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| 2. |
- Kukk, E., et al.
(författare)
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Dissociation of deuteromethane following carbon 1s core ionization
- 2002
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 66:1
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Tidskriftsartikel (refereegranskat)abstract
- Energy-resolved electron-ion coincidence spectra of the deuteromethane molecule were measured following ionization by narrow-band synchrotron radiation. The ion mass spectra were recorded in coincidence with the outer and inner valence photoelectrons and with the normal Auger electrons from the decay of the carbon 1s core hole. Complementary noncoincidence ion mass spectra were measured below and above the C 1s threshold. The fragmentation patterns of the singly and doubly ionized deuteromethane under different ionization conditions are examined. Carbon core ionization is shown to open new photodissociation pathways not available in the valence ionization photon energy regime. With the aid of ab initio quantum chemistry calculations, a two-step model of the dissociation following core ionization is proposed, showing a good agreement with the experimental findings.
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| 3. |
- Erman, P, et al.
(författare)
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Autoionization Widths of the No Rydberg-valence State Complex In the 11-12 Ev Region
- 1995
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Ingår i: Chemical Physics Letters. - : Elsevier BV. - 0009-2614. ; 239:1-3, s. 6-10
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Tidskriftsartikel (refereegranskat)abstract
- The photoion excitation spectra of (NO)-N-14 and (NO)-N-15 have been studied in the 105-112 Mn excitation region using high-order harmonic laser spectroscopy. Utilizing the small bandwidth offered by this technique, the natural widths of prominent lines in this region have been measured. These lines originate from interactions between high-lying Rydberg levels converging to the NO+ electronic ground state and a 'new' NO valence state situated close to the latter state. The present measurements show broad resonances corresponding to a decay time of 20-50 fs. This supports the interpretation that the decay takes place via rapid electronic autoionization.
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| 4. |
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| 5. |
- Erman, P., et al.
(författare)
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Non Franck-Condon effects in photoionization of molecular oxygen
- 2000
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Ingår i: Physica scripta. T. - 0281-1847. ; 62:4, s. 294-300
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Tidskriftsartikel (refereegranskat)abstract
- We present a theoretical and experimental analysis of non Franck-Condon effects in photoionization to the b (4)Sigma(g)(-), state of O-2(+). Experimentally, by dispersing the synchrotron radiation induced O-2(+) b (4)Sigma(g)(-) a (IIu)-I-4 fluorescence we derive the b (4)Sigma(g)(-), State vibrational branching ratios in the excitation energy range 21-34 eV. The vibrational branching ratios reveal features in the region 21-28 eV indicating strong non Franck-Condon effects. The experimental results have been analysed by computing ab initio the vibrational population branching ratios using a many-body perturbation method. Additionally the autoionizing neutral states existing in this energy region have been studied. We have computed the energies of the valence states up to an energy of 30 eV their transition moments for excitations from the ground state, and autoionization rates. Our calculations show, that strong non Franck-Condon effects recorded in the branching ratio spectrum (below 25 eV) are actually caused by the narrow 3 sigma(g) --> sigma(u) shape resonance, and its coupling to the 1 pi(u) --> pi(g) channel.
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| 6. |
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| 7. |
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| 8. |
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| 9. |
- Karawajczyk, A., et al.
(författare)
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Neutral fragmentation of superexcited oxygen molecules
- 2000
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 61:3, s. art. no.-32718
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Tidskriftsartikel (refereegranskat)abstract
- The mechanisms of neutral dissociation of oxygen molecules in the excitation energy range 15-25 eV have been studied in a dispersed fluorescence experiment. By detecting the fluorescence from excited oxygen atoms, we find that neutral superexcited O-2 states below 20 eV dissociate into O(g.s.) + O(3s,3p). At higher excitation energies (h nu = 20-25 eV) the curve-crossing interactions following excitations to members of the Rydberg c (4)Sigma(u)(-) series also yield atoms in Rydberg states (nl,n greater than or equal to 4). The experimental data are analyzed on the ground of many-body perturbation theory, calculations which indicate the structure of the predissociating states converging to the experimentally observed ones.
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| 10. |
- Lévy, Romain, et al.
(författare)
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Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency.
