| 1. |
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| 2. |
- Aamodt, K., et al.
(författare)
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The ALICE experiment at the CERN LHC
- 2008
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 3:S08002
-
Forskningsöversikt (refereegranskat)abstract
- ALICE (A Large Ion Collider Experiment) is a general-purpose, heavy-ion detector at the CERN LHC which focuses on QCD, the strong-interaction sector of the Standard Model. It is designed to address the physics of strongly interacting matter and the quark-gluon plasma at extreme values of energy density and temperature in nucleus-nucleus collisions. Besides running with Pb ions, the physics programme includes collisions with lighter ions, lower energy running and dedicated proton-nucleus runs. ALICE will also take data with proton beams at the top LHC energy to collect reference data for the heavy-ion programme and to address several QCD topics for which ALICE is complementary to the other LHC detectors. The ALICE detector has been built by a collaboration including currently over 1000 physicists and engineers from 105 Institutes in 30 countries, Its overall dimensions are 16 x 16 x 26 m(3) with a total weight of approximately 10 000 t. The experiment consists of 18 different detector systems each with its own specific technology choice and design constraints, driven both by the physics requirements and the experimental conditions expected at LHC. The most stringent design constraint is to cope with the extreme particle multiplicity anticipated in central Pb-Pb collisions. The different subsystems were optimized to provide high-momentum resolution as well as excellent Particle Identification (PID) over a broad range in momentum, up to the highest multiplicities predicted for LHC. This will allow for comprehensive studies of hadrons, electrons, muons, and photons produced in the collision of heavy nuclei. Most detector systems are scheduled to be installed and ready for data taking by mid-2008 when the LHC is scheduled to start operation, with the exception of parts of the Photon Spectrometer (PHOS), Transition Radiation Detector (TRD) and Electro Magnetic Calorimeter (EMCal). These detectors will be completed for the high-luminosity ion run expected in 2010. This paper describes in detail the detector components as installed for the first data taking in the summer of 2008.
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| 3. |
- Aamodt, K., et al.
(författare)
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Two-pion Bose-Einstein correlations in pp collisions at root s=900 GeV
- 2010
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Ingår i: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368. ; 82:5
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Tidskriftsartikel (refereegranskat)abstract
- We report on the measurement of two-pion correlation functions from pp collisions at root s = 900 GeV performed by the ALICE experiment at the Large Hadron Collider. Our analysis shows an increase of the Hanbury Brown-Twiss radius with increasing event multiplicity, in line with other measurements done in particle- and nuclear collisions. Conversely, the strong decrease of the radius with increasing transverse momentum, as observed at the Relativistic Heavy Ion Collider and at Tevatron, is not manifest in our data.
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| 4. |
- Aamodt, K., et al.
(författare)
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Midrapidity Antiproton-to-Proton Ratio in pp Collisons root s=0.9 and 7 TeV Measured by the ALICE Experiment
- 2010
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Ingår i: Physical Review Letters. - 1079-7114. ; 105:7
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Tidskriftsartikel (refereegranskat)abstract
- The ratio of the yields of antiprotons to protons in pp collisions has been measured by the ALICE experiment at root s = 0.9 and 7 TeV during the initial running periods of the Large Hadron Collider. The measurement covers the transverse momentum interval 0.45 < p(t) < 1.05 GeV/c and rapidity vertical bar y vertical bar < 0.5. The ratio is measured to be R-vertical bar y vertical bar<0.5 = 0.957 +/- 0.006(stat) +/- 0.0014(syst) at 0.9 Tev and R-vertical bar y vertical bar<0.5 = 0.991 +/- 0.005 +/- 0.014(syst) at 7 TeV and it is independent of both rapidity and transverse momentum. The results are consistent with the conventional model of baryon-number transport and set stringent limits on any additional contributions to baryon-number transfer over very large rapidity intervals in pp collisions.
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| 5. |
- Aamodt, K., et al.
(författare)
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Production of pions, kaons and protons in pp collisions at root s=900 GeV with ALICE at the LHC
- 2011
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:6
-
Tidskriftsartikel (refereegranskat)abstract
- The production of pi(+), pi(-), K+, K-, p, and (p) over bar at mid-rapidity has been measured in proton-proton collisions at root s = 900 GeV with the ALICE detector. Particle identification is performed using the specific energy loss in the inner tracking silicon detector and the time projection chamber. In addition, time-of-flight information is used to identify hadrons at higher momenta. Finally, the distinctive kink topology of the weak decay of charged kaons is used for an alternative measurement of the kaon transverse momentum (p(t)) spectra. Since these various particle identification tools give the best separation capabilities over different momentum ranges, the results are combined to extract spectra from p(t) = 100 MeV/c to 2.5 GeV/c. The measured spectra are further compared with QCD-inspired models which yield a poor description. The total yields and the mean pt are compared with previous measurements, and the trends as a function of collision energy are discussed.
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| 6. |
- Aamodt, K., et al.
(författare)
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Transverse momentum spectra of charged particles in proton-proton collisions at root s=900 GeV with ALICE at the LHC
- 2010
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 693:2, s. 53-68
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Tidskriftsartikel (refereegranskat)abstract
- The inclusive charged particle transverse momentum distribution is measured in proton-proton collisions at root s = 900 GeV at the LHC using the ALICE detector. The measurement is performed in the central pseudorapidity region (vertical bar eta vertical bar < 0.8) over the transverse momentum range 0.15 < p(T) < 10 GeV/c. The correlation between transverse momentum and particle multiplicity is also studied. Results are presented for inelastic (INEL) and non-single-diffractive (NSD) events. The average transverse momentum for vertical bar eta vertical bar < 0.8 is < p(T)>(INEL) = 0.483 +/- 0.001 (stat.) +/- 0.007 (syst.) GeV/c and < p(T)>(NSD) = 0.489 +/- 0.001 (stat.) +/- 0.007 (syst.) GeV/c, respectively. The data exhibit a slightly larger < p(T)> than measurements in wider pseudorapidity intervals. The results are compared to simulations with the Monte Carlo event generators PYTHIA and PHOJET. (C) 2010 Published by Elsevier B.V.
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| 7. |
- Aamodt, K., et al.
