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1.	Rao, Malla, et al. (author) Serologic correlates of protection against enterotoxigenic Escherichia coli diarrhea 2005 In: J Infect Dis. ; 191:4, s. 562-70 Journal article (peer-reviewed)abstract BACKGROUND: We conducted a nested case-control study in 397 rural Egyptian children <36 months of age to assess the correlation between serum levels of antibodies against toxin and colonization factors (CFs) and the risk of homologous enterotoxigenic Escherichia coli (ETEC) diarrhea. METHODS: Active case detection was performed via semiweekly home visits, and blood was obtained at 3-month intervals. After each serosurvey, case subjects were selected from children experiencing a CF antigen (CFA)/I-, CFA/II-, CFA/IV-, or heat-labile enterotoxin (LT)-ETEC diarrheal episode during the subsequent 3 months. Up to 5 control subjects per case subject were selected from children who did not experience an ETEC diarrheal episode during the corresponding interval. Serum titers of immunoglobulin G antibodies against CFA/I, coli surface antigen (CS) 3, CS6, and LT were measured by enzyme-linked immunosorbant assay. RESULTS: The distribution of serum titers of LT, CS3, and CS6 antibodies did not differ between the case and control subjects. For children <18 months of age, serum titers of CFA/I antibody were inversely related to the risk of CFA/I-ETEC diarrhea; reciprocal serum titers of CFA/I antibody > or =76 were associated with a 77% reduction in the odds of CFA/I-ETEC diarrhea. CONCLUSION: Induction of reciprocal serum titers of antibodies against CFA/I within or above the 76-186 range should be further evaluated as a predictor for assessment of the ability of candidate vaccines to protect against CFA/I-ETEC diarrhea.
2.	Shaheen, H. I., et al. (author) Phenotypic and genotypic analysis of enterotoxigenic Escheria coli (ETEC) obtained from Egyptian children presenting to referral hospitals. 2008 In: J Clin Microbial. Journal article (other academic/artistic)

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Type of publication: journal article (2)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Svennerholm, Ann-Mar ... (2); Savarino, Stephen (2); Frenck, Robert W Jr (2); Rao, Malla (1); Clemens, John (1); Abu-Elyazeed, Remon (1); show more...; Wierzba, Thomas (1); Naficy, Abdollah (1); Shaheen, H. I. (1); El-Ghoreb, N. (1); Hall, E. R. (1); Abdel-Messih, I. (1); Abdel-Messih, JD (1); Klena, A (1); Mansour, Z (1); El-Wakkeel, TF (1); Sanders, SB (1); Kahlil, DM (1); Rockabrand, MR (1); Monteville, P J (1); Rozmajzl, P. J. (1); show less...

University: University of Gothenburg (2)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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