- 2023
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Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 220:2
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Tidskriftsartikel (refereegranskat)abstract
- Patients with inherited CARMIL2 or CD28 deficiency have defective T cell CD28 signaling, but their immunological and clinical phenotypes remain largely unknown. We show that only one of three CARMIL2 isoforms is produced and functional across leukocyte subsets. Tested mutant CARMIL2 alleles from 89 patients and 52 families impair canonical NF-κB but not AP-1 and NFAT activation in T cells stimulated via CD28. Like CD28-deficient patients, CARMIL2-deficient patients display recalcitrant warts and low blood counts of CD4+ and CD8+ memory T cells and CD4+ TREGs. Unlike CD28-deficient patients, they have low counts of NK cells and memory B cells, and their antibody responses are weak. CARMIL2 deficiency is fully penetrant by the age of 10 yr and is characterized by numerous infections, EBV+ smooth muscle tumors, and mucocutaneous inflammation, including inflammatory bowel disease. Patients with somatic reversions of a mutant allele in CD4+ T cells have milder phenotypes. Our study suggests that CARMIL2 governs immunological pathways beyond CD28.
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| 11. |
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| 12. |
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| 14. |
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| 15. |
- Rius, J., et al.
(författare)
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Selective fragmentation of valence- and core-electron-excited CD4 and SF6 molecules
- 2002
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Ingår i: Surface review and letters. - 0218-625X. ; 9:1, s. 117-123
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Tidskriftsartikel (refereegranskat)abstract
- Electron-ion coincidence measurements with energy-resolved electrons are a powerful tool in studies of molecular fragmentation processes, since fragmentation from a specific doorway state can be monitored while the remaining reactions are discriminated. Presently, we have applied this technique in measurements of coincidence spectra of the CD4 and SF6 molecules after valence and core electron excitation. The newly constructed energy-resolved electron-ion coincidence station developed for this project has been used. Our results on CD4 are the first demonstration of a correlation between vibrations and molecular dissociation observed in this molecule. The SF6 spectra reveal strong selectivity in dissociation following distinct electronic states of the molecule. This selectivity reflects the bonding properties of the potential surfaces involved in the studied processes. The obtained results exemplify the potential of the new multicoincidence station used in this work.
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| 16. |
- Ruiz, J. A., et al.
(författare)
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Autoionisation of superexcited states in N-2 to the N2+B state
- 2003
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Ingår i: Chemical Physics Letters. - : Elsevier BV. - 0009-2614 .- 1873-4448. ; 372:02-jan, s. 139-146
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Tidskriftsartikel (refereegranskat)abstract
- Vibrationally resolved N-2(+) (B-X) (1-2) and (0-1) emission bands were recorded after photoexcitation of N-2 in the 20-46 eV energy range. The branching ratio between these transitions reveals strong non-Franck-Condon effects. Ab initio calculations using a configuration interaction method based on Kohn-Sham orbitals indicate that the autoionisation of certain superexcited states is responsible for some structures present in the branching ratio curve.
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| 17. |
- Stankiewicz, M., et al.
(författare)
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Relaxation dynamics of SF6 studied by energy-resolved electron ion coincidence technique
- 2004
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Ingår i: Journal of Electron Spectroscopy and Related Phenomena. - : Elsevier BV. - 0368-2048 .- 1873-2526. ; 137-40, s. 369-375
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Tidskriftsartikel (refereegranskat)abstract
- The mass spectra from the SF6 molecule acquired by energy-resolved electron ion coincidence (EREICO) technique using (1t(1g) + [5t(1u),1t(2u)]), (3e(g) + 1t(2g)), 4t(1u), and 5a(1g) electrons after both valence and S 2p(-1) 6a(1g) core excitation reveal a strong selectivity in the dissociation from these states. From the comparison of the obtained spectra, the influence of the core-excited state in the relaxation pathway of the molecule is studied. The S 2p --> 6a(1g) core excitation does not affect the relaxation dynamics after participator Auger decay to the (1t(1g) + [5t(1u),1t(2u)])(-1) and (4t(1u))(-l) states, but it alters the relaxation dynamics after participator Auger decay to the (3e(g) + 1t(2g))(-1) and (5a(1g))(-1) states with respect to the decay processes after direct excitation of the same orbitals. These observations point to core excitation induced dissociation in the SF6 molecule.
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| 18. |
- Thyssen, Jacob P., et al.
