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Sökning: WFRF:(Ferreira Joao Pedro)

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1.
  • Jacome, Cristina, et al. (författare)
  • Monitoring Adherence to Asthma Inhalers Using the InspirerMundi App : Analysis of Real-World, Medium-Term Feasibility Studies
  • 2021
  • Ingår i: Frontiers in Medical Technology. - : Frontiers Media S.A.. - 2673-3129. ; 3
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Poor medication adherence is a major challenge in asthma and objective assessment of inhaler adherence is needed. InspirerMundi app aims to monitor inhaler adherence while turning it into a positive experience through gamification and social support.Objective: We assessed the medium-term feasibility of the InspirerMundi app to monitor inhaler adherence in real-world patients with persistent asthma (treated with daily inhaled medication). In addition, we attempted to identify the characteristics of the patients related to higher app use.Methods: Two real-world multicenter observational studies, with one initial face-to-face visit and a 4-month telephone interview, were conducted in 29 secondary care centers from Portugal. During an initial face-to-face visit, patients were invited to use the app daily to register their asthma medication intakes. A scheduled intake was considered taken when patients took a photo of the medication (inhaler, blister, or others) using the image-based medication detection tool. Medication adherence was calculated as the number of doses taken as a percentage of the number scheduled. Interacting with the app =30 days was used as the cut-off for higher app use.Results: A total of 114 patients {median 20 [percentile 25 to percentile 75 (P25-P75) 16-36] years, 62% adults} were invited, 107 (94%) installed the app and 83 (73%) completed the 4-month interview. Patients interacted with the app for a median of 18 [3-45] days, translated on a median use rate of 15 [3-38]%. Median inhaler adherence assessed through the app was 34 [4-73]% when considering all scheduled inhalations for the study period. Inhaler adherence assessed was not significantly correlated with self-reported estimates. Median adherence for oral and other medication was 41 [6-83]% and 43 [3-73]%, respectively. Patients with higher app use were slightly older (p = 0.012), more frequently taking medication for other health conditions (p = 0.040), and more frequently prescribed long-acting muscarinic antagonists (LAMA, p = 0.024). After 4 months, Control of Allergic Rhinitis and Asthma Test (CARAT) scores improved (p < 0.001), but no differences between patients interacting with the app for 30 days or less were seen.Conclusions: The InspirerMundi app was feasible to monitor inhaler adherence in patients with persistent asthma. The persistent use of this mHealth technology varies widely. A better understanding of characteristics related to higher app use is still needed before effectiveness studies are undertaken.
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2.
  • Neves, Ana Luisa, et al. (författare)
  • Determinants of the Use of Health and Fitness Mobile Apps by Patients With Asthma : Secondary Analysis of Observational Studies
  • 2021
  • Ingår i: Journal of Medical Internet Research. - : JMIR Publications. - 1438-8871. ; 23:9
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Health and fitness apps have potential benefits to improve self-management and disease control among patients with asthma. However, inconsistent use rates have been reported across studies, regions, and health systems. A better understanding of the characteristics of users and nonusers is critical to design solutions that are effectively integrated in patients' daily lives, and to ensure that these equitably reach out to different groups of patients, thus improving rather than entrenching health inequities. Objective: This study aimed to evaluate the use of general health and fitness apps by patients with asthma and to identify determinants of usage. Methods: A secondary analysis of the INSPIRERS observational studies was conducted using data from face-to-face visits. Patients with a diagnosis of asthma were included between November 2017 and August 2020. Individual-level data were collected, including age, gender, marital status, educational level, health status, presence of anxiety and depression, postcode, socioeconomic level, digital literacy, use of health services, and use of health and fitness apps. Multivariate logistic regression was used to model the probability of being a health and fitness app user. Statistical analysis was performed in R. Results: A total of 526 patients attended a face-to-face visit in the 49 recruiting centers and 514 had complete data. Most participants were <= 40 years old (66.4%), had at least 10 years of education (57.4%), and were in the 3 higher quintiles of the socioeconomic deprivation index (70.1%). The majority reported an overall good health status (visual analogue scale [VAS] score>70 in 93.1%) and the prevalence of anxiety and depression was 34.3% and 11.9%, respectively. The proportion of participants who reported using health and fitness mobile apps was 41.1% (n=211). Multivariate models revealed that single individuals and those with more than 10 years of education are more likely to use health and fitness mobile apps (adjusted odds ratio [aOR] 2.22, 95%CI 1.05-4.75 and aOR 1.95, 95%CI 1.12-3.45, respectively). Higher digital literacy scores were also associated with higher odds of being a user of health and fitness apps, with participants in the second, third, and fourth quartiles reporting aORs of 6.74 (95%CI 2.90-17.40), 10.30 (95%CI 4.28-27.56), and 11.52 (95%CI 4.78-30.87), respectively. Participants with depression symptoms had lower odds of using health and fitness apps (aOR 0.32, 95%CI 0.12-0.83). Conclusions: A better understanding of the barriers and enhancers of app use among patients with lower education, lower digital literacy, or depressive symptoms is key to design tailored interventions to ensure a sustained and equitable use of these technologies. Future studies should also assess users' general health-seeking behavior and their interest and concerns specifically about digital tools. These factors may impact both initial engagement and sustained use.
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4.
  • Marto, João Pedro, et al. (författare)
  • Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke Registry.
  • 2023
  • Ingår i: Neurology. - 1526-632X. ; 100:7
  • Tidskriftsartikel (refereegranskat)abstract
    • COVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19.This was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection. With a doubly robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT).Of a total of 15,128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19; of those, 5,848 (38.7%) patients received IVT-only and 9,280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted OR 1.53; 95% CI 1.16-2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20-2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23-1.99), 24-hour mortality (OR 2.47; 95% CI 1.58-3.86), and 3-month mortality (OR 1.88; 95% CI 1.52-2.33). Patients with COVID-19 also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26-1.60).Patients with AIS and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non-COVID-19 patients receiving treatment. Current available data do not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in patients with COVID-19 or to establish different treatment recommendations in this subgroup of patients with ischemic stroke. Our findings can be taken into consideration for treatment decisions, patient monitoring, and establishing prognosis.The study was registered under ClinicalTrials.gov identifier NCT04895462.
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5.
  • Stanaway, Jeffrey D., et al. (författare)
  • Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
  • 2018
  • Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1923-1994
  • Tidskriftsartikel (refereegranskat)abstract
    • Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk- outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017.
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6.
  • Amaral, Rita, et al. (författare)
  • Profiling Persistent Asthma Phenotypes in Adolescents : A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies
  • 2021
  • Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 18:3
  • Tidskriftsartikel (refereegranskat)abstract
    • We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.
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7.
  • Ferreira, Joao Pedro, et al. (författare)
  • Thin slices of interaction : predicting users' task difficulty within 60 sec
  • 2012
  • Ingår i: Proceedings CHI '12 Extended Abstracts on Human Factors in Computing Systems. - New York, NY, USA : ACM Press. - 9781450310161 ; , s. 171-180
  • Konferensbidrag (refereegranskat)abstract
    • We report on an exploratory study where the first 60 seconds of the video recording of a user interaction are used to predict the user’s experienced task difficulty. This approach builds on previous work on “thin slices” of human-human behavior, and applies it to human- computer interaction. In the scenario of interacting with a photocopy machine, automated video coding showed that the Activity and Emphasis predicted 46.6% of the variance of task difficulty. This result closely follows reported results on predicting negotiation outcomes from conversational dynamics using similar variables on the speech signal.
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8.
  • Simoes Cunha, Mafalda, et al. (författare)
  • Symptoms of anxiety and depression in patients with persistent asthma : a cross-sectional analysis of the INSPIRERS studies
  • 2023
  • Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 13:5
  • Tidskriftsartikel (refereegranskat)abstract
    • ObjectivesAnxiety and depression are relevant comorbidities in asthma, but, in Portugal and Spain, data on this topic are scarce. We assessed, in patients with asthma, the frequency of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) and the European Quality of Life Five Dimension Questionnaire (EQ-5D); the level of agreement between these questionnaires, and the factors associated with these symptoms.MethodsThis is a secondary analysis of the INSPIRERS studies. A total of 614 adolescents and adults with persistent asthma (32.6 +/- 16.9 years, 64.7% female) were recruited from 30 primary care centres and 32 allergy, pulmonology and paediatric clinics. Demographic and clinical characteristics, HADS and EQ-5D were collected. A score >= 8 on Hospital Anxiety and Depression Scale-Anxiety/Hospital Anxiety and Depression Scale-Depression or a positive answer to EQ-5D item 5 indicated the presence of these symptoms. Agreement was determined by Cohen's kappa. Two multivariable logistic regressions were built.ResultsAccording to HADS, 36% of the participants had symptoms of anxiety and 12% of depression. According to EQ-5D, 36% of the participants had anxiety/depression. The agreement between questionnaires in identifying anxiety/depression was moderate (k=0.55, 95% CI 0.48 to 0.62). Late asthma diagnosis, comorbidities and female gender were predictors of anxiety/depression, while better asthma control, health-related quality of life and perception of health were associated with lower odds for anxiety/depression.ConclusionAt least 1/3 of the patients with persistent asthma experience symptoms of anxiety/depression, showing the relevance of screening these disorders in patients with asthma. EQ-5D and HADS questionnaires showed a moderate agreement in the identification of anxiety/depression symptoms. The identified associated factors need to be further investigated in long-term studies.
