| 1. |
- Lozano, Rafael, et al.
(författare)
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Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017
- 2018
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Ingår i: The Lancet. - : Elsevier. - 1474-547X .- 0140-6736. ; 392:10159, s. 2091-2138
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Tidskriftsartikel (refereegranskat)abstract
- Background: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leaving no one behind”, it is increasingly important to examine the health-related SDGs beyond national-level estimates. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), we measured progress on 41 of 52 health-related SDG indicators and estimated the health-related SDG index for 195 countries and territories for the period 1990–2017, projected indicators to 2030, and analysed global attainment. Methods: We measured progress on 41 health-related SDG indicators from 1990 to 2017, an increase of four indicators since GBD 2016 (new indicators were health worker density, sexual violence by non-intimate partners, population census status, and prevalence of physical and sexual violence [reported separately]). We also improved the measurement of several previously reported indicators. We constructed national-level estimates and, for a subset of health-related SDGs, examined indicator-level differences by sex and Socio-demographic Index (SDI) quintile. We also did subnational assessments of performance for selected countries. To construct the health-related SDG index, we transformed the value for each indicator on a scale of 0–100, with 0 as the 2·5th percentile and 100 as the 97·5th percentile of 1000 draws calculated from 1990 to 2030, and took the geometric mean of the scaled indicators by target. To generate projections through 2030, we used a forecasting framework that drew estimates from the broader GBD study and used weighted averages of indicator-specific and country-specific annualised rates of change from 1990 to 2017 to inform future estimates. We assessed attainment of indicators with defined targets in two ways: first, using mean values projected for 2030, and then using the probability of attainment in 2030 calculated from 1000 draws. We also did a global attainment analysis of the feasibility of attaining SDG targets on the basis of past trends. Using 2015 global averages of indicators with defined SDG targets, we calculated the global annualised rates of change required from 2015 to 2030 to meet these targets, and then identified in what percentiles the required global annualised rates of change fell in the distribution of country-level rates of change from 1990 to 2015. We took the mean of these global percentile values across indicators and applied the past rate of change at this mean global percentile to all health-related SDG indicators, irrespective of target definition, to estimate the equivalent 2030 global average value and percentage change from 2015 to 2030 for each indicator. Findings: The global median health-related SDG index in 2017 was 59·4 (IQR 35·4–67·3), ranging from a low of 11·6 (95% uncertainty interval 9·6–14·0) to a high of 84·9 (83·1–86·7). SDG index values in countries assessed at the subnational level varied substantially, particularly in China and India, although scores in Japan and the UK were more homogeneous. Indicators also varied by SDI quintile and sex, with males having worse outcomes than females for non-communicable disease (NCD) mortality, alcohol use, and smoking, among others. Most countries were projected to have a higher health-related SDG index in 2030 than in 2017, while country-level probabilities of attainment by 2030 varied widely by indicator. Under-5 mortality, neonatal mortality, maternal mortality ratio, and malaria indicators had the most countries with at least 95% probability of target attainment. Other indicators, including NCD mortality and suicide mortality, had no countries projected to meet corresponding SDG targets on the basis of projected mean values for 2030 but showed some probability of attainment by 2030. For some indicators, including child malnutrition, several infectious diseases, and most violence measures, the annualised rates of change required to meet SDG targets far exceeded the pace of progress achieved by any country in the recent past. We found that applying the mean global annualised rate of change to indicators without defined targets would equate to about 19% and 22% reductions in global smoking and alcohol consumption, respectively; a 47% decline in adolescent birth rates; and a more than 85% increase in health worker density per 1000 population by 2030. Interpretation: The GBD study offers a unique, robust platform for monitoring the health-related SDGs across demographic and geographic dimensions. Our findings underscore the importance of increased collection and analysis of disaggregated data and highlight where more deliberate design or targeting of interventions could accelerate progress in attaining the SDGs. Current projections show that many health-related SDG indicators, NCDs, NCD-related risks, and violence-related indicators will require a concerted shift away from what might have driven past gains—curative interventions in the case of NCDs—towards multisectoral, prevention-oriented policy action and investments to achieve SDG aims. Notably, several targets, if they are to be met by 2030, demand a pace of progress that no country has achieved in the recent past. The future is fundamentally uncertain, and no model can fully predict what breakthroughs or events might alter the course of the SDGs. What is clear is that our actions—or inaction—today will ultimately dictate how close the world, collectively, can get to leaving no one behind by 2030.
