| 1. |
- Thomas, HS, et al.
(författare)
-
- 2019
-
swepub:Mat__t
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Meech, K. J., et al.
(författare)
-
EPOXI: Comet 103P/Hartley 2 Observations from a Worldwide Campaign
- 2011
-
Ingår i: Astrophysical Journal Letters. - London : IOP. - 2041-8213 .- 2041-8205. ; 734:L1, s. 1-9
-
Tidskriftsartikel (refereegranskat)abstract
- Earth- and space-based observations provide synergistic information for space mission encounters by providing data over longer timescales, at different wavelengths and using techniques that are impossible with an in situ flyby. We report here such observations in support of the EPOXI spacecraft flyby of comet 103P/Hartley 2. The nucleus is small and dark, and exhibited a very rapidly changing rotation period. Prior to the onset of activity, the period was ~16.4?hr. Starting in 2010 August the period changed from 16.6?hr to near 19?hr in December. With respect to dust composition, most volatiles and carbon and nitrogen isotope ratios, the comet is similar to other Jupiter-family comets. What is unusual is the dominance of CO 2 -driven activity near perihelion, which likely persists out to aphelion. Near perihelion the comet nucleus was surrounded by a large halo of water-ice grains that contributed significantly to the total water production.
|
|
| 6. |
- Ademuyiwa, Adesoji O., et al.
(författare)
-
Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
-
Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
|
|
| 7. |
-
Highlights from the first year of Odin observations
- 2003
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 402, s. L39-L46
-
Tidskriftsartikel (refereegranskat)abstract
- Key Odin operational and instrumental features and highlights from our sub-millimetre and millimetre wave observations of H2O, H218O, NH3, 15NH3 and O2 are presented, with some insights into accompanying Odin Letters in this A&A issue. We focus on new results where Odin's high angular resolution, high frequency resolution, large spectrometer bandwidths, high sensitivity or/and frequency tuning capability are crucial: H2O mapping of the Orion KL, W3, DR21, S140 regions, and four comets; H2O observations of Galactic Centre sources, of shock enhanced H2O towards the SNR IC443, and of the candidate infall source IRAS 16293-2422; H218O detections in Orion KL and in comet Ikeya-Zhang; sub-mm detections of NH3 in Orion KL (outflow, ambient cloud and bar) and ρ Oph, and very recently, of 15NH3 in~Orion KL. Simultaneous sensitive searches for the 119 GHz line of O2 have resulted in very low abundance limits, which are difficult to accomodate in chemical models. We also demonstrate, by means of a quantitative comparison of Orion KL H2O results, that the Odin and SWAS observational data sets are very consistently calibrated. Odin is a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes), and the Centre National d'études Spatiales (CNES, France). The Swedish Space Corporation (SSC) has been the prime industrial contractor, and is also responsible for the satellite operation from its Odin Mission Control Centre at SSC in Solna and its Odin Control Centre at ESRANGE near Kiruna in northern Sweden. See also the SNSB Odin web page: http://www.snsb.se/eng_odin_intro.shtml
|
|
| 8. |
|
|
| 9. |
- Tomas, C, et al.
(författare)
-
Autosomal SNP typing of forensic samples with the GenPlex (TM) HID System: Results of a collaborative study
- 2011
-
Ingår i: Forensic Science International. - : Elsevier. - 1872-4973 .- 1878-0326. ; 5:5, s. 369-375
-
Tidskriftsartikel (refereegranskat)abstract
- The GenPlex (TM) HID System (Applied Biosystems - AB) offers typing of 48 of the 52 SNPforID SNPs and amelogenin. Previous studies have shown a high reproducibility of the GenPlex (TM) HID System using 250500 pg DNA of good quality. An international exercise was performed by 14 laboratories (9 in Europe and 5 in the US) in order to test the robustness and reliability of the GenPlex (TM) HID System on forensic samples. Three samples with partly degraded DNA and 10 samples with low amounts of DNA were analyzed in duplicates using various amounts of DNA. In order to compare the performance of the GenPlex (TM) HID System with the most commonly used STR kits, 500 pg of partly degraded DNA from three samples was typed by the laboratories using one or more STR kits. The median SNP typing success rate was 92.3% with 500 pg of partly degraded DNA. Three of the fourteen laboratories counted for more than two thirds of the locus dropouts. The median percentage of discrepant results was 0.2% with 500 pg degraded DNA. An increasing percentage of locus dropouts and discrepant results were observed when lower amounts of DNA were used. Different success rates were observed for the various SNPs. The rs763869 SNP was the least successful. With the exception of the MiniFiler (TM) kit (AB), GenPlex (TM) HID performed better than five other tested STR kits. When partly degraded DNA was analyzed, GenPlex (TM) HID showed a very low mean mach probability, while all STR kits except MiniFiler (TM) had very limited discriminatory power.
|
|
| 10. |
|
|
| 11. |
- Biver, N., et al.
(författare)
-
Isotopic ratios of H, C, N, O, and S in comets C/2012 F6 (Lemmon) and C/2014 Q2 (Lovejoy)
- 2016
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 589, s. Art. no. A78-
-
Tidskriftsartikel (refereegranskat)abstract
- The apparition of bright comets C/2012 F6 (Lemmon) and C/2014 Q2 (Lovejoy) in March-April 2013 and January 2015, combined with the improved observational capabilities of submillimeter facilities, offered an opportunity to carry out sensitive compositional and isotopic studies of the volatiles in their coma. We observed comet Lovejoy with the IRAM 30 m telescope between 13 and 26 January 2015, and with the Odin submillimeter space observatory on 29 January-3 February 2015. We detected 22 molecules and several isotopologues. The (H2O)-O-16 and (H2O)-O-18 production rates measured with Odin follow a periodic pattern with a period of 0.94 days and an amplitude of similar to 25%. The inferred isotope ratios in comet Lovejoy are O-16/O-18 = 499 +/- 24 and D/H = 1.4 +/- 0.4 x 10(-4) in water, S-32/S-34 = 24.7 +/- 3.5 in CS, all compatible with terrestrial values. The ratio C-12/C-13 = 109 +/- 14 in HCN is marginally higher than terrestrial and N-14/N-15 = 145 +/- 12 in HCN is half the Earth ratio. Several upper limits for D/H or C-12/C-13 in other molecules are reported. From our observation of HDO in comet C/2014 Q2 (Lovejoy), we report the first D/H ratio in an Oort Cloud comet that is not larger than the terrestrial value. On the other hand, the observation of the same HDO line in the other Oort-cloud comet, C/2012 F6 (Lemmon), suggests a D/H value four times higher. Given the previous measurements of D/H in cometary water, this illustrates that a diversity in the D/H ratio and in the chemical composition, is present even within the same dynamical group of comets, suggesting that current dynamical groups contain comets formed at very different places or times in the early solar system.
|
|
| 12. |
|
|
| 13. |
- Chiang, S. C. C., et al.
(författare)
-
Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production
- 2013
-
Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 121:8, s. 1345-1356
-
Tidskriftsartikel (refereegranskat)abstract
- Cytotoxic lymphocytes, encompassing cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, kill pathogen-infected, neoplastic, or certain hematopoietic cells through the release of perforin-containing lytic granules. In the present study, we first performed probability-state modeling of differentiation and lytic granule markers on CD8(+) T cells to enable the comparison of bona fide CTLs with NK cells. Analysis identified CD57(bright) expression as a reliable phenotype of granule marker-containing CTLs. We then compared CD3(+)CD8(+)CD57(bright) CTLs with NK cells. Healthy adult peripheral blood CD3(+)CD8(+)CD57(bright) CTLs expressed more granzyme B but less perforin than CD3(-)CD56(dim) NK cells. On stimulation, such CTLs degranulated more readily than other T-cell subsets, but had a propensity to degranulate that was similar to NK cells. Remarkably, the CTLs produced cytokines more rapidly and with greater frequency than NK cells. In patients with biallelic mutations in UNC13D, STX11, or STXBP2 associated with familial hemophagocytic lymphohistiocytosis, CTL and NK cell degranulation were similarly impaired. Therefore, cytotoxic lymphocyte subsets have similar requirements for Munc13-4, syntaxin-11, and Munc18-2 in lytic granule exocytosis. The present results provide a detailed comparison of human CD3(+)CD8(+)CD57(bright) CTLs and NK cells and suggest that analysis of CD57(bright) CTL function may prove useful in the diagnosis of primary immunodeficiencies including familial hemophagocytic lymphohistiocytosis.
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
- Frisk, Per, et al.
(författare)
-
Glucose metabolism and body composition in young adults treated with TBI during childhood
- 2011
-
Ingår i: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 46:10, s. 1303-1308
-
Tidskriftsartikel (refereegranskat)abstract
- After SCT in childhood, survivors may develop disorders of glucose metabolism. The role of obesity is controversial. We measured insulin sensitivity using the homeostasis model assessment (HOMA) and the frequently sampled i.v. glucose tolerance test (FSIVGTT), as well as body composition using dual-energy X-ray absorptiometry in 18 young adults median 18.2 years after SCT and compared them with matched controls. We also measured growth hormone (GH) secretion, and levels of leptin and adiponectin. HOMA showed insulin resistance in eight patients (44%), as opposed to none of the controls (P=0.008) and FSIVGTT showed a decreased sensitivity index in the patients (2.98 vs 4.54 mU/L/min, P=0.042). Dual energy X-ray absorptiometry showed a higher percentage fat mass in the patients (34.9 vs 24.3%, P=0.011), which correlated inversely with the sensitivity index (r=-0.52, P=0.032). The patients had a lower peak value of GH (GH(max) 9 vs 20.7 mU/L, P=0.002). Time post SCT correlated with percentage fat mass and inversely with GH(max). The patients had higher levels of leptin and lower levels of adiponectin, even after adjustment for fat mass. We propose that the decreased insulin sensitivity may primarily be explained by the adverse body composition, which may owe to long-standing GH deficiency.
|
|
| 17. |
- Frisk, U., et al.
(författare)
-
The Odin satellite - I. Radiometer design and test
- 2003
-
Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 402:3, s. L27-L34
-
Tidskriftsartikel (refereegranskat)abstract
- The Sub-millimetre and Millimetre Radiometer (SMR) is the main instrument on the Swedish, Canadian, Finnish and French spacecraft Odin. It consists of a 1.1 metre diameter telescope with four tuneable heterodyne receivers covering the ranges 486-504 GHz and 541-581 GHz, and one fixed at 118.75 GHz together with backends that provide spectral resolution from 150 kHz to 1 MHz. This Letter describes the Odin radiometer, its operation and performance with the data processing and calibration described in Paper II.
|
|
| 18. |
- Jiang, S., et al.
(författare)
-
Magnetic droplet soliton pairs
- 2024
-
Ingår i: Nature Communications. - : Nature Research. - 2041-1723. ; 15:1
-
Tidskriftsartikel (refereegranskat)abstract
- We demonstrate magnetic droplet soliton pairs in all-perpendicular spin-torque nano-oscillators (STNOs), where one droplet resides in the STNO free layer (FL) and the other in the reference layer (RL). Typically, theoretical, numerical, and experimental droplet studies have focused on the FL, with any additional dynamics in the RL entirely ignored. Here we show that there is not only significant magnetodynamics in the RL, but the RL itself can host a droplet driven by, and coexisting with, the FL droplet. Both single droplets and pairs are observed experimentally as stepwise changes and sharp peaks in the dc and differential resistance, respectively. While the single FL droplet is highly stable, the coexistence state exhibits high-power broadband microwave noise. Furthermore, micromagnetic simulations reveal that the pair dynamics display periodic, quasi-periodic, and chaotic signatures controlled by applied field and current. The strongly interacting and closely spaced droplet pair offers a unique platform for fundamental studies of highly non-linear soliton pair dynamics.
|
|
| 19. |
- Johansson, S. C., et al.
(författare)
-
Surface modification of PM gearlever
- 2010
-
Ingår i: World Powder Metallurgy Congress and Exhibition, World PM 2010; Florence; Italy; 10 October 2010 through 14 October 2010. - : European Powder Metallurgy Association (EPMA). - 9781899072194 ; 3
-
Konferensbidrag (refereegranskat)abstract
- A novel manufacturing concept for a gearlever has been evaluated by manufacturing of test components of two materials. Iron-based powders were used, and pressing and sintering was followed by a few different variants of hardening and surface densification. The components have been evaluated by means of component function testing, component fatigue testing, microstructure characterization, hardness measurements and residual stress determination. The gearlever is found to perform well in the function testing and shows also good fatigue properties that well match the demands for the intended application. The porosity in the sintered material is inhomogeneous, and some compaction-induced defects were observed in the material, which thus seems not to give any significant negative impact on the sintered product performance. The results show a doubling in hardness after hardening. If the materials were shot-peened (or shot-blasted) after hardening the surface hardness increased down to a depth of approximately 0.2 mm compared to the hardened material. The case-hardening should be applied after shot-peening to obtain significant effect on surface hardness within the outermost 0.1 mm. In principle no surface densification was created if shoot-peening was performed after hardening.
|
|
| 20. |
- Karlsson, S. C. Hannah, et al.