(författare)
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Alignment of the ALICE Inner Tracking System with cosmic-ray tracks
- 2010
-
Ingår i: Journal of Instrumentation. - 1748-0221. ; 5
-
Konferensbidrag (refereegranskat)abstract
- ALICE (A Large Ion Collider Experiment) is the LHC (Large Hadron Collider) experiment devoted to investigating the strongly interacting matter created in nucleus-nucleus collisions at the LHC energies. The ALICE ITS, Inner Tracking System, consists of six cylindrical layers of silicon detectors with three different technologies; in the outward direction: two layers of pixel detectors, two layers each of drift, and strip detectors. The number of parameters to be determined in the spatial alignment of the 2198 sensor modules of the ITS is about 13,000. The target alignment precision is well below 10 mu m in some cases (pixels). The sources of alignment information include survey measurements, and the reconstructed tracks from cosmic rays and from proton-proton collisions. The main track-based alignment method uses the Millepede global approach. An iterative local method was developed and used as well. We present the results obtained for the ITS alignment using about 10(5) charged tracks from cosmic rays that have been collected during summer 2008, with the ALICE solenoidal magnet switched off.
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| 8. |
- Aamodt, K., et al.
(författare)
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Charged-particle multiplicity measurement in proton-proton collisions at root s=0.9 and 2.36 TeV with ALICE at LHC
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 68:1-2, s. 89-108
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Tidskriftsartikel (refereegranskat)abstract
- Charged-particle production was studied in proton-proton collisions collected at the LHC with the ALICE detector at centre-of-mass energies 0.9 TeV and 2.36 TeV in the pseudorapidity range vertical bar eta vertical bar < 1.4. In the central region (vertical bar eta vertical bar < 0.5), at 0.9 TeV, we measure charged-particle pseudo-rapidity density dN(ch)/d eta = 3.02 +/- 0.01(stat.)(-0.05)(+0.08)(syst.) for inelastic interactions, and dN(ch)/d eta = 3.58 +/- 0.01 (stat.)(-0.12)(+0.12)(syst.) for non-single-diffractive interactions. At 2.36 TeV, we find dN(ch)/d eta = 3.77 +/- 0.01(stat.)(-0.12)(+0.25)(syst.) for inelastic, and dN(ch)/d eta = 4.43 +/- 0.01(stat.)(-0.12)(+0.17)(syst.) for non-single-diffractive collisions. The relative increase in charged-particle multiplicity from the lower to higher energy is 24.7% +/- 0.5%(stat.)(-2.8)(+5.7)%(syst.) for inelastic and 23.7% +/- 0.5%(stat.)(-1.1)(+4.6)%(syst.) for non-single-diffractive interactions. This increase is consistent with that reported by the CMS collaboration for non-single-diffractive events and larger than that found by a number of commonly used models. The multiplicity distribution was measured in different pseudorapidity intervals and studied in terms of KNO variables at both energies. The results are compared to proton-antiproton data and to model predictions.
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| 9. |
- Aamodt, K., et al.
(författare)
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Charged-particle multiplicity measurement in proton-proton collisions at root s=7 TeV with ALICE at LHC
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 68:3-4, s. 345-354
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Tidskriftsartikel (refereegranskat)abstract
- The pseudorapidity density and multiplicity distribution of charged particles produced in proton-proton collisions at the LHC, at a centre-of-mass energy root s = 7 TeV, were measured in the central pseudorapidity region vertical bar eta vertical bar < 1. Comparisons are made with previous measurements at root s = 0.9 TeV and 2.36 TeV. At root s = 7 TeV, for events with at least one charged particle in |eta vertical bar| < 1, we obtain dN(ch)/d eta = 6.01 +/- 0.01(stat.)(-0.12)(+0.20) (syst.). This corresponds to an increase of 57.6%+/-0.4%(stat.)(-1.8%)(+3.6) (syst.) relative to collisions at 0.9 TeV, significantly higher than calculations from commonly used models. The multiplicity distribution at 7 TeV is described fairly well by the negative binomial distribution.
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| 10. |
- Aamodt, K., et al.
(författare)
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First proton-proton collisions at the LHC as observed with the ALICE detector: measurement of the charged-particle pseudorapidity density at root s=900 GeV
- 2010
-
Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 65:1-2, s. 111-125
-
Tidskriftsartikel (refereegranskat)abstract
- On 23rd November 2009, during the early commissioning of the CERN Large Hadron Collider (LHC), two counter-rotating proton bunches were circulated for the first time concurrently in the machine, at the LHC injection energy of 450 GeV per beam. Although the proton intensity was very low, with only one pilot bunch per beam, and no systematic attempt was made to optimize the collision optics, all LHC experiments reported a number of collision candidates. In the ALICE experiment, the collision region was centred very well in both the longitudinal and transverse directions and 284 events were recorded in coincidence with the two passing proton bunches. The events were immediately reconstructed and analyzed both online and offline. We have used these events to measure the pseudorapidity density of charged primary particles in the central region. In the range vertical bar eta vertical bar < 0.5, we obtain dN(ch)/d eta = 3.10 +/- 0.13(stat.) +/- 0.22(syst.) for all inelastic interactions, and dN(ch)/d eta = 3.51 +/- 0.15(stat.) +/- 0.25(syst.) for nonsingle diffractive interactions. These results are consistent with previous measurements in proton-antiproton interactions at the same centre-of-mass energy at the CERN Sp<(p)over bar>S collider. They also illustrate the excellent functioning and rapid progress of the LHC accelerator, and of both the hardware and software of the ALICE experiment, in this early start-up phase.
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| 11. |
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| 12. |
- Clementini, G., et al.
