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Sökning: WFRF:(Facciotti F)

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  • Persson, Tomas, et al. (författare)
  • Amino acid metabolism in roots and actinorhizal nodules from Alnus glutinosa and Datisca glomerata: γ-aminobutyric acid and β-alanine are important metabolites
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Roots and nodules of the actinorhizal plants Alnus glutinosa and Datisca glomerata, as well as Frankia alni ACN14a grown in minimal and ammonium supplemented media, were analyzed for amino acid profiles. To analyze nitrogen and carbon metabolism, the transcriptome in nodules of the microsymbiont of D. glomerata, Frankia datiscae Dg1, was sequenced and compared with transcriptome data from symbiotic F. alni ACN14a (Alloisio et al. 2011). The amino acid profile of A. glutinosa roots suggests that Citrulline, Asparagine and Glutamine are transported in the xylem. Moreover, the comparatively high concentration of γ-aminobutyric acid in A. glutinosa roots suggest that this compound has a function in plant nitrogen metabolism. γ-aminobutyric acid could, as was suggested for the legume symbiosis, act as a signal factor for the plant nitrogen status to symbiotic Frankia. It could also be imported by the bacteria as a carbon and nitrogen source. Moreover, the expression of the gene for the enzyme catalyzing β-Alanine synthesis was elevated in both Frankia strains in symbiosis. Elevated concentrations of β-Alanine in nodules of D. glomerata and A. glutinosa compared to roots suggest that β-Alanine is produced by the bacteria in large amounts, possibly as a storage compound for Coenzyme A production.
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3.
  • Ricke-Hoch, Melanie, et al. (författare)
  • Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease
  • 2021
  • Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 16:8
  • Tidskriftsartikel (refereegranskat)abstract
    • The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from unaffected subjects. In COVID-19 patients, PGE2 blood levels are markedly elevated and correlate positively with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglan-din-dehydrogenase. Also living human precision cut lung slices (PCLS) infected with SARS-CoV-2 display upregulated COX-2. Regular exercise in aged individuals lowers PGE2 serum levels, which leads to increased Paired-Box-Protein-Pax-5 (PAX5) expression, a master regulator of B-cell survival, proliferation and differentiation also towards long lived memory B-cells, in human pre-B-cell lines. Moreover, PGE2 levels in serum of COVID-19 patients lowers the expression of PAX5 in human pre-B-cell lines. The PGE2 inhibitor Taxifolin reduces SARS-CoV-2-induced PGE2 production. In conclusion, SARS-CoV-2, male sex, old age, and sedentary life style increase PGE2 levels, which may reduce the early anti-viral defense as well as the development of immunity promoting severe disease courses and multiple infections. Regular exercise and Taxifolin treatment may reduce these risks and prevent severe disease courses.
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