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Sökning: WFRF:(FAGERHOLM U)

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  • Lennernäs, H, et al. (författare)
  • Regional rectal perfusion : a new in vivo approach to study rectal drug absorption in man.
  • 1995
  • Ingår i: Pharmaceutical research. - 0724-8741 .- 1573-904X. ; 12:3, s. 426-32
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: In vivo permeability measurements of drugs in the colonic/rectal region in humans are difficult. A new instrument for the perfusion of a defined and closed segment in the colon/rectum was developed. The objective of this study was to evaluate its use for studying drug absorption mechanisms in the human rectum and to investigate the effect of transmucosal water absorption on drug permeability. Six healthy subjects participated at 2 separate occasions by using a modified system for segmental rectal perfusion. The system consisted of a multichannel tube with inflatable balloons and was endoscopically introduced into the rectum. The technique was considered acceptable by the following criteria; (a) high and reproducible recovery of PEG 4000, (b) stable residence time of the solution within the test segment, (c) flux of electrolytes that agrees with previous reports, (d) mass-balance absorption of antipyrine across the rectal barrier, (e) and good acceptability to the subjects. The permeability of antipyrine in the rectal region was increased by inducing net water absorption. D-glucose was not absorbed during any study periods. The present technique is valuable for studying drug absorption from the human rectum.
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  • ul Hasan, Kamran, et al. (författare)
  • A Miniature Graphene-based Biosensor for Intracellular Glucose Measurements
  • 2015
  • Ingår i: Electrochimica Acta. - : Elsevier Ltd. - 0013-4686 .- 1873-3859. ; 174, s. 574-580
  • Tidskriftsartikel (refereegranskat)abstract
    • We report on a small and simple graphene-based potentiometric sensor for the measurement of intracellular glucose concentration. A fine borosilicate glass capillary coated with graphene and subsequently immobilized with glucose oxidase (GOD) enzyme is inserted into the intracellular environment of a single human cell. The functional groups on the edge plane of graphene assist the attachment with the free amine terminals of GOD enzyme, resulting in a better immobilization. The sensor exhibits a glucose-dependent electrochemical potential against an Ag/AgCl reference microelectrode which is linear across the whole concentration range of interest (10 - 1000 μM). Glucose concentration in human fat cell measured by our graphene-based sensor is in good agreement with nuclear magnetic resonance (NMR) spectroscopy. 
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  • Resultat 1-21 av 21

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