| 1. |
- Thomas, HS, et al.
(författare)
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- 2019
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swepub:Mat__t
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| 2. |
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| 3. |
- Meech, K. J., et al.
(författare)
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EPOXI: Comet 103P/Hartley 2 Observations from a Worldwide Campaign
- 2011
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Ingår i: Astrophysical Journal Letters. - London : IOP. - 2041-8213 .- 2041-8205. ; 734:L1, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Earth- and space-based observations provide synergistic information for space mission encounters by providing data over longer timescales, at different wavelengths and using techniques that are impossible with an in situ flyby. We report here such observations in support of the EPOXI spacecraft flyby of comet 103P/Hartley 2. The nucleus is small and dark, and exhibited a very rapidly changing rotation period. Prior to the onset of activity, the period was ~16.4?hr. Starting in 2010 August the period changed from 16.6?hr to near 19?hr in December. With respect to dust composition, most volatiles and carbon and nitrogen isotope ratios, the comet is similar to other Jupiter-family comets. What is unusual is the dominance of CO 2 -driven activity near perihelion, which likely persists out to aphelion. Near perihelion the comet nucleus was surrounded by a large halo of water-ice grains that contributed significantly to the total water production.
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| 11. |
- Larsson, B., et al.
(författare)
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First NH3 detection of the Orion Bar
- 2003
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 402, s. L69-L72
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Tidskriftsartikel (refereegranskat)abstract
- Odin has successfully observed three regions in the Orion A cloud, i.e. Ori KL, Ori S and the Orion Bar, in the 572.5 GHz rotational ground state line of ammonia, ortho-NH3 (J,K) = (1,0) -> (0,0), and the result for the Orion Bar represents the first detection in an ammonia line. Several velocity components are present in the data. Specifically, the observed line profile from the Orion Bar can be decomposed into two components, which are in agreement with observations in high-J CO lines by Wilson et al. (\cite{wilson01}). Using the source model for the Orion Bar by these authors, our Odin observation implies a total ammonia abundance of NH3/H2 = 5x 10-9. Based on observations with Odin, a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes) and Centre National d'Études Spatiales (CNES). The Swedish Space Corporation has been the industrial prime contractor.
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| 12. |
- Olofsson, Henrik, 1972, et al.
(författare)
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Odin water mapping in the Orion KL region
- 2003
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 402, s. L47-L54
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Tidskriftsartikel (refereegranskat)abstract
- New results from water mapping observations of the Orion KL region using the submm/mm wave satellite Odin (2.1\arcmin beam size at 557 GHz), are presented. The ortho-H2O \jkktrans{1}{1}{0}{1}{0}{1} ground state transition was observed in a 7arcminx 7arcmin rectangular grid with a spacing of 1\arcmin, while the same line of H218O was measured in two positions, Orion KL itself and 2\arcmin south of Orion KL. In the main water species, the KL molecular outflow is largely resolved from the ambient cloud and it is found to have an extension of 60\arcsec-110\arcsec. The H2O outflow profile exhibits a rather striking absorption-like asymmetry at the line centre. Self-absorption in the near (or ``blue'') part of the outflow (and possibly in foreground quiescent halo gas) is tentatively suggested to play a role here. We argue that the dominant part of the KL H218O outflow emission emanates from the compact (size ~ 15\arcsec) low-velocity flow and here estimate an H2O abundance of circa 10-5 compared to all H2 in the flow - an order of magnitude below earlier estimates of the H2O abundance in the shocked gas of the high-velocity flow. The narrow ambient cloud lines show weak velocity trends, both in the N-S and E-W directions. H218O is detected for the first time in the southern position at a level of ~ 0.15 K and we here estimate an H2O abundance of (1-8) x 10-8. Odin is a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes), and the Centre National d'Études Spatiales (CNES, France). The Swedish Space Corporation (SSC) was the industrial prime contractor and is also responsible for the satellite operation.
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| 13. |
- Pagani, L., et al.
(författare)
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Low upper limits on the O2 abundance from the Odin satellite
- 2003
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 402, s. L77-L81
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Tidskriftsartikel (refereegranskat)abstract
- For the first time, a search has been conducted in our Galaxy for the 119 GHz transition connecting to the ground state of O2, using the Odin satellite. Equipped with a sensitive 3 mm receiver (Tsys(SSB) = 600 K), Odin has reached unprecedented upper limits on the abundance of O2, especially in cold dark clouds where the excited state levels involved in the 487 GHz transition are not expected to be significantly populated. Here we report upper limits for a dozen sources. In cold dark clouds we improve upon the published SWAS upper limits by more than an order of magnitude, reaching N(O2)/N(H2) <= 10-7 in half of the sources. While standard chemical models are definitively ruled out by these new limits, our results are compatible with several recent studies that derive lower O2 abundances. Goldsmith et al. (\cite{SWAS2002}) recently reported a SWAS tentative detection of the 487 GHz transition of O2 in an outflow wing towards rho Oph A in a combination of 7 beams covering approximately 10arcmin x 14arcmin . In a brief (1.3 hour integration time) and partial covering of the SWAS region (~65% if we exclude their central position), we did not detect the corresponding 119 GHz line. Our 3 sigma upper limit on the O2 column density is 7.3x 1015 cm-2. We presently cannot exclude the possibility that the SWAS signal lies mostly outside of the 9\arcmin Odin beam and has escaped our sensitive detector. Based on observations with Odin, a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes) and Centre National d'Études Spatiales (CNES). The Swedish Space Corporation was the industrial prime contractor and is operating Odin.
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| 14. |
- Sandqvist, Aa., et al.
(författare)
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Odin observations of H2O in the Galactic Centre
- 2003
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 402, s. L63-L67
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Tidskriftsartikel (refereegranskat)abstract
- The Odin satellite has been used to detect emission and absorption in the 557-GHz H216O line in the Galactic Centre towards the Sgr Astar Circumnuclear Disk (CND), and the Sgr A +20 km s-1 and +50 km s-1 molecular clouds. Strong broad H2O emission lines have been detected in all three objects. Narrow H2O absorption lines are present at all three positions and originate along the lines of sight in the 3-kpc Spiral Arm, the -30 km s-1 Spiral Arm and the Local Sgr Spiral Arm. Broad H2O absorption lines near -130 km s-1 are also observed, originating in the Expanding Molecular Ring. A new molecular feature (the ``High Positive Velocity Gas'' - HPVG) has been identified in the positive velocity range of ~+120 to +220 km s-1, seen definitely in absorption against the stronger dust continuum emission from the +20 km s-1 and +50 km s-1 clouds and possibly in emission towards the position of Sgr Astar CND. The 548-GHz H218O isotope line towards the CND is not detected at the 0.02 K (rms) level. Based on observations with Odin, a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes) and Centre National d'Études Spatiales (CNES). The Swedish Space Corporation was the industrial prime contractor and is also responsible for the satellite operation.
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| 15. |
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| 16. |
- Andréasson, Hanna, et al.
(författare)
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Quantification of mtDNA mixtures in forensic evidence material using pyrosequencing
- 2006
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Ingår i: International journal of legal medicine. - : Springer Science and Business Media LLC. - 0937-9827 .- 1437-1596. ; 120:6, s. 383-390
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Tidskriftsartikel (refereegranskat)abstract
- Analysis of mtDNA variation using Sanger sequencing does not allow accurate quantification of the components of mtDNA mixtures. An alternative method to determine the specific mixture ratios in samples displaying heteroplasmy, consisting of DNA contributions from several individuals, or containing contamination would therefore be valuable. A novel quantification system for mtDNA mixture analysis has been developed based on pyrosequencing technology, in which the linear relationship between incorporated nucleotides and released light allows quantification of the components of a sample. Within five polymerase chain reaction fragments, seven variable positions in the mtDNA control and coding region were evaluated using this quantification analysis. For all single nucleotide polymorphisms quantified in this study, a linear relationship was observed between the measured and expected mixture ratios. This mtDNA quantification assay is an easy to use, fast and accurate quantification system, with the ability to resolve and interpret major and minor mtDNA components in forensic mixture samples.
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| 17. |
- Benmahi, B., et al.
(författare)
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Monitoring of the evolution of H2O vapor in the stratosphere of Jupiter over an 18-yr period with the Odin space telescope
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 641
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Tidskriftsartikel (refereegranskat)abstract
- Context. The comet Shoemaker-Levy 9 impacted Jupiter in July 1994, leaving its stratosphere with several new species, with water vapor (H2O) among them. Aims. With the aid of a photochemical model, H2O can be used as a dynamical tracer in the Jovian stratosphere. In this paper, we aim to constrain the vertical eddy diffusion (Kzz) at levels where H2O is present. Methods. We monitored the H2O disk-averaged emission at 556.936 GHz with the space telescope between 2002 and 2019, covering nearly two decades. We analyzed the data with a combination of 1D photochemical and radiative transfer models to constrain the vertical eddy diffusion in the stratosphere of Jupiter. Results. Odin observations show us that the emission of H2O has an almost linear decrease of about 40% between 2002 and 2019. We can only reproduce our time series if we increase the magnitude of Kzz in the pressure range where H2O diffuses downward from 2002 to 2019, that is, from ~0.2 mbar to ~5 mbar. However, this modified Kzz is incompatible with hydrocarbon observations. We find that even if an allowance is made for the initially large abundances of H2O and CO at the impact latitudes, the photochemical conversion of H2O to CO2 is not sufficient to explain the progressive decline of the H2O line emission, which is suggestive of additional loss mechanisms. Conclusions. The Kzz we derived from the Odin observations of H2O can only be viewed as an upper limit in the ~0.2 mbar to ~5 mbar pressure range. The incompatibility between the interpretations made from H2O and hydrocarbon observations probably results from 1D modeling limitations. Meridional variability of H2O, most probably at auroral latitudes, would need to be assessed and compared with that of hydrocarbons to quantify the role of auroral chemistry in the temporal evolution of the H2O abundance since the SL9 impacts. Modeling the temporal evolution of SL9 species with a 2D model would naturally be the next step in this area of study.
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| 18. |
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| 23. |
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| 24. |
- Fan, B. X., et al.
(författare)
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Breakdown of the Cross-Kerr Scheme for Photon Counting
- 2013
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 110:5
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Tidskriftsartikel (refereegranskat)abstract
- We show, in the context of single-photon detection, that an atomic three-level model for a transmon in a transmission line does not support the predictions of the nonlinear polarizability model known as the cross-Kerr effect. We show that the induced displacement of a probe in the presence or absence of a single photon in the signal field, cannot be resolved above the quantum noise in the probe. This strongly suggests that cross-Kerr media are not suitable for photon counting or related single-photon applications. Our results are presented in the context of a transmon in a one-dimensional microwave waveguide, but the conclusions also apply to optical systems.
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| 25. |
- Frisk, Andreas, 1983-, et al.
(författare)
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Tailoring anisotropy and domain structure in amorphous TbCo thin films through combinatorial methods
- 2016
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Ingår i: Journal of Physics D. - : IOP Publishing. - 0022-3727 .- 1361-6463. ; 49:3
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Tidskriftsartikel (refereegranskat)abstract
- We apply an in-plane external magnetic field during growth of amorphous TbCo thin films and examine the effects on the magnetic anisotropy and domain structure. A combinatorial approach is employed throughout the deposition and analysis to study a continuous range of compositions between 7–95 at.% Tb. Magnetometry measurements show that all samples have a strong out-of-plane anisotropy, much larger than any in-plane components, regardless of the presence of a growth field. However, magnetic force microscopy demonstrates that the growth field does indeed have a large effect on the magnetic domain structure, resulting in elongated domains aligned along the imprinting field direction. The results show that the anisotropy can be tuned in intricate ways in amorphous TbCo films giving rise to unusual domain structures. Furthermore the results reveal that a combinatorial approach is highly effective for mapping out these material properties.
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| 26. |
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| 27. |
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| 28. |
- Frisk, K., et al.
