| 1. |
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| 2. |
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| 3. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 4. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Sampson, Joshua N., et al.
(författare)
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Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
- 2015
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 107:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
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| 6. |
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| 7. |
- Wang, Fang, et al.
(författare)
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Emerging contaminants: A One Health perspective
- 2024
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Ingår i: Innovation. - 2666-6758. ; 5
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Forskningsöversikt (refereegranskat)abstract
- Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health. Despite global efforts to mitigate legacy pollutants, the continuous introduction of new substances remains a major threat to both people and the planet. In response, global initiatives are focusing on risk assessment and regulation of emerging contaminants, as demonstrated by the ongoing efforts to establish the UN's Intergovernmental Science-Policy Panel on Chemicals, Waste, and Pollution Prevention. This review identifies the sources and impacts of emerging contaminants on planetary health, emphasizing the importance of adopting a One Health approach. Strategies for monitoring and addressing these pollutants are discussed, underscoring the need for robust and socially equitable environmental policies at both regional and international levels. Urgent actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.
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| 8. |
- Chen, Daru, et al.
(författare)
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Wavelength-spacing continuously tunable multiwavelength erbium-doped fibre laser based on DSF and MZI
- 2007
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Ingår i: Electronics Letters. - : Institution of Engineering and Technology (IET). - 0013-5194 .- 1350-911X. ; 43:9, s. 524-525
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Tidskriftsartikel (refereegranskat)abstract
- A novel multiwavelength erbium-doped fibre laser is proposed by incorporating a section of dispersion-shifted fibre (DSF) and a Mach-Zehnder interferometer (MZI). The wavelength spacing of the fibre laser can be continuously tuned by adjusting an optical variable delay line in the MZI-based comb filter. Stable multiwavelength lasing at room temperature with the standard ITU (International Telecommunication Union) channel spacing of 0.2 nm (25 GHz), 0.4 nm (50 GHz), 0.8 nm (100 GHz) or 1.6 nm (200 GHz) is demonstrated.
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| 9. |
- Cho, Yoon Shin, et al.
(författare)
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Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
- 2012
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:1
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Tidskriftsartikel (refereegranskat)abstract
- We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D.
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| 10. |
- Duan, Chen, et al.
(författare)
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Comparative analysis of gene expression profiles between primary knee osteoarthritis and an osteoarthritis endemic to Northwestern China, Kashin-Beck disease.
- 2010
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Ingår i: Arthritis and Rheumatism. - : John Wiley & Sons. - 0004-3591 .- 1529-0131. ; 62:3, s. 771-780
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To investigate the differences in gene expression profiles of adult articular cartilage from patients with Kashin-Beck disease (KBD) versus those with primary knee osteoarthritis (OA).METHODS: The messenger RNA expression profiles of articular cartilage from patients with KBD, diagnosed according to the clinical criteria for KBD in China, were compared with those of cartilage from patients with OA, diagnosed according to the Western Ontario and McMaster Universities OA Index. Total RNA was isolated separately from 4 pairs of the KBD and OA cartilage samples, and the expression profiles were evaluated by Agilent 4x44k Whole Human Genome density oligonucleotide microarray analysis. The microarray data for selected transcripts were confirmed by quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) amplification.RESULTS: For 1.2 x 10(4) transcripts, corresponding to 58.4% of the expressed transcripts, 2-fold changes in differential expression were revealed. Expression levels higher in KBD than in OA samples were observed in a mean + or - SD 6,439 + or - 1,041 (14.6 + or - 2.4%) of the transcripts, and expression levels were lower in KBD than in OA samples in 6,147 + or - 1,222 (14.2 + or - 2.8%) of the transcripts. After application of the selection criteria, 1.85% of the differentially expressed genes (P < 0.001 between groups) were detected. These included 233 genes, of which 195 (0.4%) were expressed at higher levels and 38 (0.08%) were expressed at lower levels in KBD than in OA cartilage. Comparisons of the quantitative RT-PCR data supported the validity of our microarray data.CONCLUSION: Differences between KBD and OA cartilage exhibited a similar pattern among all 4 of the pairs examined, indicating the presence of disease mechanisms, mainly chondrocyte matrix metabolism, cartilage degeneration, and apoptosis induction pathways, which contribute to cartilage destruction in KBD.
