| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Aad, G., et al.
(författare)
-
- 2010
-
swepub:Mat__t
|
|
| 5. |
- Aad, G., et al.
(författare)
-
- 2011
-
swepub:Mat__t
|
|
| 6. |
- Aad, G., et al.
(författare)
-
- 2010
-
swepub:Mat__t
|
|
| 7. |
- Aad, G., et al.
(författare)
-
- 2010
-
swepub:Mat__t
|
|
| 8. |
- Aad, G., et al.
(författare)
-
- 2010
-
swepub:Mat__t
|
|
| 9. |
- Bi, Xiao Jun, et al.
(författare)
-
Chapter 5 Dark Matter and New Physics Beyond the Standard Model with LHAASO
- 2022
-
Ingår i: Chinese Physics C. - : IOP Publishing. - 1674-1137 .- 2058-6132. ; 46:3
-
Tidskriftsartikel (refereegranskat)abstract
- In order to reveal the nature of dark matter, it is crucial to detect its non-gravitational interactions with the standard model particles. The traditional dark matter searches focused on the so-called weakly interacting massive particles. However, this paradigm is strongly constrained by the null results of current experiments with high precision. Therefore there is a renewed interest of searches for heavy dark matter particles above TeV scale. The Large High Altitude Air Shower Observatory (LHAASO) with large effective area and strong background rejection power is very suitable to investigate the gamma-ray signals induced by dark matter annihilation or decay above TeV scale. In this document, we review the theoretical motivations and background of heavy dark matter. We review the prospects of searching for the gamma-ray signals resulted from dark matter in the dwarf spheroidal satellites and Galactic halo for LHAASO, and present the projected sensitivities. We also review the prospects of searching for the axion-like particles, which are a kind of well motivated light pseudo-scalars, through the LHAASO measurement of the very high energy gamma-ray spectra of astrophysical sources.
|
|
| 10. |
- Li, Shuqi, et al.
(författare)
-
Rtt105 functions as a chaperone for replication protein A to preserve genome stability
- 2018
-
Ingår i: EMBO Journal. - : Wiley-VCH Verlagsgesellschaft. - 0261-4189 .- 1460-2075. ; 37:17
-
Tidskriftsartikel (refereegranskat)abstract
- Generation of single-stranded DNA (ssDNA) is required for the template strand formation during DNA replication. Replication Protein A (RPA) is an ssDNA-binding protein essential for protecting ssDNA at replication forks in eukaryotic cells. While significant progress has been made in characterizing the role of the RPA-ssDNA complex, how RPA is loaded at replication forks remains poorly explored. Here, we show that the Saccharomyces cerevisiae protein regulator of Ty1 transposition 105 (Rtt105) binds RPA and helps load it at replication forks. Cells lacking Rtt105 exhibit a dramatic reduction in RPA loading at replication forks, compromised DNA synthesis under replication stress, and increased genome instability. Mechanistically, we show that Rtt105 mediates the RPA-importin interaction and also promotes RPA binding to ssDNA directly in vitro, but is not present in the final RPA-ssDNA complex. Single-molecule studies reveal that Rtt105 affects the binding mode of RPA to ssDNA These results support a model in which Rtt105 functions as an RPA chaperone that escorts RPA to the nucleus and facilitates its loading onto ssDNA at replication forks.
|
|