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10.
  • Hawkins, Stephen J., et al. (författare)
  • The Intertidal Zone of the North-East Atlantic Region
  • 2019
  • Ingår i: Interactions in the Marine Benthos: Global Patterns and Processes (Systematics Association Special Volume Series, pp. 7-46). - : Cambridge university press. - 9781108416085
  • Bokkapitel (refereegranskat)abstract
    • The rocky shores of the north-east Atlantic have been long studied. Our focus is from Gibraltar to Norway plus the Azores and Iceland. Phylogeographic processes shape biogeographic patterns of biodiversity. Long-term and broadscale studies have shown the responses of biota to past climate fluctuations and more recent anthropogenic climate change. Inter- and intra-specific species interactions along sharp local environmental gradients shape distributions and community structure and hence ecosystem functioning. Shifts in domination by fucoids in shelter to barnacles/mussels in exposure are mediated by grazing by patellid limpets. Further south fucoids become increasingly rare, with species disappearing or restricted to estuarine refuges, caused by greater desiccation and grazing pressure. Mesoscale processes influence bottom-up nutrient forcing and larval supply, hence affecting species abundance and distribution, and can be proximate factors setting range edges (e.g., the English Channel, the Iberian Peninsula). Impacts of invasive non-native species are reviewed. Knowledge gaps such as the work on rockpools and host–parasite dynamics are also outlined.
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11.
  • Hudson, Lawrence N, et al. (författare)
  • The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project
  • 2017
  • Ingår i: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188
  • Tidskriftsartikel (refereegranskat)abstract
    • The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
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12.
  • Nguyen, Thanh N, et al. (författare)
  • Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up.
  • 2023
  • Ingår i: Neurology. - 1526-632X. ; 100:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases.There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1-6.9]; p < 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1-4.6]; p < 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4-5.8]; p < 0.0001). Larger declines were observed at high-volume compared with low-volume centers (all p < 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6-0.9]; p = 0.49). Stroke was diagnosed in 1.3% [1.31-1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82-2.97], 5,656/195,539) of all stroke hospitalizations.There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year.This study is registered under NCT04934020.
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13.
  • Abbafati, Cristiana, et al. (författare)
  • 2020
  • Tidskriftsartikel (refereegranskat)
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14.
  • De Bastiani, Marco Antônio, et al. (författare)
  • Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies.
  • 2023
  • Ingår i: Brain, behavior, and immunity. - : Elsevier BV. - 1090-2139 .- 0889-1591. ; 110, s. 175-184
  • Tidskriftsartikel (refereegranskat)abstract
    • In Alzheimer's disease clinical research, glial fibrillary acidic protein (GFAP) released/leaked into the cerebrospinal fluid and blood is widely measured and perceived as a biomarker of reactive astrogliosis. However, it was demonstrated that GFAP levels differ in individuals presenting with amyloid-β (Aβ) or tau pathologies. The molecular underpinnings behind this specificity are little explored. Here we investigated biomarker and transcriptomic associations of hippocampal GFAP-positive astrocytes with Aβ and tau pathologies in humans and mouse models.We studied 90 individuals with plasma GFAP, Aβ- and Tau-PET to investigate the association between biomarkers. Then, transcriptomic analysis in hippocampal GFAP-positive astrocytes isolated from mouse models presenting Aβ (PS2APP) or tau (P301S) pathologies was conducted to explore differentially expressed genes (DEGs), Gene Ontology terms, and protein-protein interaction networks associated with each phenotype.In humans, we found that plasma GFAP associates with Aβ but not tau pathology. Unveiling the unique nature of hippocampal GFAP-positive astrocytic responses to Aβ or tau pathologies, mouse transcriptomics showed scarce overlap of DEGs between the Aβ. and tau mouse models. While Aβ GFAP-positive astrocytes were overrepresented with DEGs associated with proteostasis and exocytosis-related processes, tau hippocampal GFAP-positive astrocytes presented greater abnormalities in functions related to DNA/RNA processing and cytoskeleton dynamics.Our results offer insights into Aβ- and tau-driven specific signatures in hippocampal GFAP-positive astrocytes. Characterizing how different underlying pathologies distinctly influence astrocyte responses is critical for the biological interpretation of astrocyte biomarkers and suggests the need to develop context-specific astrocyte targets to study AD.This study was supported by Instituto Serrapilheira, Alzheimer's Association, CAPES, CNPq and FAPERGS.
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15.
  • Ferrari-Souza, Joao Pedro, et al. (författare)
  • Vascular risk burden is a key player in the early progression of Alzheimer's disease
  • 2024
  • Ingår i: NEUROBIOLOGY OF AGING. - 0197-4580 .- 1558-1497. ; 136, s. 88-98
  • Tidskriftsartikel (refereegranskat)abstract
    • Understanding whether vascular risk factors (VRFs) synergistically potentiate Alzheimer's disease (AD) progression is important in the context of emerging treatments for preclinical AD. In a group of 503 cognitively unimpaired individuals, we tested whether VRF burden interacts with AD pathophysiology to accelerate neurodegeneration and cognitive decline. Baseline VRF burden was calculated considering medical data and AD pathophysiology was assessed based on cerebrospinal fluid (CSF) amyloid-beta 1-42 (A beta 1-42) and tau phosphorylated at threonine 181 (p-tau181). Neurodegeneration was assessed with plasma neurofilament light (NfL) and global cognition with the modified version of the Preclinical Alzheimer's Cognitive Composite. The mean (SD) age of participants was 72.9 (6.1) years, and 220 (43.7%) were men. Linear mixed-effects models revealed that an elevated VRF burden synergistically interacted with AD pathophysiology to drive longitudinal plasma NfL increase and cognitive decline. Additionally, VRF burden was not associated with CSF A beta 1-42or p-tau181 changes over time. Our results suggest that VRF burden and AD pathophysiology are independent processes; however, they synergistically lead to neurodegeneration and cognitive deterioration. In preclinical stages, the combination of therapies targeting VRFs and AD pathophysiology might potentiate treatment outcomes.
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16.
  • Pascoal, Tharick A., et al. (författare)
  • Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer's disease
  • 2023
  • Ingår i: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. - : Wiley. - 2352-8729. ; 15:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: The optimal combination of amyloid-β/tau/neurodegeneration (A/T/N) biomarker profiles for the diagnosis of Alzheimer's disease (AD) dementia is unclear. Methods: We examined the discriminative accuracy of A/T/N combinations assessed with neuroimaging biomarkers for the differentiation of AD from cognitively unimpaired (CU) elderly and non-AD neurodegenerative diseases in the TRIAD, BioFINDER-1 and BioFINDER-2 cohorts (total n = 832) using area under the receiver operating characteristic curves (AUC). Results: For the diagnosis of AD dementia (vs. CU elderly), T biomarkers performed as well as the complete A/T/N system (AUC range: 0.90–0.99). A and T biomarkers in isolation performed as well as the complete A/T/N system in differentiating AD dementia from non-AD neurodegenerative diseases (AUC range; A biomarker: 0.84–1; T biomarker: 0.83–1). Discussion: In diagnostic settings, the use of A or T neuroimaging biomarkers alone can reduce patient burden and medical costs compared with using their combination, without significantly compromising accuracy.
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17.
  • Pascoal, Tharick, et al. (författare)
  • Astrocyte reactivity influences the association of amyloid-β and tau biomarkers in preclinical Alzheimer's disease.
  • 2023
  • Ingår i: Research square. - : Research Square Platform LLC.