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| 11. |
- Feitosa, Mary F., et al.
(författare)
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Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
- 2018
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Ingår i: PLOS ONE. - : Public library science. - 1932-6203. ; 13:6
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Tidskriftsartikel (refereegranskat)abstract
- Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in approximate to 131 K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P <1.0 x 10(-5)). In Stage 2, these SNVs were tested for independent external replication in individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10(-8)). For African ancestry samples, we detected 18 potentially novel BP loci (P< 5.0 x 10(-8)) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2 have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension.
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| 12. |
- Gao, Shiming, et al.
(författare)
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Bandwidth enhancement methods of telecom-region entangled twin photons via quasi-phase-matched spontaneous parametric down-conversion
- 2006
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Ingår i: Journal of nonlinear optical physics and materials. - 0218-8635. ; 15:4, s. 513-521
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Tidskriftsartikel (refereegranskat)abstract
- We theoretically present the bandwidth enhancement methods of the telecom-region entangled twin photons generated by quasi-phase-matched (QPM) spontaneous parametric down-conversion (SPDC) in periodically poled lithium niobate (PPLN) crystals. By using type I (e --> e + e) SPDC, the degenerate entangled twin photons will have a broad bandwidth and it can be further enhanced by shortening the crystal length, detuning the pump wavelength or adjusting the working temperature of the PPLN crystal. This principle provides the possibility to introduce wavelength-division-multiplexed technique into quantum information systems.
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| 13. |
- Gao, Ying, et al.
(författare)
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ALL-OPTICAL FREQUENCY CONVERTER BASED ON FIBER FOUR-WAVE MIXING FOR BIDIRECTIONAL RADIO-OVER-FIBER SYSTEMS
- 2009
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Ingår i: Microwave and optical technology letters (Print). - : Wiley. - 0895-2477 .- 1098-2760. ; 51:6, s. 1542-1545
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Tidskriftsartikel (refereegranskat)abstract
- A frequency up/down-converter is proposed based on fiber-four-wave-mixing (FWM) between the output of a dual-wavelength fiber laser and the modulated optical carrier for bidirection radio-over-fiber (RoF) systems. Frequency, up-conversion from 1.50 to 11.08 GHz and down-conversion from 10.60 to 1.02 GHz are successfully demonstrated and a small efficiency difference between up- and down-conversions has been achieved. A proposal of setting up a bidirectional RoF system based on fiber FWM frequency converter is presented.
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| 14. |
- Gao, Yun, et al.
(författare)
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Microsecond-response perovskite light-emitting diodes for active-matrix displays
- 2024
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Ingår i: NATURE ELECTRONICS. - : NATURE PORTFOLIO. - 2520-1131. ; 7:6
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Tidskriftsartikel (refereegranskat)abstract
- Perovskite light-emitting diodes (PeLEDs) could be of use in the development of active-matrix displays. However, due to ion migration in crystal structure, PeLEDs have electroluminescence rise times over milliseconds, which is problematic for the development of high-refresh-rate displays. Here, we show that the electroluminescence rise time of PeLEDs can be reduced to microseconds using an individual-particle passivation strategy. The approach is based on BF4 - ions that can passivate every nanocrystal in a perovskite emissive layer during film deposition. It leads to a defect-free film with discrete nanostructure and excellent crystallinity, which inhibits ion migration. Our strategy can be applied in perovskite nanocrystal films with different colours: red (635 nm), green (520 nm) and blue (475 nm). These PeLEDs all demonstrate response times within microseconds and high external quantum efficiencies of 22.7%, 26.2% and 18.1%, respectively. This allows us to create microsecond-response active-matrix PeLEDs that exhibit external quantum efficiencies above 20% at a display brightness of 500-3,000 cd m-2 for green devices with a resolution of 30 pixels per inch. We also develop microsecond-response red, green and blue active-matrix displays with 90 pixels per inch. An individual-particle passivation strategy that reduces ion migration in perovskite nanocrystal film can be used to make high-refresh-rate active-matrix displays with microsecond response times reduced by three orders of magnitude compared with typical perovskite light-emitting diodes.
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| 15. |
- Huang, C. Y., et al.
(författare)
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The Cardamine enshiensis genome reveals whole genome duplication and insight into selenium hyperaccumulation and tolerance
- 2021
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Ingår i: Cell Discovery. - : Springer Science and Business Media LLC. - 2056-5968. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- Cardamine enshiensis is a well-known selenium (Se)-hyperaccumulating plant. Se is an essential trace element associated with many health benefits. Despite its critical importance, genomic information of this species is limited. Here, we report a chromosome-level genome assembly of C. enshiensis, which consists of 443.4 Mb in 16 chromosomes with a scaffold N50 of 24 Mb. To elucidate the mechanism of Se tolerance and hyperaccumulation in C. enshiensis, we generated and analyzed a dataset encompassing genomes, transcriptomes, and metabolomes. The results reveal that flavonoid, glutathione, and lignin biosynthetic pathways may play important roles in protecting C. enshiensis from stress induced by Se. Hi-C analysis of chromatin interaction patterns showed that the chromatin of C. enshiensis is partitioned into A and B compartments, and strong interactions between the two telomeres of each chromosome were correlated with histone modifications, epigenetic markers, DNA methylation, and RNA abundance. Se supplementation could affect the 3D chromatin architecture of C. enshiensis at the compartment level. Genes with compartment changes after Se treatment were involved in selenocompound metabolism, and genes in regions with topologically associated domain insulation participated in cellular responses to Se, Se binding, and flavonoid biosynthesis. This multiomics research provides molecular insight into the mechanism underlying Se tolerance and hyperaccumulation in C. enshiensis.
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| 16. |
- Jin, Ying-Hui, et al.
(författare)
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Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19 : An evidence-based clinical practice guideline (updated version)
- 2020
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Ingår i: Military Medical Research. - : Springer Science and Business Media LLC. - 2054-9369. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued "A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)"; now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline. We formed a working group of clinical experts and methodologists. The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas: chemoprophylaxis, diagnosis, treatments, and discharge management. We searched the literature for direct evidence on the management of COVID-19, and assessed its certainty generated recommendations using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Recommendations were either strong or weak, or in the form of ungraded consensus-based statement. Finally, we issued 34 statements. Among them, 6 were strong recommendations for, 14 were weak recommendations for, 3 were weak recommendations against and 11 were ungraded consensus-based statement. They covered topics of chemoprophylaxis (including agents and Traditional Chinese Medicine (TCM) agents), diagnosis (including clinical manifestations, reverse transcription-polymerase chain reaction (RT-PCR), respiratory tract specimens, IgM and IgG antibody tests, chest computed tomography, chest x-ray, and CT features of asymptomatic infections), treatments (including lopinavir-ritonavir, umifenovir, favipiravir, interferon, remdesivir, combination of antiviral drugs, hydroxychloroquine/chloroquine, interleukin-6 inhibitors, interleukin-1 inhibitors, glucocorticoid, qingfei paidu decoction, lianhua qingwen granules/capsules, convalescent plasma, lung transplantation, invasive or noninvasive ventilation, and extracorporeal membrane oxygenation (ECMO)), and discharge management (including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge). We also created two figures of these recommendations for the implementation purpose. We hope these recommendations can help support healthcare workers caring for COVID-19 patients.
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| 17. |
- Kato, Norihiro, et al.
(författare)
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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
- 2015
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 47:11, s. 1282-1293
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Tidskriftsartikel (refereegranskat)abstract
- We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10−6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.
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| 18. |
- Song, Yanling, et al.
