| 1. |
- Sumaila, U. Rashid, et al.
(author)
-
WTO must ban harmful fisheries subsidies
- 2021
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544
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Journal article (other academic/artistic)
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| 2. |
- Cardoso, Evelin, et al.
(author)
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A Heuristic Approach for the Design of UAV-Based Disaster Relief in Optical Metro Networks
- 2020
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In: International Conference on Transparent Optical Networks. - 2162-7339. - 9781728184234 ; 2020-July, s. 1-5
-
Conference paper (peer-reviewed)abstract
- We propose a novel algorithm to dimension the backup elements in an optical metro network, by considering the adoption of Unmanned Aerial Vehicles (UAVs) and wireless interfaces to realize backup wireless links. Our key idea is to efficiently find the set of node pairs that have to be connected by means of multi-hop UAV-based wireless links, which are selected based on the simulation of multiple disaster events. Results, obtained over a set of meaningful scenarios, demonstrate that our solution can greatly reduce the total installation costs compared to a naive approach, which is instead solely tailored to the restoration of the disrupted links in a given disaster scenario.
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| 3. |
- Fresard, Laure, et al.
(author)
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Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts
- 2019
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In: Nature Medicine. - : NATURE PUBLISHING GROUP. - 1078-8956 .- 1546-170X. ; 25:6, s. 911-919
-
Journal article (peer-reviewed)abstract
- It is estimated that 350 million individuals worldwide suffer from rare diseases, which are predominantly caused by mutation in a single gene(1). The current molecular diagnostic rate is estimated at 50%, with whole-exome sequencing (WES) among the most successful approaches(2-5). For patients in whom WES is uninformative, RNA sequencing (RNA-seq) has shown diagnostic utility in specific tissues and diseases(6-8). This includes muscle biopsies from patients with undiagnosed rare muscle disorders(6,9), and cultured fibroblasts from patients with mitochondrial disorders(7). However, for many individuals, biopsies are not performed for clinical care, and tissues are difficult to access. We sought to assess the utility of RNA-seq from blood as a diagnostic tool for rare diseases of different pathophysiologies. We generated whole-blood RNA-seq from 94 individuals with undiagnosed rare diseases spanning 16 diverse disease categories. We developed a robust approach to compare data from these individuals with large sets of RNA-seq data for controls (n = 1,594 unrelated controls and n = 49 family members) and demonstrated the impacts of expression, splicing, gene and variant filtering strategies on disease gene identification. Across our cohort, we observed that RNA-seq yields a 7.5% diagnostic rate, and an additional 16.7% with improved candidate gene resolution.
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| 4. |
- Natalino, Carlos, Dr. 1987-, et al.
(author)
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Dimensioning Optical Clouds with Shared-Path Shared-Computing (SPSC) Protection
- 2015
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In: High Performance Switching and Routing (HPSR), 2015 IEEE 16th International Conference on. - : IEEE conference proceedings.
-
Conference paper (peer-reviewed)abstract
- Service relocation represents a promising strategy to provide flexible and resource efficient resiliency from link failures in the optical cloud environment. However, when a failure affects a node hosting a datacenter (DC), service relocation from the affected DC is not possible. One alternative to protect against DC failures relies on using design strategies that duplicate the IT (i.e., storage and processing) resources in a backup DC at the expense of increasing resource overbuild (i.e., cost) of the network. This work proposes a dimensioning strategy based on the shared-path shared-computing (SPSC) concept able to protect against any single link, server, or DC failure scenario with minimal resource overbuild for the network and IT infrastructures. SPSC is based on the intuition that only storage units need complete replication in backup DC, while processing units can be instantiated only after the occurrence of a failure, leaving the design strategy some leeway to minimize their number. As result, the proposed SPSC design shows a considerable reduction in the amount of backup resources when compared to the dedicated protection strategies.
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| 5. |
- Natalino, Carlos, 1987-, et al.
(author)
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Lifetime-Aware Provisioning in Green Optical Backbone Networks
- 2016
-
In: 2016 OPTICAL FIBER COMMUNICATIONS CONFERENCE AND EXHIBITION (OFC). - Washington, D.C. : Optical Society of America.
-
Conference paper (peer-reviewed)abstract
- We present a framework able to limit the device lifetime degradation in optical backbone networks using sleep-mode-based green strategies. Results show that our approach manages the lifetime while not compromising significantly the energy saving performance.
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| 6. |
- Natalino, Carlos, 1987-, et al.