  • Tidskriftsartikel (refereegranskat)abstract
    • An unresolved question for the understanding of Alzheimer's disease (AD) pathophysiology is why a significant percentage of amyloid β (Aβ)-positive cognitively unimpaired (CU) individuals do not develop detectable downstream tau pathology and, consequently, clinical deterioration. In vitro evidence suggests that reactive astrocytes are key to unleashing Aβ effects in pathological tau phosphorylation. In a large study ( n =1,016) across three cohorts, we tested whether astrocyte reactivity modulates the association of Aβ with plasma tau phosphorylation in CU people. We found that Aβ pathology was associated with increased plasma phosphorylated tau levels only in individuals positive for astrocyte reactivity (Ast+). Cross-sectional and longitudinal tau-PET analysis revealed that tau tangles accumulated as a function of Aβ burden only in CU Ast+ individuals with a topographic distribution compatible with early AD. Our findings suggest that increased astrocyte reactivity is an important upstream event linking Aβ burden with initial tau pathology which might have implications for the biological definition of preclinical AD and for selecting individuals for early preventive clinical trials.
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18.
  • Schaffer Aguzzoli, Cristiano, et al. (författare)
  • Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease
  • 2023
  • Ingår i: JAMA network open. - 2574-3805. ; 6:11
  • Tidskriftsartikel (refereegranskat)abstract
    • Importance: Neuropsychiatric symptoms are commonly encountered and are highly debilitating in patients with Alzheimer disease. Understanding their underpinnings has implications for identifying biomarkers and treatment for these symptoms. Objective: To evaluate whether glial markers are associated with neuropsychiatric symptoms in individuals across the Alzheimer disease continuum. Design, Setting, and Participants: This cross-sectional study was conducted from January to June 2023, leveraging data from the Translational Biomarkers in Aging and Dementia cohort at McGill University, Canada. Recruitment was based on referrals of individuals from the community or from outpatient clinics. Exclusion criteria included active substance abuse, major surgery, recent head trauma, safety contraindications for positron emission tomography (PET) or magnetic resonance imaging, being currently enrolled in other studies, and having inadequately treated systemic conditions. Main Outcomes and Measures: All individuals underwent assessment for neuropsychiatric symptoms (Neuropsychiatry Inventory Questionnaire [NPI-Q]), and imaging for microglial activation ([11C]PBR28 PET), amyloid-β ([18F]AZD4694 PET), and tau tangles ([18F]MK6240 PET). Results: Of the 109 participants, 72 (66%) were women and 37 (34%) were men; the median age was 71.8 years (range, 38.0-86.5 years). Overall, 70 had no cognitive impairment and 39 had cognitive impairment (25 mild; 14 Alzheimer disease dementia). Amyloid-β PET positivity was present in 21 cognitively unimpaired individuals (30%) and in 31 cognitively impaired individuals (79%). The NPI-Q severity score was associated with microglial activation in the frontal, temporal, and parietal cortices (β=7.37; 95% CI, 1.34-13.41; P=.01). A leave-one-out approach revealed that irritability was the NPI-Q domain most closely associated with the presence of brain microglial activation (β=6.86; 95% CI, 1.77-11.95; P=.008). Furthermore, we found that microglia-associated irritability was associated with study partner burden measured by NPI-Q distress score (β=5.72; 95% CI, 0.33-11.10; P=.03). Conclusions and Relevance: In this cross-sectional study of 109 individuals across the AD continuum, microglial activation was associated with and a potential biomarker of neuropsychiatric symptoms in Alzheimer disease. Moreover, our findings suggest that the combination of amyloid-β- and microglia-targeted therapies could have an impact on relieving these symptoms.
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19.
  • Therriault, Joseph, et al. (författare)
  • Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography.
  • 2022
  • Ingår i: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 80:2, s. 188-99
  • Tidskriftsartikel (refereegranskat)abstract
    • The recent proliferation of phosphorylated tau (p-tau) biomarkers has raised questions about their preferential association with the hallmark pathologies of Alzheimer disease (AD): amyloid-β plaques and tau neurofibrillary tangles.To determine whether cerebrospinal fluid (CSF) and plasma p-tau biomarkers preferentially reflect cerebral β-amyloidosis or neurofibrillary tangle aggregation measured with positron emission tomography (PET).This was a cross-sectional study of 2 observational cohorts: the Translational Biomarkers in Aging and Dementia (TRIAD) study, with data collected between October 2017 and August 2021, and the Alzheimer's Disease Neuroimaging Initiative (ADNI), with data collected between September 2015 and November 2019. TRIAD was a single-center study, and ADNI was a multicenter study. Two independent subsamples were derived from TRIAD. The first TRIAD subsample comprised individuals assessed with CSF p-tau (p-tau181, p-tau217, p-tau231, p-tau235), [18F]AZD4694 amyloid PET, and [18F]MK6240 tau PET. The second TRIAD subsample included individuals assessed with plasma p-tau (p-tau181, p-tau217, p-tau231), [18F]AZD4694 amyloid PET, and [18F]MK6240 tau PET. An independent cohort from ADNI comprised individuals assessed with CSF p-tau181, [18F]florbetapir PET, and [18F]flortaucipir PET. Participants were included based on the availability of p-tau and PET biomarker assessments collected within 9 months of each other. Exclusion criteria were a history of head trauma or magnetic resonance imaging/PET safety contraindications. No participants who met eligibility criteria were excluded.Amyloid PET, tau PET, and CSF and plasma assessments of p-tau measured with single molecule array (Simoa) assay or enzyme-linked immunosorbent assay.Associations between p-tau biomarkers with amyloid PET and tau PET.A total of 609 participants (mean [SD] age, 66.9 [13.6] years; 347 female [57%]; 262 male [43%]) were included in the study. For all 4 phosphorylation sites assessed in CSF, p-tau was significantly more closely associated with amyloid-PET values than tau-PET values (p-tau181 difference, 13%; 95% CI, 3%-22%; P=.006; p-tau217 difference, 11%; 95% CI, 3%-20%; P=.003; p-tau231 difference, 15%; 95% CI, 5%-22%; P<.001; p-tau235 difference, 9%; 95% CI, 1%-19%; P=.02) . These results were replicated with plasma p-tau181 (difference, 11%; 95% CI, 1%-22%; P=.02), p-tau217 (difference, 9%; 95% CI, 1%-19%; P=.02), p-tau231 (difference, 13%; 95% CI, 3%-24%; P=.009), and CSF p-tau181 (difference, 9%; 95% CI, 1%-21%; P=.02) in independent cohorts.Results of this cross-sectional study of 2 observational cohorts suggest that the p-tau abnormality as an early event in AD pathogenesis was associated with amyloid-β accumulation and highlights the need for careful interpretation of p-tau biomarkers in the context of the amyloid/tau/neurodegeneration, or A/T/(N), framework.
  •  
20.
  • Akillioglu, Hakan, et al. (författare)
  • Continuous precise workload control method
  • 2014
  • Ingår i: IEEE International Conference on Industrial Engineering and Engineering Management. - 9781479964109 ; , s. 511-515
  • Konferensbidrag (refereegranskat)abstract
    • The diversity of requirements and the frequency of change in the market can only be competed with dynamicity and responsiveness in both production and planning systems. In this sense, working principles of a novel workload control method, called continuous precise workload control are presented in this paper. The implementation of the method is based on a multi-agent based architecture. The presented approach generates dynamic non periodic release decisions exploiting real time shop floor information. The performance of the system and correlation of norm value against the assessment range are investigated through an experimented test case.
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21.
  • Akillioglu, Hakan, 1983-, et al. (författare)
  • Operational characterization of evolvable productionsystems
  • 2012
  • Ingår i: 4th CIRP Conference on Assembly Technologies and Systems – CATS 2012. ; , s. 85-90
  • Konferensbidrag (refereegranskat)abstract
    • On the way to achieve mass customization production systems have to obtain the capability of rapid reconfiguration of not only physical components but also from control point of view. Evolvable Production System targets highly adaptable mechanical and control solutions that can enhance reusability and interoperability of modules, enabling lifetime extension of the modules. The focus of EPS paradigm is to achieve overall system adaptability by autonomous modules which are dedicated to specific processes with the capability of short deployment time at shop floor without reprogramming effort. From the operational point of view EPS brings significant enhancements considering shop floor dynamics and performances therefore positioning of EPS principles and approaches in production system typology from different perspectives is essential. This has been done by two means which are process flow structure and customer order decoupling point location.
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22.