(författare)
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Growth of winter wheat adapting to climate warming may face more low-temperature damage
- 2023
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Ingår i: International Journal of Climatology. - : Wiley. - 0899-8418 .- 1097-0088. ; 43:4, s. 1970-9
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Tidskriftsartikel (refereegranskat)abstract
- China's surface air temperature is increasing due to global warming, so it is interesting that how low temperatures would be changed during the growth period of winter wheat in future. We focused on the low temperatures of winter wheat from 2021 to 2050, using temperatures under the high emission scenario Representative Concentration Pathway 8.5 (RCP8.5) projected by the RegCM4.4 regional climate model. The results showed that the annual mean temperature was projected to increase by 0.42°C⋅decade−1 in the northern and by 0.35°C⋅decade−1 in the southern winter wheat region. Furthermore, the temperature was expected to increase rapidly in spring, which could advance the dates of flowering and the start of the grain-filling period. Using the genetic parameters determined by the calibration and validation of WOFOST and bias-corrected projected meteorological data, simulations of winter wheat growth were performed over the winter wheat region for 2021–2050. The simulated number of days to the flowering period of winter wheat for 2041–2050 was on average 6.5 days less than in 2021–2030, due to the spring warming. Because of the earlier start of the growing season, winter wheat could face negative effects by being subjected to low temperatures. Indeed, the number of low-temperature days was projected to increase by 110% from 2041 to 2050 compared to 2021–2030, and the number of killing degree days (KDDs) is projected to increase by 120% at the same time. If the number of days to flowering did not change, the number of low-temperature days and KDDs only changed slightly, showing that the negative influence of low temperature was mainly caused by the advancement of the flowering date. The effect of low temperature on growth was underestimated when the response of winter wheat growth to global warming was not considered.
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| 19. |
- Sung, Yun Ju, et al.
(författare)
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A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
- 2019
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 28:15, s. 2615-2633
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Tidskriftsartikel (refereegranskat)abstract
- Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene–smoking interaction analysis and 38 were newly identified (P < 5 × 10−8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings.
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| 20. |
- Wang, Zhaoming, et al.
(författare)
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Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
- 2014
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
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| 21. |
- Xue, Qingwen, et al.
(författare)
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A Context-Aware Framework for Risky Driving Behavior Evaluation Based on Trajectory Data
- 2023
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Ingår i: IEEE Intelligent Transportation Systems Magazine. - 1939-1390 .- 1941-1197. ; 15:1, s. 70-83
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Tidskriftsartikel (refereegranskat)abstract
- Risky driving behaviors are one of the key contributors to traffic accidents. The rapid and accurate identification of them is important to improve the safety of the driving environment. This study introduces a contextaware framework for the evaluation of risky driving behaviors based on trajectory data. It consists of three models to identify the context, determine risky maneuvers, and evaluate risky driving behaviors. We first propose a surrogate-based method to label risky maneuvers considering context factors. Then, the features of driving trajectories are extracted as the input features for the evaluation of risky behavior. Based on the labeling result and maneuver features, supervised machine learning algorithms are leveraged to model their relationships for evaluations. Three feature extraction methods and five classifiers are compared in this article to select the most suitable one. Last, a context-aware evaluation framework is proposed to recognize risky driving behaviors incorporating context. The trajectory data extracted from unmanned aerial vehicles are used to validate the proposed framework. The results show that the accuracy of risky driving behaviors evaluation could reach 97%. The proposed framework in this study can effectively evaluate risky driving behaviors based on trajectory data with the consideration of context factors.
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| 22. |
- You, Xiaohu, et al.
(författare)
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Towards 6G wireless communication networks: vision, enabling technologies, and new paradigm shifts
- 2021
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Ingår i: Science China Information Sciences. - : Science Press. - 1674-733X .- 1869-1919. ; 64:1
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Forskningsöversikt (refereegranskat)abstract
- The fifth generation (5G) wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized, such as mass connectivity, ultra-reliability, and guaranteed low latency. However, 5G will not meet all requirements of the future in 2030 and beyond, and sixth generation (6G) wireless communication networks are expected to provide global coverage, enhanced spectral/energy/cost efficiency, better intelligence level and security, etc. To meet these requirements, 6G networks will rely on new enabling technologies, i.e., air interface and transmission technologies and novel network architecture, such as waveform design, multiple access, channel coding schemes, multi-antenna technologies, network slicing, cell-free architecture, and cloud/fog/edge computing. Our vision on 6G is that it will have four new paradigm shifts. First, to satisfy the requirement of global coverage, 6G will not be limited to terrestrial communication networks, which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle (UAV) communication networks, thus achieving a space-air-ground-sea integrated communication network. Second, all spectra will be fully explored to further increase data rates and connection density, including the sub-6 GHz, millimeter wave (mmWave), terahertz (THz), and optical frequency bands. Third, facing the big datasets generated by the use of extremely heterogeneous networks, diverse communication scenarios, large numbers of antennas, wide bandwidths, and new service requirements, 6G networks will enable a new range of smart applications with the aid of artificial intelligence (AI) and big data technologies. Fourth, network security will have to be strengthened when developing 6G networks. This article provides a comprehensive survey of recent advances and future trends in these four aspects. Clearly, 6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears.