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| 2. |
- Feigin, Valery L., et al.
(författare)
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Global, regional, and national burden of neurological disorders, 1990–2016 : a systematic analysis for the Global Burden of Disease Study 2016
- 2019
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Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 18:5, s. 459-480
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Tidskriftsartikel (refereegranskat)abstract
- Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach.Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer's and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable).Interpretation: Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies.Funding: Bill & Melinda Gates Foundation.
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| 3. |
- Bengtsson, Marcus, et al.
(författare)
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Handbok för att minska underhållsrelaterade slöserier
- 2016
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- ENLIGT HEMSIDAN ”www.phrases.org.uk”(2016-02-25) myntade författaren Daniel Defoe frasen ’döden och skatter’ år 1726 och fler har sedan följt i hans fotspår. En av de kanske mest kända formuleringarna kom till i ett samtal mellan Benjamin Franklin och Jean-Baptiste Leroy (1789): ”I denna värld kan ingenting sägas vara säkert, utom döden och skatterna.” (fritt översatt från engelska). Vi har även funnit en person som använt det här uttrycket kopplat till underhåll, nämligen Kevin Marshall som diskuterar underhåll av hyreshus: ”...döden, skatter och underhåll.” (”www.flat-living.co.uk”, 2016-02-25). Underhåll i någon av alla dess former är någonting alla människor på jorden upplever nästan dagligen, medvetet eller omedvetet. Det finns egentligen bara ett sätt att tackla detta – med ett leende på läpparna. Man behöver dock inte vara slösaktig. På samma sätt som väldigt få vill betala mer i skatt än vad lagen kräver så vill sällan någon betala mer för underhåll än vad nöden kräver. Det är vad denna handbok handlar om. Den vänder sig till tillverkande företag som önskar minska sina underhållsrelaterade slöserier, och därför har behov av att se över sin verksamhet. Boken vänder sig i första hand till ledningsgrupper för underhåll, underhållschefer och underhållsutvecklare/ingenjörer. Dock, för att citera en av våra samarbetspartners: ”Det är ett slöseri om bara anställda inom underhållsavdelningen läser boken.” För att nå ett hållbart resultat är vi övertygade om att medvetenheten om slöserier och underhållsrelaterade slöserier behöver höjas bland samtliga anställda i en verksamhet. Detta är anledningen till att vi vill att du använder handboken. Vi uppmanar till att du läser exemplen och diskuterar frågorna med medarbetare inom hela underhållsavdelningen, och gärna tvärfunktionellt med produktion och övriga stödfunktioner. Vårt mål är att ge vägledning för hur tillverkande företag kan arbeta med underhållsrelaterade slöserier. Boken klargör vad sådana slöserier är, samt tips och idéer på hur man kan identifiera, klassificera och kvantifiera dem. Handboken presenterar även en arbetsprocess för att minska eller ta bort underhållsrelaterade slöserier så kostnadseffektivt som möjligt. Den innehåller också korta teoriavsnitt med exempel från praktiken och frågor som ledningsgrupper och anställda inom verksamheten kan diskutera. Genom att följa arbetsprocessen kan du och ditt företag få ökad medvetenhet och förståelse för underhållsrelaterade slöserier inom er egen verksamhet. Handboken fokuserar främst på de tidiga stegen i processen eftersom de är mest avgörande för ett lyckat resultat. Underhållsrelaterade slöserier är delvis unika för varje företag. Tyvärr finns inga genvägar eller standarder för att minska eller ta bort dem. Att endast läsa handboken kommer inte att ge något resultat. Den här boken bygger på att du och ditt företag aktivt finner er egen väg för att minska eller ta bort de underhållsrelaterade slöserier ni upptäcker i er verksamhet.
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| 4. |
- Delfin, Carl, et al.
(författare)
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A Federated Database for Obesity Research : An IMI-SOPHIA Study
- 2024
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Ingår i: Life. - 0024-3019. ; 14:2
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is considered by many as a lifestyle choice rather than a chronic progressive disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) project is part of a momentum shift aiming to provide better tools for the stratification of people with obesity according to disease risk and treatment response. One of the challenges to achieving these goals is that many clinical cohorts are siloed, limiting the potential of combined data for biomarker discovery. In SOPHIA, we have addressed this challenge by setting up a federated database building on open-source DataSHIELD technology. The database currently federates 16 cohorts that are accessible via a central gateway. The database is multi-modal, including research studies, clinical trials, and routine health data, and is accessed using the R statistical programming environment where statistical and machine learning analyses can be performed at a distance without any disclosure of patient-level data. We demonstrate the use of the database by providing a proof-of-concept analysis, performing a federated linear model of BMI and systolic blood pressure, pooling all data from 16 studies virtually without any analyst seeing individual patient-level data. This analysis provided similar point estimates compared to a meta-analysis of the 16 individual studies. Our approach provides a benchmark for reproducible, safe federated analyses across multiple study types provided by multiple stakeholders.
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| 5. |
- Farzaneh, Jaleh, et al.
(författare)
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The impact of person-job fit and person-organisation fit on OCB : the mediating and moderating effects of organisational commitment and psychological empowerment
- 2014
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Ingår i: Personnel review. - : Emerald Group Publishing Limited. - 0048-3486 .- 1758-6933. ; 43:5, s. 672-691
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Drawing upon the social exchange theory and empowerment theory, this study attempts to investigate the effect of perceived person-environment fit on organisational citizenship behavior. Furthermore, this study assesses the roles of organizational commitment and psychological empowerment in this relationshsip. Design/methodology/approach: Respondents of this study were employees of the Iran Northeast Gas Transfer Company. Data were collected through conducting a survey on 500 employees, of which 412 questionnaires were used for further analysis. Confirmatory factor analysis, structural equation modelling, Baron and Kenny's (1986) procedure for examining mediator effect and finally Zhao and Cavusgil's (2006) technique of evaluating moderator effect were utilised for the analyses. Practical implications: This research has implications for organisational approaches to human resource management organisations. Findings: Results indicated that organizational commitment acts as a mediator between Person-Job and Person-Organization fit and OCB. Psychological empowerment acts as a moderator between organizational commitment and OCB. Originality/value: This study empirically synthesises the joint effect of P-O fit and P-J fit on a behavioural variable (OCB) in the social context of organisation and explains the mechanism of the effect. The pattern of relationships tested is relatively novel.
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| 6. |
- Kazerani, Farzaneh, et al.
(författare)
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Eight new species of Dolichopodinae (Diptera: Dolichopodidae) from northern Iran
- 2017
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Ingår i: Zootaxa. - : Magnolia Press. - 1175-5334 .- 1175-5326.
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Tidskriftsartikel (refereegranskat)abstract
- Dipterological surveys were conducted in different sites in western and central parts of northern Iran (Guilan, Mazandaran, Kordestan, East and West Azerbaijan and Ardabil provinces) during 2010–2011 using Malaise traps, and during 2012–2014 employing sweep nets. A total of 110 species were collected, including 42 Dolichopodinae. Eleven dolichopodine species proved new to science, eight of which are described here: Dolichopus fuscicercus sp. nov., D. subimmaculatus sp. nov., Gymnopternus flavitibia sp. nov., G. atratus sp. nov., Hercostomus setitibia sp. nov., H. albicoxa sp. nov., Poecilobothrus annulitarsis sp. nov. and P. innotabilis sp. nov. Some of these species strongly resemble European species and even share near identical conspicuous male secondary sexual characters.
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| 7. |
- Liu, Goksin, et al.
(författare)
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Conformational multiplicity of bacterial ferric binding protein revealed by small angle x-ray scattering and molecular dynamics calculations
- 2023
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Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 158:8
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Tidskriftsartikel (refereegranskat)abstract
- This study combines molecular dynamics (MD) simulations with small angle x-ray scattering (SAXS) measurements to investigate the range of conformations that can be adopted by a pH/ionic strength (IS) sensitive protein and to quantify its distinct populations in solution. To explore how the conformational distribution of proteins may be modified in the environmental niches of biological media, we focus on the periplasmic ferric binding protein A (FbpA) from Haemophilus influenzae involved in the mechanism by which bacteria capture iron from higher organisms. We examine iron-binding/release mechanisms of FbpA in varying conditions simulating its biological environment. While we show that these changes fall within the detectable range for SAXS as evidenced by differences observed in the theoretical scattering patterns calculated from the crystal structure models of apo and holo forms, detection of conformational changes due to the point mutation D52A and changes in ionic strength (IS) from SAXS scattering profiles have been challenging. Here, to reach conclusions, statistical analyses with SAXS profiles and results from different techniques were combined in a complementary fashion. The SAXS data complemented by size exclusion chromatography point to multiple and/or alternative conformations at physiological IS, whereas they are well-explained by single crystallographic structures in low IS buffers. By fitting the SAXS data with unique conformations sampled by a series of MD simulations under conditions mimicking the buffers, we quantify the populations of the occupied substates. We also find that the D52A mutant that we predicted by coarse-grained computational modeling to allosterically control the iron binding site in FbpA, responds to the environmental changes in our experiments with conformational selection scenarios that differ from those of the wild type.
