SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Fontanesi Luca) "

Sökning: WFRF:(Fontanesi Luca)

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Botvinik-Nezer, Rotem, et al. (författare)
  • Variability in the analysis of a single neuroimaging dataset by many teams
  • 2020
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 582, s. 84-88
  • Tidskriftsartikel (refereegranskat)abstract
    • Data analysis workflows in many scientific domains have become increasingly complex and flexible. Here we assess the effect of this flexibility on the results of functional magnetic resonance imaging by asking 70 independent teams to analyse the same dataset, testing the same 9 ex-ante hypotheses(1). The flexibility of analytical approaches is exemplified by the fact that no two teams chose identical workflows to analyse the data. This flexibility resulted in sizeable variation in the results of hypothesis tests, even for teams whose statistical maps were highly correlated at intermediate stages of the analysis pipeline. Variation in reported results was related to several aspects of analysis methodology. Notably, a meta-analytical approach that aggregated information across teams yielded a significant consensus in activated regions. Furthermore, prediction markets of researchers in the field revealed an overestimation of the likelihood of significant findings, even by researchers with direct knowledge of the dataset(2-5). Our findings show that analytical flexibility can have substantial effects on scientific conclusions, and identify factors that may be related to variability in the analysis of functional magnetic resonance imaging. The results emphasize the importance of validating and sharing complex analysis workflows, and demonstrate the need for performing and reporting multiple analyses of the same data. Potential approaches that could be used to mitigate issues related to analytical variability are discussed. The results obtained by seventy different teams analysing the same functional magnetic resonance imaging dataset show substantial variation, highlighting the influence of analytical choices and the importance of sharing workflows publicly and performing multiple analyses.
  •  
2.
  • Carneiro, Miguel, et al. (författare)
  • Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication
  • 2014
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 345:6200, s. 1074-1079
  • Tidskriftsartikel (refereegranskat)abstract
    • The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Pielberg, Gerli (1)
Lindblad-Toh, Kersti ... (1)
Nilsonne, Gustav (1)
Botvinik-Nezer, Rote ... (1)
Dreber Almenberg, An ... (1)
Holzmeister, Felix (1)
visa fler...
Huber, Juergen (1)
Johannesson, Magnus (1)
Kirchler, Michael (1)
Poldrack, Russell A. (1)
Schonberg, Tom (1)
Tinghög, Gustav, 197 ... (1)
Glerean, Enrico (1)
Barrell, Daniel (1)
Ruffier, Magali (1)
Albert, Frank W. (1)
Carneiro, Miguel (1)
Villafuerte, Rafael (1)
Ferrand, Nuno (1)
Andersson, Leif (1)
Alfoeldi, Jessica (1)
Di Palma, Federica (1)
Heiman, David (1)
Johnson, Jeremy (1)
Searle, Steve (1)
Turner-Maier, Jason (1)
Young, Sarah (1)
Lander, Eric S. (1)
Younis, Shady (1)
Aken, Bronwen (1)
Rafati, Nima (1)
Zhang, Lei (1)
Rubin, Carl-Johan (1)
Afonso, Sandra (1)
Heunis, Stephan (1)
Forsberg-Nilsson, Ka ... (1)
Cunningham, William ... (1)
Lamm, Claus (1)
Hamilton, Paul J., 1 ... (1)
Durnez, Joke (1)
Barrio, Alvaro Martí ... (1)
Zhang, Xu (1)
Sayyab, Shumaila (1)
Chang, Jean L. (1)
Camerer, Colin F. (1)
Iwanir, Roni (1)
Mumford, Jeanette A. (1)
Adcock, R. Alison (1)
Avesani, Paolo (1)
Baczkowski, Blazej M ... (1)
visa färre...
Lärosäte
Uppsala universitet (1)
Stockholms universitet (1)
Linköpings universitet (1)
Handelshögskolan i Stockholm (1)
Karolinska Institutet (1)
Sveriges Lantbruksuniversitet (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (2)
Medicin och hälsovetenskap (1)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy