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- Rönnqvist, Louise, 1957-, et al.
(författare)
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Cognitive performance and behavioral functions in relation to gestational age (GA) at birth
- 2015
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Ingår i: Developmental Medicine & Child Neurology. - : John Wiley & Sons. - 0012-1622 .- 1469-8749. ; 57:Suppl s4, s. 21-
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Tidskriftsartikel (refereegranskat)abstract
- Introduction:It is well established that a very preterm birth (PT) relates to increased behavioral problems. The aim of this study was to investigate effects and associations between different gestational ages (GA) at birth (term, late-to-extreme) and later functions. This study is part of an ongoing, longitudinal project.Participants and Methods:Test outcomes from WISC-IV and Achenbach’s Child-Behavior-Checklist (CBCL) in children tested at 7-8-years (M=7.7) were used to investigate group differences as effect of GA at birth. In total, 64 preterm born (PT), GA range 22-36, (divided into groups of 14 extremely-PT/EPT, 17 very-PT/VPT, and 33 moderately PT/MPT) and 64 term born (TB), were included. Additionally, associations between GA, birth weight (BW), and outcomes from WISC-IV and CBCL were investigated.Results:Multivariate analyses of variance (MANOVA) revealed significantly (p < .05) poorer WISC outcomes on Verbal Comprehension Index, Perceptual Reasoning Index, and on Full-Scale-IQ for children born EPT/VPT in comparison to MPT and TB born. Parents’ CBCL ratings reveled that EPT children had significantly higher prevalence of Attention problems, Thought problems, Aggressive and Somatic complaints. Including the PT-group only shown significant positive correlations between GA/BW respectively and full scale IQ. Higher GA/BW was related to increasing IQ scores. Significant negative correlations were seen between GA/BW respectively and TotProblem/CBCL-scale. Additionally, CBCL/DSM-Oriented Scales; Adhd-, Opposite-, and Conduct-Problems correlated significantly negative with GA/BW in the PT-born children.Conclusion:Our study provides further support for associations between increased risk of cognitive and behavior problems with decreasing GA/BW at birth.
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| 2. |
- Rönnqvist, Louise, et al.
(författare)
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Effects of twin-births on IQ, handedness, and brain volumes in 8-years-old preterm born twins and matched singletons: a pilot study
- 2016
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Ingår i: Developmental Medicine & Child Neurology. - : Wiley. - 0012-1622 .- 1469-8749. ; 58:S6, s. 57-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Children born preterm have a high prevalence of long-term cognitive and behavioral disturbances. Still, studies of how preterm-twin-births may effect brain maturation and thus, contribute to long-term effects on brain-behavioral development and functions are rare.Aim: To investigate whether brain volumes differ between twin (TPB) and singleton preterm born (SPB) and full-term born children (FTB) and associate to long-term cognitive and behavioral outcomes as well as to gestational age (GA), birth weight (BW) and head circumference (BHC) at birth.Method: A sample of 22 twin born preterm (Mean GA=32.1, BW=1781), 23 matched singletons preterm (Mean GA=31.8, BW=1751), and 22 full-term singletons were included. All children were investigated by means of their cognition functions (WISC-IV), handedness performance index and brain volumes (3 Tesla MRI) at early school ages (M=7.8y) in 40 children (9 TPB, 10 SPB, 21 FTB).Results: The FTB-children performed better than both TPB and SPB on cognitive performance, and showed higher IQ. Brain volumes, especially Gray matter were stronger associated with IQ in the twins. Furthermore it was found that the SPB singletons had smaller Total Brain volume and less Grey Matter than FTB. The twins showed a higher prevalence of non-right handedness associated to GA, than both SPB and FTB. Independently of birth status, GA, BW and BHC were found to correlate positively with IQ, Total Brain volume, and Gray-and White matter volumes.Conclusion: Discordant handedness in TPB children and associations to lower GA indicate effect of twin-births on early functional laterality. The overall associations found between low GA/BW and smaller BHC at birth in preterm born and associations with lower IQ and smaller brain volumes at 8-y indicate that a very preterm birth are a higher predictor for long-term effects on brain development and cognitive performance than twin-birth per se.
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