(author)
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Restoration in Optical Cloud Networks With Relocation and Services Differentiation
- 2016
-
In: Journal of Optical Communications and Networking. - : Optical Society of America. - 1943-0620 .- 1943-0639. ; 8:2, s. 100-111
-
Journal article (peer-reviewed)abstract
- Optical cloud networks allow for the integrated management of both optical and IT resources. In this paradigm, cloud services can be provisioned in an anycast fashion; i.e., only the source node asking for a service is specified, while it is up to the cloud control/management system to select the most suitable destination data center (DC) node. During the cloud service provisioning process, resiliency is crucial in order to guarantee continuous network operations also in the presence of failures. On the one hand, a survivability strategy needs to be able to meet the availability requirements of each specific cloud service, while on the other hand it must be efficient in using backup resources. This paper proposes a restoration-based survivability strategy, which combines the benefits of both cloud service relocation and service differentiation concepts. The former is used to enhance the restorability performance (i.e., the percentage of successfully restored cloud services) offered by restoration, while the latter ensures that critical services are given the proper consideration while backup resources are assigned. The paper proposes both an integer linear programming (ILP) formulation, which guarantees optimal results, and a heuristic, which trades the optimality of the solution achieved by the ILP for faster processing times. Simulation results show that the average service availability and restorability performance obtained by both the ILP and the heuristic are very close to that achievable using a protection-based strategy, but with the inherent benefit, in terms of efficient use of resources, offered by a restoration-based approach.
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| 7. |
- Berg, Sylvia E., 1986-, et al.
(author)
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Heterogeneous vesiculation of 2011 El Hierro xeno-pumice revealed by X-ray computed microtomography
- 2016
-
In: Bulletin of Volcanology. - : Springer Science and Business Media LLC. - 0258-8900 .- 1432-0819. ; 78:12
-
Journal article (peer-reviewed)abstract
- During the first week of the 2011 El Hierro submarine eruption, abundant light-coloured pumiceous, high-silica volcanic bombs coated in dark basanite were found floating on the sea. The composition of the light-coloured frothy material ('xeno-pumice') is akin to that of sedimentary rocks from the region, but the textures resemble felsic magmatic pumice, leaving their exact mode of formation unclear. To help decipher their origin, we investigated representative El Hierro xeno-pumice samples using X-ray computed microtomography for their internal vesicle shapes, volumes, and bulk porosity, as well as for the spatial arrangement and size distributions of vesicles in three dimensions (3D). We find a wide range of vesicle morphologies, which are especially variable around small fragments of rock contained in the xeno-pumice samples. Notably, these rock fragments are almost exclusively of sedimentary origin, and we therefore interpret them as relicts an the original sedimentary ocean crust protolith(s). The irregular vesiculation textures observed probably resulted from pulsatory release of volatiles from multiple sources during xeno-pumice formation, most likely by successive release of pore water and mineral water during incremental heating and decompression of the sedimentary protoliths.
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| 8. |
- Carracedo, Juan Carlos, et al.
(author)
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The 2011-2012 submarine eruption off El Hierro, Canary Islands : New lessons in oceanic island growth and volcanic crisis management
- 2015
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In: Earth-Science Reviews. - : Elsevier BV. - 0012-8252 .- 1872-6828. ; 150, s. 168-200
-
Journal article (peer-reviewed)abstract
- Forty years after the eruption of the Teneguía volcano on La Palma, 1971, the last volcanic event in the Canary Islands, a submarine eruption took place in 2011 off-shore El Hierro, the smallest and youngest island of the archipelago. In this paper, we review the periods of seismic unrest leading up to the 2011–2012 El Hierro eruption, the timeline of eruptive events, the erupted products, the wider societal impacts, and the insights garnered for our understanding of ocean island growth mechanisms and hazard management. Seismic precursors allowed early detection of magmatic activity and prediction of the approximate location of the eruption. White coloured “floating stones” (“xeno-pumice”) were described within the first few days of the events, the origin of which were hotly debated because of their potential implications for the character of the eruption. Due to epistemic uncertainty derived from delayed flow of scientific information and equivocal interpretations of the “floating stones”, the El Hierro 2011–2012 events were characterised by cautious civil protection measures, which greatly impacted on the residents' lives and on the island's economy. We therefore summarise the scientific lessons learned from this most recent Canary Island eruption and discuss how emergency managers might cope with similar situations of uncertainty during future eruptive events in the region.
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| 9. |
- Clark, Andrew G., et al.
(author)
-
Evolution of genes and genomes on the Drosophila phylogeny
- 2007
-
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
-
Journal article (peer-reviewed)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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| 10. |
- Day, James M. D., et al.
