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- Cossarizza, A., et al.
(författare)
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
- 2019
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Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 49:10, s. 1457-1973
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Tidskriftsartikel (refereegranskat)abstract
- These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer-reviewed by leading experts in the field, making this an essential research companion.
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- Mikityuk, K., et al.
(författare)
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Horizon-2020 ESFR-SMART project on Sodium Fast Reactor Safety: status after 18 months
- 2019
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- To improve the public acceptance of the future nuclear power in Europe we have to demonstrate that the new reactors have significantly higher safety level compared to traditional reactors. The ESFR-SMART project (European Sodium Fast Reactor Safety Measures Assessment and Research Tools) aims at enhancing further the safety of Generation-IV SFRs and in particular of the commercial-size European Sodium Fast Reactor (ESFR) in accordance with the European Sustainable Nuclear Industrial Initiative (ESNII) roadmap and in close cooperation with the Advanced Sodium Technological Reactor for Industrial Demonstration (ASTRID) program. The project aims at 5 specific objectives: 1. Produce new experimental data in order to support calibration and validation of the computational tools for each defence-in-depth level. 2. Test and qualify new instrumentations in order to support their utilization in the reactor protection system. 3. Perform further calibration and validation of the computational tools for each defence-in-depth level in order to support safety assessments of Generation-IV SFRs, using the data produced in the project as well as selected legacy data. 4. Select, implement and assess new safety measures for the commercial-size ESFR, using the GIF methodologies, the FP7 CP-ESFR project legacy, the calibrated and validated codes and being in accordance with the update of the European and international safety frameworks taking into account the Fukushima accident. 5. Strengthen and link together new networks, in particular, the network of the European sodium facilities and the network of the European students working on the SFR technology. By addressing the industry, policy makers and general public, the project is expected to make a meaningful impact on economics, environment, EU policy and society. Selected results and milestones achieved during the first eighteen months of the project will be briefly presented, including − proposal of new safety measures for ESFR; − evaluation of ESFR core performance; − benchmarking of codes; − experimental programs; and − education and training.
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| 9. |
- Wechsler, A, et al.
(författare)
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Generation of viable cholesterol-free mice
- 2003
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 302:5653, s. 2087-2087
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Tidskriftsartikel (refereegranskat)
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| 10. |
- Fridman, E., et al.
(författare)
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Networked control under round-robin protocol : Multiple sensors and non-small communication delays
- 2014
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Ingår i: Proceedings of the IEEE Conference on Decision and Control. - : IEEE conference proceedings. ; , s. 6062-6067
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Konferensbidrag (refereegranskat)abstract
- The existing results on Networked Control Systems (NCSs) in the presence of variable sampling intervals, communication delays and scheduling protocols (in the frameworks of hybrid and discrete-time systems) are confined to small communication delays (that are smaller than the sampling intervals). Recently the time-delay approach was suggested to NCSs with N = 2 sensors under Round-Robin (RR) and Try-Once-Discard (TOD) protocols [1], [2], where communication delays were allowed to be non-small. The objective of this paper is to extend the time-delay approach to NCSs under RR protocol with a general number N ≥ 2 of sensor nodes. To derive simple conditions we suggest a novel hybrid system model for the closed-loop system with time-varying delays in the dynamics and in the reset conditions. A new Lyapunov-Krasovskii method is introduced for the exponential stability of the resulting delayed hybrid systems. For the case of two sensors, the resulting conditions are computationally simpler than the existing ones of [1]. The communication delays are allowed to be greater than the sampling intervals. Polytopic type uncertainties in the system model can be easily included in the analysis. The efficiency of the time-delay approach is illustrated on the example of uncertain cart-pendulum.
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| 14. |
- Iwaki, Takuya, 1986-, et al.
(författare)
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Event-based Switching for Sampled-data Output Feedback Control : Applications to Cascade and Feedforward Control
- 2019
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Ingår i: Proceedings of the IEEE Conference on Decision and Control. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728113982 ; , s. 2592-2597
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Konferensbidrag (refereegranskat)abstract
- This paper studies sampled-data output feedback control where the states are monitored by multiple sensors. Asymptotic stability conditions for given sampling intervals for each sensor are derived. Based on these results, we then propose an event-based controller switching, in which one sensor transmits its measurement to the controller with a fixed sampling rate while another sensor transmits with a send-on-delta strategy. Such a set-up is motivated by the many potential cascade and feedforward control architectures in process industry, which could enhance performance if additional wireless sensors could be added without changing existing (wired) communication schedules. Asymptotic stability conditions of the switching event-based control systems are derived. Numerical examples illustrate how our framework reduces the effect of disturbances for both cascade and feedforward PI control systems.
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| 15. |
- Iwaki, Takuya, 1986-, et al.
(författare)
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Multi-loop periodic event-triggered actuation : applications to PID, cascade, and decoupling control
- 2022
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Ingår i: International Journal of Control. - : Informa UK Limited. - 0020-7179 .- 1366-5820. ; , s. 1-16
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Tidskriftsartikel (refereegranskat)abstract
- This paper studies periodic event-triggered actuation applied to PID, cascade, and decoupling control. We propose an event-triggered output feedback controller, in which the control command is actuated only when it exceeds its previous value by a certain threshold. An exponential stability condition is derived in the form of LMIs using a Lyapunov–Krasovskii functional based on Wirtinger's inequality. It is shown that an observer-based controller can reject an unknown step disturbance. Using this result, we propose a way to tune the event threshold subject to a given stability margin. We apply the proposed framework to PID, cascade, and decoupling control to illustrate how the event thresholds can be tuned in practice. Numerical examples show for these three control architectures how controller–actuator communication can be reduced without performance degradation.
