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Sökning: WFRF:(Forsberg Håkan)

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1.
  • Forsberg, Håkan, et al. (författare)
  • Methods for Enhancement of a Master of Engineering Programme
  • 2019
  • Konferensbidrag (refereegranskat)abstract
    • This paper describes methods we used to improve our Master of Engineering programme in Dependable Aerospace Systems together with the industry. The target audience is mainly programme coordinators/managers who are in the process to develop their programmes for future demands. The two main questions we address are: Q1 – How do we ensure a good progression within a programme to ensure the industry’s current and future needs in engineering skills? and Q2 – How do we ensure students become acquainted with research during their studies? The results indicate that our suggested method to analyse programme progression through subject abilities supports developer of engineering programmes and that our approach to undergraduate research opportunities is a way forward to introduce students to research early.
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2.
  • Hagenbjörk-Gustafsson, Annika, et al. (författare)
  • Determinants of personal exposure to some carcinogenic substances and nitrogen dioxide among the general population in five Swedish cities
  • 2014
  • Ingår i: Journal of Exposure Science and Environmental Epidemiology. - : Springer Science and Business Media LLC. - 1559-0631 .- 1559-064X. ; 24:4, s. 437-443
  • Tidskriftsartikel (refereegranskat)abstract
    • Environmental levels of airborne carcinogenic and related substances are comparatively better known than individual exposure and its determinants. We report on a personal monitoring program involving five Swedish urban populations. The aim of the program was to investigate personal exposure to benzene, 1,3-butadiene, formaldehyde, and nitrogen dioxide (NO2). The measurements were performed among 40 inhabitants during seven consecutive days, in one urban area each year, during 2000-2008. The estimated population exposure levels were 1.95 mu g/m(3) for benzene, 0.56 mu g/m(3) for 1,3-butadiene, 19.4 mu g/m(3) for formaldehyde, and 14.1,mu g/m(3) for NO2. Statistical analysis using a mixed-effects model revealed that time spent in traffic and time outdoors contributed to benzene and 1,3- butadiene exposure. For benzene, refueling a car was an additional determinant influencing the exposure level. Smoking or environmental tobacco smoke were significant determinants of exposure to NO2, benzene, and 1, 3-butadiene. Those with a gas stove had higher NO2 exposure. Living in a single-family house increased the exposure to formaldehyde significantly. In a variance component model, the between-subject variance dominated for 1,3-butadiene and formaldehyde, whereas the between-city variance dominated for NO2. For benzene, the between-subject and between-cities variances were similar.
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3.
  • Zhang, Renyun, et al. (författare)
  • Soap-film coating : High-speed deposition of multilayer nanofilms
  • 2013
  • Ingår i: Scientific Reports. - Nature Publishing Group : Springer Science and Business Media LLC. - 2045-2322. ; 3, s. Art. no. 1477-
  • Tidskriftsartikel (refereegranskat)abstract
    • The coating of thin films is applied in numerous fields and many methods are employed for the deposition of these films. Some coating techniques may deposit films at high speed; for example, ordinary printing paper is coated with micrometre-thick layers of clay at a speed of tens of meters per second. However, to coat nanometre thin films at high speed, vacuum techniques are typically required, which increases the complexity of the process. Here, we report a simple wet chemical method for the high-speed coating of films with thicknesses at the nanometre level. This soap-film coating technique is based on forcing a substrate through a soap film that contains nanomaterials. Molecules and nanomaterials can be deposited at a thickness ranging from less than a monolayer to several layers at speeds up to meters per second. We believe that the soap-film coating method is potentially important for industrial-scale nanotechnology.
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5.
  • Agelis, Sacki (författare)
  • Reconfigurable Optical Interconnection Networks for High-Performance Embedded
  • 2005
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • In embedded computer and communication system the capacity demand for interconnection networks is increasing continuously in order to achieve high-performance systems. Recent breakthroughs show that by using reconfigurability inside a single chip substantial performance gains can be added. However, in this thesis the focus is on system level reconfigurability (between chips or modules) and the performance gains that potentially can be achieved by having support for runtime reconfigurability on the system level.This thesis addresses the field of runtime system level reconfigurability with the use of optics in switches and routers for data- and telecommunications, and in multi-processor systems used for embedded signal processing. Several reconfigurable systems for switching and routing with support to adapt for asymmetric traffic patterns are proposed and compared to identify how design choices affect flexibility, performance etc. The proposed solutions are characterized by their multistage optical interconnection networks with reconfigurable shuffle patterns, where the reconfigurability is provided by micro-optical-electrical mechanical systems. More specifically, application-specific bottlenecks can be resolved by reconfiguring the interconnection network according to the current application demands. The benefits of the architectural solutions are confirmed by simulations that clearly show that the architectures can achieve high performance for both symmetric application characteristics and for several classes of asymmetric application characteristics. The final architectural solution is characterized by electronic packet-switches interconnected through an optical backplane, which is reconfigurable. Moreover, the thesis presents how several signal processing applications can be mapped to run concurrently in a time-shared scheme on a single reconfigurable multi-processor system that has high flexibility to adapt for the application currently at hand. The interconnection network is then adapted (reconfigured) according to the demands of the currently executed application in each time instance. The analysis shows that it is feasible to build such a system with today’s components.
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8.
  • Alm Fjellborg, Andreas, PhD, 1982-, et al. (författare)
  • Commuting patterns of preschool children in metropolitan Stockholm
  • 2022
  • Ingår i: Regional Science Policy & Practice. - : John Wiley & Sons. - 1757-7802. ; 14:4, s. 960-980
  • Tidskriftsartikel (refereegranskat)abstract
    • This full population study of travel-to-preschool patterns ofthe youngest children (< 6 years old) in metropolitanStockholm analyses how school markets, even at an earlystage, reproduce inequalities related to social and geograph-ical distances. Our findings show that families with foreignbackgrounds tend to convert educational capital into socialcapital by sending their children to preschools in moresocio-economically favourable neighbourhoods. Further-more, we detect avoidance behaviour among the majoritypopulation in ethnically mixed neighbourhoods, whichindicate that some native families are inclined to avoidpreschools with high shares of non-native peers.
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9.
