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- Sanne, Johan, et al.
(författare)
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Recommendations for future development of technologies for water management
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- A challenge describes both opportunities and barriers, and an enabler provides means to manage achallenge.The framework for the deliverable is based upon identifying process facilitators (e.g.workshops) and discursive abilities/devices providing enablers that partners used in order to make senseacross organizations and professional communities (developers and users) as a means to develop anddeploy digital technologies and services.IVL lead the work and edited the deliverable. Gothenburg city (CGEA), city of Amersfoort (COA) andBarcelona waste and wastewater company (BCASA) provided experiences as stakeholder and dataprovider, through user involvement.IVL Swedish Environmental Institute, Eurecat (EUT), Talkpool (TP),Civity (CIV) provided experiences from development and implementation work (focusing on stakeholderengagement and user involvement). They all contributed to the deliverable through meetings and writingone section each. Analysing the same processes from different points of view provided interesting insightsinto the development process and implications for the coming phases of the project.The Gothenburg section expresses how insights from cooperation issues from before the project, wereturned into a well-designed collaboration process (process facilitator) between developers andusers/stakeholders. In Gothenburg, engaging with various departments within the municipality and withexternal stakeholders has been a continuing learning process for IVL (case study leader).IVL graduallypresented various opportunities within the project, both in Amersfoort and Barcelona, which has beenvery much appreciated by the stakeholders. In this way, the engagement process has also enabledstakeholders to envision a number of opportunities that the new technologies empower that can becontinued beyond SCOREwater.Moreover, due to a fruitful collaboration between developers and stakeholders, both Gothenburg andBarcelona cities now envision even more opportunities and ambitions, some of which might be realizedwithin the project, some outside.Both Amersfoort and Barcelona also analyse how insights from different organizational issues influencedtheir design of process facilitators and discursive abilities.The Amersfoort section shows the influencefrom a) the different organizational structures and motives between the municipality, the for-profitcompanies and citizen volunteers and b) the differences in work processes between their policy makersand data analysts, people that seemed to be previously unfamiliar with working together.The first issuewas addressed through finding common ground in the objectives (added value as a discursive device) andthe second through designing a common process – going from simple to more complex hypothesis.In the Barcelona case, BCASA realized a) that they needed to “translate” their needs and concepts withregard to wastewater maintenance to other Catalan partners and b) that they needed to involve andengage both workers and managers at several departments for the SCOREwater project so that theyunderstand.see and value the benefits it provide and therefore engage in and support the SCOREwaterproject. EUT, TP and CIV expressed fewer specific challenges than the case studies, using familiar andproved process facilitators and discursive devices (CRISP-DM business modelling and user stories).
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- Evertsson, B, et al.
(författare)
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A comparative study of tolerability and effects on immunoglobulin levels and CD19 cell counts with ocrelizumab vs low dose of rituximab in multiple sclerosis
- 2020
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Ingår i: Multiple sclerosis journal - experimental, translational and clinical. - : SAGE Publications. - 2055-2173. ; 6:4, s. 2055217320964505-
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Tidskriftsartikel (refereegranskat)abstract
- Rituximab (RTX) and ocrelizumab (OCR) are two anti-CD20 biologics used in MS; however, comparisons on safety and efficacy are rare. Objective To compare treatment outcomes over the first year with RTX and OCR. Methods Retrospective cohort study comprising MS patients initiating RTX at the Karolinska University Hospital (Sweden; n = 311) and OCR at Rocky Mountain MS Clinic (Utah, USA; n = 161), respectively. Results Levels of immunoglobulin G measured in blood dropped 0.16 g/L (95% confidence interval 0.01 to 0.31) with each OCR infusion, but remained stable with RTX. In contrast, levels of immunoglobulin M decreased to a similar extent with both drugs. Ten and 15% of patients discontinued treatment with RTX and OCR, respectively (n.s), however, adverse events leading to treatment discontinuation were more common with OCR (6.8% vs 2.6%; p = 0.026). Only 3.1 and 1.6% discontinued OCR and RTX, respectively, due to lack of effect (n.s). The degree of B cell depletion was superior with OCR. Conclusion Overall, differences between the two treatments were small. Although the study design precludes robust conclusions regarding the risk-benefit with the studied therapies, our findings indicate that the tolerability and safety with RTX is not inferior to OCR.
