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Sökning: WFRF:(Gårevik Nina)

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1.
  • Giedraitis, Vilmantas, et al. (författare)
  • The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease
  • 2007
  • Ingår i: Neuroscience Letters. - : Elsevier BV. - 0304-3940 .- 1872-7972. ; 427:3, s. 127-131
  • Tidskriftsartikel (refereegranskat)abstract
    • Amyloid-beta (A beta) with 40 (A beta 40) and 42 (A beta 42) amino acids, the main components of amyloid plaques in the Alzheimer's disease (AD) brain, can be measured in human cerebrospinal fluid (CSF) and plasma. Whereas CSF A beta 42 is decreased in AD, some studies have reported changed plasma A beta levels in AD and in subjects with mild cognitive impairment (MCI). To this date it is unclear if and how CSF and plasma levels of A beta correlate with each other in healthy individuals, albeit earlier studies on AD patients found no correlation between CSF and plasma A beta. We have measured A beta 40 and A beta 42 in paired CSF and plasma samples from patients with AD (n=39), MCI (n=29) and healthy control subjects (n= 18). We observed a clear correlation between CSF and plasma levels for both A beta 40 and A beta 42 in healthy individuals, whereas no such correlation could be seen for AD or MCI cases. Similarly to other studies we also found low levels of A beta 42 in AD CSF, whereas there were no significant differences in plasma A beta levels between the diagnostic groups. Our findings suggest that the normal equilibrium between CSF and plasma A beta may be disrupted with the initiation of amyloid deposition in the brain.
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2.
  • Gårevik, Nina (författare)
  • Quantitative influence of exogenous androgens on serum lipid profile and endocrine functions
  • 2013
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Anabolic androgenic steroids (AAS) in doping have been a concern predominantly in sports. The focus has now switched to the doping in the society which is a significant problem for the public health. The abuse of AAS is associated with mental and somatic side effects and with the use of several other drugs including narcotics. This thesis focuses on the effects of AAS, particularly nandrolone and testosterone, on the serum lipid profile and endocrine functions. We found a frequent co-abuse of AAS and narcotics among young people taken into custody for criminal activity. The two most common abused AAS were nandrolone and testosterone. We found a sustained suppression of LH and FSH for several months, sometimes 1 year. The suppression correlated significantly with the 19- norandrosterone (19-NA) metabolite of nandrolone in urine in individuals without co- abuse of narcotics. In healthy volunteers LH remained supressed up to 6 weeks after a dose of 500 mg and even suppressed below lower limit of reference range for two individuals. These results indicate that AAS have a more profound endocrine effect on the hypothalamic-pituitary-adrenal -axis than previously known. Altered blood-lipids profile was normalized within 6 months after cessation of AAS abuse. We found an early effect on the blood-lipid profile after a single dose of testosterone enanthate. Two days after testosterone injection, total cholesterol was increased and followed by a decrease in HDL and ApoA1 four and fourteen days after dose. The minimal dose for these alterations in the blood lipids and for increased serum testosterone concentrations was 250 mg. The impact on the cholesterol homeostasis may be mediated by an increase of the HMGCR expression. There was a marked impact of the uridine glucuronosyl transferase 2B17 (UGT2B17) polymorphism on the T/E ratio in AAS abusers and some of the testosterone abusers did not test positive due to a genetic deletion polymorphism of the UGT2B17. Increased knowledge and understanding of side-effects induced by AAS is important in order to find measures for treatment and care of these abusers.
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