  • Alm Fjellborg, Andreas, PhD, 1982-, et al. (författare)
  • Even in preschools : analysing the preschool and neighbourhood segregation gap in Swedish municipalities
  • 2023
  • Ingår i: European Sociological Review. - : Oxford University Press. - 0266-7215 .- 1468-2672. ; 39:5, s. 677-691
  • Tidskriftsartikel (refereegranskat)abstract
    • Preschool segregation has not been the focus of research efforts to the same extent as compulsory school segregation. This is at least in part a consequence of the lack of large-scale, registry-based data sources on where children live and where they attend preschool. This paper presents a full-population account of discrepancies between preschool segregation and neighbourhood segregation covering the Swedish population. Data includes preschool children as well as their parents’ income, education, ethnic background, and place of residence. Findings indicate that while preschool segregation does not differ from neighbourhood segregation to the same extent as previous research has shown for school segregation, there are systematic differences affecting the level of segregation across Sweden and in various types of municipalities. Studies on school level show segregation by foreign background and income to be most prominent, whilst preschool segregation mostly concerns parents’ educational attainment. Furthermore, the findings show that the geographical distribution of private and public preschools affects levels of segregation. This conclusion supports the general argument that the free-choice reform in the Swedish school system tends to raise levels of school segregation above the levels of residential segregation—even in preschools.
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11.
  • Andersson, Camilla, et al. (författare)
  • Achievements and experiences from science–policy interaction in the field of air pollution : Synthesising 20 years of research and outreach,thinking about future needs
  • 2021
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • For 20 years, the Swedish Environmental Protection Agency together with the MISTRA research foundation have funded five air pollution research programmes with focus on producing knowledge that supports policy and emission control in national and international arenas. The research has been multidisciplinary and has included research on emissions, atmospheric transport and transformation processes, human health effects, ecosystem effects, and emission control strategies. Research has also been conducted on the interaction between air pollution and climate change.Over these years, the link between the research programmes and the development of emission control strategies and policies in Sweden, the EU, and the UNECE Air Convention has been of high importance. This report presents how the research programmes have created societal benefits through support for the development of air pollution policies and emission control measures. The report also identifies future research needs to ensure continued progress towards even better air quality for future generations.
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12.
  • Andersson, Henrik, et al. (författare)
  • Contacting paper-based supercapacitors to printed electronics on paper substrates
  • 2012
  • Ingår i: Nordic Pulp & Paper Research Journal. - 0283-2631 .- 2000-0669. ; 27:2, s. 476-480
  • Tidskriftsartikel (refereegranskat)abstract
    • Hybrid printed electronics, in which printed structures and silicon-based components co-exist will likely be among the first commercial solutions. In this case the paper substrate acts much in the same way as circuit boards, containing conductive tracks and acting as a carrier for the electrical components. It is important to consider the contacting of the components to be able to produce low resistance electrical contacts to the conductive tracks. Supercapacitors are able to deliver a large amount of current in a short time and are a good option for short term energy storage and if the printed product is to be used only one, or a few times, it can be the only power source needed. When manufacturing printed electronics, the overall resistance of the printed tracks as well as the contact resistance of the mounted components will add up to the total resistance of the system. A high resistance will cause a voltage drop from the power source to the component. This will waste power that goes to Joule heating and also the voltage and current available to components may be too low to drive them. If the intention is to use a power supply such as batteries or solar cells this becomes a limitation. In this article have been tested several conductive adhesives used to contact paper based supercapacitors to ink jet printed silver tracks on paper. The best adhesive gives about 0.3 Ω per contact, a factor 17 better compared to the worst which gave 5 Ω. The peak power that is possible to take out from a printed system with a flexible battery and super capacitors is about 10 times higher than compared with the same system with only the battery.
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13.
  • Andersson, Staffan, et al. (författare)
  • 24-hour electrocardiographic study in myotonic dystrophy
  • 1988
  • Ingår i: Cardiology. - : S. Karger AG. - 0008-6312 .- 1421-9751. ; 75:4, s. 241-249
  • Tidskriftsartikel (refereegranskat)abstract
    • Thirty-eight consecutive adult patients with myotonic dystrophy were included in a study with electrocardiography at rest and 24-hour ambulatory electrocardiography. The patients were subdivided into three groups according to the severity of the disease. The prevalence of abnormal electrocardiograms at rest was 31, 50 and 100% in patients with mild, moderate and severe disease, respectively. The main characteristics observed at ambulatory electrocardiography were a high frequency of sinus bradycardia (58%) and intermittent atrioventricular block II (8%). These bradyarrhythmias were not correlated to the severity of the disease. Sustained atrial fibrillation or flutter was found in 3 patients (8%), all with the most severe form of the disease. Ambulatory electrocardiography should be used deliberately in the evaluation of patients with myotonic dystrophy and symptoms compatible with cardiac arrhythmias.
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14.
  • Andersson, Staffan, et al. (författare)
  • Assessment of autonomic nerve function in myotonic dystrophy
  • 1990
  • Ingår i: Journal of the Autonomic Nervous System. - : Elsevier BV. - 0165-1838 .- 1872-7476. ; 29:3, s. 187-192
  • Tidskriftsartikel (refereegranskat)abstract
    • The function of the autonomic nervous system was studied in 23 patients with myotonic dystrophy, from a defined population in northern Sweden with an extremely high prevalence of this disease. Heart rate variability tests showed only minor signs of parasympathetic dysfunction. Blood pressure and plasma noradrenaline measurements in recumbent and upright positions showed no signs of sympathetic neuropathy. Increased plasma levels of noradrenaline was an unexpected finding. Our study does not support the hypothesis that cardiac arrhythmias, orthostatic hypotension, gastrointestinal motility disturbances and urinary bladder dysfunction in myotonic dystrophy are caused by autonomic neuropathy, and we believe that these symptoms should rather be ascribed to a defective function of the target organs
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15.
  • Andersson, Staffan, et al. (författare)
  • Echocardiographic features of myotonic dystrophy
  • 1989
  • Ingår i: American Journal of Noninvasive Cardiology. - : S. Karger AG. - 0258-4425 .- 2504-2378. ; 3:6, s. 354-358
  • Tidskriftsartikel (refereegranskat)abstract
    • Thirty adult patients with myotonic dystrophy from a defined population in northern Sweden were examined by echocardiograms were found in 1 of 7 (14%) patients with mild disease, 7 of 13 (54%) patients with moderate disease, and 6 of 10 (60%) patients with severe disease
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18.