(författare)
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Development of a database for cemented carbides : Thermodynamic modeling and experiments
- 2001
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Ingår i: Journal of phase equilibria (Print). - 1054-9714 .- 1544-1032. ; 22:6, s. 645-655
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Tidskriftsartikel (refereegranskat)abstract
- A new database, for thermodynamic information for cemented carbides has been developed. A full description of the alloy system C-Co-N-Nb-Ta-Ti-W is presented. The work has involved both thermodynamic evaluations of lower order systems and experimental investigations. Full new assessments of the quaternary Ti-W-C-N, Ta-W-C-N, and Nb-W-C-N systems have been performed, including tests of the influence of model parameters on miscibility gaps in higher order systems. A new improved description of the Co-W-C system based on new experiments is used in the present work. The main results of the experimental work are measurements of the composition of the cubic carbide in selected equilibria; measurements of the temperatures of the liq + fcc + WC + gr. and liq + fcc + WC + M6C equilibria in the Co-W-C and Co-W-X-C (X = Ti, Ta, Nb) systems; and measurements of the solubility of Ti, Ta, and Nb in liquid in multicomponent alloys. The results of the assessments have been implemented into a new database. The database has successfully been used in a parallel project to simulate the formation of gamma -phase free zones in cemented carbides. A few other applications of industrial relevance are presented.
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| 29. |
- Frisk, Pia, et al.
(författare)
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Introduction of the second-generation direct-acting antivirals (DAAs) in chronic hepatitis C : a register-based study in Sweden
- 2018
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Ingår i: European Journal of Clinical Pharmacology. - : SPRINGER HEIDELBERG. - 0031-6970 .- 1432-1041. ; 74:7, s. 971-978
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Tidskriftsartikel (refereegranskat)abstract
- Introduction of the direct-acting antivirals (DAAs) for treatment of chronic hepatitis C (CHC) infection has been challenging in all health systems. In Sweden, a national protocol for managed introduction was developed. It was optional, but all county councils agreed to implement and follow it. The purpose of this study was to study (a) cure rates among all patients initiated on treatment in 2014-2015, (b) prescribers' adherence to the drug recommendations and treatment eligibility criteria in the protocol, and (c) introduction rate in the six Swedish healthcare regions. A cross-sectional study where national data from the Prescribed Drug Register and the quality register InfCare Hepatitis defined the study population, and clinical data from the Patient Register and InfCare Hepatitis were used to monitor outcomes. Descriptive statistics were used. A total of 3447 patients were initiated on treatment during 2014-2015. The overall cure rate, based on data from 85% of the cohort, was 96%, with variation between genotypes. Adherence to drug recommendations increased over time and varied between 43.2 and 94.2%. Adherence to the treatment eligibility criteria was initially 80% and increased to 87% when treatment restrictions were widened. The introduction rate differed initially between the regions and reached stable levels 15-18 months after the launch of the first DAA. The estimated overall cure rate was 96%, with some variations between genotypes. A high level of adherence to the introduction protocol as well as similar introduction rates in the health care regions indicate that the introduction protocol, alongside with other measures taken, contributed considerably to a rapid uptake and equal distribution of DAAs in Sweden.
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| 30. |
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| 31. |
- Frisk, Pia, et al.
(författare)
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Selection bias in pharmacy-based patient surveys
- 2014
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Ingår i: Pharmacoepidemiology and Drug Safety. - : Wiley. - 1053-8569 .- 1099-1557. ; 23:2, s. 128-139
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Tidskriftsartikel (refereegranskat)abstract
- PurposeTo evaluate if there is a selection bias in drug utilization surveys on prescription drugs regularly conducted in Swedish pharmacies, to describe the direction of this potential bias and discuss the implications for the results. MethodsAge and gender distributions within patient survey samples from drug utilization surveys conducted during 2006-2010 are compared to the age and gender distribution of all Swedish patients, receiving the same drug or drugs, as given by the Swedish Prescribed Drug Register. The differences between the proportions of patients within the age and gender segments of each pair of survey/register data were calculated. ResultsIn 25 (81%) out of 31 included surveys, patients aged 75 years or older are significantly underrepresented, as they are less likely to visit the pharmacy to collect their prescription drugs themselves and thus disqualify for the interviews. Data on women show similar results as overall survey data, whereas the underrepresentation of the oldest age group among men appears in a lower proportion of the surveys, 67%. The general consequence is a selection towards a healthier survey sample, but the consequences in the individual surveys vary, depending on what drug is being studied. ConclusionPharmacy-based patient surveys provide a convenient data collection method for patient self-reported data, but patients aged 75 years or older are consistently underrepresented. In surveys where this may influence the main research question, data should also be collected with other methods reaching the oldest patients.