(author)
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Mantle source characteristics and magmatic processes during the 2021 La Palma eruption
- 2022
-
In: Earth and Planetary Science Letters. - : Elsevier. - 0012-821X .- 1385-013X. ; 597
-
Journal article (peer-reviewed)abstract
- The 2021 eruption of La Palma (September 19-December 13) was the first subaerial eruption in the Canary Islands in 50 years. Approximately 0.2 km3 of lava erupted from a newly formed, broadly basaltic composite volcanic edifice on the northwestern flank of the Cumbre Vieja volcanic ridge. Comprehensive sampling of the olivine-and clinopyroxene-phyric lavas over the eruption period reveals temporal changes in mineralogy and bulk rock geochemistry from tephrite to basanite. Initial tephrite lavas have low MgO (-6 wt.%) and elevated TiO2 (-4 wt.%) and contain amphibole crystals and gabbroic micro -xenoliths. In contrast, lavas with progressively more mafic compositions erupted to approximately day 20 of the eruption and thereafter remained as basanite (-8 wt.% MgO; 3.7 wt.% TiO2) until eruption termination. Temporal changes in lava chemistry reflect initial eruption of fractionated magmas that crystallized 5-10% olivine and clinopyroxene, as well as minor spinel, sulfide, and magnetite, followed by later eruption of deeper-sourced and more primitive magma. Vanadium-in-olivine oxybarometry indicates parental magmas were oxidized (fO2 = +1.5 to +2 FMQ) with 8.2 +/- 0.8 wt.% MgO and were generated from between 2.5-3% partial melting of a mantle source potentially containing a pyroxenite component (Xpx = 0.31 +/- 0.12). Day 1-20 tephrites have more radiogenic 187Os/188Os (0.143-0.148) and lower Pd, Pt, Ir and Os contents than post day 20 basanites (187Os/188Os = 0.141-0.145). Combined with available seismic data, the lavas provide a high-resolution record of eruptive evolution. Initial fractionated tephrite magma was stored in the upper lithosphere up to four years prior to eruption, consistent with pre-cursor seismicity and the presence of partially reacted amphibole and micro-xenoliths. The later lavas of the eruption were fed by more primitive basanitic parental magmas that were likely sourced from the deeper portion of the magma storage system that is underplating the island. Precursor events to the 2021 La Palma eruption involved seismicity and magma emplacement, storage and differentiation, which was followed by mobilisation, eruption, and eventual exhaustion of stored magma and partial melts. This magmatic progression is similar to that documented from the 1949 and 1971 Cumbre Vieja eruptions. Ocean islands with limited basaltic magma supply show similarities to the magmatic evolution observed in large silicic systems, where initial magma emplacement and differentiation is followed by later magma remobilisation that induces volcanic activity.
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| 11. |
- Dayton, Kyle, et al.
(author)
-
Deep magma storage during the 2021 La Palma eruption
- 2023
-
In: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 9:6
-
Journal article (peer-reviewed)abstract
- The 2021 La Palma eruption provided an unpreceded opportunity to test the relationship between earthquake hypocenters and the location of magma reservoirs. We performed density measurements on CO2-rich fluid in-clusions (FIs) hosted in olivine crystals that are highly sensitive to pressure via calibrated Raman spectroscopy. This technique can revolutionize our knowledge of magma storage and transport during an ongoing eruption, given that it can produce precise magma storage depth constraints in near real time with minimal sample prep-aration. Our FIs have CO2 recorded densities from 0.73 to 0.98 g/cm3, translating into depths of 15 to 27 km, which falls within the reported deep seismic zone recording the main melt storage reservoir.
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| 12. |
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| 13. |
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| 14. |
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| 15. |
- Haycock, Philip C., et al.
(author)
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Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
- 2017
-
In: JAMA Oncology. - : American Medical Association. - 2374-2437 .- 2374-2445. ; 3:5, s. 636-651
-
Journal article (peer-reviewed)abstract
- IMPORTANCE: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. OBJECTIVE: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. DATA SOURCES: Genomewide association studies (GWAS) published up to January 15, 2015. STUDY SELECTION: GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. DATA EXTRACTION AND SYNTHESIS: Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. MAIN OUTCOMES AND MEASURES: Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. RESULTS: Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [ 95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [ 95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [ 95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [ 95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [ 95% CI, 0.05-0.15]). CONCLUSIONS AND RELEVANCE: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases.
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| 16. |
- Koenig, Julian, et al.
(author)
-
Cortical thickness and resting-state cardiac function across the lifespan : A cross-sectional pooled mega-analysis
- 2021
-
In: Psychophysiology. - : Wiley. - 0048-5772 .- 1469-8986 .- 1540-5958. ; 58:7
-
Journal article (peer-reviewed)abstract
- Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting-state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega-analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12–87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS—or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.
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| 17. |
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| 18. |
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| 19. |
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| 20. |
- Monti, Paolo, 1973-, et al.