(författare)
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Testing parallaxes with local Cepheids and RR Lyrae stars
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 605
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Tidskriftsartikel (refereegranskat)abstract
- Context. Parallaxes for 331 classical Cepheids, 31 Type II Cepheids, and 364 RR Lyrae stars in common between Gaia and the HIPPARCOS and Tycho-2 catalogues are published in Gaia Data Release 1 (DR1) as part of the Tycho-Gaia Astrometric Solution (TGAS). Aims. In order to test these first parallax measurements of the primary standard candles of the cosmological distance ladder, which involve astrometry collected by Gaia during the initial 14 months of science operation, we compared them with literature estimates and derived new period-luminosity (PL), period-Wesenheit (PW) relations for classical and Type II Cepheids and infrared PL, PL-metallicity (PLZ), and optical luminosity-metallicity (MV-[Fe/H]) relations for the RR Lyrae stars, with zero points based on TGAS.Methods. Classical Cepheids were carefully selected in order to discard known or suspected binary systems. The final sample comprises 102 fundamental mode pulsators with periods ranging from 1.68 to 51.66 days (of which 33 with sigma(omega)/omega < 0 : 5). The Type II Cepheids include a total of 26 W Virginis and BL Herculis stars spanning the period range from 1.16 to 30.00 days (of which only 7 with sigma(omega)/omega 0 : 5). The RR Lyrae stars include 200 sources with pulsation period ranging from 0.27 to 0.80 days (of which 112 with sigma(omega)/omega < 0 : 5). The new relations were computed using multi- band (V; I; J; K-s) photometry and spectroscopic metal abundances available in the literature, and by applying three alternative approaches: (i) linear least-squares fitting of the absolute magnitudes inferred from direct transformation of the TGAS parallaxes; (ii) adopting astrometry-based luminosities; and (iii) using a Bayesian fitting approach. The last two methods work in parallax space where parallaxes are used directly, thus maintaining symmetrical errors and allowing negative parallaxes to be used. The TGAS-based PL; PW; PLZ, and MV [Fe/H] relations are discussed by comparing the distance to the Large Magellanic Cloud provided by different types of pulsating stars and alternative fitting methods.Results. Good agreement is found from direct comparison of the parallaxes of RR Lyrae stars for which both TGAS and HST measurements are available. Similarly, very good agreement is found between the TGAS values and the parallaxes inferred from the absolute magnitudes of Cepheids and RR Lyrae stars analysed with the Baade-Wesselink method. TGAS values also compare favourably with the parallaxes inferred by theoretical model fitting of the multi-band light curves for two of the three classical Cepheids and one RR Lyrae star, which were analysed with this technique in our samples. The K-band PL relations show the significant improvement of the TGAS parallaxes for Cepheids and RR Lyrae stars with respect to the HIPPARCOS measurements. This is particularly true for the RR Lyrae stars for which improvement in quality and statistics is impressive.Conclusions. TGAS parallaxes bring a significant added value to the previous HIPPARCOS estimates. The relations presented in this paper represent the first Gaia-calibrated relations and form a work-in-progress milestone report in the wait for Gaia-only parallaxes of which a first solution will become available with Gaia Data Release 2 (DR2) in 2018.
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| 13. |
- Prusti, T., et al.
(författare)
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The Gaia mission
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 595
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Tidskriftsartikel (refereegranskat)abstract
- Gaia is a cornerstone mission in the science programme of the European Space Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric concept was changed to a direct-imaging approach. Both the spacecraft and the payload were built by European industry. The involvement of the scientific community focusses on data processing for which the international Gaia Data Processing and Analysis Consortium (DPAC) was selected in 2007. Gaia was launched on 19 December 2013 and arrived at its operating point, the second Lagrange point of the Sun-Earth-Moon system, a few weeks later. The commissioning of the spacecraft and payload was completed on 19 July 2014. The nominal five-year mission started with four weeks of special, ecliptic-pole scanning and subsequently transferred into full-sky scanning mode. We recall the scientific goals of Gaia and give a description of the as-built spacecraft that is currently (mid-2016) being operated to achieve these goals. We pay special attention to the payload module, the performance of which is closely related to the scientific performance of the mission. We provide a summary of the commissioning activities and findings, followed by a description of the routine operational mode. We summarise scientific performance estimates on the basis of in-orbit operations. Several intermediate Gaia data releases are planned and the data can be retrieved from the Gaia Archive, which is available through the Gaia home page.
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| 14. |
- Brown, A. G. A., et al.
(författare)
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Gaia Data Release 1 Summary of the astrometric, photometric, and survey properties
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 595
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Tidskriftsartikel (refereegranskat)abstract
- Context. At about 1000 days after the launch of Gaia we present the first Gaia data release, Gaia DR1, consisting of astrometry and photometry for over 1 billion sources brighter than magnitude 20.7. Aims. A summary of Gaia DR1 is presented along with illustrations of the scientific quality of the data, followed by a discussion of the limitations due to the preliminary nature of this release. Methods. The raw data collected by Gaia during the first 14 months of the mission have been processed by the Gaia Data Processing and Analysis Consortium (DPAC) and turned into an astrometric and photometric catalogue. Results. Gaia DR1 consists of three components: a primary astrometric data set which contains the positions, parallaxes, and mean proper motions for about 2 million of the brightest stars in common with the HIPPARCOS and Tycho-2 catalogues - a realisation of the Tycho-Gaia Astrometric Solution (TGAS) - and a secondary astrometric data set containing the positions for an additional 1.1 billion sources. The second component is the photometric data set, consisting of mean G-band magnitudes for all sources. The G-band light curves and the characteristics of similar to 3000 Cepheid and RR Lyrae stars, observed at high cadence around the south ecliptic pole, form the third component. For the primary astrometric data set the typical uncertainty is about 0.3 mas for the positions and parallaxes, and about 1 mas yr(-1) for the proper motions. A systematic component of similar to 0.3 mas should be added to the parallax uncertainties. For the subset of similar to 94 000 HIPPARCOS stars in the primary data set, the proper motions are much more precise at about 0.06 mas yr(-1). For the secondary astrometric data set, the typical uncertainty of the positions is similar to 10 mas. The median uncertainties on the mean G-band magnitudes range from the mmag level to similar to 0.03 mag over the magnitude range 5 to 20.7. Conclusions. Gaia DR1 is an important milestone ahead of the next Gaia data release, which will feature five-parameter astrometry for all sources. Extensive validation shows that Gaia DR1 represents a major advance in the mapping of the heavens and the availability of basic stellar data that underpin observational astrophysics. Nevertheless, the very preliminary nature of this first Gaia data release does lead to a number of important limitations to the data quality which should be carefully considered before drawing conclusions from the data.
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| 15. |
- van Leeuwen, F., et al.