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- Kläppe, U., et al.
(författare)
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Cardiac troponin T is elevated and increases longitudinally in ALS patients
- 2022
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Ingår i: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. - : Taylor and Francis Ltd.. - 2167-8421 .- 2167-9223. ; 23:1-2, s. 58-65
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To test whether high-sensitivity cardiac troponin T (hs-cTnT) could act as a diagnostic or prognostic biomarker in ALS, comparing hs-cTnT to neurofilament light (NfL). Methods: We performed a case-control study, including 150 ALS patients, 28 ALS mimics, and 108 healthy controls, and a follow-up study of the ALS patients, during 2014–2020 in Stockholm, Sweden. We compared concentrations of hs-cTnT in plasma and NfL in the cerebrospinal fluid between cases and controls. To evaluate the diagnostic performance, we calculated the area under the curve (AUC). Hazard ratios (HRs) were estimated from Cox models to assess associations between hs-cTnT and NfL at ALS diagnosis and risk of death. The longitudinal analysis measured changes of hs-cTnT and NfL since ALS diagnosis. Results: We noted higher levels of hs-cTnT in ALS patients (median: 16.5 ng/L) than in ALS mimics (11 ng/L) and healthy controls (6 ng/L). Both hs-cTnT and NfL could distinguish ALS patients from ALS mimics, with higher AUC noted for NfL (AUC 0.88; 95%CI 0.79–0.97). Disease progression correlated weakly with hs-cTnT (Pearson’s r = 0.18, p = 0.04) and moderately with NfL (Pearson’s r = 0.41, p < 0.001). Shorter survival was associated with higher levels of NfL at diagnosis (HR 1.08, 95%CI 1.04–1.11), but not hs-cTnT. hs-cTnT increased (12.61 ng/L per year, 95%CI 7.14–18.06) whereas NfL decreased longitudinally since ALS diagnosis. Conclusions: NfL is a stronger diagnostic and prognostic biomarker than hs-cTnT for ALS. However, hs-cTnT might constitute a disease progression biomarker as it increases longitudinally. The underlying causes for this increase need to be investigated.
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- Powell, M.S, et al.
(författare)
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Optimisation opportunities for HPGR circuits
- 2012
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Ingår i: 11th AusIMM Mill Operators’ Conference.
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Konferensbidrag (refereegranskat)abstract
- Based on a thorough review of the Mogalakwena North Concentrator of Anglo Platinum Operations, a wide range of issues were identified that form bottlenecks to the operation. In order to address these, a series of surveys were conducted and the entire dry circuit modelled in detail. From this a full simulation of the plant has been developed, this includes updated models of the HPGR, crusher, bins and screens. These have been implemented in the researchers MDK version of JKSimMet and in a prototype dynamic simulator based on the Matlab Simulink software.The observations, measurements and simulations have provided guidance and quantified the influence of proposed circuit modifications. Based on these a number of upgrades are being planned aimed at ensuring full utilisation of the installed equipment. The circuit demonstrates a potential expansion of over 30% through minor improvements and 70% with the addition of some strategic equipment.
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- Yazdani, S, et al.
(författare)
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T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression
- 2022
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 6733-
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Tidskriftsartikel (refereegranskat)abstract
- Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving neuroinflammation and T cell infiltration in the central nervous system. However, the contribution of T cell responses to the pathology of the disease is not fully understood. Here we show, by flow cytometric analysis of blood and cerebrospinal fluid (CSF) samples of a cohort of 89 newly diagnosed ALS patients in Stockholm, Sweden, that T cell phenotypes at the time of diagnosis are good predictors of disease outcome. High frequency of CD4+FOXP3− effector T cells in blood and CSF is associated with poor survival, whereas high frequency of activated regulatory T (Treg) cells and high ratio between activated and resting Treg cells in blood are associated with better survival. Besides survival, phenotypic profiling of T cells could also predict disease progression rate. Single cell transcriptomics analysis of CSF samples shows clonally expanded CD4+ and CD8+ T cells in CSF, with characteristic gene expression patterns. In summary, T cell responses associate with and likely contribute to disease progression in ALS, supporting modulation of adaptive immunity as a viable therapeutic option.
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