| 1. |
- Bénard, A, et al.
(författare)
-
Survey of European programmes for the epidemiological surveillance of congenital toxoplasmosis.
- 2008
-
Ingår i: Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin. - 1560-7917. ; 13:15
-
Tidskriftsartikel (refereegranskat)abstract
- The objective of this investigation was to describe systems for the epidemiological surveillance of congenital toxoplasmosis implemented in European countries. In September 2004, a questionnaire, adapted from the evaluation criteria published by the United States Centers for Disease Control and Prevention, was sent to a panel of national correspondents in 35 countries in the European geographical area with knowledge of the epidemiological surveillance systems implemented in their countries. Where necessary, we updated the information until July 2007. Responses were received from 28 countries. Some 16 countries reported routine surveillance for toxoplasmosis. In 12 countries (Bulgaria, Cyprus, Czech Republic, England and Wales, Estonia, Ireland, Latvia, Lithuania, Malta, Poland, Scotland and Slovakia), surveillance was designed to detect only symptomatic toxoplasmosis, whether congenital or not. Four countries reported surveillance of congenital toxoplasmosis, on a regional basis in Italy and on a national basis in Denmark, France and Germany. In conclusion, epidemiological surveillance of congenital toxoplasmosis needs to be improved in order to determine the true burden of disease and to assess the effectiveness of and the need for existing prevention programmes.
|
|
| 2. |
- Bronner, Ulf, et al.
(författare)
-
Evaluation of rapid diagnostic tests for malaria in Swedish travellers
- 2011
-
Ingår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - : Wiley. - 0903-4641 .- 1600-0463. ; 119:2, s. 88-92
-
Tidskriftsartikel (refereegranskat)abstract
- Rapid diagnostic tests (RDTs) for malaria have become valuable tools for the diagnosis of malaria in both endemic and non-endemic areas. During a 7-year period, first the MalaQuick rapid test and then the NOW Malaria test, were evaluated by well-trained laboratory technicians in a university hospital laboratory of parasitology. A total of 635 blood samples were selected from 4731 blood specimens obtained from travellers at the emergency department, at wards and at out-patient clinics. The samples were analysed by microscopy and RDT. Malaria parasites were detected in the blood films of 134 (21%) samples. The sensitivity of the RDT for Plasmodium falciparum was 97.7% (84 of 86 samples) with a negative predictive value of 99.6%. The two false-negative results were associated with low levels of parasitaemia. For non-falciparum species the sensitivity was only 58.3% (28 of 48 samples). Based on the excellent ability of the RDTs to detect P. falciparum infections, we recommend the use of the NOW Malaria test as a complement to microscopy in the laboratory.
|
|
| 3. |
- Byrnes, Andrea, et al.
(författare)
-
Gene expression in peripheral blood leukocytes in monozygotic twins discordant for chronic fatigue : no evidence of a biomarker
- 2009
-
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 4:6, s. e5805-
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Chronic fatiguing illness remains a poorly understood syndrome of unknown pathogenesis. We attempted to identify biomarkers for chronic fatiguing illness using microarrays to query the transcriptome in peripheral blood leukocytes. METHODS: Cases were 44 individuals who were clinically evaluated and found to meet standard international criteria for chronic fatigue syndrome or idiopathic chronic fatigue, and controls were their monozygotic co-twins who were clinically evaluated and never had even one month of impairing fatigue. Biological sampling conditions were standardized and RNA stabilizing media were used. These methodological features provide rigorous control for bias resulting from case-control mismatched ancestry and experimental error. Individual gene expression profiles were assessed using Affymetrix Human Genome U133 Plus 2.0 arrays. FINDINGS: There were no significant differences in gene expression for any transcript. CONCLUSIONS: Contrary to our expectations, we were unable to identify a biomarker for chronic fatiguing illness in the transcriptome of peripheral blood leukocytes suggesting that positive findings in prior studies may have resulted from experimental bias.
|
|
| 4. |
- Derouin, Francis, et al.
(författare)
-
Prevention of toxoplasmosis in transplant patients.
- 2008
-
Ingår i: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. - : Elsevier BV. - 1469-0691. ; 14:12, s. 1089-101
-
Tidskriftsartikel (refereegranskat)abstract
- Toxoplasmosis is a life-threatening opportunistic infection that affects haematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients. Its incidence in these patients is closely related to the prevalence of toxoplasmosis in the general population, which is high in Europe. In SOT recipients, toxoplasmosis results mainly from transmission of the parasite with the transplanted organ from a Toxoplasma-seropositive donor to a Toxoplasma-seronegative recipient. This risk is high in cases of transplantation of organs that are recognized sites of encystation of the parasite, e.g. the heart, and is markedly lower in other SOT recipients. Clinical symptoms usually occur within the first 3 months after transplantation, sometimes as early as 2 weeks post transplant, and involve febrile myocarditis, encephalitis or pneumonitis. In HSCT recipients, the major risk of toxoplasmosis results from the reactivation of a pre-transplant latent infection in seropositive recipients. The median point of disease onset is estimated at 2 months post transplant, with <10% of cases occurring before 30 days and 15-20% later than day 100. Toxoplasmosis usually manifests as encephalitis or pneumonitis, and frequently disseminates with multiple organ involvement. Diagnosis of toxoplasmosis is based on the demonstration of parasites or parasitic DNA in blood, bone marrow, cerebrospinal fluid, bronchoalveolar lavage fluid or biopsy specimens, and serological tests do not often contribute to the diagnosis. For prevention of toxoplasmosis, serological screening of donors and recipients before transplantation allows the identification of patients at higher risk of toxoplasmosis, i.e. seropositive HSCT recipients and mismatched (seropositive donor/seronegative recipients) SOT recipients. Preventing toxoplasmosis disease in those patients presently relies on prophylaxis via prescription of co-trimoxazole.
|
|
| 5. |
- Dudarev, Alexey A, et al.