(författare)
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Gaia Data Release 1 : Open cluster astrometry: Performance, limitations, and future prospects
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 601
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Tidskriftsartikel (refereegranskat)abstract
- Context. The first Gaia Data Release contains the Tycho-Gaia Astrometric Solution (TGAS). This is a subset of about 2 million stars for which, besides the position and photometry, the proper motion and parallax are calculated using Hipparcos and Tycho-2 positions in 1991.25 as prior information. Aims. We investigate the scientific potential and limitations of the TGAS component by means of the astrometric data for open clusters. Methods. Mean cluster parallax and proper motion values are derived taking into account the error correlations within the astrometric solutions for individual stars, an estimate of the internal velocity dispersion in the cluster, and, where relevant, the effects of the depth of the cluster along the line of sight. Internal consistency of the TGAS data is assessed. Results. Values given for standard uncertainties are still inaccurate and may lead to unrealistic unit-weight standard deviations of least squares solutions for cluster parameters. Reconstructed mean cluster parallax and proper motion values are generally in very good agreement with earlier Hipparcos-based determination, although the Gaia mean parallax for the Pleiades is a significant exception. We have no current explanation for that discrepancy. Most clusters are observed to extend to nearly 15 pc from the cluster centre, and it will be up to future Gaia releases to establish whether those potential cluster-member stars are still dynamically bound to the clusters. Conclusions. The Gaia DR1 provides the means to examine open clusters far beyond their more easily visible cores, and can provide membership assessments based on proper motions and parallaxes. A combined HR diagram shows the same features as observed before using the Hipparcos data, with clearly increased luminosities for older A and F dwarfs.
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| 16. |
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| 17. |
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| 18. |
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| 19. |
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| 20. |
- Porra, L., et al.
(författare)
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Quantitative Imaging of Regional Aerosol Deposition, Lung Ventilation and Morphology by Synchrotron Radiation CT
- 2018
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Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- To understand the determinants of inhaled aerosol particle distribution and targeting in the lung, knowledge of regional deposition, lung morphology and regional ventilation, is crucial. No single imaging modality allows the acquisition of all such data together. Here we assessed the feasibility of dual-energy synchrotron radiation imaging to this end in anesthetized rabbits; both in normal lung (n = 6) and following methacholine (MCH)-induced bronchoconstriction (n = 6), a model of asthma. We used K-edge subtraction CT (KES) imaging to quantitatively map the regional deposition of iodine-containing aerosol particles. Morphological and regional ventilation images were obtained, followed by quantitative regional iodine deposition maps, after 5 and 10 minutes of aerosol administration. Iodine deposition was markedly inhomogeneous both in normal lung and after induced bronchoconstrition. Deposition was significantly reduced in the MCH group at both time points, with a strong dependency on inspiratory flow in both conditions (R-2 = 0.71; p < 0.0001). We demonstrate for the first time, the feasibility of KES CT for quantitative imaging of lung deposition of aerosol particles, regional ventilation and morphology. Since these are among the main factors determining lung aerosol deposition, we expect this imaging approach to bring new contributions to the understanding of lung aerosol delivery, targeting, and ultimately biological efficacy.
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| 21. |
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| 22. |
- Antonioli, Roberto Pinto, et al.
(författare)
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On the Energy Efficiency of Cell-Free Systems With Limited Fronthauls : Is Coherent Transmission Always the Best Alternative?
- 2022
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Ingår i: IEEE Transactions on Wireless Communications. - : Institute of Electrical and Electronics Engineers (IEEE). - 1536-1276 .- 1558-2248. ; 21:10, s. 8729-8743
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Tidskriftsartikel (refereegranskat)abstract
- Existing works concluded that coherent transmission outperforms non-coherent transmission in the downlink of cell-free systems when the fronthaul links have unlimited capacity. Since the capacity of the fronthaul links of cell-free networks is typically limited, in this paper we ask the question whether this conclusion holds under more realistic assumptions on the fronthaul capacity. To answer this question, we study and compare the performance of these transmission strategies by formulating novel energy efficiency (EE) maximization problems for both strategies, where we explicitly consider realistic fronthaul capacity and power consumption constraints. Despite the non-convexity of these problems, we derive closed-form equations to find suboptimal solutions of both problems using a unified framework that combines successive convex approximation and the Dinkelbach algorithm. Numerical results show that the performance of coherent transmission is severely impacted by limited fronthaul capacities, power consumption on the fronthaul links, user-centric cluster size and the number of antennas at the access points, such that in many cases non-coherent transmission achieves higher EE than coherent transmission. Based on these results, we provide deployment guidelines on when to use coherent or non-coherent transmission to maximize the EE of cell-free systems with limited fronthauls.
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| 23. |
- Ardah, Khaled, et al.
(författare)
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Hybrid Analog-Digital Beamforming Design for SE and EE Maximization in Massive MIMO Networks
- 2020
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Ingår i: IEEE Transactions on Vehicular Technology. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 0018-9545 .- 1939-9359. ; 69:1, s. 377-389
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Tidskriftsartikel (refereegranskat)abstract
- Hybrid analog-digital (HAD) beamforming architectures have been proposed to facilitate the practical implementation of massive multiple-input multiple-output (MIMO) systems by reducing the number of employed radio frequency chains. While most prior studies have aimed to maximize spectral efficiency (SE), the present paper proposes a two-stage HAD beamforming design for multi-user MIMO systems that can be used to maximize either the system's overall energy efficiency (EE) or SE. This problem is nonconvex and NP-hard due to the joint optimization between the analog and digital domains and the constant modulus constraints required by the analog domain. To address this problem, we propose a decoupled two-stage design wherein the first stage, the analog beamforming parts are updated, which are then taken into account in the second stage to design the digital beamforming parts to maximize the system's EE or SE. We consider two widely-used HAD beamforming techniques that utilize either fully-connected (FC) or partially-connected (PC) architectures employing variable phase-shifters. Using the most recently available data for the circuitry power consumption of the components, we compare the performance of these two HAD architectures with that of the fully-digital (FD) architecture in terms of the total circuitry power consumption, and achieved SE and EE. We find that there is a certain number of users above which the FC architecture has higher circuitry power consumption than the FD counterpart, in contrast to the PC architecture that always has lower circuitry power consumption. More importantly, our results reveal, contrary to the common opinion, that depending on the circuitry parameters the FD architecture may achieve not only higher SE, but also higher EE than the HAD architectures.
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| 24. |
- Baroffio, L., et al.