  • Andres, Britta, et al. (författare)
  • Characterization of nanographite and graphene produced in a high-pressure homogenizer
  • 2014
  • Ingår i: Graphene Week 2014.
  • Konferensbidrag (refereegranskat)abstract
    • Supercapacitor electrodes are often made of porous carbon materials such as activated carbon, but also graphene was frequently used as active electrode material. Graphene can be produced by mechanical exfoliation, chemical exfoliation, chemical vapor deposition or other elaborate methods. These techniques are relatively expensive and produce small quantities only. Recently we presented a method to produce nanographite and graphene by mechanical exfoliation of graphite in a high-pressure homogenizer. In our contribution “Large-scale production of graphene” by Nicklas Blomquist we suggest to optimize the geometry of the shear zone and increase the feeding pressure to obtain a higher yield.In this study we evaluated the influence of these process optimizations on the structural and electrical properties of the nanographite-graphene mixture. The produced dispersions were characterized in terms of particle size and shape by using a particle size analyzer, a transmission electron microscope (TEM) and an atomic force microscope (AFM). In order to analyze the performance of the produced material as electrodes for supercapacitors, electrodes were produced by vacuum filtration. The electrodes were studied by sheet-resistance and capacitance measurements. Furthermore, the structure of the electrode surface and the cross section of the electrode were visualized by using a scanning electron microscope (SEM).Comparisons with previously produced nanographite-graphene dispersions showed an increase in yield of the exfoliated nanomaterials. The optimized shear zone increased the production of nanosized particles and flakes and enhanced the material quality.
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19.
  • Andres, Britta, 1986-, et al. (författare)
  • Electrode Mass Balancing as an Inexpensive and Simple Method to Increase the Capacitance of Electric Double-Layer Capacitors
  • 2016
  • Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:9, s. 1-12
  • Tidskriftsartikel (refereegranskat)abstract
    • Symmetric electric double-layer capacitors (EDLCs) have equal masses of the same active material in both electrodes. However, having equal electrode masses may prevent the EDLC to have the largest possible specific capacitance if the sizes of the hydrated anions and cations in the electrolyte differ because the electrodes and the electrolyte may not be completely utilized. Here we demonstrate how this issue can be resolved by mass balancing. If the electrode masses are adjusted according to the size of the ions, one can easily increase an EDLC's specific capacitance. To that end, we performed galvanostatic cycling to measure the capacitances of symmetric EDLCs with different electrode mass ratios using four aqueous electrolytes-Na2SO4, H2SO4, NaOH, and KOH (all with a concentration of 1 M)-and compared these to the theoretical optimal electrode mass ratio that we calculated using the sizes of the hydrated ions. Both the theoretical and experimental values revealed lower-than-1 optimal electrode ratios for all electrolytes except KOH. The largest increase in capacitance was obtained for EDLCs with NaOH as electrolyte. Specifically, we demonstrate an increase of the specific capacitance by 8.6% by adjusting the electrode mass ratio from 1 to 0.86. Our findings demonstrate that electrode mass balancing is a simple and inexpensive method to increase the capacitance of EDLCs. Furthermore, our results imply that one can reduce the amount of unused material in EDLCs and thus decrease their weight, volume and cost.
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20.
  • Andres, Britta, 1986-, et al. (författare)
  • Enhanced electrical and mechanical properties of nanographite electrodes for supercapacitors by addition of nanobrillated cellulose
  • 2014
  • Konferensbidrag (refereegranskat)abstract
    • Graphene and other porous carbon materials are widely used as electrodes in supercapacitors. In order to form mechanically stable electrodes, binders can be added to the conducting electrode material. However, most binders degrade the electrical performance of the electrodes. Here we show that by using nanobrillated cellulose (NFC) as binder the electrical properties, such as sheet-resistance, were enhanced. NFC is a good ion conductor and improves the access of ions to the electrodes. Thus electrodes made of a mixture of nanographite and NFC achieved larger capacitances in supercapacitors than electrodes with nanographite only. The lowest sheet-resistance and the highest capacitance were measured at NFC contents of 10-15% in ratio to the total amount of active material. Furthermore, NFC formed a network that improved the mechanical stability of the electrodes signicantly. Beside the mechanical stability, NFC stabilized the aqueous nanographite dispersion that was used to prepare the electrodes. NFC avoids the restacking of the delaminated graphene akes by forming a ber network between the graphene layers.
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21.
  • Andres, Britta, et al. (författare)
  • Enhanced electrical and mechanical properties of nanographite electrodes for supercapacitors by addition of nanofibrillated cellulose
  • 2014
  • Ingår i: Physica status solidi. B, Basic research. - : Wiley. - 0370-1972 .- 1521-3951. ; 251:12, s. 2581-2586
  • Tidskriftsartikel (refereegranskat)abstract
    • Graphene and porous carbon materials are widely used as electrodes in supercapacitors. In order to form mechanically stable electrodes, binders can be added to the conducting electrode material. However, most bindersdegrade the electrical performance of the electrodes. Here we show that by using nanofibrillated cellulose(NFC) as binder the electrical properties, such as capacitance, were enhanced. The highest capacitance was measured at a NFC content of approximately 10% in ratio to the total amount of active material. NFC is a good ionconductor and improves the access of ions in the electrodes. Thus, electrodes made of a mixture of nanographite and NFC achieved larger capacitances in supercapacitors than electrodes with nanographite only. In addition to electrical properties, NFC enhanced the mechanical stability and wet strength of the electrodes significantly. Furthermore, NFC stabilized the aqueous nanographite dispersions, which improved the processability. Galvanostatic cycling was performed and an initial transient behaviour of the supercapacitors during the first cycles was observed. However, stabilized supercapacitors showed efficiencies of 98–100 %.
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24.
  • Andres, Britta, et al. (författare)
  • Supercapacitors with graphene coated paper electrodes
  • 2012
  • Ingår i: Nordic Pulp & Paper Research Journal. - 0283-2631 .- 2000-0669. ; 27:2, s. 481-485
  • Tidskriftsartikel (refereegranskat)abstract
    • Paper based supercapacitors are prepared by stacking a paper between two graphene electrodes and soaking these in an aqueous electrolyte. We demonstrate that supercapacitors can easily be manufactured by using proven paper technologies. Several different electrode materials were compared and two types of contacting material, silver and graphite foil were tested. The influence of the paper used as separator was also investigated. The supercapacitors with a graphene-gold nanoparticle composite as electrodes showed a specific capacitance of up to 100 F/g and an energy density of 1.27 Wh/kg. The energy density can further be increased by using other electrolytes. The silver contacts showed a pseudo capacitance, which the graphite contacts did not. The papers tested had a minor effect on the capacitance, but they have an influence on the weight and the volume of the supercapacitor.