  • Bäck, Magnus, et al. (författare)
  • Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness
  • 2022
  • Ingår i: European Heart Journal Open. - : Oxford University Press. - 2752-4191. ; 2:2
  • Tidskriftsartikel (refereegranskat)abstract
    • AIMS: Long-chain polyunsaturated fatty acids (PUFAs) generate diverse bioactive lipid mediators, which tightly regulate vascular inflammation. The effects of omega-3 PUFA supplementation in cardiovascular prevention however remain controversial. In addition to direct dietary intake, fatty acid desaturases (FADS) determine PUFA levels. Increased arterial stiffness represents an independent predictor of mortality and cardiovascular events. The aim of the present study was to determine the association of PUFA intake, FADS1 genotype, and FADS expression with arterial stiffness.METHODS AND RESULTS: A cross-sectional population-based cohort study of 1464 participants without overt cardiovascular disease was conducted. Dietary intake was assessed using a food frequency questionnaire. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV), and the FADS1 locus variant was determined. Blood cell transcriptomics was performed in a subset of 410 individuals. Pulse wave velocity was significantly associated with the FADS1 locus variant. Differential associations between PWV and omega-3 PUFA intake were observed depending on the FADS1 genotype. High omega-3 PUFA intake attenuated the FADS1 genotype-dependent associations. Carriers of the minor FADS1 locus variant exhibited increased expression of FADS2, which is associated with PWV.CONCLUSION: Taken together, these findings point to FADS1 genotype-dependent associations of omega-3 PUFA intake on subclinical cardiovascular disease. These findings may have implications for identifying responders and non-responders to omega-3 PUFA supplementation and open up for personalized dietary counselling in cardiovascular prevention.
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23.
  • Chau, Kénora, et al. (författare)
  • Obesity and metabolic features associated with long-term developing diastolic dysfunction in an initially healthy population-based cohort
  • 2018
  • Ingår i: Clinical Research in Cardiology. - : Springer Science and Business Media LLC. - 1861-0684 .- 1861-0692. ; 107:10, s. 887-896
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Diastolic dysfunction (DD) is increasingly common. However, its metabolic determinants are poorly known. This study aims to determine which metabolic and inflammatory features predict DD in initially healthy adults. Methods: We prospectively analyzed the association between metabolic features and DD in 728 initially healthy adults aged 30–60 from Eastern France enrolled in the STANISLAS population-based cohort. Clinical and biological cardiovascular features were collected at baseline (1994–1995). DD was assessed twenty years later (2011–2016) by echocardiography using current international guidelines. For replication purposes, 1463 subjects from the Malmö Preventive Project cohort were analyzed. Results: In the STANISLAS cohort, 191 subjects (26.2%) developed DD. In age-sex-adjusted logistic models, significant predictors of DD were body mass index (BMI, odds ratio for 1-standard-deviation increase (OR) 1.28, 95% CI 1.08–1.52), waist circumference (WC, OR 1.48, 95% CI 1.18–1.84), waist-hip ratio (OR 1.53, 95% CI 1.16–2.02), systolic blood pressure (OR 1.19, 95% CI 1.00–1.43) and triglycerides (TG, OR 1.18, 95% CI 1.00–1.40). Subjects with elevated WC (> 80th percentile) and TG (> 50th percentile) had a twofold higher DD risk (age-sex-adjusted odds ratio 2.00, 95% CI 1.20–3.31, P = 0.008), whereas no such interplay was observed for BMI. In the Malmö cohort, BMI was similarly associated with DD; participants with both elevated BMI and TG were at higher DD risk (age-sex-adjusted odds ratio 1.61, 95% CI 1.18–2.20, P = 0.002). Conclusions: Subjects with elevated WC and TG may have a higher long-term DD risk. Prevention targeting visceral obesity may help reduce the incidence of DD.
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24.
  • Dewan, Pooja, et al. (författare)
  • Impact of multimorbidity on mortality in heart failure with reduced ejection fraction: which comorbidities matter most? An analysis of PARADIGM-HF and ATMOSPHERE
  • 2023
  • Ingår i: European Journal of Heart Failure. - 1388-9842 .- 1879-0844. ; 25:5, s. 687-97
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims: Multimorbidity, the coexistence of two or more chronic conditions, is synonymous with heart failure (HF). How risk related to comorbidities compares at individual and population levels is unknown. The aim of this study is to examine the risk related to comorbidities, alone and in combination, both at individual and population levels. Methods and results: Using two clinical trials in HF–the Prospective comparison of ARNI (Angiotensin Receptor–Neprilysin Inhibitor) with ACEI (Angiotensin-Converting Enzyme Inhibitor) to Determine Impact on Global Mortality and morbidity in HF trial (PARADIGM-HF) and the Aliskiren Trial to Minimize Outcomes in Patients with Heart Failure trials (ATMOSPHERE)–we identified the 10 most common comorbidities and examined 45 possible pairs. We calculated population attributable fractions (PAF) for all-cause death and relative excess risk due to interaction with Cox proportional hazard models. Of 15 066 patients in the study, 14 133 (93.7%) had at least one and 11 867 (78.8%) had at least two of the 10 most prevalent comorbidities. The greatest individual risk among pairs was associated with peripheral artery disease (PAD) in combination with stroke (hazard ratio [HR] 1.73; 95% confidence interval [CI] 1.28–2.33) and anaemia (HR 1.71; 95% CI 1.39–2.11). The combination of chronic kidney disease (CKD) and hypertension had the highest PAF (5.65%; 95% CI 3.66–7.61). Two pairs demonstrated significant synergistic interaction (atrial fibrillation with CKD and coronary artery disease, respectively) and one an antagonistic interaction (anaemia and obesity). Conclusions: In HF, the impact of multimorbidity differed at the individual patient and population level, depending on the prevalence of and the risk related to each comorbidity, and the interaction between individual comorbidities. Patients with coexistent PAD and stroke were at greatest individual risk whereas, from a population perspective, coexistent CKD and hypertension mattered most.
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25.
  • Dias-Ferreira, Joao, et al. (författare)
  • BIOSOARM : a bio-inspired self-organising architecture for manufacturing cyber-physical shopfloors
  • 2016
  • Ingår i: Journal of Intelligent Manufacturing. - : Springer. - 0956-5515 .- 1572-8145. ; , s. 1-24
  • Tidskriftsartikel (refereegranskat)abstract
    • Biological collective systems have been an important source of inspiration for the design of production systems, due to their intrinsic characteristics. In this sense, several high level engineering design principles have been distilled and proposed on a wide number of reference system architectures for production systems. However, the application of bio-inspired concepts is often lost due to design and implementation choices or are simply used as heuristic approaches that solve specific hard optimization problems. This paper proposes a bio-inspired reference architecture for production systems, focused on highly dynamic environments, denominated BIO-inspired Self-Organising Architecture for Manufacturing (BIOSOARM). BIOSOARM aims to strictly adhere to bio-inspired principles. For this purpose, both shopfloor components and product parts are individualized and extended into the virtual environment as fully decoupled autonomous entities, where they interact and cooperate towards the emergence of a self-organising behaviour that leads to the emergence of the necessary production flows. BIOSOARM therefore introduces a fundamentally novel approach to production that decouples the system’s operation from eventual changes, uncertainty or even critical failures, while simultaneously ensures the performance levels and simplifies the deployment and reconfiguration procedures. BIOSOARM was tested into both flow-line and “job shop”-like scenarios to prove its applicability, robustness and performance, both under normal and highly dynamic conditions.
  •  
26.
  • Dias-Ferreira, Joao, et al. (författare)
  • Characterization of an Agile Bio-inspired Shop-Floor
  • 2014
  • Ingår i: 2014 12TH IEEE INTERNATIONAL CONFERENCE ON INDUSTRIAL INFORMATICS (INDIN). - : IEEE conference proceedings. - 9781479949052 ; , s. 404-410
  • Konferensbidrag (refereegranskat)abstract
    • Sustainability is currently one of the biggest challenges and drivers of manufacturing industry. With traditional automation approaches becoming evermore inadequate to support sustainable mass customized production, the research focus is moving towards agile systems that enact companies with the ability to quickly reconfigure their shop-floors by seamlessly deploying or removing modules. Such systems are envisioned as key for attaining a profitable and sustainable industrial development. In this sense, this paper attempts to characterize an innovative approach that relies on bio-inspired concepts as the main control mechanism, in order to foster sustainability by attaining the necessary shop-floor agility. Furthermore an experimental setup is presented and the results are analysed, in order to understand the influence and impact of the main properties of the approach towards the system performance.