(författare)
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Demo : Enabling image analysis tasks in visual sensor networks
- 2014
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Ingår i: Proceedings of the 8th ACM/IEEE International Conference on Distributed Smart Cameras, ICDSC 2014. - New York, NY, USA : Association for Computing Machinery (ACM). - 9781450329255 ; , s. a46-
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Konferensbidrag (refereegranskat)abstract
- This demo showcases some of the results obtained by the GreenEyes project, whose main objective is to enable visual analysis on resource-constrained multimedia sensor networks. The demo features a multi-hop visual sensor network operated by BeagleBones Linux computers with IEEE 802.15.4 communication capabilities, and capable of recognizing and tracking objects according to two different visual paradigms. In the traditional compress-then-analyze (CTA) paradigm, JPEG compressed images are transmitted through the network from a camera node to a central controller, where the analysis takes place. In the alternative analyze-then-compress (ATC) paradigm, the camera node extracts and compresses local binary visual features from the acquired images (either locally or in a distributed fashion) and transmits them to the central controller, where they are used to perform object recognition/tracking. We show that, in a bandwidth constrained scenario, the latter paradigm allows to reach better results in terms of application frame rates, still ensuring excellent analysis performance.
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| 25. |
- Baroffio, L., et al.
(författare)
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GreenEyes : Networked energy-aware visual analysis
- 2015
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Ingår i: 2015 IEEE International Conference on Multimedia and Expo Workshops, ICMEW 2015. - : IEEE conference proceedings. - 9781479970797
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Konferensbidrag (refereegranskat)abstract
- The GreenEyes project aims at developing a comprehensive set of new methodologies, practical algorithms and protocols, to empower wireless sensor networks with vision capabilities. The key tenet of this research is that most visual analysis tasks can be carried out based on a succinct representation of the image, which entails both global and local features, while it disregards the underlying pixel-level representation. Specifically, GreenEyes will pursue the following goals: i) energy-constrained extraction of visual features; ii) rate-efficiency modelling and coding of visual feature; iii) networking streams of visual features. This will have a significant impact on several scenarios including, e.g., smart cities and environmental monitoring.
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| 26. |
- Carvalho, E. de, et al.
(författare)
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EU FP7 INFSO-ICT-317669 METIS, D3.1 Positioning of multi-node/multi-antenna technologies
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This document describes the research activity in multi-node/multi-antenna technologies within METIS and positions it with respect to the state-of-the-art in the academic literature and in the standardization bodies. Based on the state-of-the-art and as well as on the METIS objectives,we set the research objectives and we group the different activities (or technology components) into research clusters with similar research objectives. The technologycomponents and the research objectives have been set to achieve an ambidextrous purpose. On one side we aim at providing the METIS system with those technological components that are a natural but non-trivial evolution of 4G. On the other side, we aim at seeking for disruptivetechnologies that could radically change 5G with respect to 4G. Moreover, we mapped the different technology components to METIS’ other activities and to the overall goals of theproject.
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| 27. |
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| 28. |
- de Araujo, Gilderlan T., et al.
(författare)
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Semi-Blind Joint Channel and Symbol Estimation for IRS-Assisted MIMO Systems
- 2023
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Ingår i: IEEE Transactions on Signal Processing. - : Institute of Electrical and Electronics Engineers (IEEE). - 1053-587X .- 1941-0476. ; 71, s. 1184-1199
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Tidskriftsartikel (refereegranskat)abstract
- Intelligent reflecting surface (IRS) is a promising technology for the 6$\text{th}$ generation of wireless systems, realizing the smart radio environment concept. This paper presents a novel tensor-based receiver for Intelligent reflecting surface (IRS)-assisted multiple-input multiple-output communications capable of jointly estimating the channels and the transmitted data streams in a semi-blind fashion. Assuming a fully passive IRS architecture and introducing a simple space-time coding scheme at the transmitter, the received signal model can be advantageously built using the PARATUCK tensor model, which can be seen as a hybrid of parallel factor analysis and Tucker models. A semi-blind receiver is derived by exploiting the algebraic structure of the PARATUCK tensor model. We first formulate a semi-blind receiver based on a trilinear alternating least squares method that iteratively estimates the two involved - IRS-base station and user terminal-IRS - communication channels and the transmitted symbol matrix. We discuss identifiability conditions that ensure the joint semi-blind recovery of the involved channel and symbol matrices and propose a joint design of the coding and IRS reflection matrices to optimize the receiver performance. We also formulate an enhanced two-stage semi-blind receiver that efficiently exploits the direct link to refine the channel and symbol estimates iteratively. In particular, we discuss the impact of an imperfect IRS absorption (residual reflection) on the performance of the proposed receiver. Numerical results are proposed for performance evaluation in several system settings in terms of the normalized mean squared error of the estimated channels and the achieved symbol error rate, corroborating the merits of the proposed semi-blind receiver in comparison to competing methods.
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| 29. |
- de Araujo, Gilderlan T., et al.
(författare)
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Semi-Blind Joint Channel and Symbol Estimation in IRS-Assisted Multiuser MIMO Networks
- 2022
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Ingår i: IEEE Wireless Communications Letters. - : Institute of Electrical and Electronics Engineers (IEEE). - 2162-2337 .- 2162-2345. ; 11:7, s. 1553-1557
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Tidskriftsartikel (refereegranskat)abstract
- Intelligent reflecting surface (IRS) is a promising technology for beyond of the wireless communications. In fully passive IRS-assisted systems, channel estimation is challenging and should be carried out only at the base station or at the terminals since the elements of the IRS are incapable of processing signals. In this letter, we formulate a tensor-based semi-blind receiver that solves the joint channel and symbol estimation problem in an IRS-assisted multi-user multiple-input multiple-output system. The proposed approach relies on a generalized PARATUCK tensor model of the signals reflected by the IRS, based on a two-stage closed-form semi-blind receiver using Khatri-Rao and Kronecker factorizations. Simulation results demonstrate the superior performance of the proposed semi-blind receiver, in terms of the normalized mean squared error and symbol error rate, as well as a lower computational complexity, compared to recently proposed parallel factor analysis-based receivers.
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| 30. |
- Elamain, Omaima Abubakr, et al.
(författare)
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Optically isotropic state in bent core nematic mixtures with rod like molecules induced by direct current electric field
- 2013
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 103:16
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Tidskriftsartikel (refereegranskat)abstract
- One of the most important characteristic of the liquid crystal displays is the contrast of the generated images. The dark state of the display is a prerequisite for a high image contrast. Optically isotropic state was observed in bent core nematic mixtures containing rod like molecules induced by low applied dc electric field. It is found that the switching properties of these nematic mixtures depend on the concentration of the rod like molecules. Comparatively high concentrations of rod like molecules in the mixtures resulted in an improvement of the contrast and switching properties of the bent core nematic mixtures, thus demonstrating their potential for display applications.