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| 8. |
- Oss Boll, Heloísa, et al.
(författare)
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Graph neural networks for clinical risk prediction based on electronic health records : A survey
- 2024
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Ingår i: Journal of Biomedical Informatics. - Maryland Heights, MO : Academic Press. - 1532-0464 .- 1532-0480. ; 151
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Forskningsöversikt (refereegranskat)abstract
- Objective: This study aims to comprehensively review the use of graph neural networks (GNNs) for clinical risk prediction based on electronic health records (EHRs). The primary goal is to provide an overview of the state-of-the-art of this subject, highlighting ongoing research efforts and identifying existing challenges in developing effective GNNs for improved prediction of clinical risks. Methods: A search was conducted in the Scopus, PubMed, ACM Digital Library, and Embase databases to identify relevant English-language papers that used GNNs for clinical risk prediction based on EHR data. The study includes original research papers published between January 2009 and May 2023. Results: Following the initial screening process, 50 articles were included in the data collection. A significant increase in publications from 2020 was observed, with most selected papers focusing on diagnosis prediction (n = 36). The study revealed that the graph attention network (GAT) (n = 19) was the most prevalent architecture, and MIMIC-III (n = 23) was the most common data resource. Conclusion: GNNs are relevant tools for predicting clinical risk by accounting for the relational aspects among medical events and entities and managing large volumes of EHR data. Future studies in this area may address challenges such as EHR data heterogeneity, multimodality, and model interpretability, aiming to develop more holistic GNN models that can produce more accurate predictions, be effectively implemented in clinical settings, and ultimately improve patient care. © 2024 The Authors
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| 9. |
- Rajabi, Nona, et al.
(författare)
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Mental Face Image Retrieval Based on a Closed-Loop Brain-Computer Interface
- 2023
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Ingår i: Augmented Cognition. - : Springer Nature. ; , s. 26-45
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Konferensbidrag (refereegranskat)abstract
- Retrieval of mental images from measured brain activity may facilitate communication, especially when verbal or muscular communication is impossible or inefficient. The existing work focuses mostly on retrieving the observed visual stimulus while our interest is on retrieving the imagined mental image. We present a closed-loop BCI framework to retrieve mental images of human faces. We utilize EEG signals as binary feedback to determine the relevance of an image to the target mental image. We employ the feedback to traverse the latent space of a generative model to propose new images closer to the actual target image. We evaluate the proposed framework on 13 volunteers. Unlike previous studies, we do not restrict the possible attributes of the resulting images to predefined semantic classes. Subjective and objective tests validate the ability of our model to retrieve face images similar to the actual target mental images.
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| 10. |
- Soltani, Farzaneh, et al.
(författare)
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Assessing Climate Change Impact on Water Balance Components Using Integrated Groundwater–Surface Water Models (Case Study: Shazand Plain, Iran)
- 2023
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Ingår i: Water (Switzerland). - : MDPI AG. - 2073-4441. ; 15:4
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Tidskriftsartikel (refereegranskat)abstract
- Assessing the status of water resources is essential for long-term planning related to water and many other needs of a country. According to climate reports, climate change is on the rise in all parts of the world; however, this phenomenon will have more consequences in arid and semi-arid regions. The aim of this study is to evaluate the effects of climate change on groundwater, surface water, and their exchanges in Shazand plain in Iran, which has experienced a significant decline in streamflow and groundwater level in recent years. To address this issue, we propose the use of the integrated hydrological model MODFLOW-OWHM to simulate groundwater level, surface water routing, and their interactions; a climate model, NorESM, under scenario SSP2, for climate data prediction; and, finally, the HEC-HMS model to predict future river discharge. The results predict that, under future climate conditions, the river discharges at the hydrometric stations of the region may decrease by 58%, 63%, 75%, and 81%. The average groundwater level in 2060 may decrease significantly by 15.1 m compared to 2010. The results of this study reveal the likely destructive effects of climate change on water resources in this region and highlight the need for sustainable management methods to mitigate these future effects.
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