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| 32. |
- Frisk, Per, et al.
(författare)
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Skin infection caused by Mycobacterium szulgai after allogenic bone marrow transplantation
- 2003
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Ingår i: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 31:6, s. 511-513
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Tidskriftsartikel (refereegranskat)abstract
- Infections are responsible for a large part of the morbidity and mortality after BMT because of the sustained impairment of host defenses. We report a case of cutaneous infection caused by Mycobacterium szulgai in a boy who underwent BMT with marrow from a matched unrelated donor.
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| 33. |
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| 34. |
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| 35. |
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| 36. |
- Frisk, T., et al.
(författare)
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Live-cell imaging of natural killer cell mediated tumor rejection in arrays of microwells
- 2010
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Ingår i: 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. - 9781618390622 ; , s. 950-952
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Konferensbidrag (refereegranskat)abstract
- Due to the inherent heterogeneity of immune cell populations a comprehensive view of immune functions can only be achieved by collecting data from many individual cells. We here demonstrate a novel multi-well microchip platform for cell analysis, which we use to study the interaction between natural killer (NK) cells and their target cells.
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| 37. |
- Frisk, U., et al.
(författare)
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The Odin satellite - I. Radiometer design and test
- 2003
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 402:3, s. L27-L34
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Tidskriftsartikel (refereegranskat)abstract
- The Sub-millimetre and Millimetre Radiometer (SMR) is the main instrument on the Swedish, Canadian, Finnish and French spacecraft Odin. It consists of a 1.1 metre diameter telescope with four tuneable heterodyne receivers covering the ranges 486-504 GHz and 541-581 GHz, and one fixed at 118.75 GHz together with backends that provide spectral resolution from 150 kHz to 1 MHz. This Letter describes the Odin radiometer, its operation and performance with the data processing and calibration described in Paper II.
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| 38. |
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| 39. |
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| 40. |
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Highlights from the first year of Odin observations
- 2003
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 402, s. L39-L46
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Tidskriftsartikel (refereegranskat)abstract
- Key Odin operational and instrumental features and highlights from our sub-millimetre and millimetre wave observations of H2O, H218O, NH3, 15NH3 and O2 are presented, with some insights into accompanying Odin Letters in this A&A issue. We focus on new results where Odin's high angular resolution, high frequency resolution, large spectrometer bandwidths, high sensitivity or/and frequency tuning capability are crucial: H2O mapping of the Orion KL, W3, DR21, S140 regions, and four comets; H2O observations of Galactic Centre sources, of shock enhanced H2O towards the SNR IC443, and of the candidate infall source IRAS 16293-2422; H218O detections in Orion KL and in comet Ikeya-Zhang; sub-mm detections of NH3 in Orion KL (outflow, ambient cloud and bar) and ρ Oph, and very recently, of 15NH3 in~Orion KL. Simultaneous sensitive searches for the 119 GHz line of O2 have resulted in very low abundance limits, which are difficult to accomodate in chemical models. We also demonstrate, by means of a quantitative comparison of Orion KL H2O results, that the Odin and SWAS observational data sets are very consistently calibrated. Odin is a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes), and the Centre National d'études Spatiales (CNES, France). The Swedish Space Corporation (SSC) has been the prime industrial contractor, and is also responsible for the satellite operation from its Odin Mission Control Centre at SSC in Solna and its Odin Control Centre at ESRANGE near Kiruna in northern Sweden. See also the SNSB Odin web page: http://www.snsb.se/eng_odin_intro.shtml
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| 41. |
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| 42. |
- Hodik, Monika, et al.