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25.
  • Aronsson, Håkan, 1961-, et al. (författare)
  • Managing health care decisions and improvement through simulation modeling
  • 2011
  • Ingår i: Quality Management in Health Care. - : Wolters Kluwer. - 1063-8628 .- 1550-5154. ; 20:1, s. 15-29
  • Tidskriftsartikel (refereegranskat)abstract
    • Simulation modeling is a way to test changes in a computerized environment to give ideas for improvements before implementation. This article reviews research literature on simulation modeling as support for health care decision making. The aim is to investigate the experience and potential value of such decision support and quality of articles retrieved. A literature search was conducted, and the selection criteria yielded 59 articles derived from diverse applications and methods. Most met the stated research-quality criteria. This review identified how simulation can facilitate decision making and that it may induce learning. Furthermore, simulation offers immediate feedback about proposed changes, allows analysis of scenarios, and promotes communication on building a shared system view and understanding of how a complex system works. However, only 14 of the 59 articles reported on implementation experiences, including how decision making was supported. On the basis of these articles, we proposed steps essential for the success of simulation projects, not just in the computer, but also in clinical reality. We also presented a novel concept combining simulation modeling with the established plan-do-study-act cycle for improvement. Future scientific inquiries concerning implementation, impact, and the value for health care management are needed to realize the full potential of simulation modeling.
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26.
  • Artman, Henrik, 1968-, et al. (författare)
  • Effektiv miljötillsyn : slutrapport
  • 2013
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Målsättningen har varit att ta fram ny kunskap inom miljötillsynen och därigenom uppnå en effektivare miljötillsyn samt att få in nya vetenskapliga perspektiv på miljötillsyn.I rapporten studeras metoder för inspektioner och det kommunikativa samspelet mellan inspektören och företrädare för den verksamhet som inspekteras, hur den institutionella ramen för inspektionsprocessen fungerar samt visar på möjligheter att mäta effekterna av inspektioner och tillsyn.Naturvårdsverket kommer att ha resultatet som ett kunskapsunderlag i fortsatt arbete med tillsynsvägledning och utveckling av hur tillsyn och tillsynsvägledning kan följas upp och utvärderas.
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27.
  • Balliu, Enkeleda, et al. (författare)
  • Laser-assisted reduction of graphene oxide for paper based large area flexible electronics
  • 2016
  • Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE - International Society for Optical Engineering. - 9781628419719
  • Konferensbidrag (refereegranskat)abstract
    • In this work we present a promising method for fabrication of conductive tracks on paper based substrates by laser assisted reduction of Graphene Oxide (GO). Printed electronics on paper based substrates is be coming more popular due to lower cost and recyclability. Fabrication of conductive tracks is of great importance where metal, carbon and polymer inks are commonly used. An emerging option is reduced graphene oxide (r-GO), which can be a good conductor. Here we have evaluated reduction of GO by using a 532 nm laser source, showing promising results with a decrease of sheet resistance from >100 M Ω/Sqr for unreduced GO down to 126 Ω/Sqr. without any observable damage to the paper substrates.
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28.
  • Balliu, Enkeleda, PhD student, et al. (författare)
  • Laser processing of graphene oxide on different coated paper substrates
  • 2016
  • Ingår i: 14th TAPPI Advanced Coating Symposium 2016. - : TAPPI Press. - 9781510877658 ; , s. 97-101
  • Konferensbidrag (refereegranskat)abstract
    • Development of printed electronics is increasing each year, where many electrical components such as transistors and sensors are now printable. The most commonly used substrate have been plastics, but there is an increasing interest in using paper as substrate. The paper industry is a very large and mature industry with large production capacity and well developed processes. It is therefore of interest to investigate how it would be possible to combine printed electronics and paper based products. This can for example be to print sensors on packages, to use large scale roll-to-roll production for solar cells. To be able to achieve such goals it is of importance to develop methods of applying electrically active materials in the large, high speed roll-to-roll processes used in the paper industry. In this article we discuss coating of graphene oxide (GO) on large areas after which it is selectively reduced into electrically conductive reduced graphene oxide (rGO) by laser processing. Graphene oxide is an inexpensive, carbon based material very suitable to be deposited as a coating, and the selective activation of makes it possible to fabricate conductive patterns at high speeds. We have evaluated several different paper substrates on which GO was coated. The reduction was performed using an 532 nm laser source and the results are promising, showing that it is possible to fabricate selectively conductive patterns on paper substrates by coating and reduction of GO. 
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29.
  • Bjerle, P, et al. (författare)
  • Electrocardiographic findings in myotonic dystrophy
  • 1988
  • Ingår i: British Heart Journal. - : BMJ. - 0007-0769. ; 59:1, s. 47-52
  • Tidskriftsartikel (refereegranskat)abstract
    • Sixty five patients with myotonic dystrophy, from a defined population in northern Sweden with an extremely high prevalence of this disease, were examined by electrocardiography. The patients were subdivided into three groups according to the severity of the disease. Abnormal electrocardiograms were found in 6 (35%) patients with mild disease, 12 (50%) patients with moderate disease, and 23 (96%) patients with severe disease. First degree atrioventricular block and left anterior hemiblock were the most commonly encountered abnormalities in patients with mild and moderate disease, whereas atrial fibrillation and flutter, abnormal Q waves, and repolarisation abnormalities were more common in patients with severe disease. This study shows that the heart is often affected by myotonic dystrophy. These effects can be detected by electrocardiography in early and mild forms of the disease. The effect on the heart is progressive and clinically important atrial arrhythmias and electrocardiographic abnormalities which are useful in differential diagnosis are common in severe forms of the disease.
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30.