(författare)
-
Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy
- 2013
-
Ingår i: Cancer Gene Therapy. - : Springer Science and Business Media LLC. - 0929-1903 .- 1476-5500. ; 20:7, s. 386-393
-
Tidskriftsartikel (refereegranskat)abstract
- B-cell malignancies upregulate the B-cell lymphoma 2 (Bcl-2) family inhibitors of the intrinsic apoptosis pathway, making them therapy resistant. However, small-molecule inhibitors of Bcl-2 family members such as ABT-737 restore a functional apoptosis pathway in cancer cells, and its oral analog ABT-263 (Navitoclax) has entered clinical trials. Gene engineered chimeric antigen receptor (CAR) T cells also show promise in B-cell malignancy, and as they induce apoptosis via the extrinsic pathway, we hypothesized that small-molecule inhibitors of the Bcl-2 family may potentiate the efficacy of CAR T cells by engaging both apoptosis pathways. CAR T cells targeting CD19 were generated from healthy donors as well as from pre-B-ALL (precursor-B acute lymphoblastic leukemia) patients and tested together with ABT-737 to evaluate apoptosis induction in five B-cell tumor cell lines. The CAR T cells were effective even if the cell lines exhibited different apoptosis resistance profiles, as shown by analyzing the expression of apoptosis inhibitors by PCR and western blot. When combining T-cell and ABT-737 therapy simultaneously, or with ABT-737 as a presensitizer, tumor cell apoptosis was significantly increased. In conclusion, the apoptosis inducer ABT-737 enhanced the efficacy of CAR T cells and could be an interesting drug candidate to potentiate T-cell therapy.
|
|
| 21. |
- Larsson, B., et al.
(författare)
-
First NH3 detection of the Orion Bar
- 2003
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 402, s. L69-L72
-
Tidskriftsartikel (refereegranskat)abstract
- Odin has successfully observed three regions in the Orion A cloud, i.e. Ori KL, Ori S and the Orion Bar, in the 572.5 GHz rotational ground state line of ammonia, ortho-NH3 (J,K) = (1,0) -> (0,0), and the result for the Orion Bar represents the first detection in an ammonia line. Several velocity components are present in the data. Specifically, the observed line profile from the Orion Bar can be decomposed into two components, which are in agreement with observations in high-J CO lines by Wilson et al. (\cite{wilson01}). Using the source model for the Orion Bar by these authors, our Odin observation implies a total ammonia abundance of NH3/H2 = 5x 10-9. Based on observations with Odin, a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes) and Centre National d'Études Spatiales (CNES). The Swedish Space Corporation has been the industrial prime contractor.
|
|
| 22. |
- Lehnert, O., et al.
(författare)
-
New Ordovician-Silurian drill cores from the Siljan impact structure in central Sweden: an integral part of the Swedish Deep Drilling Program
- 2012
-
Ingår i: Gff. - : Informa UK Limited. - 1103-5897 .- 2000-0863. ; 134:2, s. 87-98
-
Tidskriftsartikel (refereegranskat)abstract
- New drill cores from the largest known impact structure in Europe, the relict of the Siljan meteorite crater, provide new possibilities to reconstruct Early Palaeozoic marine environments and ecosystems, and to document changes in sedimentary facies, sea level and palaeoclimate in Baltoscandia. The impact crater is an important target of the project "Concentric Impact Structures in the Palaeozoic" within the framework of the "Swedish Deep Drilling Program". Two core sections, Mora 001 and Solberga 1, have been analysed. The sedimentary successions of these core sections include strata of late Tremadocian through late Wenlock ages. Our preliminary studies show not only that several of the classical Palaeozoic units of Sweden are represented in the area, but also that other significantly different facies are preserved in the Siljan district. An erosional unconformity representing a substantial hiatus occurs between Middle Ordovician limestone and a Llandovery-Wenlock (Silurian) shale succession in the western part of the Siljan structure and suggests an extended period of uplift and erosion. This may be related to forebulge migration due to flexural loading by the Caledonian thrust sheet to the west. Thus, this part of Sweden, previously regarded as a stable cratonic area, presumably was affected by the Caledonian collision between Baltica and Laurentia.
|
|
| 23. |
- Pagani, L., et al.