(författare)
-
Food and water security issues in Russia I : Food security in the general population of the Russian Arctic, Siberia and the Far East
- 2013
-
Ingår i: International Journal of Circumpolar Health. - : International Association of Circumpolar Health Publishers. - 1239-9736 .- 2242-3982. ; 72, s. 1-10
-
Tidskriftsartikel (refereegranskat)abstract
- Background. Problems related to food security in Russian Arctic (dietary imbalance, predominance ofcarbohydrates, shortage of milk products, vegetables and fruits, deficit of vitamins and microelements,chemical, infectious and parasitic food contamination) have been defined in the literature. But no standardprotocol of food security assessment has been used in the majority of studies.Objectives. Our aim was to obtain food security indicators, identified within an Arctic collaboration,for selected regions of the Russian Arctic, Siberia and the Far East, and to compare food safety in theseterritories.Study design and methods. In 18 regions of the Russian Arctic, Siberia and the Far East, the followingindicators of food security were analyzed: food costs, food consumption, and chemical and biological foodcontamination for the period 2000-2011.Results. Food costs in the regions are high, comprising 2343% of household income. Only 4 out of 10 foodgroups (fish products, cereals, sugar, plant oil) are consumed in sufficient amounts. The consumption of milkproducts, eggs, vegetables, potatoes, fruits (and berries) is severely low in a majority of the selected regions.There are high levels of biological contamination of food in many regions. The biological and chemicalcontamination situation is alarming, especially in Chukotka. Only 7 food pollutants are under regularcontrol; among pesticides, only DDT. Evenki AO and Magadan Oblast have reached peak values in foodcontaminants compared with other regions. Mercury in local fish has not been analyzed in the majority of theregions. In 3 regions, no monitoring of DDToccurs. Aflatoxins have not been analyzed in 5 regions. Nitrateshad the highest percentage in excess of the hygienic threshold in all regions. Excesses of other pollutants indifferent regions were episodic and as a rule not high.Conclusion. Improvement of the food supply and food accessibility in the regions of the Russian Arctic,Siberia and the Far East is of utmost importance. Both quantitative and qualitative control of chemical andbiological contaminants in food is insufficient and demands radical enhancement aimed at improving foodsecurity.
|
|
| 6. |
- Edvinsson, Benjamin, et al.
(författare)
-
A prospective study of diagnosis of Toxoplasma gondii infection after bone marrow transplantation.
- 2008
-
Ingår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - : Wiley. - 0903-4641 .- 1600-0463. ; 116:5, s. 345-51
-
Tidskriftsartikel (refereegranskat)abstract
- Active infection with Toxoplasma gondii in immunocompromised transplant recipients can lead to toxoplasmosis, which may have a rapid disease course and in some cases be fatal. It is of paramount importance to diagnose toxoplasmosis at an early stage, and to initiate specific treatment to improve the outcome. Polymerase chain reaction (PCR) is today the primary diagnostic tool to diagnose toxoplasmosis in immunocompromised patients. Timely diagnosis may, however, be difficult if toxoplasmosis is at first asymptomatic. To investigate the magnitude of toxoplasmosis after bone marrow transplantation (BMT), we conducted a screening study by PCR where 21 autologous and 12 allogeneic BMT recipients were included. Peripheral blood samples were taken one week prior to BMT; thereafter, blood samples were drawn weekly for the first 6 months, and monthly up to one year after BMT. The samples were analyzed by conventional PCR and real-time PCR. T. gondii DNA was detected in peripheral blood from one patient 5 days post allogeneic BMT. There were no clinical signs of toxoplasmosis. Medical records were reviewed and showed a previously undiagnosed eye infection in another allogeneic BMT recipient. These two patients were seropositive for T. gondii. We concluded that monitoring for T. gondii DNA in peripheral blood samples using PCR might be a valuable method for identifying toxoplasma-seropositive stem cell transplant recipients.
|
|
| 7. |
- Edvinsson, B, et al.
(författare)
-
Rapid genotyping of Toxoplasma gondii by pyrosequencing
- 2007
-
Ingår i: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. - : Elsevier BV. - 1198-743X .- 1469-0691. ; 13:4, s. 424-429
-
Tidskriftsartikel (refereegranskat)
|
|
| 8. |
- Edvinsson, B, et al.
(författare)
-
Real-time PCR targeting a 529-bp repeat element for diagnosis of toxoplasmosis
- 2006
-
Ingår i: Clinical Microbiology and Infection. - : Elsevier BV. - 1198-743X .- 1469-0691. ; 12:2, s. 131-136
-
Tidskriftsartikel (refereegranskat)abstract
- Sensitive and rapid detection of infection with Toxoplasma gondii in transplanted immunocompromised patients is crucial for a good prognosis. Two DNA fragments are used currently for detecting T. gondii infection by PCR, i.e., the B1 gene and a 529-bp repeat element that exists in 200-300 copies/genome. This study investigated whether targeting the 529-bp repeat element gives better sensitivity and accuracy than can be obtained when targeting the B1 gene (35 copies) when concentrations of T. gondii DNA are low. The results demonstrated that detection of the 529-bp repeat element increased diagnostic sensitivity and accuracy. Addition of an internal amplification control did not affect the PCR performance and was useful in order to monitor PCR inhibition by non-specific DNA in the LightCycler instrument. The real-time PCR was used successfully in a clinical context to monitor parasitaemia in the blood of a transplant recipient suffering from toxoplasmosis.
|
|
| 9. |
- Edvinsson, Benjamin, et al.
(författare)
-
Toxoplasmosis in immunocompromized patients
- 2009
-
Ingår i: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 41:5, s. 368-371
-
Tidskriftsartikel (refereegranskat)abstract
- Infection with the cosmopolitan parasite Toxoplasma gondii is often associated with severe consequences and a high mortality rate in immunocompromized patients. Non-specific symptoms make diagnosis challenging. Monitoring of patients at risk is of value. We here present 8 cases of toxoplasmosis in immunocompromized patients with suggestions for preventive monitoring.
|
|
| 10. |
- Evengård, Birgitta, 1952-, et al.
(författare)
-
Climate change influences infectious diseases both in the Arctic and the tropics : joining the dots
- 2009
-
Ingår i: Global Health Action. - : Informa UK Limited. - 1654-9716 .- 1654-9880. ; 2
-
Tidskriftsartikel (refereegranskat)abstract
- Climate change is incontestably a phenomenon of global causes and impacts. However, as much as the contribution of different regions and countries to climate change differs, as much differ the impacts. This paper examines the current and potential impact of climate change on infectious diseases in regions that could not be more different: the Arctic and the tropics (The Arctic is the area north of the Arctic Circle (66.6°N), while the tropics lie between the Tropic of Cancer (23.4°N) and the Tropic of Capricorn (23.4°S)). Despite obvious differences in environmental and socio-economic contexts, there are commonalities between these areas, both in the mechanisms through which climate change influences disease transmission and in the adaptation responses health systems can and should mount. We hope that the lessons in this comparison can be distilled both by policy makers and researchers in both regions. The purpose of this article is ‘to join the dots’ and thus stimulate discussion. Inevitably, the different dots (issues) themselves cannot be elaborated on in detail here. For this, we refer the interested reader to a wide-ranging list of references.
|
|
| 11. |
- Evengård, Birgitta, 1952-, et al.
