| 1. |
- Hibar, Derrek P., et al.
(författare)
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Novel genetic loci associated with hippocampal volume
- 2017
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
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| 2. |
- Fisher, Tatjana A., et al.
(författare)
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A way to health through psycho-immunological wellbeing : Example of Indigenous People of Russian North
- 2016
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Ingår i: Proc. IIId Intl Conference "Psychological Health of the Person: Life Resource and Life Potential".
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Konferensbidrag (refereegranskat)abstract
- The research was carried out into the changes within psychic and immune domains ofthe Russian Nenets people migrating from the traditional northern habitat (tundra) to urbanenvironment. It is noted that in the process of significantly changing lifestyle supposedlysingle ethnic group can be clearly sub-divided according to the differences in adaptationdynamics. This division reflects sociological differences and is connected to the psychoimmunologicalaspects. Thus, with the adaptation of forest Nenets to the new conditions ofexistence (from the tundra to the urban centers), we found a division of a whole ethnic groupinto two groups according to a social attribute, which is fixed at the psychophysiologicallevel. First, psychic and immune domains are not only sharing a number of commonfeatures but also can have deep evolutionary connections and can be governed by similarlaws. Second, the psyche and the immune system show the most important functions andproperties that ensure an effective existence, generalizing the values of adaptation, protectionand vitality into a single structure. Such a concept is closed to “wholeness” and “integrity” showing that the distribution of vital forces or body resources can adjust the condition orcope with the pre-illness or even disease.
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| 3. |
- Sukhovey, Yurij G., et al.
(författare)
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Functional Conjugation of the Different Regulatory Responses to the Stress Stimuli in Healthy Human Subjects
- 2016
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Ingår i: Open Journal of Applied Sciences. - : Scientific Research Publishing, Inc.. - 2165-3917 .- 2165-3925. ; 6, s. 489-500
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Tidskriftsartikel (refereegranskat)abstract
- Present article discusses the physiological mechanisms of the state employees adaptation duringactive training in temporary groups. It is suggested that adaptive mechanisms to adverse effectsmay be studied basing on the concept of functional isomorphism of the psychic and immune systems.Adaptive mechanisms were studied through the monitoring of the stress factors’ impact upon thelaw enforcement officers when training outside the places of permanent deployment. The specificpurpose of present study was to evaluate the physiological indicators of the psychic, immune andendocrine systems dynamics at different stages of adaptation of the live organism to a stressfulsituation, hoping to get better insight into possible relations between psychic and immune domains.Through monitoring of the dynamics of the endocrine and immune responses to the psychic stimuli,it was possible to correlate the stages of the stress onset to the phases of specific immune reactions.Strong correlations between the parameters characterizing activation of the psychic and immuneresponses support the hypothesis of the presence of “strong cooperation” between psychic andimmune domains. It supports earlier hypothesis that we are monitoring
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