(author)
-
Restoring optical cloud services using relocation
- 2014
-
Conference paper (peer-reviewed)abstract
- Optical cloud is a very popular concept by which storage and computing resources (i.e., IT resources) are distributed over different datacenter (DC) locations interconnected via high-speed optical wavelength division multiplexing (WDM) links. In this paradigm cloud services are provisioned in an anycast fashion, where only the source node needs to be specified in the routing and resource assignment phase, while any DC (with enough IT resources) can be used to accommodate a cloud service. Anycast provisioning has a number of advantages already recognized by optical cloud providers [1][2]. This kind of provisioning paradigm allows, for example, for the live relocation of the already provisioned cloud services, referred to as the service relocation concept. It means that if the DC location is not essential for the execution of a certain cloud service, multiple relocations of the job to other DC locations are possible. This allows for a more efficient management of both the cloud and the transport network resources. Service relocation has also the potential to bring an extra degree of flexibility to survivability strategies. By providing the option for relocating a cloud service it is possible to use a backup path terminating at a DC that is different from the one used by the primary path. This benefit has been assessed in the literature showing the ability to improve resources efficiency by using service relocation in conjunction with path protection strategies [1]. Another instance in which service relocation might be beneficial is when it is combined with restoration-based survivability strategies. These strategies are very efficient in using backup resources, i.e., they are dynamically provisioned only upon a failure, but restoration-based approaches suffer from a certain risk that the backup network resources might not be available when needed [3]. Service relocation can potentially alleviate this problem. This talk presents a study where the objective is to inves- igate if relocating a cloud service disrupted by a network failure is beneficial in terms of both restorability and average connection availability. To this end the talk will present a number of results based on the solution of an efficient and scalable heuristic algorithm able to jointly solve the restoration and service relocation problem. These results are also benchmarked against the performance of an integer linear programming (ILP) model [4] optimizing the same objective function as the heuristic. In summary it can be concluded that by using relocation the average service availability can be significantly improved requiring only a minimal fraction of the cloud services to be relocated. In addition the proposed heuristic behaves very closely to the optimal ILP results in terms of both restorability and average connection availability.
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| 21. |
- Natalino, Carlos, et al.
(author)
-
Optimal lifetime-aware operation of green optical backbone networks
- 2016
-
In: IEEE Journal on Selected Areas in Communications. - : Institute of Electrical and Electronics Engineers (IEEE). - 0733-8716 .- 1558-0008. ; 34:12, s. 3915-3926
-
Journal article (peer-reviewed)abstract
- This paper targets the lifetime-aware management of a set of optical line amplifiers (OLAs) in an optical network exploiting sleep mode (SM) in order to save energy. We first present a simple model to predict the OLA lifetime. We then provide different mixed-integer linear programming (MILP) formulations, which jointly consider energy saving and lifetime. The proposed MILP formulations are then solved on different realistic scenarios, by taking into account the spatial and temporal variations of traffic demands. Results show that our lifetime-aware approach outperforms classical energy saving ILP formulations, which instead tend to notably decrease the OLA lifetime. More important, the proposed approaches can achieve a good lifetime performance without consuming significantly more energy than purely energy-aware strategies.
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| 22. |
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| 23. |
- Rodriguez-Palmero, Agusti, et al.
(author)
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DLG4-related synaptopathy : a new rare brain disorder
- 2021
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In: Genetics in Medicine. - : Elsevier BV. - 1098-3600 .- 1530-0366. ; 23:5, s. 888-899
-
Journal article (peer-reviewed)abstract
- PurposePostsynaptic density protein-95 (PSD-95), encoded by DLG4, regulates excitatory synaptic function in the brain. Here we present the clinical and genetic features of 53 patients (42 previously unpublished) with DLG4 variants.MethodsThe clinical and genetic information were collected through GeneMatcher collaboration. All the individuals were investigated by local clinicians and the gene variants were identified by clinical exome/genome sequencing.ResultsThe clinical picture was predominated by early onset global developmental delay, intellectual disability, autism spectrum disorder, and attention deficit–hyperactivity disorder, all of which point to a brain disorder. Marfanoid habitus, which was previously suggested to be a characteristic feature of DLG4-related phenotypes, was found in only nine individuals and despite some overlapping features, a distinct facial dysmorphism could not be established. Of the 45 different DLG4 variants, 39 were predicted to lead to loss of protein function and the majority occurred de novo (four with unknown origin). The six missense variants identified were suggested to lead to structural or functional changes by protein modeling studies.ConclusionThe present study shows that clinical manifestations associated with DLG4 overlap with those found in other neurodevelopmental disorders of synaptic dysfunction; thus, we designate this group of disorders as DLG4-related synaptopathy.
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| 24. |
- Sobas, Marta, et al.