(författare)
-
CLINF : climate-change effects on the epidemiology of infectious diseases, and the associated impacts on northern societies
- 2021
-
Ingår i: Nordic perspectives on the responsible development of the Arctic. - Cham : Springer Nature. - 9783030523237 - 9783030523268 - 9783030523244 ; , s. 49-70
-
Bokkapitel (refereegranskat)abstract
- The research initiative CLINF addresses a central issue in planning for the responsible development of the North: an understanding of the impact of climate change on the geographic distribution and epidemiology of climate sensitive infectious diseases (CSIs), and their associated consequences for Arctic health, economic growth, and societal prosperity. Changes in infectious diseases transmission patterns are a likely consequence of changing climates, a neglected problem that is likely to have a profound effect on northern societies, including indigenous cultures. There is an urgent need to learn more about the complex underlying dynamic relationships, and apply this information to the prediction of future CSI impacts, using more complete, better validated, and integrated data and models. This chapter provides an overview of the thoughts behind the CLINF NCoE (Nordic Centre of Excellence), and the integrative context expressed therein. The most recent findings regarding climate change in the Arctic, as published by IPCC and other global networks, are presented. In the international CLINF consortium of researchers, nine human and 18 animal husbandry diseases have been selected for study due to their potential for being climate sensitive. The human infections were selected by an international consortium of researchers, to represent fundamentally different transmission processes. The main CLINF objectives are the construction of practical tools for the decision-makers who are responsible for the development of northern societies. By contributing to the development of an early warning system for increased risks for CSIs to spread at the local level effective policy responses may be formulated. The overall aim of CLINF is to support the sustainability of Arctic development.
|
|
| 12. |
- Evengård, Birgitta, 1952-, et al.
(författare)
-
Healthy ecosystems for human and animal health : Science diplomacy for responsible development in the Arctic
- 2021
-
Ingår i: Polar Record. - : Cambridges Institutes Press. - 0032-2474 .- 1475-3057. ; 57
-
Tidskriftsartikel (refereegranskat)abstract
- Climate warming is occurring most rapidly in the Arctic, which is both a sentinel and a driver of further global change. Ecosystems and human societies are already affected by warming. Permafrost thaws and species are on the move, bringing pathogens and vectors to virgin areas. During a five-year project, the CLINF - a Nordic Center of Excellence, funded by the Nordic Council of Ministers, has worked with the One Health concept, integrating environmental data with human and animal disease data in predictive models and creating maps of dynamic processes affecting the spread of infectious diseases. It is shown that tularemia outbreaks can be predicted even at a regional level with a manageable level of uncertainty. To decrease uncertainty, rapid development of new and harmonised technologies and databases is needed from currently highly heterogeneous data sources. A major source of uncertainty for the future of contaminants and infectious diseases in the Arctic, however, is associated with which paths the majority of the globe chooses to follow in the future. Diplomacy is one of the most powerful tools Arctic nations have to influence these choices of other nations, supported by Arctic science and One Health approaches that recognise the interconnection between people, animals, plants and their shared environment at the local, regional, national and global levels as essential for achieving a sustainable development for both the Arctic and the globe.
|
|
| 13. |
|
|
| 14. |
- Evengård, Birgitta, 1952-, et al.
(författare)
-
Säker tillgång till mat och vatten prioriterad fråga för Arktis
- 2013
-
Ingår i: Läkartidningen. - Stockholm. - 0023-7205 .- 1652-7518. ; 110:05, s. CCF7-
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Arktis befinner sig i förändring. Dessa förändringar beror på mänskliga aktiviteter i regionen och på den globala klimatförändringen, som märks först och mest i norr till exempel där den sibiriska tundran övergår i gräsbevuxen terräng. Djur och människor som bor i den här delen av världen är redan påverkade av förändringarna och kommer att förbli så under lång tid framöver. Ursprungsbefolkningar runt om i Arktis samlar sig i protester, nu senast i Kanada. De många ursprungsbefolkningarna i Arktis lever ofta nära naturen och är därför mer sårbara än andra, men även samhällen med god infrastruktur påverkas av miljöförändringar. I Sverige märkte vi nyligen detta, när närmare 100 000 personer i Östersund och Skellefteå med omgivningar vintern 2010–2011 fick koka sitt vatten under månader på grund av att en parasit (Cryptosporidium) kom in i vattnet. Olika slags system behöver kontrolleras regelbundet, så att säkra datatolkningar kan ges till beslutsfattare, för att vidta åtgärder i tid för ökad säkerhet.
|
|
| 15. |
- Evengård, Birgitta, 1952-, et al.
(författare)
-
The epidemiology of chronic fatigue in the Swedish Twin Registry
- 2005
-
Ingår i: Psychological Medicine. - 0033-2917 .- 1469-8978. ; 35:9, s. 1317-1326
-
Tidskriftsartikel (refereegranskat)abstract
- CFS-like illness may be more common that previously acknowledged. There is a marked increase in risk by gender. Previous reports that CFS is more prevalent in individuals in certain occupational categories were not confirmed and may have been due to confounding by gender.
|
|
| 16. |
|
|
| 17. |
- Forlenza, Michael J, et al.
(författare)
-
Epidemiology of cancer-related fatigue in the Swedish twin registry
- 2005
-
Ingår i: Cancer. - : Wiley. - 0008-543X .- 1097-0142. ; 104:9, s. 2022-2031
-
Tidskriftsartikel (refereegranskat)abstract
- A greater proportion of individuals who were listed in a national cancer registry reported experiencing fatigue compared with individuals in the general population.
|
|
| 18. |
|
|
| 19. |
- Furberg, Maria, 1970-, et al.