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27.
  • Ferreira, Joao F., et al. (författare)
  • SmartBugs : A Framework to Analyze Solidity Smart Contracts
  • 2020
  • Ingår i: 35th IEEE/ACM International Conference on Automated Software Engineering, ASE 2020, 22 September 2020 - 25 September 2020. - New York, NY, USA : Association for Computing Machinery (ACM). ; , s. 1349-1352
  • Konferensbidrag (refereegranskat)abstract
    • Over the last few years, there has been substantial research on automated analysis, testing, and debugging of Ethereum smart contracts. However, it is not trivial to compare and reproduce that research. To address this, we present SmartBugs, an extensible and easy-to-use execution framework that simplifies the execution of analysis tools on smart contracts written in Solidity, the primary language used in Ethereum. SmartBugs is currently distributed with support for 10 tools and two datasets of Solidity contracts. The first dataset can be used to evaluate the precision of analysis tools, as it contains 143 annotated vulnerable contracts with 208 tagged vulnerabilities. The second dataset contains 47,518 unique contracts collected through Etherscan. We discuss how SmartBugs supported the largest experimental setup to date both in the number of tools and in execution time. Moreover, we show how it enables easy integration and comparison of analysis tools by presenting a new extension to the tool SmartCheck that improves substantially the detection of vulnerabilities related to the DASP10 categories Bad Randomness, Time Manipulation, and Access Control (identified vulnerabilities increased from 11% to 24%).
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28.
  • Ferreira, João, et al. (författare)
  • Visualization tool to support multi-agent mechatronic based systems
  • 2012
  • Ingår i: IECON 2012 - 38th Annual Conference on IEEE Industrial Electronics Society. - : IEEE. - 9781467324212 - 9781467324199 - 9781467324205 ; , s. 4372-4377
  • Konferensbidrag (refereegranskat)abstract
    • There has been an increasing interest from industry in distributed architectures since they promote a plug-and-produce and robust environment, where adaptability and fault tolerance are native. Much research has been conducted in this field mainly supported by multi-agent and service oriented technologies. Nevertheless the retrieval and visualization of information in distributed systems is a relatively unexplored area. Although the dynamic nature of the multi-agent systems allows gathering information in a prompt manner, doing so might affect the performance of the mechatronic agents. In this sense, the present paper details the architecture of a visualization tool that introduces a reliable but non-invasive approach to retrieve data from distributed platforms as well as a new way to visualize and interpret the information gathered from mechatronic based systems.
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29.
  • Henry, Albert, et al. (författare)
  • Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization
  • 2022
  • Ingår i: Circulation. - : Ovid Technologies (Wolters Kluwer Health). - 0009-7322 .- 1524-4539. ; 145:16, s. 1205-1217
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Heart failure (HF) is a highly prevalent disorder for which disease mechanisms are incompletely understood. The discovery of disease-associated proteins with causal genetic evidence provides an opportunity to identify new therapeutic targets.Methods: We investigated the observational and causal associations of 90 cardiovascular proteins, which were measured using affinity-based proteomic assays. First, we estimated the associations of 90 cardiovascular proteins with incident heart failure by means of a fixed-effect meta-analysis of 4 population-based studies, composed of a total of 3019 participants with 732 HF events. The causal effects of HF-associated proteins were then investigated by Mendelian randomization, using cis-protein quantitative loci genetic instruments identified from genomewide association studies in more than 30 000 individuals. To improve the precision of causal estimates, we implemented an Mendelian randomization model that accounted for linkage disequilibrium between instruments and tested the robustness of causal estimates through a multiverse sensitivity analysis that included up to 120 combinations of instrument selection parameters and Mendelian randomization models per protein. The druggability of candidate proteins was surveyed, and mechanism of action and potential on-target side effects were explored with cross-trait Mendelian randomization analysis.Results: Forty-four of ninety proteins were positively associated with risk of incident HF (P<6.0x10(-4)). Among these, 8 proteins had evidence of a causal association with HF that was robust to multiverse sensitivity analysis: higher CSF-1 (macrophage colony-stimulating factor 1), Gal-3 (galectin-3) and KIM-1 (kidney injury molecule 1) were positively associated with risk of HF, whereas higher ADM (adrenomedullin), CHI3L1 (chitinase-3-like protein 1), CTSL1 (cathepsin L1), FGF-23 (fibroblast growth factor 23), and MMP-12 (matrix metalloproteinase-12) were protective. Therapeutics targeting ADM and Gal-3 are currently under evaluation in clinical trials, and all the remaining proteins were considered druggable, except KIM-1.Conclusions: We identified 44 circulating proteins that were associated with incident HF, of which 8 showed evidence of a causal relationship and 7 were druggable, including adrenomedullin, which represents a particularly promising drug target. Our approach demonstrates a tractable roadmap for the triangulation of population genomic and proteomic data for the prioritization of therapeutic targets for complex human diseases.
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30.
  • Kobayashi, Masatake, et al. (författare)
  • Machine Learning-Derived Echocardiographic Phenotypes Predict Heart Failure Incidence in Asymptomatic Individuals
  • 2022
  • Ingår i: JACC: Cardiovascular Imaging. - : Elsevier BV. - 1876-7591 .- 1936-878X. ; 15:2, s. 193-208
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: This study sought to identify homogenous echocardiographic phenotypes in community-based cohorts and assess their association with outcomes.BACKGROUND: Asymptomatic cardiac dysfunction leads to a high risk of long-term cardiovascular morbidity and mortality; however, better echocardiographic classification of asymptomatic individuals remains a challenge.METHODS: Echocardiographic phenotypes were identified using K-means clustering in the first generation of the STANISLAS (Yearly non-invasive follow-up of Health status of Lorraine insured inhabitants) cohort (N = 827; mean age: 60 ± 5 years; men: 48%), and their associations with vascular function and circulating biomarkers were also assessed. These phenotypes were externally validated in the Malmö Preventive Project cohort (N = 1,394; mean age: 67 ± 6 years; men: 70%), and their associations with the composite of cardiovascular mortality (CVM) or heart failure hospitalization (HFH) were assessed as well.RESULTS: Three echocardiographic phenotypes were identified as "mostly normal (MN)" (n = 334), "diastolic changes (D)" (n = 323), and "diastolic changes with structural remodeling (D/S)" (n = 170). The D and D/S phenotypes had similar ages, body mass indices, cardiovascular risk factors, vascular impairments, and diastolic function changes. The D phenotype consisted mainly of women and featured increased levels of inflammatory biomarkers, whereas the D/S phenotype, consisted predominantly of men, displayed the highest values of left ventricular mass, volume, and remodeling biomarkers. The phenotypes were predicted based on a simple algorithm including e', left ventricular mass and volume (e'VM algorithm). In the Malmö cohort, subgroups derived from e'VM algorithm were significantly associated with a higher risk of CVM and HFH (adjusted HR in the D phenotype = 1.87; 95% CI: 1.04 to 3.37; adjusted HR in the D/S phenotype = 3.02; 95% CI: 1.71 to 5.34).CONCLUSIONS: Among asymptomatic, middle-aged individuals, echocardiographic data-driven classification based on the simple e'VM algorithm identified profiles with different long-term HF risk. (4th Visit at 17 Years of Cohort STANISLAS-Stanislas Ancillary Study ESCIF [STANISLASV4]; NCT01391442).
  •  
31.
  • Maffei, Antonio, et al. (författare)
  • Characterisation of the student perception of the concept of flexibility in the manufacturing domain : Highlighting the patterns of effective learning
  • 2014
  • Ingår i: Global Journal of Engineering Education. - 1328-3154. ; 16:2, s. 80-87
  • Tidskriftsartikel (refereegranskat)abstract
    • This work introduces a phenomenographic analysis of the concept of flexibility in the domain of production science. Flexibility is a cornerstone in the education of industrial and production engineers; however, it still appears as a broadly and even inconsistently defined construct. In order to clarify what is or should be learnt, this work analyses first the established literature to extract a working characterisation of the flexibility concept. The resulting understanding is then used to represent the experts' perception of the topic, which in turn is used as the ideal level of understanding that a student should achieve herself/himself when studying such a concept. The second phase of the work aims at disclosing and classifying the multifaceted perceptions of flexibility that two classes of industrial engineering students have after two courses in which the focal concept of manufacturing flexibility has been presented using two different approaches. The research is based on a survey completed by students. The data collected have consequently been structured into a finite set of clusters according to: a) the level of understanding of the key concept; and b) the nature of the shown knowledge. The classification is, then, the basis for defining an epistemologically sound approach to develop suitable teaching and learning activities to ensure optimal acquisition of the concept of flexibility.