(author)
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Real-world study of children and young adults with myeloproliferative neoplasms: identifying risks and unmet needs
- 2022
-
In: BLOOD ADVANCES. - : ELSEVIER. - 2473-9529 .- 2473-9537. ; 6:17, s. 5171-5183
-
Journal article (peer-reviewed)abstract
- Myeloproliferative neoplasms (MPNs) are uncommon in children/young adults. Here, we present data on unselected patients diagnosed before 25 years of age included from 38 centers in 15 countries. Sequential patients were included. We identified 444 patients, with median follow-up 9.7 years (0-47.8). Forty-nine (11.1%) had a history of thrombosis at diagnosis, 49 new thrombotic events were recorded (1.16% patient per year [pt/y]), perihepatic vein thromboses were most frequent (47.6% venous events), and logistic regression identified JAK2V617F mutation (P = .016) and hyperviscosity symptoms (visual disturbances, dizziness, vertigo, headache) as risk factors (P = .040). New hemorrhagic events occurred in 44 patients (9.9%, 1.04% pt/y). Disease transformation occurred in 48 patients (10.9%, 1.13% pt/y), usually to myelofibrosis (7.5%) with splenomegaly as a novel risk factor for transformation in essential thrombocythemia (ET) (P= .000) in logistical regression. Eight deaths (1.8%) were recorded, 3 after allogeneic stem cell transplantation. Concerning conventional risk scores: International Prognostic Score for Essential Thrombocythemia-Thrombosis and new International Prognostic Score for Essential Thrombocythemia-Thrombosis differentiated ET patients in terms of thrombotic risk. Both scores identified high-risk patients with the same median thrombosis-free survival of 28.5 years. No contemporary scores were able to predict survival for young ET or polycythemia vera patients. Our data represents the largest real-world study of MPN patients age < 25 years at diagnosis. Rates of thrombotic events and transformation were higher than expected compared with the previous literature. Our study provides new and reliable information as a basis for prospective studies, trials, and development of harmonized international guidelines for the specific management of young patients with MPN.
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| 25. |
- Souza, Lamartine, et al.
(author)
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Impact of Non-Stationary Noise on xDSL Systems: an Experimental Analysis
- 2007
-
In: Proceedings of SPIE, the International Society for Optical Engineering. - : SPIE. ; 6603
-
Conference paper (peer-reviewed)abstract
- Broadband services require data rates that can only be achieved by using relatively high spectrum frequencies. At such high frequencies, the DSL (Digital Subscriber Line) signal is more susceptible to external noise sources, such as radio frequency interference and impulsive noise. This paper aims to characterize how the impulsive noise impacts on services and applications for a broadband system using an ADSL2+ loop. The first approach was to use the impulsive noise defined in the standards G.996.1 (Test Procedures for DSL Transceivers) from ITU-T and TR-048 (ADSL Interoperability Test Plan) from DSL Forum. In this approach we have also used a HDSL (High Bit Rate DSL) and white noise disturbers on the line. The impulsive noises c1 and c2 (defined in G.996.1) are injected into the circuit at the CO (Central Office) end and CPE (Customer Premises Equipment) end of the loop simulator. Additionally, it was analyzed the spikes of noise's impact on the ADSL2+ line. In this case, pre-defined models of NEXT (Near-end crosstalk) and white noise are injected on CO and CPE side, simultaneously. Metrics like packet rate, lost packet count, bandwidth, short-term average transfer delay, and errored seconds are used to characterize the DSL loop under the noise impairments.
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| 26. |
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| 27. |
- Troll, Valentin, et al.
(author)
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Nannofossils: the smoking gun for the Canarian hotspot
- 2015
-
In: Geology Today. - : Wiley. - 0266-6979 .- 1365-2451. ; 31:4, s. 137-145
-
Journal article (peer-reviewed)abstract
- The origin of volcanism in the Canary Islands has been a matter of controversy for several decades. Discussions have hinged on whether the Canaries owe their origin to seafloor fractures associated with the Atlas Mountain range or to an underlying plume or hotspot of superheated mantle material. However, the debate has recently come to a conclusion following the discovery of nannofossils preserved in the products of the 2011–2012 submarine eruption at El Hierro, which tell us about the age and growth history of the western-most island of the archipelago. Light coloured, pumice-like ‘floating rocks’ were found on the sea surface during the first days of the eruption and have been shown to contain fragments of pre-island sedimentary strata. These sedimentary rock fragments were picked up by ascending magma and transported to the surface during the eruption, and remarkably retained specimens of pre-island Upper Cretaceous to Pliocene calcareous nannofossils (e.g. coccolithophores). These marine microorganisms are well known biostratigraphical markers and now provide crucial evidence that the westernmost and youngest island in the Canaries is underlain by the youngest sediment relative to the other islands in the archipelago. This finding supports an age progression for the onset of volcanism at the individual islands of the archipeligo. Importantly, as fracture-related volcanism is known to produce non-systematic age-distributions within volcanic alignments, the now-confirmed age progression corroberates to the relative motion of the African plate over an underlying mantle plume or hotspot as the cause for the present-day Canary volcanism.