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| 31. |
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| 32. |
- Fodor, George A., 1954-, et al.
(författare)
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The implications of the object/unified modeling language approach to the problem of fault detection and isolation in dynamical systems
- 1999
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Ingår i: Proceedings of the 1999 IEEE International Symposium on Computer Aided Control System Design. - New York, USA : IEEE conference proceedings. - 0780355008 ; , s. 176-181
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Konferensbidrag (refereegranskat)abstract
- There is a growing trend to use object-based implementations and modeling in industrial control applications. However, the object-based approach imposes new theoretical and practical problems. Those problems are due to a higher abstraction level that is achievable with objects as compared to the more traditional, state-based fault detection and isolation methods (FDI) approaches. This paper presents a description of the problems and solutions to them in the framework of a discrete FDI method referred to as ontological control. The results are also relevant in respect to domain-independent failure recovery methods... (Fodor et al., 1997)
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| 33. |
- Fodor, Gabor, et al.
(författare)
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An Overview of Massive MIMO Technology Components in METIS
- 2017
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Ingår i: IEEE Communications Magazine. - : Institute of Electrical and Electronics Engineers (IEEE). - 0163-6804 .- 1558-1896. ; 55:6, s. 155-161
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Tidskriftsartikel (refereegranskat)abstract
- As the standardization of full-dimension MIMO systems in the Third Generation Partnership Project progresses, the research community has started to explore the potential of very large arrays as an enabler technology for meeting the requirements of fifth generation systems. Indeed, in its final deliverable, the European 5G project METIS identifies massive MIMO as a key 5G enabler and proposes specific technology components that will allow the cost-efficient deployment of cellular systems taking advantage of hundreds of antennas at cellular base stations. These technology components include handling the inherent pilot-data resource allocation trade-off in a near optimal fashion, a novel random access scheme supporting a large number of users, coded channel state information for sparse channels in frequency-division duplexing systems, managing user grouping and multi-user beamforming, and a decentralized coordinated transceiver design. The aggregate effect of these components enables massive MIMO to contribute to the METIS objectives of delivering very high data rates and managing dense populations.
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| 34. |
- Fodor, George, 1954-, et al.
(författare)
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Modeling the real-time recovery of complex control systems : A fuzzy approach
- 1997
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Ingår i: 1997 IEEE International Conference on Systems, Man, and Cybernetics. - New York, USA : IEEE conference proceedings. - 0780340531 ; , s. 2163-2168
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Konferensbidrag (refereegranskat)abstract
- This paper presents an approach to complex system recovery based on a fuzzy specification method. The method can be applied when controllers of different types and makes are connected in a common control architecture. The method allows a controller B to trigger a recovery operation on a controller A when B has the recovery specification of A. The approach has important potential applications in industry, e.g. as a possible complement to PLC standards such as IEC1131, and to the design of hybrid and complex control systems
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| 35. |
- Fodor, Gabor, 1964-, et al.
(författare)
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Recent advances in acquiring channel state information in cellular MIMO systems
- 2019
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Ingår i: Infocommunications Journal. - : Scientific Association for Infocommunications. - 2061-2079. ; 11:3, s. 2-12
-
Tidskriftsartikel (refereegranskat)abstract
- In cellular multi-user multiple input multiple output (MU-MIMO) systems the quality of the available channel state information (CSI) has a large impact on the system performance. Specifically, reliable CSI at the transmitter is required to determine the appropriate modulation and coding scheme, transmit power and the precoder vector, while CSI at the receiver is needed to decode the received data symbols. Therefore, cellular MUMIMO systems employ predefined pilot sequences and configure associated time, frequency, code and power resources to facilitate the acquisition of high quality CSI for data transmission and reception. Although the trade-off between the resources used for pilot and user data transmission has been known for long, the near-optimal configuration of the available system resources for pilot and data transmission is a topic of current research efforts. Indeed, since the fifth generation of cellular systems utilizes heterogeneous networks in which base stations are equipped with a large number of transmit and receive antennas, the appropriate configuration of pilot-data resources becomes a critical design aspect. In this article, we review recent advances in system design approaches that are designed for the acquisition of CSI and discuss some of the recent results that help to dimension the pilot and data resources specifically in cellular MU-MIMO systems.
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| 36. |
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| 37. |
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| 38. |
- Gomes, Paulo R. B., et al.
(författare)
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Channel Estimation in RIS-Assisted MIMO Systems Operating Under Imperfections
- 2023
-
Ingår i: IEEE Transactions on Vehicular Technology. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9545 .- 1939-9359. ; 72:11, s. 1-14
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Tidskriftsartikel (refereegranskat)abstract
- The promising gains of reconfigurable intelligent surface (RIS)-assisted multiple-input multiple-output (MIMO) systems, in terms of extended coverage and enhanced capacity, are critically dependent on the accuracy of the channel state information. However, traditional channel estimation (CE) schemes are not applicable in RIS-assisted MIMO networks, since passive RISs typically lack the signal processing capabilities that are assumed by CE algorithms. This becomes problematic when physical imperfections or electronic impairments affect the RIS due to its exposition to different environmental effects or caused by hardware limitations from the circuitry. While these real-world effects are typically ignored in the literature, in this article we propose efficient CE schemes for RIS-assisted MIMO systems taking different imperfections into account. Specifically, we propose two sets of tensor-based algorithms, based on the parallel factor analysis decomposition schemes. First, assuming a long-term model - where the RIS imperfections, modeled as unknown phase shifts, are static within the channel coherence time - we formulate an iterative alternating least squares (ALS)-based algorithm for the joint estimation of the unknown phase deviations and the communication channels. Then, we develop the short-term imperfection model, which allows both amplitude and phase RIS imperfections to be non-static with respect to the channel coherence time. We propose two iterative ALS-based and closed-form higher-order singular value decomposition-based algorithms for jointly estimating the channels and the unknown impairments. We also investigate the computational complexity and the identifiability of the proposed algorithms and study the effect of various imperfections on the CE quality. Simulation results show the effectiveness of our proposed tensor-based algorithms in terms of estimation accuracy and computational complexity.