(författare)
-
Facing the limit of resilience : perceptions of climate change among reindeer herding Sami in Sweden
- 2011
-
Ingår i: Global Health Action. - Häggeby : Co-Action publishing. - 1654-9716 .- 1654-9880. ; 4:8417, s. 11-
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The Arctic area is a part of the globe where the increase in global temperature has had the earliest noticeable effect and indigenous peoples, including the Swedish reindeer herding Sami, are amongst the first to be affected by these changes.OBJECTIVE: To explore the experiences and perceptions of climate change among Swedish reindeer herding Sami.STUDY DESIGN: In-depth interviews with 14 Swedish reindeer herding Sami were performed, with purposive sampling. The interviews focused on the herders experiences of climate change, observed consequences and thoughts about this. The interviews were analysed using content analysis.RESULTS: ONE CORE THEME EMERGED FROM THE INTERVIEWS: facing the limit of resilience. Swedish reindeer-herding Sami perceive climate change as yet another stressor in their daily struggle. They have experienced severe and more rapidly shifting, unstable weather with associated changes in vegetation and alterations in the freeze-thaw cycle, all of which affect reindeer herding. The forecasts about climate change from authorities and scientists have contributed to stress and anxiety. Other societal developments have lead to decreased flexibility that obstructs adaptation. Some adaptive strategies are discordant with the traditional life of reindeer herding, and there is a fear among the Sami of being the last generation practising traditional reindeer herding.CONCLUSIONS: The study illustrates the vulnerable situation of the reindeer herders and that climate change impact may have serious consequences for the trade and their overall way of life. Decision makers on all levels, both in Sweden and internationally, need improved insights into these complex issues to be able to make adequate decisions about adaptive climate change strategies.
|
|
| 20. |
- Garnaud, C., et al.
(författare)
-
Toxoplasma gondii-specific IgG avidity testing in pregnant women
- 2020
-
Ingår i: Clinical Microbiology and Infection. - : Elsevier. - 1198-743X .- 1469-0691. ; 26:9, s. 1155-1160
-
Forskningsöversikt (refereegranskat)abstract
- Background: The parasite Toxoplasma gondii can cause congenital toxoplasmosis following primary infection in a pregnant woman. It is therefore important to distinguish between recent and past infection when both T. gondii-specific IgM and IgG are detected in a single serum in pregnant women. Toxoplasma gondii-specific IgG avidity testing is an essential tool to help to date the infection. However, interpretation of its results can be complex.Objectives: To review the benefits and limitations of T. gondii-specific avidity testing in pregnant women, to help practitioners to interpret the results and adapt the patient management.Sources: PubMed search with the keywords avidity, toxoplasmosis and Toxoplasma gondii for articles published from 1989 to 2019.Content: Toxoplasma gondii-specific IgG avidity testing remains a key tool for dating a T. gondii infection in immunocompetent pregnant women. Several commercial assays are available and display comparable performances. A high avidity result obtained on a first-trimester serum sample is indicative of a past infection, which occurred before pregnancy. To date, a low avidity result must still be considered as non-informative to date the infection, although some authors suggest that very low avidity results are highly suggestive of recent infections depending on the assay. Interpretation of low or grey zone avidity results on a first-trimester serum sample, as well as any avidity result on a second-trimester or third-trimester serum sample, is more complex and requires recourse to expert toxoplasmosis laboratories. Implications: Although used for about 30 years, T. gondii-specific avidity testing has scarcely evolved. The same difficulties in interpretation have persisted over the years. Some authors have proposed additional thresholds to exclude an infection of <9 months, or in contrast to confirm a recent infection. Such thresholds would be of great interest to adapt management of pregnant women and avoid unnecessary treatment; however, they need confirmation and further studies.
|
|
| 21. |
- Gilbert, Ruth E, et al.
(författare)
-
Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe.
- 2008
-
Ingår i: PLoS neglected tropical diseases. - : Public Library of Science (PLoS). - 1935-2735. ; 2:8, s. e277-
-
Tidskriftsartikel (refereegranskat)abstract
- T. gondii causes more severe ocular disease in congenitally infected children in Brazil compared with Europe. The marked differences in the frequency, size and multiplicity of retinochoroidal lesions may be due to infection with more virulent genotypes of the parasite that predominate in Brazil but are rarely found in Europe.
|
|
| 22. |
- Gollub, Erica L, et al.
(författare)
-
Effectiveness of health education on Toxoplasma-related knowledge, behaviour, and risk of seroconversion in pregnancy.
- 2008
-
Ingår i: European Journal of Obstetrics, Gynecology, and Reproductive Biology. - : Elsevier BV. - 0301-2115 .- 1872-7654. ; 136:2, s. 137-45
-
Tidskriftsartikel (refereegranskat)abstract
- We conducted a bibliographic literature search using MEDLINE to review the effectiveness of health education on Toxoplasma-related knowledge, behaviour, and risk of seroconversion in pregnant women. We pre-selected studies that used comparative study designs (randomized clinical trial, quasi-experimental design or historical control), that were conducted among pregnant women, and which employed specific, Toxoplasma-related outcome measures: knowledge, behaviour, or Toxoplasma infection rate. Four studies met the inclusion criteria. All had serious methodological flaws. A Belgian study reported a significant decrease in the incidence of Toxoplasma seroconversion after the introduction of intensive counselling for pregnant women about toxoplasmosis. In Poland, a significant increase in knowledge was observed after a multi-pronged, public health educational program was launched. In Canada, an increase in knowledge and prevention behaviours was reported in the intervention group receiving counselling by trained facilitators compared with the control group. In France, no significant changes in risk behaviour were observed following a physician-delivered intervention. This review highlights the weakness of the literature in the area and the lack of studies measuring actual seroconversion. There is suggestive evidence that health education approaches may help reduce risk of congenital toxoplasmosis but this problem requires further study using more rigorous research design and methodology.
|
|
| 23. |
|
|
| 24. |
|
|
| 25. |
- Gräns, Hanna, et al.
(författare)
-
Reduced levels of oestrogen receptor beta mRNA in Swedish patients with chronic fatigue syndrome.