(författare)
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Effect of abrocitinib vs. dupilumab on skin pain : an analysis of the phase 3 JADE COMPARE and JADE DARE trials
- 2023
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Ingår i: British Journal of Dermatology. - : Oxford University Press. - 0007-0963 .- 1365-2133. ; 188:Suppl. 3
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Skin pain is a common and bothersome symptom of atopic dermatitis (AD) that is associated with a substantial burden. To assess the efficacy of abrocitinib vs. dupilumab on skin pain in patients with moderate-to-severe AD. Data from patients aged ≥18 years who received oral abrocitinib 200 mg once daily (QD) or subcutaneous dupilumab 300 mg once every 2 weeks in combination with topical therapy in the phase 3 trials JADE COMPARE (NCT03720470) and JADE DARE (NCT04345367) were analysed. Data from patients who received abrocitinib 100 mg QD or placebo in the JADE COMPARE trial were also included in this analysis. Patients rated their skin pain using the Skin Pain Numerical Rating Scale (NRS) item of the Pruritus and Symptoms Assessment for Atopic Dermatitis (PSAAD) instrument [‘How painful was your skin over the past 24 h?’ on a scale from 0 (not painful) to 10 (extremely painful) ] in JADE COMPARE or the Skin Pain Numerical Rating Scale [SP-NRS, which queried patients for the severity of their ‘worst skin pain’ in the past 24 h on a scale from 0 (no skin pain) to 10 (worst skin pain imaginable)] in JADE DARE. Least squares mean (LSM) changes from baseline and proportions of patients who achieved a ≥4-point improvement from baseline in PSAAD skin pain score or SP-NRS were assessed through Week 16 (JADE COMPARE) or Week 26 (JADE DARE). The JADE COMPARE analysis (Skin Pain NRS item of the PSAAD) was performed post hoc, whereas the JADE DARE analysis (SP-NRS) was prespecified. At Week 2 of JADE COMPARE, LSM change from baseline in PSAAD skin pain score was greater with abrocitinib 200 mg [−2.8 (95% CI, −3.1, −2.5)] than with abrocitinib 100 mg [−2.1 (−2.3, −1.8)], dupilumab [−2.0 (−2.3, −1.8)], or placebo [−1.3 (−1.6, −0,9)]; improvements were sustained through Week 16 of treatment with abrocitinib 200 mg [−4.1 (−4.4, −3.8)], abrocitinib 100 mg [−3.3 (−3.6, −3.0)] and dupilumab [−4.0 (−4.2, −3.7)] compared with placebo [−1.8 (−2.2, −1.4)]. In JADE DARE, LSM change from baseline in SP-NRS was significantly greater with abrocitinib 200 mg vs. dupilumab at Week 2 [−3.7 (−3.9, −3.4) vs. −2.6 (−2.8, −2.3); P < 0.0001] and week 12 [−4.5 (−4.7, −4.2) vs. −4.0 (−4.3, −3.8); P = 0.0116]; no significant differences were observed between the treatment arms at Week 16 [−4.4 (−4.7, −4.2) vs. −4.2 (−4.4, −4.0); P = 0.16], Week 20 [−4.8 (−5.0, −4.5) vs. −4.5 (−4.7 vs. −4.2); P = 0.06] or Week 26 [−4.5 (−4.8, −4.3)] vs. −4.3 (−4.6, −4.1); P = 0.27]. The proportions of patients who achieved a ≥4-point improvement in PSAAD skin pain score at week 2 of JADE COMPARE were greater with abrocitinib 200 mg (43%) than with abrocitinib 100 mg (23%), dupilumab (24%) or placebo (14%). At Week 16, these proportions increased to 76% (abrocitinib 200 mg), 57% (abrocitinib 100 mg) and 70% (dupilumab) compared with placebo (29%). In JADE DARE, the proportions of patients who achieved a ≥4-point improvement in SP-NRS were significantly greater with abrocitinib 200 mg vs. dupilumab at Week 2 (58% vs. 36%; P < 0.0001) and Week 12 (71% vs. 61%; P = 0.0098) but not at subsequent timepoints. Similar to previous findings on the effect of abrocitinib on itch, these results suggest that abrocitinib 200 mg provides greater early skin pain relief in patients with moderate-to-severe AD compared with dupilumab, but the difference between the treatments diminishes with time. At earlier time points, skin pain improvement with abrocitinib 100 mg was similar to that with dupilumab.
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