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1.	Johansson, Patrik, et al. (author) A drug association map of glioblastoma informs precision targeting of p53-dependent metabolic states Journal article (other academic/artistic)
2.	Johansson, Patrik, et al. (author) A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma 2020 In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 32:2 Journal article (peer-reviewed)abstract Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease presents with a complex spectrum of genomic aberrations, but the pharmacological consequences of these aberrations are partly unknown. Here, we report an integrated pharmacogenomic analysis of 100 patient-derived GBM cell cultures from the human glioma cell culture (HGCC) cohort. Exploring 1,544 drugs, we find that GBM has two main pharmacological subgroups, marked by differential response to proteasome inhibitors and mutually exclusive aberrations in TP53 and CDKN2A/B. We confirm this trend in cell and in xenotransplantation models, and identify both Bcl-2 family inhibitors and p53 activators as potentiators of proteasome inhibitors in GBM cells, We can further predict the responses of individual cell cultures to several existing drug classes, presenting opportunities for drug repurposing and design of stratified trials. Our functionally profiled biobank provides a valuable resource for the discovery of new treatments for GBM.
3.	Johansson, Patrik, et al. (author) Decoding glioblastoma drug responses using an open access library of patient derived cell models Other publication (other academic/artistic)

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Type of publication: journal article (2); other publication (1)

Type of content: other academic/artistic (2); peer-reviewed (1)

Author/Editor: Nelander, Sven (3); Johansson, Patrik (3); Martens, Ulf (3); Häggblad, Maria (3); Kundu, Soumi (3); Lundgren, Bo (3); show more...; Baskaran, Sathishkum ... (3); Schmidt, Linnea (3); Frigault, Melanie M. (3); Krona, Cecilia, 1976 (2); Gallant, Caroline J. (2); Elgendy, Ramy (2); Doroszko, Milena (2); Almstedt, Elin (2); Elfineh, Lioudmila (2); Lane, David P. (2); Vinel, Claire (2); Marino, Silvia (2); Lundsten, Sara (2); Swartling, Fredrik J ... (1); Gallant, Caroline (1); Jörnsten, Rebecka (1); Almstedt, Elin, 1988 ... (1); Rosén, Emil (1); Nestor, Marika, 1976 ... (1); Uhrbom, Lene (1); Krona, Cecilia (1); Holmberg Olausson, K ... (1); Nestor, Marika (1); Sipila, Petra (1); Kling, Teresia (1); Elfineh, Ludmila (1); Ferrer Gago, Fernand ... (1); Hakkarainen, Aleksi (1); Awe, Olatilewa (1); Lönnstedt, Ingrid (1); Hurt, Elaine (1); show less...

University: Uppsala University (3); Stockholm University (1); Karolinska Institutet (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (3); Natural sciences (1)

Year: 2020 (1)

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