- 2007
-
Ingår i: Journal of Clinical Pathology. - : BMJ. - 0021-9746 .- 1472-4146. ; 60:2, s. 195-8
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Chronic fatigue syndrome (CFS) is an illness with unknown aetiology and pathophysiology. The difference in incidence by sex observed for CFS indicates a role for oestrogen and oestrogen receptors in disease development. Furthermore, an immunomediated pathogenesis has been suggested for CFS, providing an additional connection to oestrogen, which displays immunomodular functions. AIMS: To investigate a possible association of oestrogen receptor (ER) mRNAs and two ERbeta single-nucleotide polymorphisms (SNPs) with CFS. METHODS: Messenger RNA levels of ERalpha, ERbeta wt and ERbeta cx were investigated in peripheral blood mononuclear cells from 30 patients with CFS and 36 healthy controls by quantitative real-time polymerase chain reaction. Two ERbeta SNPs were scored in the same material. RESULTS: The CFS group showed significantly lower mRNA expression levels of ERbeta wt compared with the healthy control group. No differences were observed for ERalpha or ERbeta cx between patients and controls. There were no significant differences in frequency for the investigated ERbeta SNPs between cases and controls. CONCLUSIONS: The reduced ERbeta wt expression level observed in this study is consistent with an immune-mediated pathogenesis of CFS. Additionally, the observation that ERbeta wt expression is decreased in CFS could provide an entry point to identify interesting, potentially disease-causing, candidate molecules for further study. A possible connection between oestrogen, oestrogen receptors and CFS should be evaluated further.
|
|
| 26. |
- Hannestad, Ulf, et al.
(författare)
-
beta-Alanine and gamma-aminobutyric acid in chronic fatigue syndrome.
- 2007
-
Ingår i: Clinica Chimica Acta. - : Elsevier BV. - 0009-8981 .- 1873-3492. ; 376:1-2, s. 23-9
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Due to the occurrence of sleep disturbances and fatigue in chronic fatigue syndrome (CFS), an investigation was performed to examine if there is an abnormal excretion of gamma-aminobutyric acid (GABA) and/or its structural analogue beta-alanine in the urine from CFS patients. Both GABA and beta-alanine are inhibitory neurotransmitters in the mammalian central nervous system. METHODS: The 24 h urine excretion of GABA and beta-alanine was determined by isotope dilution gas chromatography mass spectrometry in 33 CFS patients and 43 healthy controls. The degree of symptoms in both patients and controls was measured by grading of three typical CFS symptoms using a Visual Analogue Scale. RESULTS: Men had a significantly higher excretion of both beta-alanine and GABA than women. Comparing CFS patients with healthy controls showed no significant difference in excretion of neither beta-alanine nor GABA. No correlation was found between the excretion of beta-alanine or GABA and any of the three characteristic CFS symptoms measured. However, two female and two male CFS patients excreted considerably higher amounts of beta-alanine in their 24 h urine samples than control subjects. CONCLUSIONS: Increased excretion of beta-alanine was found in a subgroup of CFS patients, indicating that there may be a link between CFS and beta-alanine in some CFS patients.
|
|
| 27. |
|
|
| 28. |
|
|
| 29. |
- Kato, K, et al.
(författare)
-
A population-based twin study of functional somatic syndromes
- 2009
-
Ingår i: Psychological Medicine. - : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 39:3, s. 497-505
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The mechanisms underlying the co-occurrence of the functional somatic syndromes are largely unknown. No empirical study has explicitly examined how genetic and environmental factors influence the co-morbidity of these syndromes. We aimed to examine how the co-morbidity of functional somatic syndromes is influenced by genetic and environmental factors that are in common to the syndromes. METHOD: A total of 31318 twins in the Swedish Twin Registry aged 41-64 years underwent screening interviews via a computer-assisted telephone system from 1998 to 2002. Four functional somatic syndromes (chronic widespread pain, chronic fatigue, irritable bowel syndrome, and recurrent headache) and two psychiatric disorders (major depression and generalized anxiety disorder) were assessed using structured questions based on standard criteria for each illness in a blinded manner. RESULTS: Multivariate twin analyses revealed that a common pathway model with two latent traits that were shared by the six illnesses fit best to the women's data. One of the two latent traits loaded heavily on the psychiatric disorders, whereas the other trait loaded on all four of the functional somatic syndromes, particularly chronic widespread pain, but not on the psychiatric disorders. All illnesses except the psychiatric disorders were also affected by genetic influences that were specific to each. CONCLUSIONS: The co-occurrence of functional somatic syndromes in women can be best explained by affective and sensory components in common to all these syndromes, as well as by unique influences specific to each of them. The findings clearly suggest a complex view of the multifactorial pathogenesis of these illnesses.
|
|
| 30. |
- Kato, Kenji, et al.
(författare)
-
Chronic widespread pain and its comorbidities : a population-based study
- 2006
-
Ingår i: Archives of Internal Medicine. - : American Medical Association (AMA). - 0003-9926 .- 1538-3679. ; 166:15, s. 1649-1654
-
Tidskriftsartikel (refereegranskat)abstract
- Associations between CWP and most comorbidities are mediated by unmeasured genetic and family environmental factors in the general population. The extent of mediation via familial factors is likely to be disorder specific.
|
|
| 31. |
- Kato, Kenji, et al.
(författare)
-
Importance of genetic influences on chronic widespread pain
- 2006
-
Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 54:5, s. 1682-1686
-
Tidskriftsartikel (refereegranskat)abstract
- Individual differences in the likelihood of developing chronic widespread pain reflect modest genetic influences. There are no significant sex differences in the type or expression of the genes responsible for chronic widespread pain or in the magnitude of the relative importance of these influences on chronic widespread pain.
|
|
| 32. |
- Kato, Kenji, et al.
(författare)
-
Premorbid predictors of chronic fatigue
- 2006
-
Ingår i: Archives of General Psychiatry. - : American Medical Association (AMA). - 0003-990X .- 1538-3636. ; 63:11, s. 1267-1272
-
Tidskriftsartikel (refereegranskat)abstract
- Elevated premorbid stress is a significant risk factor for chronic fatigue-like illness, the effect of which may be buffered by genetic influences. Emotional instability assessed 25 years earlier is associated with chronic fatigue through genetic mechanisms contributing to both personality style and expression of the disorder. These findings suggest plausible mechanisms for chronic fatiguing illness.
|
|
| 33. |
- Leibovici, Didier G., et al.