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| 39. |
- Gomes, Paulo R.B., et al.
(författare)
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Tensor-Based Channel Estimation for RIS-Assisted Communications with Non-Ideal Phase Shift Responses
- 2022
-
Ingår i: 2022 Workshop on Communication Networks and Power Systems, WCNPS 2022. - : Institute of Electrical and Electronics Engineers (IEEE).
-
Konferensbidrag (refereegranskat)abstract
- Reconfigurable intelligent surface (RIS) is a candidate technology for future wireless networks. It is known that the promised gains of RIS-Assisted communications depend on the channel estimation performance. When the RIS is affected by imperfections, the associated phase shift responses present a non-ideal behavior, which translates into unknown, and possibly time-varying, phase deviations. Such perturbations can be caused by physical, electronic, or environmentalrelated conditions. In this scenario, traditional channel estimation schemes may fail to provide sufficiently accurate channel estimates. In this work, considering a time-varying RIS imperfection model, we propose an efficient and low-complexity tensor-based method to estimate the involved communication channels under unknown phase-shift responses. The proposed algorithm relies on a tensor modeling of the received signals and has a closed-form solution based on the higher order singular value decomposition. Simulation results show the effectiveness of our proposed solution in terms of estimation accuracy and computational complexity compared to the benchmark method.
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| 40. |
- Gomes, P. R. B., et al.
(författare)
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Tensor-Based Modeling and Processing for Channel Estimation in Two-Hop V2X MIMO Systems
- 2019
-
Ingår i: 2019 IEEE Conference on Standards for Communications and Networking, CSCN 2019. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781728108643
-
Konferensbidrag (refereegranskat)abstract
- Efficient vehicle-to-everything (V2X) communications improve traffic safety, enable autonomous driving and help to reduce environmental impacts. To achieve these objectives, accurate channel estimation in highly mobile scenarios becomes necessary. In this paper, we propose a tensor modeling-based approach for channel estimation and receiver design in a two-hop multiple-input multiple-output V2X communication system. Specifically, by exploiting a Tucker-2 modeling of the received signals, and relying on the joint estimation of the two-hop link, we formulate simple tensor-based closed-form and iterative semi-blind receivers. Furthermore, motivated by the parallel factor analysis (PARAFAC) structure of the time-varying multipath channel, we develop an iterative algorithm for estimating key parameters of the two-hop channel - including angles of departure, angles of arrival and path gains - from the factor matrices of the estimated channel tensors. Simulation results illustrate the performance of the proposed channel estimation and receiver algorithms in selected V2X communications scenarios.
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| 41. |
- Grantner, Janos L., et al.
(författare)
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Applications of the Fuzzy State Fuzzy Output Finite State Machine to the Problem of Recovery from Violation of Ontological Assumptions
- 2000
-
Ingår i: International Journal of Smart Engineering System Design. - : Taylor & Francis Group. - 1025-5818. ; 2:3, s. 177-199
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Tidskriftsartikel (refereegranskat)abstract
- A programmable logic controller (PC) carries out a control algorithm under violations of theontological assumptions (VOA) when the plant does not meet one or more unstated but essential assumptions used in the design of the control algorithm. This paper presents a recovery technique based on the theory of Fuzzy State Fuzzy Output Finite State Machines (FSFO-FSM). The appeal of this approach is that the only known recovery results today are for fuzzy controllers. A common drawback of most linguistic models is that they are essentially static and thus not suitable to model the sequential behavior of a PC program. A FSFO-FSM can act as a sequentialmachine during the normal course of control, yet it possesses all the required linguistic properties during a VOA. This approach can enhance substantially the safety and operational range of existing PC and embedded control applications. This paper describes the control problem, presents results based on simulations, and show architectural constraints when applying this principle to real-world application.
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| 42. |
- Grantner, J.L., et al.
(författare)
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Hybrid fuzzy-Boolean automata for ontological controllers
- 1998
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Ingår i: The 1998 IEEE International Conference on Fuzzy Systems Proceedings. - New York, USA : IEEE conference proceedings. - 078034863X ; , s. 400-404
-
Konferensbidrag (refereegranskat)abstract
- This paper introduces a hybrid fuzzy-Boolean finite state machine (HFB FSM) model for ontological control. Ontological control is a novel type supervisory control that deals with the problems of error detection and recovery in complex control systems. The HFB FSM is used as a specification method for the problem of recovery when an autonomous control system encounters unexpected changes in its environment. The method allows a controller B (the ontological controller) to trigger a recovery operation on controller A when B has the recovery specification of A. The approach has important potential applications in industry
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| 43. |
- Grantner, Janos L., et al.
(författare)
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The virtual fuzzy state machine approach : a domain-independent fault detection and recovery method for object-based control systems
- 1999
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Ingår i: Proceedings of the 18th International Conference of the North American Fuzzy Information Processing Society (NAFIPS). - : IEEE conference proceedings. - 0780352114 ; , s. 158-162
-
Konferensbidrag (refereegranskat)abstract
- The current trend of using object based design for real time control systems has the implication that traditional state based fault detection and recovery methods cannot be used directly. This problem is even more difficult for domain independent fault detection and recovery since most such methods are based on a formal analysis of the global state set. The paper presents a domain independent fault isolation, detection and recovery method for object based control systems based on constraints of the object architecture. Variations of the control behavior from normal cases are detected using a fuzzy state machine approach
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| 44. |
- Grantner, Janos L., et al.
(författare)
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Using fuzzy logic for bounded recovery of autonomous agents
- 1997
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Ingår i: 1997 Annual Meeting of the North American Fuzzy Information Processing Society. - New York, USA : IEEE conference proceedings. ; , s. 317-322
-
Konferensbidrag (refereegranskat)abstract
- The solution to the problem of application-independent fault recovery of autonomous agents requires a specification method for the agent's capacity to act outside of its normal operational limits. This paper presents a recovery method based upon the theory of a fuzzy finite state machine. A fuzzy specification is given for the bounds within which an autonomous agent is capable to recover after an unexpected situation has occurred in its environment. It has been shown that the three main components of the recovery problem: fault detection, fault recovery, and the properties of the actuator/sensor gear of an autonomous agent are interrelated. The suggested method can be implemented either by an application-independent software algorithm, or by fuzzy logic hardware
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| 45. |
- Isacsson, G., et al.
