 21-28 eV indicating strong non Franck-Condon effects. The experimental results have been analysed by computing ab initio the vibrational population branching ratios using a many-body perturbation method. Additionally the autoionizing neutral states existing in this energy region have been studied. We have computed the energies of the valence states up to an energy of 30 eV their transition moments for excitations from the ground state, and autoionization rates. Our calculations show, that strong non Franck-Condon effects recorded in the branching ratio spectrum (below 25 eV) are actually caused by the narrow 3 sigma(g) --> sigma(u) shape resonance, and its coupling to the 1 pi(u) --> pi(g) channel.
|
|
| 16. |
|
|
| 17. |
|
|
| 18. |
- Karawajczyk, A., et al.
(författare)
-
Neutral fragmentation of superexcited oxygen molecules
- 2000
-
Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 61:3, s. art. no.-32718
-
Tidskriftsartikel (refereegranskat)abstract
- The mechanisms of neutral dissociation of oxygen molecules in the excitation energy range 15-25 eV have been studied in a dispersed fluorescence experiment. By detecting the fluorescence from excited oxygen atoms, we find that neutral superexcited O-2 states below 20 eV dissociate into O(g.s.) + O(3s,3p). At higher excitation energies (h nu = 20-25 eV) the curve-crossing interactions following excitations to members of the Rydberg c (4)Sigma(u)(-) series also yield atoms in Rydberg states (nl,n greater than or equal to 4). The experimental data are analyzed on the ground of many-body perturbation theory, calculations which indicate the structure of the predissociating states converging to the experimentally observed ones.
|
|
| 19. |
- Lévy, Romain, et al.
(författare)
-
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency.
- 2023
-
Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 220:2
-
Tidskriftsartikel (refereegranskat)abstract
- Patients with inherited CARMIL2 or CD28 deficiency have defective T cell CD28 signaling, but their immunological and clinical phenotypes remain largely unknown. We show that only one of three CARMIL2 isoforms is produced and functional across leukocyte subsets. Tested mutant CARMIL2 alleles from 89 patients and 52 families impair canonical NF-κB but not AP-1 and NFAT activation in T cells stimulated via CD28. Like CD28-deficient patients, CARMIL2-deficient patients display recalcitrant warts and low blood counts of CD4+ and CD8+ memory T cells and CD4+ TREGs. Unlike CD28-deficient patients, they have low counts of NK cells and memory B cells, and their antibody responses are weak. CARMIL2 deficiency is fully penetrant by the age of 10 yr and is characterized by numerous infections, EBV+ smooth muscle tumors, and mucocutaneous inflammation, including inflammatory bowel disease. Patients with somatic reversions of a mutant allele in CD4+ T cells have milder phenotypes. Our study suggests that CARMIL2 governs immunological pathways beyond CD28.
|
|
| 20. |
- Rius, J., et al.
(författare)
-
Selective fragmentation of valence- and core-electron-excited CD4 and SF6 molecules
- 2002
-
Ingår i: Surface review and letters. - 0218-625X. ; 9:1, s. 117-123
-
Tidskriftsartikel (refereegranskat)abstract
- Electron-ion coincidence measurements with energy-resolved electrons are a powerful tool in studies of molecular fragmentation processes, since fragmentation from a specific doorway state can be monitored while the remaining reactions are discriminated. Presently, we have applied this technique in measurements of coincidence spectra of the CD4 and SF6 molecules after valence and core electron excitation. The newly constructed energy-resolved electron-ion coincidence station developed for this project has been used. Our results on CD4 are the first demonstration of a correlation between vibrations and molecular dissociation observed in this molecule. The SF6 spectra reveal strong selectivity in dissociation following distinct electronic states of the molecule. This selectivity reflects the bonding properties of the potential surfaces involved in the studied processes. The obtained results exemplify the potential of the new multicoincidence station used in this work.
|
|
| 21. |
|
|
| 22. |
|
|
| 23. |
|
|
| 24. |
- Stankiewicz, M., et al.
(författare)
-
Relaxation dynamics of SF6 studied by energy-resolved electron ion coincidence technique
- 2004
-
Ingår i: Journal of Electron Spectroscopy and Related Phenomena. - : Elsevier BV. - 0368-2048 .- 1873-2526. ; 137-40, s. 369-375
-
Tidskriftsartikel (refereegranskat)abstract
- The mass spectra from the SF6 molecule acquired by energy-resolved electron ion coincidence (EREICO) technique using (1t(1g) + [5t(1u),1t(2u)]), (3e(g) + 1t(2g)), 4t(1u), and 5a(1g) electrons after both valence and S 2p(-1) 6a(1g) core excitation reveal a strong selectivity in the dissociation from these states. From the comparison of the obtained spectra, the influence of the core-excited state in the relaxation pathway of the molecule is studied. The S 2p --> 6a(1g) core excitation does not affect the relaxation dynamics after participator Auger decay to the (1t(1g) + [5t(1u),1t(2u)])(-1) and (4t(1u))(-l) states, but it alters the relaxation dynamics after participator Auger decay to the (3e(g) + 1t(2g))(-1) and (5a(1g))(-1) states with respect to the decay processes after direct excitation of the same orbitals. These observations point to core excitation induced dissociation in the SF6 molecule.
|
|
| 25. |
|
|
