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- Ali, S., et al.
(författare)
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Concentration of fluoride in groundwater of India : A systematic review, meta-analysis and risk assessment
- 2019
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Ingår i: Groundwater for Sustainable Development. - : Elsevier. - 2352-801X. ; 9
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Forskningsöversikt (refereegranskat)abstract
- It is a well-known fact that the Indian groundwater is polluted by fluoride. However, for the first time in India, non-carcinogenic risk assessments and meta-analysis of fluoride exposure to humans were carried out due to consumption of groundwater. In this context, we collected fluoride concentration data in groundwater across India by systematic searches conducted in various international search engines databases. Here, we demonstrated a detailed meta-analysis and meta-regression of fluoride and evaluated health risk assessment. For this purpose, meta-analysis of 63 studies on fluoride in groundwater in India, comprising 57381 samples are included. We found that 1.) The pooled concentration of fluoride in India is around 2.37 mg/L with 95% confident interval (1.46–3.28 mg/L) which is higher than WHO and national standards limit of 1.5 mg/L. 2) The meta-analysis of data suggests that in rural parts of the country, fluoride concentration is 1.85 times higher than urban areas. 3) The concentration of fluoride in groundwater decreased significantly (p < 0.05) with increase in rainfall and longitude. The risk assessment via oral and dermal route exposure reveals that the consumers in majority of the regions are at considerable non-carcinogenic risk and children are at higher risk than adults (Total hazard quotient > 1). The findings are helpful in identifying the affected areas of India and we recommend that the safer options of drinking water should be adopted.
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- Burney, P., et al.
(författare)
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A case-control study of the relation between plasma selenium and asthma in European populations : a GAL2EN project
- 2008
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 63:7, s. 865-871
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: There is evidence that selenium levels are relatively low in Europe and may be falling. Low levels of selenium or low activity of some of the enzymes dependent on selenium have been associated with asthma. METHODS: The GA(2)LEN network has organized a multicentre case-control study in Europe to assess the relation of plasma selenium to asthma. The network compared 569 cases in 14 European centres with a diagnosis of asthma and reporting asthma symptoms in the last 12 months with 576 controls from the same centres with no diagnosis of asthma and no asthmatic symptoms in the last 12 months. RESULTS: All cases and controls were selected from the same population defined by age and place of residence. Mean plasma selenium concentrations among the controls ranged from 116.3 microg/l in Palermo to 67.7 microg/l in Vienna and 56.1 microg/l among the children in Oslo. Random effects meta-analysis of the results from the centres showed no overall association between asthma and plasma selenium [odds ratio (OR)/10 microg/l increase in plasma selenium: 1.04; 95% confidence interval (CI): 0.89-1.21] though there was a significantly protective effect in Lodz (OR: 0.48; 95% CI: 0.29-0.78) and a marginally significant adverse effect in Amsterdam (OR: 1.68; 95% CI: 0.98-2.90) and Ghent (OR: 1.35; 95% CI: 1.03-1.77). CONCLUSION: This study does not support a role for selenium in protection against asthma, but effect modification and confounding cannot be ruled out.
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