(författare)
-
Low upper limits on the O2 abundance from the Odin satellite
- 2003
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 402, s. L77-L81
-
Tidskriftsartikel (refereegranskat)abstract
- For the first time, a search has been conducted in our Galaxy for the 119 GHz transition connecting to the ground state of O2, using the Odin satellite. Equipped with a sensitive 3 mm receiver (Tsys(SSB) = 600 K), Odin has reached unprecedented upper limits on the abundance of O2, especially in cold dark clouds where the excited state levels involved in the 487 GHz transition are not expected to be significantly populated. Here we report upper limits for a dozen sources. In cold dark clouds we improve upon the published SWAS upper limits by more than an order of magnitude, reaching N(O2)/N(H2) <= 10-7 in half of the sources. While standard chemical models are definitively ruled out by these new limits, our results are compatible with several recent studies that derive lower O2 abundances. Goldsmith et al. (\cite{SWAS2002}) recently reported a SWAS tentative detection of the 487 GHz transition of O2 in an outflow wing towards rho Oph A in a combination of 7 beams covering approximately 10arcmin x 14arcmin . In a brief (1.3 hour integration time) and partial covering of the SWAS region (~65% if we exclude their central position), we did not detect the corresponding 119 GHz line. Our 3 sigma upper limit on the O2 column density is 7.3x 1015 cm-2. We presently cannot exclude the possibility that the SWAS signal lies mostly outside of the 9\arcmin Odin beam and has escaped our sensitive detector. Based on observations with Odin, a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes) and Centre National d'Études Spatiales (CNES). The Swedish Space Corporation was the industrial prime contractor and is operating Odin.
|
|
| 24. |
|
|
| 25. |
- Ponten, E, et al.
(författare)
-
A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1
- 2022
-
Ingår i: Journal of medical genetics. - : BMJ. - 1468-6244 .- 0022-2593. ; 59:2, s. 141-146
-
Tidskriftsartikel (refereegranskat)abstract
- Germline pathogenic variants in DICER1 cause DICER1 syndrome, an autosomal dominant, pleiotropic tumour predisposition syndrome with variable expressivity and reduced penetrance for specific dysplastic and neoplastic lesions. Recently, a syndrome with the acronym GLOW (Global developmental delay, Lung cysts, Overgrowth, Wilms tumour) was described in two children with mosaic missense mutations in hotspot residues of the DICER1 RNase IIIb domain.MethodsWhole genome sequencing, exome sequencing, Sanger sequencing, digital PCR and a review of Wilms tumours with DICER1 RNase III domain mutations were performed.ResultsA de novo heterozygous c.4031C>T (p.S1344L) variant in the sequence encoding the RNase IIIa domain of DICER1 was detected. Clinical investigations revealed a phenotype that resembles the GLOW subphenotype of DICER1 syndrome.ConclusionThe phenotypic overlap between patients with p.S1344L mutation and GLOW syndrome provide clinical support for recent discoveries that RNase IIIa-Ser1344 site mutations impede miRNA-5p biogenesis analogous to DICER1 hotspot mutations in the RNase IIIb domain. We show that an individual with a heterozygous germline p.S1344L mutation has a severe form of DICER1 syndrome (‘DICER1 syndrome plus’), with notable features of intellectual disability, macrocephaly, physical abnormalities, Wilms tumour and a well-differentiated fetal adenocarcinoma of the lung.
|
|
| 26. |
|
|
| 27. |
|
|
| 28. |
|
|
| 29. |
|
|
| 30. |
|
|
| 31. |
|
|
| 32. |
|
|
| 33. |
- Bengtsson, S., et al.
(författare)
-
New Aluminium Alloy Tailored For Powder Bed Fusion - Laser Beam Process
- 2022
-
Ingår i: World PM 2022 Congress Proceedings.