  • Blomquist, Nicklas, 1987-, et al. (författare)
  • Large-Scale Production of Nanographite by Tube-Shear Exfoliation in Water
  • 2016
  • Ingår i: PLOS ONE. - : Nicklas Blomquist. - 1932-6203. ; 11:4
  • Tidskriftsartikel (refereegranskat)abstract
    • The number of applications based on graphene, few-layer graphene, and nanographite is rapidly increasing. A large-scale process for production of these materials is critically needed to achieve cost-effective commercial products. Here, we present a novel process to mechanically exfoliate industrial quantities of nanographite from graphite in an aqueous environment with low energy consumption and at controlled shear conditions. This process, based on hydrodynamic tube shearing, produced nanometer-thick and micrometer-wide flakes of nanographite with a production rate exceeding 500 gh-1 with an energy consumption about 10 Whg-1. In addition, to facilitate large-area coating, we show that the nanographite can be mixed with nanofibrillated cellulose in the process to form highly conductive, robust and environmentally friendly composites. This composite has a sheet resistance below 1.75 Ω/sq and an electrical resistivity of 1.39×10-4 Ωm and may find use in several applications, from supercapacitors and batteries to printed electronics and solar cells. A batch of 100 liter was processed in less than 4 hours. The design of the process allow scaling to even larger volumes and the low energy consumption indicates a low-cost process.
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31.
  • Blomquist, Nicklas, 1987-, et al. (författare)
  • Metal-free supercapacitor with aqueous electrolyte and low-cost carbon materials
  • 2017
  • Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • Electric double-layer capacitors (EDLCs) or supercapacitors (SCs) are fast energy storage devices with high pulse efficiency and superior cyclability, which makes them useful in various applications including electronics, vehicles and grids. Aqueous SCs are considered to be more environmentally friendly than those based on organic electrolytes. Because of the corrosive nature of the aqueous environment, however, expensive electrochemically stable materials are needed for the current collectors and electrodes in aqueous SCs. This results in high costs for a given energy-storage capacity. To address this, we developed a novel low-cost aqueous SC using graphite foil as the current collector and a mix of graphene, nanographite, simple water-purification carbons and nanocellulose as electrodes. The electrodes were coated directly onto the graphite foil by using casting frames and the SCs were assembled in a pouch cell design. With this approach, we achieved a material cost reduction of greater than 90% while maintaining approximately one-half of the specific capacitance of a commercial unit, thus demonstrating that the proposed SC can be an environmentally friendly, low-cost alternative to conventional SCs.
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32.
  • Brännvall, Karin, et al. (författare)
  • Central nervous system stem/progenitor cells form neurons and peripheral glia after transplantation to the dorsal root ganglion.
  • 2006
  • Ingår i: NeuroReport. - 0959-4965 .- 1473-558X. ; 17:6, s. 623-628
  • Tidskriftsartikel (refereegranskat)abstract
    • We asked whether neural stem/progenitor cells from the cerebral cortex of E14.5 enhanced green fluorescent protein transgenic mice are able to survive grafting and differentiate in the adult rat dorsal root ganglion. Neurospheres were placed in lumbar dorsal root ganglion cavities after removal of the dorsal root ganglia. Alternatively, dissociated neurospheres were injected into intact dorsal root ganglia. Enhanced green fluorescent protein-positive cells in the dorsal root ganglion cavity were located in clusters and expressed beta-III-tubulin or glial fibrillary acidic protein after 1 month, whereas after 3 months, surviving grafted cells expressed only glial fibrillary acidic protein. In the intact adult DRG, transplanted neural stem/progenitor cells surrounded dorsal root ganglion cells and fibers, and expressed glial but not neuronal markers. These findings show that central nervous system stem/progenitor cells can survive and differentiate into neurons and peripheral glia after xenotransplantation to the adult dorsal root ganglion.
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33.
  • Claesson, Andreas, et al. (författare)
  • Simulation and education Outline and validation of a new dispatcher-assisted cardiopulmonary resuscitation educational bundle using the Delphi method
  • 2024
  • Ingår i: Resuscitation Plus. - : ELSEVIER. - 2666-5204. ; 17
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim: Dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) is time-dependent. To date, evidence-based training programmes for dispatchers are lacking. This study aimed to reach expert consensus on an educational bundle content for dispatchers to provide DA-CPR using the Delphi Method: An educational bundle was created by the Swedish Resuscitation Council consisting of three parts: e-learning on DA-CPR, basic life support training and audit of emergency out-of-hospital cardiac arrest calls. Thereafter, a two-round modified Delphi study was conducted between November 2022 and March 2023; 37 experts with broad clinical and/or scientific knowledge of DA-CPR were invited. In the first round, the experts participated in the e-learning module and answered a questionnaire with 13 closed and open questions, whereafter the e-learning part of the bundle was revised. In the second round, the revised e-learning part was evaluated using Likert scores (20 items). The predefined consensus level was set Results: Delphi rounds one and two were assessed by 20 and 18 of the invited experts, respectively. In round one, 18 experts (18 of 20, 90%) stated that they did not miss any content in the programme. In round two, the scale-level content validity index based on the average method (S-CVI/AVE, 0.99) and scale-level content validity index based on universal agreement (S-CVI/UA, 0.85) exceeded the threshold level of 80%. Conclusion: Expert consensus on the educational bundle content was reached using the Delphi method. Further work is required to evaluate its effect in real-world out-of-hospital cardiac arrest calls.
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34.
  • Dahlstedt, Magnus, et al. (författare)
  • Systemet med fritt skolval måste bytas ut
  • 2018
  • Ingår i: Svenska Dagbladet.
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • Ökad segregation och deprofessionalisering av läraryrket är några av effekterna av det fria skolvalet. Nu krävs en grundlig utredning med siktet inställt på att hitta alternativ till nuvarande marknadssystem, skriver ett flertal forskare.
  •  
35.