(författare)
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Enterovirus infection of human islets of Langerhans affects beta-cell function resulting in disintegrated islets, decreased glucose stimulated insulin secretion and loss of Golgi structure
- 2016
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Ingår i: BMJ OPEN DIABETES RESEARCH & CARE. - : BMJ. - 2052-4897. ; 4:1
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Tidskriftsartikel (refereegranskat)abstract
- Aims/hypothesis: In type 1 diabetes (T1D), most insulin-producing beta cells are destroyed, but the trigger is unknown. One of the possible triggers is a virus infection and the aim of this study was to test if enterovirus infection affects glucose stimulated insulin secretion and the effect of virus replication on cellular macromolecules and organelles involved in insulin secretion. Methods: Isolated human islets were infected with different strains of coxsackievirus B (CVB) virus and the glucose-stimulated insulin release (GSIS) was measured in a dynamic perifusion system. Classical morphological electron microscopy, large-scale electron microscopy, so-called nanotomy, and immunohistochemistry were used to study to what extent virus-infected beta cells contained insulin, and real-time PCR was used to analyze virus induced changes of islet specific genes. Results: In islets infected with CVB, GSIS was reduced in correlation with the degree of virus-induced islet disintegration. The expression of the gene encoding insulin was decreased in infected islets, whereas the expression of glucagon was not affected. Also, in islets that were somewhat disintegrated, there were uninfected beta cells. Ultrastructural analysis revealed that virus particles and virus replication complexes were only present in beta cells. There was a significant number of insulin granules remaining in the virus-infected beta cells, despite decreased expression of insulin mRNA. In addition, no typical Golgi apparatus was detected in these cells. Exposure of islets to synthetic dsRNA potentiated glucose-stimulated insulin secretion. Conclusions/interpretation: Glucose-stimulated insulin secretion; organelles involved in insulin secretion and gene expression were all affected by CVB replication in beta cells.
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| 43. |
- Jarvis, Kirsten B., et al.
(författare)
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Asymptomatic Right Atrial Thrombosis After Acute Lymphoblastic Leukemia Treatment
- 2021
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Ingår i: Journal of pediatric hematology/oncology (Print). - : Lippincott Williams & Wilkins. - 1077-4114 .- 1536-3678. ; 43:4, s. E564-E566
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Tidskriftsartikel (refereegranskat)abstract
- Right atrial thrombosis is a rare, but potentially serious complication of acute lymphoblastic leukemia treatment. We conducted a retrospective multicenter study to assess the incidence, treatment, and outcome of asymptomatic right atrial thrombosis detected at routine echocardiography of children after acute lymphoblastic leukemia treatment in the Nordic and Baltic countries. Eleven (2.7%, 95% confidence interval, 1.4-4.9) of 406 patients had asymptomatic right atrial thrombosis, ranging from 10 to 25 mm at detection. Three patients were treated with anticoagulation. None of the thromboses affected cardiac function, and they showed neither sign of progress nor spontaneous or treatment-related regress at follow-up.
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| 44. |
- Johansen, I. B., et al.
(författare)
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Bigger is not better: cortisol-induced cardiac growth and dysfunction in salmonids
- 2017
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Ingår i: Journal of Experimental Biology. - : The Company of Biologists. - 0022-0949 .- 1477-9145. ; 220:14, s. 2545-2553
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Tidskriftsartikel (refereegranskat)abstract
- Stress and elevated cortisol levels are associated with pathological heart growth and cardiovascular disease in humans and other mammals. We recently established a link between heritable variation in post-stress cortisol production and cardiac growth in salmonid fish too. A conserved stimulatory effect of the otherwise catabolic steroid hormone cortisol is probably implied, but has to date not been established experimentally. Furthermore, whereas cardiac growth is associated with failure of the mammalian heart, pathological cardiac hypertrophy has not previously been described in fish. Here, we show that rainbow trout (Oncorhynchus mykiss) treated with cortisol in the diet for 45 days have enlarged hearts with lower maximum stroke volume and cardiac output. In accordance with impaired cardiac performance, overall circulatory oxygen-transporting capacity was diminished as indicated by reduced aerobic swimming performance. In contrast to the well-known adaptive/physiological heart growth observed in fish, cortisol-induced growth is maladaptive. Furthermore, the observed heart growth was associated with up-regulated signature genes of mammalian cardiac pathology, suggesting that signalling pathways mediating cortisol-induced cardiac remodelling in fish are conserved from fish to mammals. Altogether, we show that excessive cortisol can induce pathological cardiac remodelling. This is the first study to report and integrate the etiology, physiology and molecular biology of cortisol-induced pathological remodelling in fish.