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| 28. |
- Troll, Valentin, et al.
(author)
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Pre-Teide Volcanic Activity on the Northeast Volcanic Rift Zone
- 2013
-
In: Teide Volcano. - Berlin, Heidelberg : Springer Berlin/Heidelberg. - 9783642258923 - 9783642258930 ; , s. 75-92
-
Book chapter (peer-reviewed)abstract
- The northeast rift zone of Tenerife (NERZ) presents a partially eroded volcanic rift that offers a superb opportunity to study the structure and evolution of oceanic rift zones. Field data, structural observations, isotopic dating, magnetic stratigraphy, and isotope geochemistry have recently become available for this rift and provide a reliable temporal framework for understanding the structural and petrological evolution of the entire rift zone. The NERZ appears to have formed in several major pulses of activity with a particularly high production rate in the Pleistocene (ca. 0.99 and 0.56 Ma). The rift underwent several episodes of flank creep and eventual catastrophic collapses driven by intense intrusive activity and gravitational adjustment. Petrologically, a variety of mafic rock types, including crystal-rich ankaramites, have been documented, with most samples isotopically typical of the “Tenerife signal”. Some of the NERZ magmas also bear witness to contamination by hydrothermally altered components of the island edifice and/or sediments. Isotope geochemistry furthermore points to the generation of the NERZ magmas from an upwelling column of mantle plume material mixed with upper asthenospheric mantle. Finally, persistent isotopic similarity through time between the NERZ and the older central edifices on Tenerife provides strong evidence for a genetic link between Tenerife’s principal volcanic episodes.
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| 29. |
- Troll, Valentin R., et al.
(author)
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Sacred ground; the Maipés necropolis of north-west Gran Canaria : the Maipés necropolis of north-west Gran Canaria
- 2019
-
In: Geology Today. - : Wiley. - 0266-6979. ; 35:2, s. 55-62
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Journal article (peer-reviewed)abstract
- Gran Canaria, like most of the Canary Islands, shows evidence for young basaltic volcanism in the form of cinder cones and valley-hugging lava flows. These landforms were of no particular use to the aboriginal population, nor to the subsequent Spanish settlers, and young lava flows and lava fields are still referred to as ‘malpaÃs’ (badlands) in the Canary Islands. In north-west Gran Canaria, one such lava flow fills the bottom of a steep-sided valley, which reaches the sea at the present day village of Agaete. The lava flow erupted c. 3030 ± 90 yr bp and displays a total length of ∌ 11 km. At its distal end, just outside Agaete, it hosts one of Europe’s largest and most important pre-historic burial sites constructed of volcanic rock: the Maipés necropolis. Over 700 pre-historic tombs (or tumuli) constructed from the aa-type clinker materials have been identified on top of the valley-filling lava flow. The up to soccer-ball sized vesicular clinker fragments are sufficiently low in density to provide abundant, workable basalt blocks for the construction of the tumuli, allowing the pre-hispanic aboriginal population to create a large and magnificent ‘sacred ground’ in an otherwise barren landscape.
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| 30. |
- Troll, Valentin R., et al.
(author)
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Volcanic particles in agriculture and gardening
- 2017
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In: Geology Today. - : Wiley. - 0266-6979 .- 1365-2451. ; 33:4, s. 148-154
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Journal article (peer-reviewed)abstract
- Volcanic pyroclasts of small size, such as lapilli and small pumice stones, are widely used in agriculture, gardening, and for pot plants as natural inorganic mulch. The technique of using pyroclasts to enhance topsoil stems from the eighteenth century, and specifically from the ad 1730–1736 eruption on Lanzarote. Critical observations on plant development during and after the eruption showed that the vegetation died when buried under a thick layer of lapilli, but grew vigorously when covered thinly. While the agriculture of Lanzarote was restricted to cereals before the eruption, it diversified to many kinds of fruit and vegetables afterwards, including the production of the famous MalvasÃa wines in the Canaries. The population of Lanzarote doubled in the years after the eruption, from about 5000 in 1730 to near 10 000 in 1768, predominantly as a result of the higher agricultural productivity. This outcome led to widespread use of lapilli and pumice fragments throughout the islands and eventually the rest of the globe. Lapilli and pumice provide vesicle space for moisture to be retained longer within the planting soil, which can create an environment for micro-bacteria to thrive in. Through this route, nutrients from volcanic matter are transported into the surrounding soil where they become available to plant life. The detailed processes that operate within the pyroclasts are less well understood, such as the breakdown of nutrients from the rock matrix and transport into the soil by biological action. Further studies promise significant potential to optimize future agricultural efforts, particularly in otherwise arid areas of the globe.