(författare)
-
Associating land cover changes with patterns of incidences of climate-sensitive infections : An example on tick-borne diseases in the nordic area
- 2021
-
Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 18:20
-
Tidskriftsartikel (refereegranskat)abstract
- Some of the climate-sensitive infections (CSIs) affecting humans are zoonotic vector-borne diseases, such as Lyme borreliosis (BOR) and tick-borne encephalitis (TBE), mostly linked to various species of ticks as vectors. Due to climate change, the geographical distribution of tick species, their hosts, and the prevalence of pathogens are likely to change. A recent increase in human incidences of these CSIs in the Nordic regions might indicate an expansion of the range of ticks and hosts, with vegetation changes acting as potential predictors linked to habitat suitability. In this paper, we study districts in Fennoscandia and Russia where incidences of BOR and TBE have steadily increased over the 1995–2015 period (defined as ’Well Increasing districts’). This selection is taken as a proxy for increasing the prevalence of tick-borne pathogens due to increased habitat suitability for ticks and hosts, thus simplifying the multiple factors that explain incidence variations. This approach allows vegetation types and strengths of correlation specific to the WI districts to be differentiated and compared with associations found over all districts. Land cover types and their changes found to be associated with increasing human disease incidence are described, indicating zones with potential future higher risk of these diseases. Combining vegetation cover and climate variables in regression models shows the interplay of biotic and abiotic factors linked to CSI incidences and identifies some differences between BOR and TBE. Regression model projections up until 2070 under different climate scenarios depict possible CSI progressions within the studied area and are consistent with the observed changes over the past 20 years.
|
|
| 34. |
- Ma, Yan, et al.
(författare)
-
Linking climate and infectious disease trends in the Northern/Arctic Region
- 2021
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
-
Tidskriftsartikel (refereegranskat)abstract
- Recognition of climate-sensitive infectious diseases is crucial for mitigating health threats from climate change. Recent studies have reasoned about potential climate sensitivity of diseases in the Northern/Arctic Region, where climate change is particularly pronounced. By linking disease and climate data for this region, we here comprehensively quantify empirical climate-disease relationships. Results show significant relationships of borreliosis, leptospirosis, tick-borne encephalitis (TBE), Puumala virus infection, cryptosporidiosis, and Q fever with climate variables related to temperature and freshwater conditions. These data-driven results are consistent with previous reasoning-based propositions of climate-sensitive infections as increasing threats for humans, with notable exceptions for TBE and leptospirosis. For the latter, the data imply decrease with increasing temperature and precipitation experienced in, and projected for, the Northern/Arctic Region. This study provides significant data-based underpinning for simplified empirical assessments of the risks of several infectious diseases under future climate change.
|
|
| 35. |
- Nilsson, Annika E, et al.
(författare)
-
Food security in the Arctic : Preliminary reflections from a resilience perspective
- 2013
-
Ingår i: Arctic Resilience: Interim Report 2013. - Stockholm : Arctic Council. - 9789186125431 - 9789186125424 ; , s. 113-117
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Chapter 10 discusses food security, which is emerging as a major cross-cutting issue in a changingArctic. The preliminary reflections presented in the chapter highlight that food security bringstogether concerns over a range of interacting environmental, social, economic, political andcultural changes. These include: food and water-borne diseases; increasing incidence of lifestylediseases; high costs of healthy foods; contamination; changing ecosystems that impede access tofood; high fuel costs; and loss of traditional knowledge. The chapter concludes that food security isintimately interlinked with social relations and cultural well-being.
|
|
| 36. |
- Nilsson, Lena Maria, 1965-, et al.
(författare)
-
Food and water security indicators in an arctic health context : a report by the AHHEG/SDWG, and the AMAP/HHAG during the Swedish chairmanship of the Arctic Council 2011-2013
- 2013
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this report is to provide a basis for indicator selection that is relevant for food and water security in the circumpolar areas and which could be used in international collaborations of surveillance in the Arctic. Indicators used in scientific papers and in official statistics from all eight countries involved have been considered. We found 21 potential indicators of food and water security that could be used for further initiatives in an Arctic health context. During an international workshop 12 of these indicators of food security (n=6) and water security (n=6) were promoted, 5 were considered in need of further development and 4 were rejected.Indicators considered to be usable from an Arctic health perspective differed from indicators in focus in international FAO discussions on food and water security. As a first step, focusing on data already available in most Arctic countries, we suggest a joint effort focusing on:Healthy weightSelf estimated proportion of traditional food in diet (SLiCA questionnaire can be used as baseline for indigenous people)Presence of hunter/fisher/collector/herder in family/householdCost of a nutritious food basket in relation to incomeFood borne diseases – incidence rates and seroprevalence in humanFood related contaminantsPer capita renewable waterAccessibility of running water (SLiCA data can be used as baseline for indigenous people)Waterborne diseases – incidence rates and seroprevalence in humanWater related contaminantsAuthorized water quality assuranceWater safety plansIn a second phase selected indicators of interest should be further developed by organized expert groups. An international joint effort to collect data from the Arctic nations and regions should then be performed, with the aim to reduce inequality and improve the service for all Arctic people.Continuing collaborations between the two health groups in the Arctic Council, especially concerning food related contaminants, use of existing biobanks, and future joint biosampling was considered necessary especially from a food security perspective. Concrete projects will be developed as main pillars of phase 2.
|
|
| 37. |
- Nyberg, F., et al.
(författare)
-
"The Laundry Bag Project" - Unequal distribution of dermatological healthcare resources for male and female psoriatic patients in Sweden
- 2008
-
Ingår i: International Journal of Dermatology. - : Wiley. - 0011-9059 .- 1365-4632. ; 47:2, s. 144-149
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Psoriasis and eczema are common dermatological diseases that occur with approximately equal frequency in men and in women. The aim of this study was to determine whether men and women with dermatological diseases in need of ultra-violet radiation (UV) treatment receive equal care. Methods: We conducted a retrospective analysis of records of all patients referred to and seen at our clinic during 2003 with diagnoses of psoriasis or eczema. We performed a gender-based analysis of the number, type, and estimated cost of the treatments given to each patient. We evaluated similar data from a Swedish Psoriasis Association (SPA) treatment center and from the state pharmacy monopoly (Apoteksstatistiken). Results: Men with eczema or psoriasis received more help with emollients than did women and were given a greater number of UV treatments. At our clinic and at the SPA center, women constituted 37 and 42%, respectively, of the individuals who received UV treatment, yet, they received only 34 and 36% of the treatments, respectively. Women were prescribed self-care more often than men, with 61% of prescriptions for emollients and 48% of specific topical treatments for psoriasis dispensed to women. Conclusions: We discovered previously unrecognized gender differences in standard dermatological treatment for common diagnoses at our hospital. To ensure optimal care for each patient, treatment disparity should be recognized and gender-based analyzes be carried out when planning dermatological health care. © 2008 The International Society of Dermatology.
|
|
| 38. |
- Omazic, Anna, et al.