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| 45. |
- Justtanont, Kay, 1965, et al.
(författare)
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W Hya through the Eye of Odin
- 2005
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Ingår i: Astronomy & Astrophysics. ; 439, s. 627-633
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Tidskriftsartikel (refereegranskat)
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| 46. |
- Justtanont, K., et al.
(författare)
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W Hya through the eye of Odin. Satellite observations of circumstellar submillimetre H2O line emission
- 2005
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 439, s. 627-633
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Tidskriftsartikel (refereegranskat)abstract
- We present Odin observations of the AGB star W Hya in the ground-state transition of ortho-H{2}O, 1{10}-101, at 557 GHz. The line is clearly of circumstellar origin. Radiative transfer modelling of the water lines observed by Odin and ISO results in a mass-loss rate of (2.5±0.5)×10-7 Mȯ yr-1, and a circumstellar H{2}O abundance of (2.0±1.0)×10-3. The inferred mass-loss rate is consistent with that obtained from modelling the circumstellar CO radio line emission, and also with that obtained from the dust emission modelling combined with a dynamical model for the outflow. The very high water abundance, higher than the cosmic oxygen abundance, can be explained by invoking an injection of excess water from evaporating icy bodies in the system. The required extra mass of water is quite small, on the order of 0.1 Moplus.
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| 47. |
- Kristiansen, Ingela, 1961-
(författare)
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Medical, cognitive and motor outcome after treatment of pilocytic astrocytoma in the posterior fossa in childhood
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Introduction: Pilocytic astrocytoma is the most common brain tumour in childhood. The aim of the studies was to investigate late medical, cognitive and motor complications in patients treated in childhood for pilocytic astrocytoma in the posterior fossa. Methods: We present a retrospective study including 193 children treated for CNS tumours 1995-2006 and, from the same cohort, 3 descriptive studies including 20 patients (out of 27 eligible patients) treated for pilocytic astrocytoma in the posterior fossa 1995-2011. The patients participated in an interview, a neurological investigation, screening tools for psychiatric symptoms, health-related quality of life (HRQoL), and tests of cognitive, language, academic and motor functions. Results: Ten patients reported problems with motor skills, mainly from the upper limbs, and 8 reported learning difficulties. None had low results in screening for psychiatric symptoms or HRQoL. Intelligence tests showed average results, but 5 scored <-1 SD (70-84) and 3 low average (85-92) on full scale IQ. Patients scored average compared with norms in tests of executive function, except for significantly lower results in inhibition/switching (p= 0.004). In language and academic tests patients scored significantly lower results in naming ability (p=0.049), inference (p=0.046) and reading speed (p=0.024). Results in tests of motor function were normal, but in the Bruininks-Oseretsky Test of Motor Proficiency, patients had significantly lower results in manual dexterity (p=0.008). In the Mini-Balance Evaluation Systems Test, patients had significantly lower results compared with matched controls (p=0.036). Patients who reported learning difficulties had worse results in the performed tests. Conclusions: Although long-term functional outcome for patients treated for pilocytic astrocytoma was generally favourable, 40% of the patients display cognitive, learning and motor difficulties. Therefore, it is imperative to identify those in need of more thorough cognitive and motor follow-up programmes, including pedagogic interventions in school and training of motor functions.
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| 48. |
- Kristiansen, Ingela, et al.