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| 31. |
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| 32. |
- Wiesmaier, Sebastian, et al.
(author)
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Magma Mixing in the 1100 AD Montaña Reventada Composite Lava Flow : Interaction of Rift Zone and Central Complex Magmatism
- 2013
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In: Teide Volcano. - Berlin, Heidelberg : Springer Berlin/Heidelberg. - 9783642258923 - 9783642258930 ; , s. 191-211
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Book chapter (peer-reviewed)abstract
- Zoned eruption deposits frequently show a lower felsic and an upper maficmember, thought to reflect eruption from a large, stratified magmachambers. In contrast, however, the Montaña Reventada composite flow inTenerife consists of a lower basanite and a much thicker upper phonolite. Asharp interface separates the basanite and phonolite, and a chilled margin atthis contact indicates the basanite was still hot upon emplacement of thephonolite, i.e. the two magmas erupted in very quick succession. Threetypes of mafic to intermediate inclusions are found in the phonolite, whichcomprise foamy quenched ones, inclusions with chilled margins and thosethat are physically mingled, reflecting progressive mixing with adecreasing temperature contrast between the end-member magmasinvolved. Analysis of basanite, phonolite and inclusions for majors, tracesand Sr, Nd and Pb isotopes show the inclusions to be derived from binarymixing of basanite and phonolite end-members in ratios of 2:1–4:1.Although basanite and phonolite magmas were erupted in quick succession, contrasting206Pb/204Pb ratios show them to be geneticallydistinct. The Montaña Reventada basanite and phonolite first came intocontact just prior to eruption and had seemingly limited interaction time.Montaña Reventada erupted from the transition zone between twoplumbing systems, the phonolitic Teide-Pico Viejo complex and thebasanitic Northwest rift zone. A rift zone basanite dyke most likelyintersected a previously emplaced phonolite magma pocket, leading toeruption of geochemically and texturally unaffected basanite, followed byinclusion-rich phonolite that exploited the already established conduit.
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| 33. |
- Wiesmaier, Sebastian, et al.
(author)
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Magma mixing in the 1100 AD Montaña Reventada composite lava flow, Tenerife, Canary Islands : Interaction between rift zone and central volcano plumbing systems
- 2011
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In: Contributions to Mineralogy and Petrology. - : Springer. - 0010-7999 .- 1432-0967. ; 162:3, s. 651-669
-
Journal article (peer-reviewed)abstract
- Zoned eruption deposits commonly show a lower felsic and an upper mafic member, thought to reflect eruption from large, stratified magma chambers. In contrast, the Montaña Reventada composite flow (Tenerife) consists of a lower basanite and a much thicker upper phonolite. A sharp interface separates basanite and phonolite, and chilled margins at this contact indicate the basanite was still hot upon emplacement of the phonolite, i.e. the two magmas erupted in quick succession. Four types of mafic to intermediate inclusions are found in the phonolite. Inclusion textures comprise foamy quenched ones, others with chilled margins and yet others that are physically mingled, reflecting progressive mixing with a decreasing temperature contrast between the end-members. Analysis of basanite, phonolite and inclusions for majors, traces and Sr, Nd and Pb isotopes show the inclusions to be derived from binary mixing of basanite and phonolite end-members in ratios of 2:1 to 4:1. Although, basanite and phonolite magmas were in direct contact, contrasting 206Pb/204Pb ratios show that they are genetically distinct (19.7193(21)–19.7418(31) vs. 19.7671(18)–19.7807(23), respectively). We argue that the Montaña Reventada basanite and phonolite first met just prior to eruption and had limited interaction time only. Montaña Reventada erupted from the transition zone between two plumbing systems, the phonolitic Teide-Pico Viejo complex and the basanitic Northwest rift zone. A rift zone basanite dyke most likely intersected the previously emplaced phonolite magma chamber. This led to eruption of geochemically and texturally unaffected basanite, with the inclusion-rich phonolite subsequently following into the established conduit.
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| 34. |
- Wiesmaier, Sebastian, et al.