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| 16. |
- Liu, K., et al.
(författare)
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Generalized Jensen inequalities with application to stability analysis of systems with distributed delays over infinite time-horizons
- 2016
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Ingår i: Automatica. - : Elsevier. - 0005-1098 .- 1873-2836. ; 69, s. 222-231
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Tidskriftsartikel (refereegranskat)abstract
- The Jensen inequality has been recognized as a powerful tool to deal with the stability of time-delay systems. Recently, a new inequality that encompasses the Jensen inequality was proposed for the stability analysis of systems with finite delays. In this paper, we first present a generalized integral inequality and its double integral extension. It is shown how these inequalities can be applied to improve the stability result for linear continuous-time systems with gamma-distributed delays. Then, for the discrete-time counterpart we provide an extended Jensen summation inequality with infinite sequences, which leads to less conservative stability conditions for linear discrete-time systems with Poisson-distributed delays. The improvements obtained by the introduced generalized inequalities are demonstrated through examples.
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| 17. |
- Liu, K., et al.
(författare)
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Stability analysis of discrete-time systems with poisson-distributed delays
- 2016
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Ingår i: Proceedings of the IEEE Conference on Decision and Control. - : IEEE conference proceedings. - 9781479978861 ; , s. 7736-7741
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Konferensbidrag (refereegranskat)abstract
- This paper is concerned with the stability analysis of linear discrete-time systems with poisson-distributed delays. Firstly, the exponential stability condition of system with poisson-distributed delays is derived when the corresponding system with the zero-delay or the system without the delayed term is asymptotically stable. Then, an augmented Lyapunov functional is suggested to handle the case that the corresponding system without the delay as well as the system without the delayed term are not necessary to be asymptotically stable. Furthermore, we show that the results can be further improved by formulating the system as a higher-order augmented one and applying the corresponding augmented Lyapunov functional. Finally, the efficiency of the proposed results is illustrated by some numerical examples.
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| 18. |
- Liu, K., et al.
(författare)
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Survey on time-delay approach to networked control
- 2019
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Ingår i: Annual Reviews in Control. - : Elsevier. - 1367-5788 .- 1872-9088. ; 48, s. 57-79
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Forskningsöversikt (refereegranskat)abstract
- This paper provides a survey on time-delay approach to networked control systems (NCSs). The survey begins from a brief summary on fundamental network-induced issues in NCSs and the main approaches to the modelling of NCSs. In particular, a comprehensive introduction to time-delay approach to sampled-data and networked control is provided. Then, recent results on time-delay approach to event-triggered control are recalled. The survey highlights time-delay approach developed to modelling, analysis and synthesis of NCSs, under communication constraints, with a particular focus on Round-Robin, Try-once-discard and stochastic protocols. The time-delay approach allows communication delays to be larger than the sampling intervals in the presence of scheduling protocols. Moreover, some results on networked control of distributed parameter systems are surveyed. Finally, conclusions and some future research directions are briefly addressed.
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| 19. |
- Olausson, E, et al.
(författare)
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Diffuse myocardial fibrosis associates with incident ventricular arrhythmia in implantable cardioverter defibrillator recipients
- 2023
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Ingår i: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- BackgroundDiffuse myocardial fibrosis (DMF) quantified by extracellular volume (ECV) may represent a vulnerable phenotype and associate with life threatening ventricular arrhythmias more than focal myocardial fibrosis. This principle remains important because 1) risk stratification for implantable cardioverter defibrillators (ICD) remains challenging, and 2) DMF may respond to current or emerging medical therapies (reversible substrate).ObjectivesTo evaluate the association between quantified by ECV in myocardium without focal fibrosis by late gadolinium enhancement (LGE) with time from ICD implantation to 1) appropriate shock, or 2) shock or anti-tachycardia pacing.MethodsAmong patients referred for cardiovascular magnetic resonance (CMR) without congenital disease, hypertrophic cardiomyopathy, or amyloidosis who received ICDs (n=215), we used Cox regression to associate ECV with incident ICD therapy.ResultsAfter a median of 2.9 (IQR 1.5-4.2) years, 25 surviving patients experienced ICD shock and 44 experienced shock or anti-tachycardia pacing. ECV ranged from 20.2% to 39.4%. No patient with ECV<25% experienced an ICD shock. ECV associated with both endpoints, e.g., hazard ratio 2.17 (95%CI 1.17-4.00) for every 5% increase in ECV, p=0.014 in a stepwise model for ICD shock adjusting for ICD indication, age, smoking, atrial fibrillation, and myocardial infarction, whereas focal fibrosis by LGE and global longitudinal strain (GLS) did not.ConclusionsDMF measured by ECV associates with ventricular arrhythmias requiring ICD therapy in a dose-response fashion, even adjusting for potential confounding variables, focal fibrosis by LGE, and GLS. ECV-based risk stratification and DMF representing a therapeutic target to prevent ventricular arrhythmia warrant further investigation.Condensed AbstractAnalogous to heart failure and mortality outcomes, diffuse myocardial fibrosis (DMF) quantified by extracellular volume (ECV) may represent a more vulnerable phenotype for life-threatening ventricular arrhythmia than focal myocardial fibrosis. In patients referred for cardiovascular magnetic resonance, we identified 215 subsequently receiving implantable cardioverter defibrillators (ICD). After a median of 2.9 (IQR 1.5-4.2) years, 25 patients experienced ICD shock and 44 experienced shock or anti-tachycardia pacing. ECV associated with ICD therapy in Cox regression models. Focal fibrosis variables or global longitudinal strain did not. ECV-based risk stratification and DMF representing a therapeutic target to prevent ventricular arrhythmia warrant further investigation.
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