  •  
32.
  • Maffei, Antonio, 1982-, et al. (författare)
  • Characterization of the Student Perception of Flexibility in the Manufacturing Domain : Highlighting the Patterns of Effective Learning
  • 2014
  • Ingår i: Proceeding of: 8th International Technology, Education and Development Conference - INTED 2014, At Valencia, Spain. - Valencia.
  • Konferensbidrag (refereegranskat)abstract
    • The word “flexibility” is often abused and not univocally understood within the manufacturing science domain and in particular in the context of industrial automation. Since the raise of industrial robots in the 1960’, different researchers and practitioners have been using such a common word with different meanings. This has generated a very articulated concept, spanning from capability of a system to increase the production volumes to ability to handle product mix variation. Several authors have tried to count the current meanings of such a word in manufacturing and someone arrived to more than 50!. In spite of this fuzziness in both the definition and scope, the concept of flexibility remain one of the cornerstones in the curriculum of industrial and production engineers, and it appears in many courses along the bachelor and master studies. The apparent paradox that higher education institutions have to teach things that are not even well-defined and agreed in the scientific world is, in fact, quite a usual practice. In order to clarify what is, or should be, learnt this work analyzes first the established literature to extract a “working” characterization of the flexibility concept. The resulting understanding is then used to represent the experts’ perception of the topic which in turn is used as ideal level of understanding that a student should achieve her/himself when studying such a concept.   The second phase of the work aims at disclosing and classifying the multifaceted perceptions of flexibility that two different classes of industrial engineering students have after two courses in which the focal concept of manufacturing flexibility has been presented using two different approaches. The research is based on a phenomenographic analysis of a series of well-designed interviews to the students. The collected data have consequently been structured in a finite set of clusters according of: (1) the level of understanding of the key concept (as expressed in the Bloom’s taxonomy) and (2) the nature of the shown knowledge (as presented in the SOLO taxonomy). The classification is then the basis for defining an epistemological sound approach to develop suitable teaching and learning activities to ensure optimal acquisition of the concept of flexibility.
  •  
33.
  • Maffei, Antonio, 1982-, et al. (författare)
  • CHARACTERIZATION OF THE STUDENT PERCEPTION OF THE CONCEPT OF FLEXIBILITY IN THE MANUFACTURING DOMAIN : HIGHLIGHTING THE PATTERNS OF EFFECTIVE LEARNING
  • 2014
  • Ingår i: INTED2014. - : IATED-INT ASSOC TECHNOLOGY EDUCATION A& DEVELOPMENT. - 9788461684120 ; , s. 4759-4767
  • Konferensbidrag (refereegranskat)abstract
    • The word "flexibility" is often abused and not univocally understood within the manufacturing science domain and in particular in the context of industrial automation. Since the raise of industrial robots in the 1960', different researchers and practitioners have been using such a common word with different meanings. This has generated a very articulated concept, spanning from capability of a system to increase the production volumes to ability to handle product mix variation. Several authors have tried to count the current meanings of such a word in manufacturing and someone arrived to more than 50 [1]!. In spite of this fuzziness in both the definition and scope, the concept of flexibility remain one of the cornerstones in the curriculum of industrial and production engineers, and it appears in many courses along the bachelor and master studies. The apparent paradox that higher education institutions have to teach things that are not even well-defined and agreed in the scientific world is, in fact, quite a usual practice. In order to clarify what is, or should be, learnt this work analyzes first the established literature to extract a "working" characterization of the flexibility concept. The resulting understanding is then used to represent the experts' perception of the topic which in turn is used as ideal level of understanding that a student should achieve her/himself when studying such a concept. The second phase of the work aims at disclosing and classifying the multifaceted perceptions of flexibility that two different classes of industrial engineering students have after two courses in which the focal concept of manufacturing flexibility has been presented using two different approaches. The research is based on a phenomenographic analysis of a series of well-designed interviews to the students [2]. The collected data have consequently been structured in a finite set of clusters according of: (1) the level of understanding of the key concept (as expressed in the Bloom's taxonomy [3]) and (2) the nature of the shown knowledge (as presented in the SOLO taxonomy [4]). The classification is then the basis for defining an epistemological sound approach to develop suitable teaching and learning activities to ensure optimal acquisition of the concept of flexibility.
  •  
34.
  • Maffei, Antonio, et al. (författare)
  • Emerging Behavior as Driver for the Sustainability of a Modular, "Skills-Centric" Production System
  • 2011
  • Ingår i: IEEE AFRICON 2011. - : IEEE.
  • Konferensbidrag (refereegranskat)abstract
    • The current main challenge for the future production system lies in the correct integration of the issues related to sustainability and to agility. The "Evolvable Paradigm" addresses this concern with a new way of engineering the whole production system. The concept of Skill is declined as common denominator between the definitions of manufacturing process and manufacturing equipment. Each production module holds some of the skills that compose the process definition and it is endowed with the necessary intelligence to come together with the other modules in an organized society. This work introduces the approach adopted in the IDEAS project (Instantly Deployable Evolvable Assembly System) to cope with the above mentioned requirement through the presented paradigm. While fully featured and described IDEAS mechatronic architecture allows rapid reconfiguration of the system, the issue of sustainability is targeted by the open definition of the concepts of skill and skills interaction. The result of skill aggregation is hereby called Emergent Behavior and in the proposed model it can be seen as the main driver for the sustainable use of the system.
  •  
35.
  • Monzo, Luca, et al. (författare)
  • Visit-to-visit blood pressure variation and outcomes in heart failure with reduced ejection fraction: findings from the Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms trial.
  • 2020
  • Ingår i: Journal of hypertension. - 1473-5598. ; 38:3, s. 420-425
  • Tidskriftsartikel (refereegranskat)abstract
    • Visit-to-visit office blood pressure (BP) variability (BPV) has been associated with morbidity and mortality outcomes in several cardiovascular conditions. The aim of this study was to evaluate the association between BPV and outcomes in patients with heart failure and reduced ejection fraction and the effect of eplerenone on BPV.We evaluated the associations between BPV, calculated as SBP coefficient of variation (SBP-CoV=SD/mean×100%), and the primary composite endpoint of cardiovascular mortality or heart failure hospitalization (HFH), and its components, in 2549 patients from the Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms trial. Lower SBP-CoV was independently associated with a higher risk of all the studied outcomes, while higher as well as lower SBP-CoV were associated with a higher risk of cardiovascular death. After a median follow-up period of 21 months the risk of the composite outcome of cardiovascular death or HFH was almost double in the lower SBP-CoV tertile as compared with the intermediate tertile [adjusted hazard ratio: 2.01, 95% confidence interval (1.62-2.51), P<0.001]. The relationship between SBP-CoV and outcomes was not modified by eplerenone (P value for interaction=0.48). An interaction was detected between mean SBP and SBP-CoV for the primary outcome (P=0.048) and for HFH (P=0.018). The effect modification was slight, but lower SBP-CoV was associated with worse outcomes in patients with both low and high SBP, while this interaction was less clear for patients with SBP in the 'normal' range.In our patients with heart failure and reduced ejection fraction and mild symptoms, both a lower and higher SBP-CoV were associated with worse outcomes. SBP-CoV did not modify the benefit of eplerenone. Further studies are warranted to clarify the role of BPV in heart failure. CLINICALTRIALS.NCT00232180.
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36.
  • Neves, Pedro, 1985-, et al. (författare)
  • Context and Implications of Learning in Evolvable Production Systems
  • 2011
  • Ingår i: IECON 2011. - New York : IEEE. - 9781612849720 ; , s. 2740-2745
  • Konferensbidrag (refereegranskat)abstract
    • More than ever the impact of market turbulence, high product customization and sustainability can be perceived through the increase of dynamics and complexity of manufacturing and business environments. Modular and distributed control structures are nowadays a consensual way, common to the majority of modern paradigms, to deal with unpredictability and volatility of markets. With modern paradigms aiming on adaptability, evolution and reconfiguration as a way to deal with this reality, learning mechanism have become very important to achieve such requirements. This paper presents an exploratory discussion on the topic of agent-based learning applied in a modern production paradigm such as Evolvable Production Systems (EPS).
  •  
37.
  • Neves, Pedro, et al. (författare)
  • Data-mining approach to support layout configuration decision-making in Evolvable Production Systems
  • 2014
  • Ingår i: Conference Proceedings / IEEE International Conference on Systems, Man and Cybernetics. - : IEEE. - 1062-922X. ; 2014-January:January, s. 3649-3656
  • Tidskriftsartikel (refereegranskat)abstract
    • Computational and communication capabilities are increasingly being used in all devices. In the production context this leads to the generation of massive amounts of data that are rarely proficuously used. More particularly the application of data-mining techniques to infer knowledge from systems’ operation to improve its design decisions remains fairly unexplored. This article presents an approach to extract system design and configuration rules from Evolvable Production Systems. Furthermore it provides the empirical results from two test-cases that support the hypothesis that a simulation-data-mining approach can help reducing the complexity of the work carried by system designers and production managers. 
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38.
  • Neves, Pedro, et al. (författare)
  • Data-mining approach to support layout configuration decision-making in Evolvable Production Systems
  • 2014
  • Ingår i: Proceedings 2014 IEEE International Conference on Systems, Man, and Cybernetics (SMC) October 5-8, 2014, San Diego, CA, USA. - : IEEE conference proceedings. - 9781479938407 ; , s. 3649-3656
  • Konferensbidrag (refereegranskat)abstract
    • Computational and communication capabilities are increasingly being used in all devices. In the production context this leads to the generation of massive amounts of data that are rarely proficuously used. More particularly the application of data-mining techniques to infer knowledge from systems’ operation to improve its design decisions remains fairly unexplored. This article presents an approach to extract system design and configuration rules from Evolvable Production Systems. Furthermore it provides the empirical results from two test-cases that support the hypothesis that a simulation-data-mining approach can help reducing the complexity of the work carried by system designers and production managers.
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39.
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40.
  • Neves, Pedro, et al. (författare)
  • Exploring reconfiguration alternatives in Self-Organising Evolvable Production Systems through Simulation
  • 2014
  • Ingår i: 2014 12TH IEEE INTERNATIONAL CONFERENCE ON INDUSTRIAL INFORMATICS (INDIN). - : IEEE conference proceedings. - 9781479949052 ; , s. 511-518
  • Konferensbidrag (refereegranskat)abstract
    • Simulation has played an important role along the years to predict systems' behaviour before their deployment. In the case of self-organising mechatronic systems simulation tools can help researchers and practitioners understanding the full potential of the solution as well as its underlying limitations. Self-organising mechatronic systems have passed a feasibility study and presented promising results. However they are rarely explored in industry in part due to the lack of methods to support their design and configuration and the difficulty to predict the systems' behaviour before their deployment. Given the cost and development time associated with building self-organising mechatronic systems this research problem has been left quite unattended. In this article we present a tool that enables the creation and simulation of Evolvable Production Systems and their self-organising behaviour. The generated operational results can posteriorly be used to analyse the suitability of different design and configuration alternatives for different product types and volumes.
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41.
  • Neves, Pedro, et al. (författare)
  • Layout validation and re-configuration in Plug&Produce systems
  • 2016
  • Ingår i: Assembly Automation. - : EMERALD GROUP PUBLISHING LTD. - 0144-5154 .- 1758-4078. ; 36:4, s. 412-428
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose - This paper aims to provide a method and decision support tool to enhance swift reconfiguration of Plug&Produce (P&P) systems in the presence of continuously changing production orders. Design/methodology/approach - The paper reviews different production scenarios and system design and configuration methods and more particularly specifies the need of decision support tools for P&P systems that integrate configuration and planning activities. This problem is then addressed by proposing a method that helps reduce the solution space of the reconfiguration problem and allows the timely selection of the most promising reconfiguration alternative. Findings - The proposed method was found to be helpful in reducing the reconfiguration alternatives that need to be considered and in selecting the most promising one for different orders. The advantages and limitations of this method are identified, and an illustrative test case of the approach is presented, corroborating the method applicability in the absence of large queues in the system. Originality/value - This paper addresses a less explored domain within the P&P systems research field, which is the system reconfiguration. It proposed a method to support system validation and reconfiguration jointly with an illustrative test case. This represents an original contribution to the P&P research field, and it can have impact in improving agility and decreasing the complexity of reconfiguration activities to cope with constantly changing production orders.
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42.
  • Neves, Pedro, et al. (författare)
  • Prospection of methods to support design and configuration of self-organizing mechatronic systems
  • 2013
  • Ingår i: Proceedings - 2013 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2013. - : IEEE. - 9780769551548 ; , s. 3854-3861
  • Konferensbidrag (refereegranskat)abstract
    • There is a substantial difference between traditional industrial systems and systems resultant from emerging production paradigms in terms of both conceptualization and implementation. Backwards compatibility is fundamental in assessing the potential transitional period whereby legacy technology will operate under the conceptual framework of modern approaches. However, before this point can be reached it is necessary to further investigate, assess and quantify the behavior of modern approaches that increasingly rely in self-organization. This article's goal is to give an overview of the behavioral assessment problematic, in the context of self-organizing mechatronic systems, and provide a discussion on opportunities to explore rule-extraction techniques to better understand the influence of design and configuration on the overall system behavior. Although the discussion widely applies to almost all emerging production paradigms the Evolvable Production System paradigm is used as case to bring context and clarity to the discussion.
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43.
  • Oliveira, Helena Rodrigues, et al. (författare)
  • Biogas potential of biowaste: A case study in the state of Rio de Janeiro, Brazil
  • 2024
  • Ingår i: Renewable energy. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0960-1481 .- 1879-0682. ; 221
  • Tidskriftsartikel (refereegranskat)abstract
    • Anaerobic digestion has been widely applied for waste treatment, renewable energy generation , biofertilizer production. The biogas potential in Brazil is sizable, but the state of Rio de Janeiro is largely dependent on fossil fuels , there is a lack of biogas potential assessments in the state. Thus, this study evaluated biomethane, electricity and biofertilizer potentials in the region. Three different scenarios of biomass supply were considered for four major biowaste streams: sewage sludge; cattle manure; sugarcane processing waste; and food waste. Biomethane generation from the assessed sources could reach 0.6-1.3 billion Nm(3) year(-1), corresponding to 1,768-3,961 GWh year(-1) of electricity , 1.6-3.3 million Mg year- 1 of biofertilizer. Cattle manure was responsible for 73-84% of the projected biomethane production, presenting an opportunity to reduce the sig-nificant emissions from livestock farming. The estimated biofertilizer production could meet the demands of the state , the produced electricity could offset up to 10% of the demand. The gas grid could facilitate the dis-tribution of upgraded biomethane, and 10-22% of the natural gas demand could be met. The findings of this work highlight the high potential for biogas generation in Rio de Janeiro, which is up to seven times larger than the current production.
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44.
  • Pedro, Joana Reis, et al. (författare)
  • Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes
  • 2020
  • Ingår i: Brain Research Bulletin. - : Elsevier BV. - 0361-9230. ; 161, s. 106-115
  • Tidskriftsartikel (refereegranskat)abstract
    • Here we aimed to unify some previous controversial reports on changes in both cannabinoid CB1 receptor (CB1R) expression and glucose metabolism in the forebrain of rodent models of diabetes. We determined how glucose metabolism and its modulation by CB1R ligands evolve in the frontal cortex of young adult male Wistar rats, in the first 8 weeks of streptozotocin-induced type-1 diabetes (T1D). We report that frontocortical CB1R protein density was biphasically altered in the first month of T1D, which was accompanied with a reduction of resting glucose uptake ex vivo in acute frontocortical slices that was normalized after eight weeks in T1D. This early reduction of glucose uptake in slices was also restored by ex vivo treatment with both the non-selective CB1R agonists, WIN55212−2 (500 nM) and the CB1R-selective agonist, ACEA (3 μM) while it was exacerbated by the CB1R-selective antagonist, O-2050 (500 nM). These results suggest a gain-of-function for the cerebrocortical CB1Rs in the control of glucose uptake in diabetes. Although insulin and IGF-1 receptor protein densities remained unaffected, phosphorylated GSKα and GSKβ levels showed different profiles 2 and 8 weeks after T1D induction in the frontal cortex. Altogether, the biphasic response in frontocortical CB1R density within a month after T1D induction resolves previous controversial reports on forebrain CB1R levels in T1D rodent models. Furthermore, this study also hints that cannabinoids may be useful to alleviate impaired glucoregulation in the diabetic cortex.
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45.