-
Konferensbidrag (refereegranskat)abstract
- The powder bed fusion - laser beam (PBF-LB) process can produce parts with complex geometry. Light weight designs can be created and by using light alloys further weight savings can be achieved. However, minimizing printing defects using standard aluminium alloys, such as 2000, 6000 and 7000 series alloys, have proved to be difficult since they are all prone to solidification cracking. In the present study, two aluminium alloys are addressed: The first alloy is the AlSi10Mg alloy known for easy printing and consistent quality in PBF-LB printing process. The second material is a novel alloy from self-developed Al-Mn-Cr-Zr family of alloys designed to inherently resist solidification cracking, while also providing strong ageing response. The quality of printing and the resulting mechanical properties are compared. The results show that the new material prints in a robust way and that the mechanical properties are superior to those of AlSi10Mg.
|
|
| 34. |
|
|
| 35. |
- Biver, N., et al.
(författare)
-
Radio observations of Comet 9P/Tempel 1 before and after Deep Impact
- 2007
-
Ingår i: Icarus. - : Elsevier BV. - 1090-2643 .- 0019-1035. ; 191:2, s. 494-512
-
Tidskriftsartikel (refereegranskat)abstract
- Comet 9P/Tempel 1 was the target of a multi-wavelength worldwide investigation in 2005. The NASA Deep Impact mission reached the comet on 4.24 July 2005, delivering a 370-kg impactor which hit the comet at 10.3 km s -1 . Following this impact, a cloud of gas and dust was excavated from the comet nucleus. The comet was observed in 2005 prior to and after the impact, at 18-cm wavelength with the Nançay radio telescope, in the millimeter range with the IRAM and CSO radio telescopes, and at 557 GHz with the Odin satellite. OH observations at Nançay provided a 4-month monitoring of the outgassing of the comet from March to June, followed by the observation of H 2 O with Odin from June to August 2005. The peak of outgassing was found to be around 1 × 10 28 molec. s -1 between May and July. Observations conducted with the IRAM 30-m radio telescope in May and July 2005 resulted in detections of HCN, CH 3 OH and H 2 S with classical abundances relative to water (0.12, 2.7 and 0.5%, respectively). In addition, a variation of the HCN production rate with a period of 1.73 ± 0.10 days was observed in May 2005, consistent with the 1.7-day rotation period of the nucleus. The phase of these variations, as well as those of CN seen in July by Jehin et al. [Jehin, E., Manfroid, J., Hutsemékers, D., Cochran, A.L., Arpigny, C., Jackson, W.M., Rauer, H., Schulz, R., Zucconi, J.-M., 2006. Astrophys. J. 641, L145-L148], is consistent with a rotation period of the nucleus of 1.715 days and a strong variation of the outgassing activity by a factor 3 from minimum to maximum. This also implies that the impact took place on the rising phase of the "natural" outgassing which reached its maximum ≈4 h after the impact. Post-impact observations at IRAM and CSO did not reveal a significant change of the outgassing rates and relative abundances, with the exception of CH 3 OH which may have been more abundant by up to one order of magnitude in the ejecta. Most other variations are linked to the intrinsic variability of the comet. The Odin satellite monitored nearly continuously the H 2 O line at 557 GHz during the 38 h following the impact on the 4th of July, in addition to weekly monitoring. Once the periodic variations related to the nucleus rotation are removed, a small increase of outgassing related to the impact is present, which corresponds to the release of ≈ 5000 ± 2000 tons of water. Two other bursts of activity, also observed at other wavelengths, were seen on 23 June and 7 July; they correspond to even larger releases of gas. © 2006 Elsevier Inc. All rights reserved.
|
|
| 36. |
- Biver, N., et al.
(författare)
-
Radio observations of Comet 9P/Tempel 1 before and after Deep Impact
- 2007
-
Ingår i: Icarus. - : Elsevier BV. - 1090-2643 .- 0019-1035. ; 187:1, s. 253-271
-
Tidskriftsartikel (refereegranskat)abstract
- Comet 9P/Tempel 1 was the target of a multi-wavelength worldwide investigation in 2005. The NASA Deep Impact mission reached the comet on 4.24 July 2005, delivering a 370-kg impactor which hit the comet at 10.3 km s -1 . Following this impact, a cloud of gas and dust was excavated from the comet nucleus. The comet was observed in 2005 prior to and after the impact, at 18-cm wavelength with the Nançay radio telescope, in the millimeter range with the IRAM and CSO radio telescopes, and at 557 GHz with the Odin satellite. OH observations at Nançay provided a 4-month monitoring of the outgassing of the comet from March to June, followed by the observation of H 2 O with Odin from June to August 2005. The peak of outgassing was found to be around 1 × 10 28 molec. s -1 between May and July. Observations conducted with the IRAM 30-m radio telescope in May and July 2005 resulted in detections of HCN, CH 3 OH and H 2 S with classical abundances relative to water (0.12, 2.7 and 0.5%, respectively). In addition, a variation of the HCN production rate with a period of 1.73 ± 0.10 days was observed in May 2005, consistent with the 1.7-day rotation period of the nucleus. The phase of these variations, as well as those of CN seen in July by Jehin et al. [Jehin, E., Manfroid, J., Hutsemékers, D., Cochran, A.L., Arpigny, C., Jackson, W.M., Rauer, H., Schulz, R., Zucconi, J.-M., 2006. Astrophys. J. 641, L145-L148], is consistent with a rotation period of the nucleus of 1.715 days and a strong variation of the outgassing activity by a factor 3 from minimum to maximum. This also implies that the impact took place on the rising phase of the "natural" outgassing which reached its maximum ≈4 h after the impact. Post-impact observations at IRAM and CSO did not reveal a significant change of the outgassing rates and relative abundances, with the exception of CH 3 OH which may have been more abundant by up to one order of magnitude in the ejecta. Most other variations are linked to the intrinsic variability of the comet. The Odin satellite monitored nearly continuously the H 2 O line at 557 GHz during the 38 h following the impact on the 4th of July, in addition to weekly monitoring. Once the periodic variations related to the nucleus rotation are removed, a small increase of outgassing related to the impact is present, which corresponds to the release of ≈ 5000 ± 2000 tons of water. Two other bursts of activity, also observed at other wavelengths, were seen on 23 June and 7 July; they correspond to even larger releases of gas. © 2006 Elsevier Inc. All rights reserved.
|
|
| 37. |
|
|
| 38. |
|
|
| 39. |
|
|
| 40. |
- Crovisier, J., et al.
(författare)
-
The chemical composition of 9P/tempel 1 from radio observations
- 2009
-
Ingår i: ESO Astrophysics Symposia. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1431-2433 .- 1611-6143. - 9783540769583 ; 2009, s. 243-248
-
Konferensbidrag (refereegranskat)abstract
- In 2005, as part of a world-wide multi-wavelength investigation of comet 9P/Tempel 1 in support to the Deep Impact mission, we conducted radio spectroscopic observations with the Nançay radio telescope, the Odin satellite, the CSO 10-m and the IRAM 30-m telescopes. We report here our results concerning the chemical composition of the comet. The relative abundances of the detected species (H2O, CH3OH, H2S, HCN) or their upper limits (CO, H2CO, CS) are comparable to the mean values observed in other comets. No significant changes of the outgassing rates (except possibly for CH3OH) or of the molecular abundances were observed following the impact.
|
|
| 41. |
- Dawson, J. A., et al.
(författare)
-
Assessing the tongue colour of newly born infants may help to predict the need for supplemental oxygen in the delivery room
- 2015
-
Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 104:4, s. 356-359
-
Tidskriftsartikel (refereegranskat)abstract
- AimIt takes several minutes for infants to become pink after birth. Preductal oxygen saturation (SpO(2)) measurements are used to guide the delivery of supplemental oxygen to newly born infants, but pulse oximetry is not available in many parts of the world. We explored whether the pinkness of an infants tongue provided a useful indication that supplemental oxygen was required. MethodsThis was a prospective observational study of infants delivered by Caesarean section. Simultaneous recording of SpO(2) and visual assessment of whether the tongue was pink or not was made at 1-7 and 10min after birth. ResultsThe 38 midwives and seven paediatric trainees carried out 271 paired assessments on 68 infants with a mean (SD) birthweight of 3214 (545) grams and gestational age of 38 (2) weeks. When the infant did not have a pink tongue, this predicted SpO(2) of less than70% with a sensitivity of 26% and a specificity of 96%. ConclusionTongue colour was a specific but insensitive sign that indicated when SpO(2) was less than70%. When the tongue is pink, it is likely that an infant has an SpO(2) of more than 70% and does not require supplemental oxygen.
|
|
| 42. |
- de Bruijn, Winnie, et al.