(författare)
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Motor performance in children and adults treated for low-grade astrocytoma in the posterior fossa during childhood
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Introduction Pilocytic astrocytoma is the most common brain tumor in childhood. The aim was to investigate if patients treated for pilocytic astrocytoma in the poste- rior fossa had motor complications and affected motor and process skills.Methods This descriptive single-center study includes 8 children and 12 adults, treated for this tumor. Motor performance was investigated with Bruininks- Oseretsky Test of Motor Proficiency, Second Edition (BOT-2), and dynamic balance with The Mini-Balance Evaluation Systems Test (Mini-BESTest), including a con- trol group. Physiological Cost Index (PCI), Six-Minute Walk Test (6MWT), hand grip strength and Assessment of Motor and Process Skills (AMPS) were also evalu- ated.Results Ten patients reported motor difficulties, mainly from the upper limbs. BOT- 2 showed average results except manual dexterity, that was significantly below mean (p=0.008). In the Mini-BESTest patients had significantly lower results com- pared with controls (p=0.036). PCI, 6MWT, and hand grip strength showed average results. In AMPS, 30% of the patients scored below the cut-off level for difficulties with motor skills.Conclusions Motor performance for patients treated for pilocytic astrocytoma in the posterior fossa is satisfactory. However, some patients display difficulties with bal- ance, manual dexterity and motor skills. It is important to identify those in need of motor follow-up and training.Department of Neuroscience/Rehabilitation, Uppsala University, Uppsala, Sweden1
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| 49. |
- Kudra, Marina, 1992, et al.
(författare)
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Robust Preparation of Wigner-Negative States with Optimized SNAP-Displacement Sequences
- 2022
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Ingår i: PRX Quantum. - : AMER PHYSICAL SOC. - 2691-3399. ; 3:3
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Tidskriftsartikel (refereegranskat)abstract
- Hosting nonclassical states of light in three-dimensional microwave cavities has emerged as a promising paradigm for continuous-variable quantum information processing. Here we experimentally demonstrate high-fidelity generation of a range of Wigner-negative states useful for quantum computation, such as Schrodinger-cat states, binomial states, Gottesman-Kitaev-Preskill states, as well as cubic phase states. The latter states have been long sought after in quantum optics and have never been achieved experimentally before. We use a sequence of interleaved selective number-dependent arbitrary phase (SNAP) gates and displacements. We optimize the state preparation in two steps. First we use a gradient-descent algorithm to optimize the parameters of the SNAP and displacement gates. Then we optimize the envelope of the pulses implementing the SNAP gates. Our results show that this way of creating highly nonclassical states in a harmonic oscillator is robust to fluctuations of the system parameters such as the qubit frequency and the dispersive shift.
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| 50. |
- Larsson, Bengt, et al.
(författare)
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Molecular oxygen in the rho Ophiuchi cloud
- 2007
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 466:3, s. 5-
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Tidskriftsartikel (refereegranskat)abstract
- Context: Molecular oxygen, O2, has been expected historically to be an abundant component of the chemical species in molecular clouds and, as such, an important coolant of the dense interstellar medium. However, a number of attempts from both ground and from space have failed to detect O2 emission.Aims: The work described here uses heterodyne spectroscopy from space to search for molecular oxygen in the interstellar medium. Methods: The Odin satellite carries a 1.1 m sub-millimeter dish and a dedicated 119 GHz receiver for the ground state line of O2. Starting in 2002, the star forming molecular cloud core ρ Oph A was observed with Odin for 34 days during several observing runs.Results: We detect a spectral line at v_LSR =+3.5 km s-1 with Δ v_FWHM=1.5 km s-1, parameters which are also common to other species associated with ρ Oph A. This feature is identified as the O2 (NJ = 11 - 1_0) transition at 118 750.343 MHz.Conclusions: The abundance of molecular oxygen, relative to H{2} , is 5 × 10-8 averaged over the Odin beam. This abundance is consistently lower than previously reported upper limits.Based on observations with Odin, a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes) and Centre National d'Étude Spatiale (CNES). The Swedish Space Corporation has been the industrial prime contractor and also is operating the satellite. Appendix A is only available in electronic form at http://www.aanda.org
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