  • Dellgren, Linus, et al. (författare)
  • Phenotypic screening for quinolone resistance in Escherichia coli
  • 2019
  • Ingår i: European Journal of Clinical Microbiology and Infectious Diseases. - : SPRINGER. - 0934-9723 .- 1435-4373. ; 38:9, s. 1765-1771
  • Tidskriftsartikel (refereegranskat)abstract
    • Recent studies show that rectal colonization with low-level ciprofloxacin-resistant Escherichia coli (ciprofloxacin minimal inhibitory concentration (MIC) above the epidemiological cutoff point, but below the clinical breakpoint for resistance), i.e., in the range amp;gt; 0.06-0.5 mg/L is an independent risk factor for febrile urinary tract infection after transrectal ultrasound-guided biopsy (TRUS-B) of the prostate, adding to the other risk posed by established ciprofloxacin resistance in E. coli (MIC amp;gt; 0.5 mg/L) as currently defined. We aimed to identify the quinolone that by disk diffusion best discriminates phenotypic wild-type isolates (ciprofloxacin MIC amp;lt;= 0.06 mg/L) of E. coli from isolates with acquired resistance, and to determine the resistance genotype of each isolate. The susceptibility of 108 E. coli isolates was evaluated by ciprofloxacin, levofloxacin, moxifloxacin, nalidixic acid, and pefloxacin disk diffusion and correlated to ciprofloxacin MIC (broth microdilution) using EUCAST methodology. Genotypic resistance was identified by PCR and DNA sequencing. The specificity was 100% for all quinolone disks. Sensitivity varied substantially, as follows: ciprofloxacin 59%, levofloxacin 46%, moxifloxacin 59%, nalidixic acid 97%, and pefloxacin 97%. We suggest that in situations where low-level quinolone resistance might be of importance, such as when screening for quinolone resistance in fecal samples pre-TRUS-B, a pefloxacin (S amp;gt;= 24 mm) or nalidixic acid (S amp;gt;= 19 mm) disk, or a combination of the two, should be used. In a setting where plasmid-mediated resistance is prevalent, pefloxacin might perform better than nalidixic acid.
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36.
  • Ekman, A, et al. (författare)
  • Swedish Clean Air and Climate Research Programme – SCAC Final report second phase
  • 2020
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • The SCAC-2 program was initiated to provide an extended scientific knowledge base in national and international discussions and negotiations on the development of new air pollution policies and measures. Specifically, the program was focused on four main areas where additional knowledge was needed to support further actions: air pollution and climate interactions and hemispheric transport; air pollution and human health with focus on particles from transport and domestic wood burning; ecosystem effects (and air pollution – climate interactions) of ozone and nitrogen, the latter with emphasis on national nitrogen budgets and biodiversity. Finally, integrated assessment modelling and identification of the most efficient abatement strategies was included.
  •  
37.
  • Elmarghani, Ahmed, 1975-, et al. (författare)
  • Contribution of pharmaceuticals, fecal bacteria and endotoxin to the inflammatory responses to inland waters
  • 2014
  • Ingår i: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 488-489, s. 228-235
  • Tidskriftsartikel (refereegranskat)abstract
    • The increasing contamination of freshwater with pharmaceuticals, surfactants, pesticides and other organic compounds are of major concern. As these contaminants are detected at trace levels in the environment it is important to determine if they elicit biological responses at the observed levels. In addition to chemical pollutants, there is also a concern for increasing levels of bacteria and other microorganisms in freshwater systems. In an earlier study, we observed the activation of inflammatory systems downstream of a wastewater treatment plant (WWTP) in southern Sweden. We also observed that the water contained unidentified components that were pro-inflammatory and potentiated the immune response in human urinary bladder epithelial cells. In order to determine if these effects were unique for the studied site or represent a common response in Swedish water, we have now performed a study on three WWTPs and their recipient waters in central Sweden. Analysis of immune responses in urinary bladder epithelial cells, monocyte-like cells and blood mononuclear cells confirm that these waters activate the immune system as well as induce pro-inflammatory responses. The results indicate that the cytokine profiles correlate to the endotoxin load of the waters rather than to the levels of pharmaceuticals or culturable bacteria load, suggesting that measurements of endotoxin levels and immune responses would be a valuable addition to the analysis of inland waters.
  •  
38.
  • Engqvist, Cecilia, et al. (författare)
  • Interactions between single latex particles and silica surfaces studied with AFM
  • 2007
  • Ingår i: Colloids and Surfaces A. - : Elsevier BV. - 0927-7757 .- 1873-4359. ; 302:03-jan, s. 197-203
  • Tidskriftsartikel (refereegranskat)abstract
    • The spreading of single styrene-acrylic latex particles on silicon oxide C surfaces was studied using atomic force microscopy (AFM). Three latexes with different glass transition temperature (Tg) were used and the effects of temperature, time and preparation method were investigated. Particle sizes and shape were measured with AFM and the contact angles were calculated. The observed rate for the spreading of latex particles was low and it took several days before the particles reached steady state, even at temperatures well above their T-g. The experimental particle spreading results deviated with two orders of magnitude from predictions Using the WLF equation for polymer diffusion. The deviation could be attributed to polymer-surface interactions that slowed down the particle spreading. The work of adhesion was calculated using two models. The results from using the regular Young-Dupre equation and a modified version of this equation that also included the mechanical properties (E-modulus and Poisson's ratio) of the latexes, were compared. For soft latex particles the results from the two models agreed well and were of the order of 75 J/m(2), but for glassy latexes the Young-Dupre equation underestimated the work of adhesion.
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39.
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40.
  • Erikson, Anders, et al. (författare)
  • Ten years' experience of enzyme infusion therapy of Norrbottnian (type 3) Gaucher disease.
  • 2006
  • Ingår i: Acta Paediatr. - 0803-5253. ; 95:3, s. 312-7
  • Tidskriftsartikel (refereegranskat)abstract
    • AIM: To study the long-term effects of enzyme replacement therapy on the neurological signs of chronic neuronopathic Gaucher disease and to evaluate some biochemical parameters for monitoring the treatment. METHODS: Eight patients from the Norrbottnian cohort were followed during 10 y of treatment. They were followed with regular clinical observations, biochemical tests and psychometric testing. RESULTS: After the start of treatment, their general well-being improved and was stable during the follow-up. In three of the patients there were some indications of slow neurological deterioration. The mean results of psychometric testing did not decrease. Glucosylceramide and chitotriosidase levels were useful in monitoring the treatment. The chemokine CCL18 also seems to be a useful parameter for future monitoring. CONCLUSIONS: Enzyme replacement therapy seems to slow down further neurological and mental deterioration in mild chronic neuronopathic (type 3) Gaucher disease.
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41.
  •  
42.
