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Sökning: WFRF:(Ferro Marc)

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1.
  • Ferro, Marc D., et al. (författare)
  • NeuroRoots, a bio-inspired, seamless brain machine interface for long-term recording in delicate brain regions
  • 2024
  • Ingår i: AIP Advances. - : AIP Publishing. - 2158-3226. ; 14:8
  • Tidskriftsartikel (refereegranskat)abstract
    • Scalable electronic brain implants with long-term stability and low biological perturbation are crucial technologies for high-quality brain-machine interfaces that can seamlessly access delicate and hard-to-reach regions of the brain. Here, we created "NeuroRoots," a biomimetic multi-channel implant with similar dimensions (7 mu m wide and 1.5 mu m thick), mechanical compliance, and spatial distribution as axons in the brain. Unlike planar shank implants, these devices consist of a number of individual electrode "roots," each tendril independent from the other. A simple microscale delivery approach based on commercially available apparatus minimally perturbs existing neural architectures during surgery. NeuroRoots enables high density single unit recording from the cerebellum in vitro and in vivo. NeuroRoots also reliably recorded action potentials in various brain regions for at least 7 weeks during behavioral experiments in freely-moving rats, without adjustment of electrode position. This minimally invasive axon-like implant design is an important step toward improving the integration and stability of brain-machine interfacing.
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2.
  • Williamson, Adam, et al. (författare)
  • Controlling Epileptiform Activity with Organic Electronic Ion Pumps
  • 2015
  • Ingår i: Advanced Materials. - : Wiley-VCH Verlag. - 0935-9648 .- 1521-4095. ; 27:20, s. 3138-3144
  • Tidskriftsartikel (refereegranskat)abstract
    • In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.
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