  • Rocha De Sousa, Amandio, et al. (författare)
  • Hospital prevalence of visual of visual impairment caused by diabetic retinopathy
  • 2015
  • Ingår i: Acta Ophthalmologica. - : Wiley. - 1755-375X .- 1755-3768. ; 93:S255
  • Tidskriftsartikel (refereegranskat)abstract
    • PurposeTo investigate cases of visual impairment caused by diabetic retinopathy (DR) in a hospital population.MethodsAs part of an observational study to estimate the prevalence and costs of visual impairment in Portugal (PCVIP study), clinical records of all patients attending the ophthalmology department of a tertiary hospital were analysed looking for patients meeting the inclusion criteria. Inclusion criteria were: (i) presenting visual acuity in the better eye <5/10 (20/40) and/or (ii) visual field <20°. Diagnosis of cases with VI were classified according with ICD9. Results reported here were selected from the total number of patients with VI by filtering ICD9 codes staring by 362.ResultsIn 12 weeks, 1920 cases of VI were detected, 586 (31%) caused by any type of DR. From those: 54% were caused by non-proliferative-DR, 40% by proliferative-DR and 6% by diabetic macular oedema. The mean age of the patients with VI caused by DR was 69.4 (sd = 9.5) years and 57% were female. The estimated hospital prevalence (for 52 weeks) of VI caused by DR is 39% (95%CI = 38–41).ConclusionsOur results show that DR remains the leading cause of VI in the population attending our hospital. Information about the number of patients reaching VI will be fundamental to assess the cost-benefits of treatments and public health campaigns to reduce the burden of diabetic retinopathy in Portugal.
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46.
  • Santos, Catarina L, et al. (författare)
  • Modulation of Frankia alni ACN14a oxidative stress response: activity, expression and phylogeny of catalases
  • 2007
  • Ingår i: Physiologia Plantarum. - : Wiley. - 0031-9317 .- 1399-3054. ; 130, s. 454-463
  • Tidskriftsartikel (refereegranskat)abstract
    • The finding that an oxidative burst was a general phenomenon in the response of hosts challenged by various symbiotic or pathogenic microbes has stimulated increasing interest in investigating the enzymology of antioxidant protection in bacteria. The question of whether the antioxidant mechanisms have been a decisive evolutionary driving force for the nitrogen-fixing microsymbiont Frankia spp. is still open. In this study, Frankia alni strain ACN14a, which is a mid-range infective strain, was used as a model to explore the basal oxidative stress response in terms of enzymatic activity, relative expression and phylogeny. Non-denaturing polyacrylamide gels stained for catalatic activity revealed the presence of two monofunctional catalases KatA and KatB (EC number 1.11.1.6), which activity was shown to increase when the cells were challenged with the oxidants H2O2 and methyl viologen. Real-time RT-PCR targeting the two genes showed a consistent increase in the number of transcripts when the RNA was extracted from oxidative stress-induced cells. Comparison between the expression and the activity data suggests that posttranscriptional mechanisms might be involved in the regulation of catalases in F. alni. Furthermore, upstream of katA, a fur gene coding for a ferric uptake regulator was found, forming a gene pair that functionally resembles the conserved actinobacterial synton fur–katG, which contains a gene coding for a catalase–peroxidase. Phylogenetic analysis of the F. alni fur–katA synton suggests that this genomic organization was the result of genome reshuffling events.
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47.
  • Schrage, Benedikt, et al. (författare)
  • Association between a hospitalization for heart failure and the initiation/discontinuation of guideline-recommended treatments: an analysis from the Swedish Heart Failure Registry
  • 2023
  • Ingår i: European Journal of Heart Failure. - : WILEY. - 1388-9842 .- 1879-0844. ; 25:7, s. 1132-1144
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims To investigate whether a heart failure (HF) hospitalization is associated with initiation/discontinuation of guideline-directed medical HF therapy (GDMT) and consequent outcomes.Methods and results Among patients in the Swedish HF registry with an ejection fraction <50% enrolled in 2009-2018, initiation/discontinuation of GDMT was investigated by assessing dispensations of GDMT in those with versus without a HF hospitalization. Of 14 737 patients, 6893 (47%) were enrolled when hospitalized for HF. Initiation of GDMT was more likely than discontinuation following a HF hospitalization compared to a control group of patients without a HF hospitalization (odds ratio range 2.1-4.0 vs. 1.4-1.6 for the individual medications), although the proportion of patients not on GDMT was still high (8.1-44.0%). Key patient characteristics triggering less use of GDMT (i.e. less initiation or more discontinuation) were older age and worse renal function. Following a HF hospitalization, initiation of renin-angiotensin system inhibitors/angiotensin receptor-neprilysin inhibitors or beta-blockers was associated with lower and their discontinuation with higher mortality risk, but no association with mortality was observed for initiation/discontinuation of mineralocorticoid receptor antagonists.Conclusions Following a HF hospitalization, initiation of GDMT was more likely than discontinuation, although still limited. Perceived or actual low tolerance were barriers to GDMT implementation. Early re-/initiation of GDMT was associated with better survival. Our findings represent a call for further implementing the current guideline recommendation for an early re-/initiation of GDMT following a HF hospitalization.
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48.
  • Schrage, Benedikt, et al. (författare)
  • Lower socioeconomic status predicts higher mortality and morbidity in patients with heart failure
  • 2021
  • Ingår i: Heart. - : BMJ PUBLISHING GROUP. - 1355-6037 .- 1468-201X. ; 107:3, s. 229-236
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective It is not fully understood whether and how socioeconomic status (SES) has a prognostic impact in patients with heart failure (HF). We assessed SES and its association with patient characteristics and outcomes in a contemporary and well-characterised HF cohort. Methods Socioeconomic risk factors (SERF) were defined in the Swedish HF Registry based on income (low vs high according to the annual median value), education level (no degree/compulsory school vs university/secondary school) and living arrangement (living alone vs cohabitating). Results Of 44 631 patients, 21% had no, 33% one, 30% two and 16% three SERF. Patient characteristics strongly and independently associated with lower SES were female sex and no specialist referral. Additional independent associations were older age, more severe HF, heavier comorbidity burden, use of diuretics and less use of HF devices. Lower SES was associated with higher risk of HF hospitalisation/mortality, and overall cardiovascular and non-cardiovascular events. These associations persisted after extensive adjustment for patient characteristics, treatments and care. The magnitude of the association increased linearly with the increasing number of coexistent SERF: HR (95% CI) 1.09 (1.05 to 1.13) for one, 1.16 (1.12 to 1.20) for two and 1.22 (1.18 to 1.28) for three SERF (p<0.01). Conclusions In a contemporary and well-characterised HF cohort and after comprehensive adjustment for confounders, lower SES was linked with multiple factors such as less use of HF devices and age, but most strongly with female sex and lack of specialist referral; and associated with greater risk of morbidity/mortality.
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49.
  • Zamora, Juan Carlos, et al. (författare)
  • Considerations and consequences of allowing DNA sequence data as types of fungal taxa
  • 2018
  • Ingår i: IMA Fungus. - : INT MYCOLOGICAL ASSOC. - 2210-6340 .- 2210-6359. ; 9:1, s. 167-185
  • Tidskriftsartikel (refereegranskat)abstract
    • Nomenclatural type definitions are one of the most important concepts in biological nomenclature. Being physical objects that can be re-studied by other researchers, types permanently link taxonomy (an artificial agreement to classify biological diversity) with nomenclature (an artificial agreement to name biological diversity). Two proposals to amend the International Code of Nomenclature for algae, fungi, and plants (ICN), allowing DNA sequences alone (of any region and extent) to serve as types of taxon names for voucherless fungi (mainly putative taxa from environmental DNA sequences), have been submitted to be voted on at the 11th International Mycological Congress (Puerto Rico, July 2018). We consider various genetic processes affecting the distribution of alleles among taxa and find that alleles may not consistently and uniquely represent the species within which they are contained. Should the proposals be accepted, the meaning of nomenclatural types would change in a fundamental way from physical objects as sources of data to the data themselves. Such changes are conducive to irreproducible science, the potential typification on artefactual data, and massive creation of names with low information content, ultimately causing nomenclatural instability and unnecessary work for future researchers that would stall future explorations of fungal diversity. We conclude that the acceptance of DNA sequences alone as types of names of taxa, under the terms used in the current proposals, is unnecessary and would not solve the problem of naming putative taxa known only from DNA sequences in a scientifically defensible way. As an alternative, we highlight the use of formulas for naming putative taxa (candidate taxa) that do not require any modification of the ICN.
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