(författare)
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Bibloc and Monobloc Oral appliances in the Treatment of Obstructive Sleep apnoea : a Multicenter, Randomized, Blinded, Parallel-Group Trial
- 2017
-
Ingår i: Sleep Medicine. - : Elsevier. - 1389-9457 .- 1878-5506. ; 40:Suppl 1, s. E142-E143
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Introduction: The clinical benefit of bibloc over monobloc appliances has not been established in randomized trials treating obstructive sleep apnoea (OSA). We hypothesized that the two types of appliances are equally effective in treating moderate to severe OSA. Materials and methods: We performed a blinded, multicenter, randomized, controlled, prospective, parallel-group trial including patients aged 18 years or older who had moderate-to-severe OSA. Patients were randomly assigned to receive either a bibloc or a monobloc appliance with the intention to protrude the mandible 75% of the individual maximal protrusion capacity. At baseline a one-night respiratory polygraphy was done without any respiratory support. The polygraphy was iterated with the appliance in place at a 6-week follow-up. The primary outcome was the absolute change in the apnoea-hypopnea-index (AHI) from baseline to the 6-week follow-up, analysed in the per-protocol population. All patients who received an appliance were included in the safety analysis. This trial is registered with ClinicalTrials.gov, number NCT02148510, and approved by Uppsala Regional Ethical Review Board, Sweden (#2014/021). Results: We recruited patients from three dental specialist clinics in Sweden; enrolment of 302 patients was done between March 2014 and April 2016; 146 randomized to bibloc and 156 to monobloc appliance. Twenty-three patients in the bibloc group and 17 in the monobloc group were withdrawn due to reasons like appliance could not be fitted, lack of compliance, adverse events or non-valid follow-up polygraphy i.e. a per-protocol group of 123 bibloc and 139 monobloc treated patients. The mean change of AHI from baseline to 6 weeks of treatment was -13.8 (95% CI -16.1 to -11.5; p < 0.001) in the bibloc group and -12.5 (95% CI -14.8 to -10.3; p < 0.001) in the monobloc group. The mean difference was not significant between the groups (-1.3 (95% CI -4.5 to 1.9). The most common adverse event in the orofacial region was upper airway infection followed by complains from various parts of the mouth, jaws and teeth. Conclusions: Bibloc and monobloc appliance treatment was equal in their effects in treating OSA as measured by at home polygraphic respiratory measures and the appliances were associated with a similar degree of adverse events. Acknowledgements: Funding from Uppsala-Örebro Regional Research Council and Vastmanland County Council, Sweden.
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| 46. |
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| 47. |
- Muppirisetty, L. Srikar, et al.
(författare)
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Location-aided pilot contamination elimination for massive MIMO systems
- 2016
-
Ingår i: 2015 IEEE Global Communications Conference, GLOBECOM 2015. - New York : IEEE conference proceedings.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Massive MIMO systems, while being a promising technology for 5G systems, face a number of practical challenges. Among those, pilot contamination stands out as a key bottleneck to design high-capacity beamforming methods. We propose and analyze a location-aided approach to reduce the pilot contamination effect in uplink channel estimation for massive MIMO systems. The proposed method exploits the location of user terminals, scatterers, and base stations. The approach removes the need for direct estimation of large covariance matrices and provides good channel estimation performance in the large antenna regime.
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| 48. |
- Paiva, A. R. L., et al.
(författare)
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Kalman-Filter-Based Tracking of Millimeter-Wave Channel Parameters for V2X Applications
- 2019
-
Ingår i: 2019 IEEE Conference on Standards for Communications and Networking, CSCN 2019. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728108643
-
Konferensbidrag (refereegranskat)abstract
- The spectrum of millimeter waves, when properly exploited, represents an important asset for achieving the high data rates and low latencies required by applications in vehicular communications. However, vehicle scenarios are characterized by high mobility, which results in frequent misalignment of beams. Therefore, in these types of scenarios, beam tracking algorithms are important because they can keep the beams aligned with a low training overhead. Kalman filters are strong candidates for the implementation of such algorithms, because they ensure high channel tracking performance over a wide range of signal-to-noise-ratios (SNR) and are easy to implement. This work evaluates the performance of channel tracking methods based on Kalman filters for high mobility. Our numerical results show that the proposed Kalman filter-based channel tracking method has high performance at low SNR regimes compared to least square-based methods, and improve the robustness when using planar instead of linear arrays. Moreover, the proposed channel tracking method is shown to perform well in multipath fading scenarios, while achieving high performance in the presence of strong line-of-sight components.
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| 49. |
- Pierantozzi, E., et al.
(författare)
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Impaired Intracellular Ca2+ Dynamics, M-Band and Sarcomere Fragility in Skeletal Muscles of Obscurin KO Mice
- 2022
-
Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 23:3
-
Tidskriftsartikel (refereegranskat)abstract
- Obscurin is a giant sarcomeric protein expressed in striated muscles known to establish several interactions with other proteins of the sarcomere, but also with proteins of the sarcoplasmic reticulum and costameres. Here, we report experiments aiming to better understand the contribution of obscurin to skeletal muscle fibers, starting with a detailed characterization of the diaphragm muscle function, which we previously reported to be the most affected muscle in obscurin (Obscn) KO mice. Twitch and tetanus tension were not significantly different in the diaphragm of WT and Obscn KO mice, while the time to peak (TTP) and half relaxation time (HRT) were prolonged. Differences in force-frequency and force-velocity relationships and an enhanced fatigability are observed in an Obscn KO diaphragm with respect to WT controls. Voltage clamp experiments show that a sarcoplasmic reticulum’s Ca2+ release and SERCA reuptake rates were decreased in muscle fibers from Obscn KO mice, suggesting that an impairment in intracellular Ca2+ dynamics could explain the observed differences in the TTP and HRT in the diaphragm. In partial contrast with previous observations, Obscn KO mice show a normal exercise tolerance, but fiber damage, the altered sarcomere ultrastructure and M-band disarray are still observed after intense exercise. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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| 50. |
- Proletov, Ian, et al.
(författare)
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Primary and secondary glomerulonephritides 1.
- 2014
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Ingår i: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - : Oxford University Press (OUP). - 1460-2385. ; 29 Suppl 3:May, s. 186-200
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Tidskriftsartikel (refereegranskat)
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