  • Forsberg, Anders, et al. (författare)
  • Landmark-Based Software for Anatomical Measurements : A Precision Study
  • 2009
  • Ingår i: Clinical anatomy (New York, N.Y. Print). - : Wiley. - 0897-3806 .- 1098-2353. ; 22:4, s. 456-462
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to develop a software program, called Landmarker, which would aid studies of complex anatomical morphometry by simplifying the manual identification of landmarks in 3D images. We also tested its precision on routine magnetic resonance imaging (MRI) scans. To understand human biological variation, there is a need to identify morphological characteristics from the exterior and the interior of human anatomy. MRI, as opposed to other radiographic methods (mainly based on X-ray techniques), supplies good soft tissue contrast, which allows for more complex assessments than what bony landmarks can provide. Because automation of this assessment is highly demanding, one of the primary goals for the new software was to enable more rapid identification of landmark sets in 3D image data. Repeat acquisition of head MRIs having a resolution of 0.94 x 0.94 x 1.20 mm3 were performed on 10 volunteers. Intra- and interoperator, as well as interacquisition variations of manual identification of exterior, craniofacial interior, and brain landmarks were studied. The average distances between landmarks were <1.8 mm, <2.3 mm, and <2.0 mm in the intra- and interoperator, and interacquisition evaluations, respectively. This study presents new software for time efficient identification of complex craniofacial landmarks in 3D MRI. To the best of our knowledge, no evaluation of software for rapid landmark-based analysis of complex anatomies from 3D MR data has yet been presented. This software may also be useful for studies in other anatomical regions and for other types of image data.
  •  
43.
  • Forsberg, Christer, et al. (författare)
  • Principle, calibration, and application of the in situ alkali chloride monitor
  • 2009
  • Ingår i: Review of Scientific Instruments. - : American Institute of Physics. - 0034-6748 .- 1089-7623. ; 80:2, s. 023104-1-023104-4
  • Tidskriftsartikel (refereegranskat)abstract
    •  The extended use of biomass for heat and power production has caused increased operational problems with fouling and high-temperature corrosion in boilers. These problems are mainly related to the presence of alkali chlorides (KCl and NaCl) at high concentrations in the flue gas. The In-Situ Alkali Chloride Monitor (IACM) was developed by Vattenfall Research and Development AB for measuring the alkali chloride concentration in hot flue gases (>650 oC). The measurement technique is based on molecular differential absorption spectroscopy in the UV range. Simultaneous measurement of SO2 concentration is also possible. The measuring range is 1-50 ppm for the sum of KCl and NaCl concentrations, and 4-750 ppm for SO2. This paper describes the principle of the IACM as well as its calibration. Furthermore, an example of its application in an industrial boiler is given.
  •  
44.
  • Forsberg, Daniel, et al. (författare)
  • Quantitative analysis of the patellofemoral motion pattern using semi-automatic processing of 4D CT data
  • 2016
  • Ingår i: International Journal of Computer Assisted Radiology and Surgery. - : SPRINGER HEIDELBERG. - 1861-6410 .- 1861-6429. ; 11:9, s. 1731-1741
  • Tidskriftsartikel (refereegranskat)abstract
    • To present a semi-automatic method with minimal user interaction for quantitative analysis of the patellofemoral motion pattern. 4D CT data capturing the patellofemoral motion pattern of a continuous flexion and extension were collected for five patients prone to patellar luxation both pre- and post-surgically. For the proposed method, an observer would place landmarks in a single 3D volume, which then are automatically propagated to the other volumes in a time sequence. From the landmarks in each volume, the measures patellar displacement, patellar tilt and angle between femur and tibia were computed. Evaluation of the observer variability showed the proposed semi-automatic method to be favorable over a fully manual counterpart, with an observer variability of approximately 1.5 for the angle between femur and tibia, 1.5 mm for the patellar displacement, and 4.0-5.0 for the patellar tilt. The proposed method showed that surgery reduced the patellar displacement and tilt at maximum extension with approximately 10-15 mm and 15-20 for three patients but with less evident differences for two of the patients. A semi-automatic method suitable for quantification of the patellofemoral motion pattern as captured by 4D CT data has been presented. Its observer variability is on par with that of other methods but with the distinct advantage to support continuous motions during the image acquisition.
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45.
  • Forsberg, Elenita, 1961-, et al. (författare)
  • Assessing progression of clinical reasoning through Virtual Patients
  • 2014
  • Ingår i: Ottawa Conference Abstracts. ; , s. 71-72
  • Konferensbidrag (refereegranskat)abstract
    • BackgroundThere have been discussions to use more formative assessments in health care education to contribute to students’ deep learning. Feedback is important, but a lot of student’s do not do anything with it. Thus, interventions which force students to reflect the new knowledge need to be introduced.In order to explore if formative VP-based exams had an impact on development of clinical reasoning ability and achievement of clinical decision making, we let postgraduate pediatric nurse students complete self-evaluation forms in connection with three VP- based assessments to follow their progress.Summary of WorkAfter performed assessment and before answering the self-evaluation form, the students’ were asked to take part of the feedback section of the VP-system and the recommended interactions in the VP system. Data was conducted using content analysis with a deductive approach. Kolb’s’ model of Learning Cycle guided the analysis.Summary of ResultsThe result showed a perceived progression of clinical reasoning skills by the students. After the first assessment the students described uncertainty and that knowledge gaps were exposed, at the second exam the awareness of clinical reasoning was obvious and the students were more certain of knowing how. Finally, self-efficacy in patient solving was expressed.ConclusionsVP-based assessments with self-evaluation early in the education resulted in a gain of students’ own identification of the concept of clinical reasoning, awareness of what to focus on, and pay attention to during clinical practice.Take-home Messages VP with reflective tools is excellent to use in formative assessments to identify progress and to visualize the expected clinical competence.
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46.
  • Forsberg, Elenita, 1961-, et al. (författare)
  • Assessing progression of clinical reasoning through virtual patients : An exploratory study
  • 2016
  • Ingår i: Nurse Education in Practice. - Kidlington : Elsevier BV. - 1471-5953 .- 1873-5223. ; 16:1, s. 97-103
  • Tidskriftsartikel (refereegranskat)abstract
    • To avoid test-driven learning, there have been discussions regarding the use of more formative assessments in health care education to promote students' deep learning. Feedback is important in formative assessment, but many students ignore it; therefore, interventions should be introduced which stimulate them to reflect on the new knowledge. The aim for this study was to explore if Virtual Patient (VP)-based formative assessments, in connection with self-evaluations, had an impact on postgraduate pediatric nursing students' development of clinical reasoning abilities. Students' self-evaluations served as the basis for measuring progress. Data was analysed using deductive content analysis. The findings showed a clear progression of the clinical reasoning ability of the students. After the first assessment, the students described feelings of uncertainty and that their knowledge gaps were exposed. At the mid-course assessment the awareness of improved clinical reasoning was obvious and the students were more certain of knowing how to solve the VP cases. In the final assessment, self-efficacy was expressed. VP -based assessments, in connection with self-evaluations, early in the education resulted in a gain of students' own identification of the concept of clinical reasoning, awareness of what to focus on during clinical practice and visualised expected clinical competence.