(författare)
-
Introduction and Utilization of High Priced HCV Medicines across Europe : Implications for the Future
- 2016
-
Ingår i: Frontiers in Pharmacology. - : Frontiers Media SA. - 1663-9812. ; 7
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Infection with the Hepatitis C Virus (HCV) is a widespread transmittable disease with a diagnosed prevalence of 2.0%. Fortunately, it is now curable in most patients. Sales of medicines to treat HCV infection grew 2.7% per year between 2004 and 2011, enhanced by the launch of the protease inhibitors (Hs) boceprevir (BCV) and telaprevir (TVR) in addition to ribavirin and pegylated interferon (pegIFN). Costs will continue to rise with new treatments including sofosbuvir, which now include interferon free regimens. Objective: Assess the uptake of BCV and TVR across Europe from a health authority perspective to offer future guidance on dealing with new high cost medicines. Methods: Cross-sectional descriptive study of medicines to treat HCV (pegIEN, ribavirin, BCV and TVR) among European countries from 2008 to 2013. Utilization measured in defined daily doses (DDDs)/1000 patients/quarter (DIOs) and expenditure in Euros/DDD. Health authority activities to influence treatments categorized using the 4E methodology (Education, Engineering, Economics and Enforcement). Results: Similar uptake of BCV and TVR among European countries and regions, ranging from 0.5 DIQ in Denmark, Netherlands and Slovenia to 1.5 DIQ in Tayside and Catalonia in 2013. However, different utilization of the new Pls vs. ribavirin indicates differences in dual vs. triple therapy, which is down to factors including physician preference and genotypes. Reimbursed prices for BCV and TVR were comparable across countries. Conclusion: There was reasonable consistency in the utilization of BCV and TVR among European countries in comparison with other high priced medicines. This may reflect the social demand to limit the transmission of HCV. However, the situation is changing with new curative medicines for HCV genotype 1 (GT1) with potentially an appreciable budget impact. These concerns have resulted in different prices across countries, with their impact on budgets and patient outcomes monitored in the future to provide additional guidance.
|
|
| 43. |
|
|
| 44. |
|
|
| 45. |
|
|
| 46. |
- Ebbestad, Jan Ove R., et al.
(författare)
-
Terminal Ordovician stratigraphy of the Siljan district, Sweden
- 2015
-
Ingår i: GFF. - : Informa UK Limited. - 1103-5897 .- 2000-0863. ; 137:1, s. 36-56
-
Forskningsöversikt (refereegranskat)abstract
- Integration of new isotopic data and earlier biostratigraphic information from eight sections through the terminal Ordovician (Pirgu and Porkuni stages) of the Siljan district, Sweden, allows a more precise correlation of sections in terms of biostratigraphy and carbon isotope dating. Four levels with positive delta C-13 excursions are identified (from bottom) - the Moe, an unnamed excursion, Paroveja and Hirnantian Carbon Isotope Excursion (HICE). The delta C-13 values through the Boda Limestone are 1-2 parts per thousand higher than usual in Baltica, only the values for the HICE remains within what is expected. Background values increase from 1.5 parts per thousand in the bottom of the core of the Boda Limestone up to 3 parts per thousand in the top of it. The HICE is identified in five of eight sections and the main peak falls according to inferred correlation within the Metabolograptus persculptus Biozone, at or close to the Hindella beds in the Upper Boda Member. The late Katian (Pirgu) age of Holorhynchus in the Siljan district is clear and its co-occurrence with the chitinozoan Belonechitina gamachiana in Estonia supports a Katian age for this zone. The base of the Ozarkodina hassi Biozone may occur within units B-C of the Upper Boda Member and in the upper part of the Loka Formation and most likely is correlated with the M. persculptus Biozone. The Hirnantia-Dalmanitina faunas reported from the lowermost part of the Loka Formation and units B-D of the Upper Boda Member seem to range through all the Hirnantian, but detailed morphological studies allow to distinguish an older (=extraordinarius) and a younger (=persculptus) fauna.
|
|
| 47. |
|
|
| 48. |
|
|
| 49. |
|
|
| 50. |
|
|
