| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Lannergard, A, et al.
(författare)
-
Immune function in Swedish élite orienteers
- 2001
-
Ingår i: Scandinavian journal of medicine & science in sports. - : Wiley. - 0905-7188 .- 1600-0838. ; 11, s. 274-
-
Tidskriftsartikel (refereegranskat)
|
|
| 6. |
- Waldenström, A, et al.
(författare)
-
Coxsackie B3 myocarditis induces a decrease in energy charge and accumulation of hyaluronan in the mouse heart.
- 1993
-
Ingår i: European Journal of Clinical Investigation. - 0014-2972 .- 1365-2362. ; 23:5, s. 277-82
-
Tidskriftsartikel (refereegranskat)abstract
- Interstitial oedema in chronic inflammation and ischaemia is related to an accumulation of hyaluronan (hyaluronic acid; HA) in the interstitium. As interstitial oedema will affect the oxygen transport in the interstitium we have evaluated whether accumulation of HA is related to signs of myocardial energy depletion in virus induced myocarditis. Myocarditis was induced in Balb/c mice by inoculation of Coxsackie B3 virus. The extractable HA content of the myocardium increased progressively from a baseline value of 153 +/- 26 micrograms g-1 dry weight to a maximum of 286 +/- 78 micrograms g-1 dry weight at day 7, whereafter there was a slight decline. Affinity histochemistry visualized HA in the endo-perimysium in healthy myocardium. At day 5 after Coxsackie B3 inoculation there was a general widening of the endomysium, which exhibited a positive staining for HA. In conjunction with focal inflammatory infiltrates the staining for HA was even more pronounced. The energy rich adenylates were reversibly affected by the Coxsackie B3 infection. There was a slight, but significant decline in EC from 0.74 +/- 0.05 in the control group to a minimum value of 0.64 +/- 0.10 at day 5, whereafter a restitution was observed at days 7 and 10. The total adenine nucleotide pool was similarly decreased from 27.8 +/- 2.9 mumol g-1 dry weight in controls to 24.6 +/- 2.1 micrograms g-1 dry weight at day 5, and normalized at days 7 and 10. The data suggest that virus induced myocarditis is associated with a local accumulation of HA in the myocardium.(ABSTRACT TRUNCATED AT 250 WORDS)
|
|
| 7. |
- Waldenström, A, et al.
(författare)
-
Ionophoric interaction with the myocyte sarcolemma : a new insight into the pathophysiology of degenerative myocardial disease.
- 1993
-
Ingår i: Scandinavian Journal of Infectious Diseases. Supplementum. - 0300-8878 .- 1651-2502. ; 88, s. 131-4
-
Tidskriftsartikel (refereegranskat)abstract
- A certain group of compounds often derived from microbes known as ionophores function as ion channels when incorporated in biological membranes. Different ionophores have a relative specificity for certain cations such as Ca2+ or K+. When such compounds are integrated in the cell membrane of a host cell a leakage of the ion in question is induced and the physiologic ion gradient will be dissipated. This will activate ion pumps at the expense of ATP in order to restore the physiologic ion gradient. This effect is seen for a number of different viruses including Coxsackie B3. Based on own experiments we suggest that this ionophoric effect is important in the pathophysiology of myocarditis. We have shown that mice with Coxsackie B3 myocarditis have low myocardial ATP and high ADP and AMP levels. This pattern of abnormal energy metabolism is also seen in patients with Syndrome X. It is suggested that the ECG and thallium perfusion scintigram suggestive of ischemia in such patients is rather due to the effect of an ionophore leading to an extracellular potassium shift.
|
|
| 8. |
- Wesslén, Lars, et al.
(författare)
-
An increase in sudden unexpected cardiac deaths among young Swedish orienteers during 1979-1992
- 1996
-
Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 17:6, s. 902-910
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Sixteen cases of sudden unexpected cardiac death, 15 males and one female, are known to have occurred among young Swedish orienteers from 1979 to 1992, of which seven cases occurred between 1989 and 1992. This is considered to be indicative of an increased death rate. RESULTS: Histopathological evaluation showed myocarditis in a higher than expected proportion of cases. In one such case, which we studied before the sudden unexpected death occurred, the victim had suffered a Chlamydia pneumoniae infection verified by serology, and a nucleotide sequence was found in the heart and lung by means of the polymerase chain reaction (PCR) that hybridized with a probe specific for that organism. Male Swedish orienteers do not, however, seem to have an increased rate of exposure to this agent. No further sudden unexpected deaths among young orienteers have occurred over the past 3.5 years. At the beginning of that period, attempts were made to modify training habits and attitudes.
|
|