(författare)
-
Discrepancies in data reporting of zoonotic infectious diseases across the Nordic countries : a call for action in the era of climate change
- 2019
-
Ingår i: International Journal of Circumpolar Health. - : Taylor & Francis. - 1239-9736 .- 2242-3982. ; 78:1
-
Tidskriftsartikel (refereegranskat)abstract
- Emerging infections have in recent years caused enormous health problems. About 70% of these infections are zoonotic e.g. arise from natural foci in the environment. As climate change impacts ecosystems there is an ongoing transition of infectious diseases in humans. With the fastest changes of the climate occurring in the Arctic, this area is important to monitor for infections with potentials to be climate sensitive. To meet the increasing demand for evidence-based policies regarding climate-sensitive infectious diseases, epidemiological studies are vital. A review of registered data for nine potentially climate-sensitive infections, collected from health authorities in Denmark/Greenland, Finland, Iceland, Norway and Sweden, found that performing such studies across countries is constrained by incompatible reporting systems and differences in regulations. To address this, international standardisation is recommended.
|
|
| 39. |
- Omazic, Anna, et al.
(författare)
-
Identifying climate-sensitive infectious diseases in animals and humans in Northern regions
- 2019
-
Ingår i: Acta Veterinaria Scandinavica. - : BioMed Central. - 0044-605X .- 1751-0147. ; 61:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: General knowledge on climate change effects and adaptation strategies has increased significantly in recent years. However, there is still a substantial information gap regarding the influence of climate change on infectious diseases and how these diseases should be identified. From a One Health perspective, zoonotic infections are of particular concern. The climate in Northern regions is changing faster than the global average. This study sought to identify climate-sensitive infectious diseases (CSIs) of relevance for humans and/or animals living in Northern regions. Inclusion criteria for CSIs were constructed using expert assessments. Based on these principles, 37 potential CSIs relevant for Northern regions were identified. A systematic literature search was performed in three databases using an explicit stepwise approach to determine whether the literature supports selection of these 37 potential CSIs.Results: In total, 1275 nominated abstracts were read and categorised using predefined criteria. Results showed that arthropod vector-borne diseases in particular are recognised as having potential to expand their distribution towards Northern latitudes and that tick-borne encephalitis and borreliosis, midge-borne bluetongue and the parasitic infection fasciolosis can be classified as climate-sensitive. Many of the other potential CSIs considered are affected by extreme weather events, but could not be clearly classified as climate-sensitive. An additional literature search comparing awareness of climate influences on potential CSIs between 1997-2006 and 2007-2016 showed an increase in the number of papers mentioning effects of climate change.Conclusions: The four CSIs identified in this study could be targeted in a systematic surveillance programme in Northern regions. It is evident that climate change can affect the epidemiology and geographical range of many infectious diseases, but there were difficulties in identifying additional CSIs, most likely because other factors may be of equal or greater importance. However, climate-ecological dynamics are constantly under change, and therefore diseases may fall in or out of the climate-sensitive definition over time. There is increasing awareness in the literature of the effects of climate change on infectious diseases over time.
|
|
| 40. |
- Orlov, Dmitry, et al.
(författare)
-
Healthy Ecosystems Are a Prerequisite for Human Health-A Call for Action in the Era of Climate Change with a Focus on Russia
- 2020
-
Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 17:22
-
Forskningsöversikt (refereegranskat)abstract
- Throughout history, humans have experienced epidemics. The balance of living in nature encircled by microorganisms is delicate. More than 70% of today's emerging infections are zoonotic, i.e., those in which microorganisms transmitted from animals infect humans. Species are on the move at speeds never previously recorded, among ongoing climate change which is especially rapid at high latitudes. This calls for intensified international surveillance of Northern infectious diseases. Russia holds the largest area of thawing permafrost among Northern nations, a process which threatens to rapidly disrupt the balance of nature. In this paper, we provide details regarding Russian health infrastructure in order to take the first steps toward a collaborative international survey of Northern infections and international harmonization of the procured data.
|
|
| 41. |
- Osika, Ingrid, et al.
(författare)
-
[The laundry-basket project : gender differences to the very skin. Different treatment of some common skin diseases in men and women].
- 2005
-
Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 102:40, s. 2846-2851
-
Tidskriftsartikel (refereegranskat)abstract
- In this study, we have analysed the treatment traditions in a dermatological outpatient clinic, from a gender perspective. Eczema and psoriasis were of similar frequency in male and female patients, while a higher number of female patients had eczema of the hands. Ultraviolet light (UV) treatment was given to a higher number of male patients in all diagnostic groups including eczema of the hands. In addition, a higher number of given treatments was given to the male patients than to the female patients. As for prescriptions to male and female patients from our department and in Stockholm county (1.8 mill.), a much larger amount of preparations for local treatment was received by female patients, especially emollients. Male patients had received more of calcipotriol creme in addition to their being treated more intensively at the clinic. In a sub-group analysis on patients with psoriasis vulgaris on our clinic and in a patient cooperation-based treatment department, we found the same relation between male and female treatment as in the larger group. On follow-up, the number of female patients with psoriasis who were given treatment at our clinic had increased, but the number of treatments given to men was still higher than for female patients. An economic analysis of these findings show a great overweight of clinic-based treatment costs for male patients, while female patients receive emollients for self-care to a greater extent. We conclude that more studies are needed to clarify the basis of these findings.
|
|
| 42. |
|
|
| 43. |
- Parkinson, Alan J., et al.
(författare)
-
Climate change and health in the Arctic
- 2014
-
Ingår i: Climate change and global health. - : CABI Publishing. - 9781780642659 - 9781780644578 ; , s. 319-334
-
Bokkapitel (refereegranskat)
|
|
| 44. |
- Parkinson, Alan J., et al.