(author)
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Magmatic Differentiation in the Teide–Pico Viejo Succession : Isotope Analysis as a Key to Deciphering the Origin of Phonolite Magma
- 2013
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In: Teide Volcano. - Berlin, Heidelberg : Springer Berlin/Heidelberg. - 9783642258923 - 9783642258930 ; , s. 173-190
-
Book chapter (peer-reviewed)abstract
- In Tenerife, lavas of the recent Teide–Pico Viejo central complex show a marked bimodality in composition from initially mafic lava (200–30 ka) to highly differentiated phonolite (30–0 ka). Groundmass Sr–Nd–Pb–O and feldspar 18O data demonstrate open system behaviour for the petrogenesis of Teide–Pico Viejo felsic lavas, but contamination by ocean sediment can be excluded due to the low 206Pb/204Pb ratios of North Atlantic sediment. Isotope mixing hyperbolae require an assimilant of predominantly felsic composition for the Teide–Pico Viejo succession. Unsystematic and heterogeneous variation of 18O in fresh and unaltered feldspars across the Teide–Pico Viejo succession indicates magmatic addition of diverse 18O assimilants, best matched by nepheline syenites that occur as fresh and altered lithic blocks in voluminous pre-Teide ignimbrite deposits. Rare earth element modelling indicates that nepheline syenite needs to be melted in bulk to form a suitable end-member composition. Energy-Constrained Assimilation Fractional Crystallisation (EC-AFC) modelling reproduces the bulk of the succession, which implies that the petrogenesis of Teide–Pico Viejo lavas is governed by the coupled assimilation of nepheline syenite during fractional crystallisation. The most differentiated (and most radiogenic) lava computes to >97.8 % assimilant, likely represented by a nepheline syenite bulk melt that formed by underplating with juvenile mafic material. These recent research developments therefore recognise a wider variability of magmatic differentiation processes at Teide–Pico Viejo than previously considered.
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| 35. |
- Wiseman, Frances K, et al.
(author)
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Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.
- 2018
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In: Brain : a journal of neurology. - : Oxford University Press (OUP). - 1460-2156. ; 141:8, s. 2457-2474
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Journal article (peer-reviewed)abstract
- Down syndrome, caused by trisomy of chromosome 21, is the single most common risk factor for early-onset Alzheimer's disease. Worldwide approximately 6 million people have Down syndrome, and all these individuals will develop the hallmark amyloid plaques and neurofibrillary tangles of Alzheimer's disease by the age of 40 and the vast majority will go on to develop dementia. Triplication of APP, a gene on chromosome 21, is sufficient to cause early-onset Alzheimer's disease in the absence of Down syndrome. However, whether triplication of other chromosome 21 genes influences disease pathogenesis in the context of Down syndrome is unclear. Here we show, in a mouse model, that triplication of chromosome 21 genes other than APP increases amyloid-β aggregation, deposition of amyloid-β plaques and worsens associated cognitive deficits. This indicates that triplication of chromosome 21 genes other than APP is likely to have an important role to play in Alzheimer's disease pathogenesis in individuals who have Down syndrome. We go on to show that the effect of trisomy of chromosome 21 on amyloid-β aggregation correlates with an unexpected shift in soluble amyloid-β 40/42 ratio. This alteration in amyloid-β isoform ratio occurs independently of a change in the carboxypeptidase activity of the γ-secretase complex, which cleaves the peptide from APP, or the rate of extracellular clearance of amyloid-β. These new mechanistic insights into the role of triplication of genes on chromosome 21, other than APP, in the development of Alzheimer's disease in individuals who have Down syndrome may have implications for the treatment of this common cause of neurodegeneration.
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| 36. |
- Zaczek, Kirsten, et al.
(author)
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Nannofossils in 2011 El Hierro eruptive products reinstate plume model for Canary Islands
- 2015
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5, s. 7945-
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Journal article (peer-reviewed)abstract
- The origin and life cycle of ocean islands have been debated since the early days of Geology. In the case of the Canary archipelago, its proximity to the Atlas orogen led to initial fracture-controlled models for island genesis, while later workers cited a Miocene-Quaternary east-west age-progression to support an underlying mantle-plume. The recent discovery of submarine Cretaceous volcanic rocks near the westernmost island of El Hierro now questions this systematic age-progression within the archipelago. If a mantle-plume is indeed responsible for the Canaries, the onshore volcanic age-progression should be complemented by progressively younger pre-island sedimentary strata towards the west, however, direct age constraints for the westernmost pre-island sediments are lacking. Here we report on new age data obtained from calcareous nannofossils in sedimentary xenoliths erupted during the 2011 El Hierro events, which date the sub-island sedimentary rocks to between late Cretaceous and Pliocene in age. This age-range includes substantially younger pre-volcanic sedimentary rocks than the Jurassic to Miocene strata known from the older eastern islands and now reinstate the mantle-plume hypothesis as the most plausible explanation for Canary volcanism. The recently discovered Cretaceous submarine volcanic rocks in the region are, in turn, part of an older, fracture-related tectonic episode.
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