  •  
47.
  • Forsberg, Elenita, 1961-, et al. (författare)
  • Clinical reasoning in nursing, a think-aloud study using virtual patients – A base for an innovative assessment
  • 2013
  • Ingår i: Nurse Education Today. - Amsterdam : Elsevier. - 0260-6917 .- 1532-2793. ; 34:4, s. 538-542
  • Tidskriftsartikel (refereegranskat)abstract
    • In health-care education, it is important to assess the competencies that are essential for the professional role. To develop clinical reasoning skills is crucial fornursing practice and therefore an important learning outcome in nursing education programmes. Virtual patients (VPs) are interactive computer simulations of real-life clinical scenarios and have been suggested for use not only for learning, but also for assessment of clinical reasoning. The aim of this study was to investigate how experienced paediatric nurses reason regarding complex VP cases and how they make clinical decisions. The study was also aimed to give information about possible issues that should be assessed in clinical reasoning exams for post-graduate students in diploma specialist paediatric nursing education. The information from this study is believed to be of high value when developing scoring and grading models for a VP-based examination for the specialist diploma in paediatricnursing education. Using the think-aloud method, data were collected from 30 RNs working in Swedish paediatric departments, and child or school health-care centres. Content analysis was used to analyse the data. The results indicate that experienced nurses try to consolidate their hypotheses by seeing a pattern and judging the value of signs, symptoms, physical examinations, laboratory tests and radiology. They show high specific competence but earlier experience of similar cases was also of importance for the decision making. The nurses thought it was an innovative assessment focusing on clinical reasoning and clinical decision making. They thought it was an enjoyable way to be assessed and that all three main issues could be assessed using VPs. In conclusion, VPs seem to be a possible model for assessing the clinical reasoning process and clinical decision making, but how to score and grade such exams needs further research. © 2013 Elsevier Ltd. All rights reserved.
  •  
48.
  • Forsberg, Elenita, 1961-, et al. (författare)
  • Evaluation of a novel scoring and grading model for vp-based exams in postgraduate nurse education
  • 2015
  • Ingår i: Nurse Education Today. - Kidlington : Elsevier BV. - 0260-6917 .- 1532-2793. ; 35:12, s. 1246-1251
  • Tidskriftsartikel (refereegranskat)abstract
    • For Virtual Patient-based exams, several scoring and grading methods have been proposed, but none have yet been validated. The aim of this study was to evaluate a new scoring and grading model for VP-based exams in postgraduate paediatric nurse education. The same student group of 19 students performed a VP-based exam in three consecutive courses. When using the scoring and grading assessment model, which contains a deduction system for unnecessary or unwanted actions, a progression was found in the three courses: 53% of the students passed the first exam, 63% the second and 84% passed the final exam. The most common reason for deduction of points was due to students asking too many interview questions or ordering too many laboratory tests. The results showed that the new scoring model made it possible to judge the students' clinical reasoning process as well as their progress.
  •  
49.
  •  
50.
  • Forsberg, Gustaf, et al. (författare)
  • Risk factors for ventilator-associated lower respiratory tract infection in COVID-19, a retrospective multicenter cohort study in Sweden
  • 2024
  • Ingår i: Acta Anaesthesiologica Scandinavica. - : John Wiley & Sons. - 0001-5172 .- 1399-6576. ; 68:2, s. 226-235
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Ventilator-associated lower respiratory tract infections (VA-LRTI) increase morbidity and mortality in intensive care unit (ICU) patients. Higher incidences of VA-LRTI have been reported among COVID-19 patients requiring invasive mechanical ventilation (IMV). The primary objectives of this study were to describe clinical characteristics, incidence, and risk factors comparing patients who developed VA-LRTI to patients who did not, in a cohort of Swedish ICU patients with acute hypoxemic respiratory failure due to COVID-19. Secondary objectives were to decipher changes over the three initial pandemic waves, common microbiology and the effect of VA-LTRI on morbidity and mortality.Methods: We conducted a multicenter, retrospective cohort study of all patients admitted to 10 ICUs in southeast Sweden between March 1, 2020 and May 31, 2021 because of acute hypoxemic respiratory failure due to COVID-19 and were mechanically ventilated for at least 48 h. The primary outcome was culture verified VA-LRTI. Patient characteristics, ICU management, clinical course, treatments, microbiological findings, and mortality were registered. Logistic regression analysis was conducted to determine risk factors for first VA-LRTI.Results: Of a total of 536 included patients, 153 (28.5%) developed VA-LRTI. Incidence rate of first VA-LRTI was 20.8 per 1000 days of IMV. Comparing patients with VA-LRTI to those without, no differences in mortality, age, sex, or number of comorbidities were found. Patients with VA-LRTI had fewer ventilator-free days, longer ICU stay, were more frequently ventilated in prone position, received corticosteroids more often and were more frequently on antibiotics at intubation. Regression analysis revealed increased adjusted odds-ratio (aOR) for first VA-LRTI in patients treated with corticosteroids (aOR 2.64 [95% confidence interval [CI]] [1.31-5.74]), antibiotics at intubation (aOR 2.01 95% CI [1.14-3.66]), and days of IMV (aOR 1.05 per day of IMV, 95% CI [1.03-1.07]). Few multidrug-resistant pathogens were identified. Incidence of VA-LRTI increased from 14.5 per 1000 days of IMV during the first wave to 24.8 per 1000 days of IMV during the subsequent waves.Conclusion: We report a high incidence of culture-verified VA-LRTI in a cohort of critically ill COVID-19 patients from the first three pandemic waves. VA-LRTI was associated with increased morbidity but not 30-, 60-, or 90-day mortality. Corticosteroid treatment, antibiotics at intubation and time on IMV were associated with increased aOR of first VA-LRTI.
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