(författare)
-
Climate change and infectious diseases in the Arctic : Establishment of a circumpolar working group
- 2014
-
Ingår i: International Journal of Circumpolar Health. - : Taylor & Francis. - 1239-9736 .- 2242-3982. ; 73
-
Tidskriftsartikel (refereegranskat)abstract
- The Arctic, even more so than other parts of the world, has warmed substantially over the past few decades. Temperature and humidity influence the rate of development, survival and reproduction of pathogens and thus the incidence and prevalence of many infectious diseases. Higher temperatures may also allow infected host species to survive winters in larger numbers, increase the population size and expand their habitat range. The impact of these changes on human disease in the Arctic has not been fully evaluated. There is concern that climate change may shift the geographic and temporal distribution of a range of infectious diseases. Many infectious diseases are climate sensitive, where their emergence in a region is dependent on climate-related ecological changes. Most are zoonotic diseases, and can be spread between humans and animals by arthropod vectors, water, soil, wild or domestic animals. Potentially climate-sensitive zoonotic pathogens of circumpolar concern include Brucella spp., Toxoplasma gondii, Trichinella spp., Clostridium botulinum, Francisella tularensis, Borrelia burgdorferi, Bacillus anthracis, Echinococcus spp., Leptospira spp., Giardia spp., Cryptosporida spp., Coxiella burnetti, rabies virus, West Nile virus, Hantaviruses, and tick-borne encephalitis viruses.
|
|
| 45. |
|
|
| 46. |
- Pecl, Gretta T., et al.
(författare)
-
Climate-driven 'species-on-the-move' provide tangible anchors to engage the public on climate change
- 2023
-
Ingår i: People and Nature. - : John Wiley & Sons. - 2575-8314. ; 5:5, s. 1384-1402
-
Tidskriftsartikel (refereegranskat)abstract
- Over recent decades, our understanding of climate change has accelerated greatly, but unfortunately, observable impacts have increased in tandem. Both mitigation and adaptation have not progressed at the level or scale warranted by our collective knowledge on climate change. More effective approaches to engage people on current and future anthropogenic climate change effects are urgently needed. Here, we show how species whose distributions are shifting in response to climate change, that is, ‘species-on-the-move’, present an opportunity to engage people with climate change by linking to human values, and our deep connections with the places in which we live, in a locally relevant yet globally coherent narrative. Species-on-the-move can impact ecosystem structure and function, food security, human health, livelihoods, culture and even the climate itself through feedback to the climate system, presenting a wide variety of potential pathways for people to understand that climate change affects them personally as individuals. Citizen science focussed on documenting changes in biodiversity is one approach to foster a deeper engagement on climate change. However, other possible avenues, which may offer potential to engage people currently unconnected with nature, include arts, games or collaborations with rural agriculture (e.g. new occurrences of pest species) or fisheries organisations (e.g. shifting stocks) or healthcare providers (e.g. changing distributions of disease vectors). Through the importance we place on the aspects of life impacted by the redistribution of species around us, species-on-the-move offer emotional pathways to connect with people on the complex issue of climate change in profound ways that have the potential to engender interest and action on climate change. Read the free Plain Language Summary for this article on the Journal blog.
|
|
| 47. |
- Petersen, E, et al.
(författare)
-
Diagnosis of pulmonary infection with Toxoplasma gondii in immunocompromised HIV-positive patients by real-time PCR
- 2006
-
Ingår i: European Journal of Clinical Microbiology and Infectious Diseases. - : Springer Science and Business Media LLC. - 0934-9723 .- 1435-4373. ; 25:6, s. 401-404
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of the study presented here was to evaluate the use of PCR for improving the diagnosis of Toxoplasma gondii infection in immunocompromised hosts. Three hundred thirty-two bronchoalveolar lavage (BAL) fluid samples were analyzed by real-time PCR targeting a 529 bp element of T. gondii. In positive samples, the genotype of the parasite was determined by sequence analysis of the GRA6 gene. Positive results were achieved for 2% (7/332) of the samples tested. Genotyping was possible in two samples and revealed GRA6 type II T. gondii. PCR for detecting T. gondii in BAL samples should be performed in all immunosuppressed HIV-positive patients with symptoms of a systemic infection of unknown etiology. Trimethoprim-sulfamethoxazole prophylaxis does not exclude concomitant infection with T. gondii.
|
|
| 48. |
- Preet, Raman, et al.
(författare)
-
The gender perspective in climate change and global health
- 2010
-
Ingår i: Global Health Action. - : Informa UK Limited. - 1654-9716 .- 1654-9880. ; 3, s. 5720-
-
Tidskriftsartikel (refereegranskat)abstract
- Despite recognizing the differential effects of climate change on health of women and men as a consequence of complex social contexts and adaptive capacities, the study finds gender to be an underrepresented or non-existing variable both in research and studied policy documents in the field of climate change and health.
|
|
| 49. |
- Rautio, Arja, et al.
(författare)
-
Climate Change in the Arctic : The Need for a Broader Gender Perspective in Data Collection
- 2021
-
Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 18:2
-
Forskningsöversikt (refereegranskat)abstract
- Climate change in the Arctic affects both environmental, animal, and human health, as well as human wellbeing and societal development. Women and men, and girls and boys are affected differently. Sex-disaggregated data collection is increasingly carried out as a routine in human health research and in healthcare analysis. This study involved a literature review and used a case study design to analyze gender differences in the roles and responsibilities of men and women residing in the Arctic. The theoretical background for gender-analysis is here described together with examples from the Russian Arctic and a literature search. We conclude that a broader gender-analysis of sex-disaggregated data followed by actions is a question of human rights and also of economic benefits for societies at large and of the quality of services as in the health care.
|
|
| 50. |
- Samoilov, Andrei E., et al.
(författare)
-
Lethal Outcome of Leptospirosis in Southern Russia : Characterization of Leptospira Interrogans Isolated from a Deceased Teenager
- 2020
-
Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 17:12
-
Tidskriftsartikel (refereegranskat)abstract
- This article describes a lethal case of leptospirosis that occurred in Southern Russia. TheLeptospirastrain was isolated and characterized using a microscopic agglutination test, MALDI-TOF mass spectrometry, targeted PCR, and high-throughput sequencing. We show that molecular and mass-spectrometry methods can be an alternative to conventional methods of leptospirosis diagnostics andLeptospirastudy, which require highly qualified staff and can be performed only at specialized laboratories. We also report the first whole genome ofL.interrogansisolated in Russia.
|
|