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| 23. |
- Zhang, Huai, et al.
(författare)
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A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease.
- 2024
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Ingår i: Hepatology international. - 1936-0541.
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Tidskriftsartikel (refereegranskat)abstract
- With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020, it is important to establish consensus for the coding of MAFLD in ICD-11. This will inform subsequent revisions of ICD-11.Using the Qualtrics XM and WJX platforms, questionnaires were sent online to MAFLD-ICD-11 coding collaborators, authors of papers, and relevant association members.A total of 890 international experts in various fields from 61 countries responded to the survey. We also achieved full coverage of provincial-level administrative regions in China. 77.1% of respondents agreed that MAFLD should be represented in ICD-11 by updating NAFLD, with no significant regional differences (77.3% in Asia and 76.6% in non-Asia, p=0.819). Over 80% of respondents agreed or somewhat agreed with the need to assign specific codes for progressive stages of MAFLD (i.e. steatohepatitis) (92.2%), MAFLD combined with comorbidities (84.1%), or MAFLD subtypes (i.e., lean, overweight/obese, and diabetic) (86.1%).This global survey by a collaborative panel of clinical, coding, health management and policy experts, indicates agreement that MAFLD should be coded in ICD-11. The data serves as a foundation for corresponding adjustments in the ICD-11 revision.
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| 24. |
- Zheng, Shao Fei, et al.
(författare)
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Theoretical and Three-Dimensional Molecular Dynamics Study of Droplet Wettability and Mobility on Lubricant-Infused Porous Surfaces
- 2023
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Ingår i: Langmuir. - 0743-7463. ; 39:37, s. 13371-13385
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Tidskriftsartikel (refereegranskat)abstract
- Profiting from their slippery nature, lubricant-infused porous surfaces endow with droplets excellent mobility and consequently promise remarkable heat transfer improvement for dropwise condensation. To be a four-phase wetting system, the droplet wettability configurations and the corresponding dynamic characteristics on lubricant-infused porous surfaces are closely related to many factors, such as multiple interfacial interactions, surface features, and lubricant thickness, which keeps a long-standing challenge to promulgate the underlying physics. In this work, thermodynamically theoretical analysis and three-dimensional molecular dynamics simulations with the coarse-grained water and hexane models are carried out to explore droplet wettability and mobility on lubricant-infused porous surfaces. Combined with accessible theoretical criteria, phase diagrams of droplet configurations are constructed with a comprehensive consideration of interfacial interactions, surface structures, and lubricant thickness. Subsequently, droplet sliding and coalescence dynamics are quantitatively defined under different configurations. Finally, in terms of the promotion of dropwise condensation, a non-cloaking configuration with the encapsulated state underneath the droplet is recommended to achieve high droplet mobility owing to the low viscous drag of the lubricant and the eliminated pinning effect of the contact line. On the basis of the low oil-water and water-solid interactions, a stable lubricant layer with a relatively low thickness is suggested to construct slippery surfaces.
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| 25. |
- Bao, Chunxiong, et al.
(författare)
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Bidirectional optical signal transmission between two identical devices using perovskite diodes
- 2020
-
Ingår i: NATURE ELECTRONICS. - : NATURE PUBLISHING GROUP. - 2520-1131. ; 3:3, s. 156-164
-
Tidskriftsartikel (refereegranskat)abstract
- A solution-processed perovskite diode that functions as both optical transmitter and receiver can be used to build a monolithic pulse sensor and a bidirectional optical communication system. The integration of optical signal generation and reception into one device-thus allowing a bidirectional optical signal transmission between two identical devices-is of value in the development of miniaturized and integrated optoelectronic devices. However, conventional solution-processable semiconductors have intrinsic material and design limitations that prevent them from being used to create such devices with a high performance. Here we report an efficient solution-processed perovskite diode that is capable of working in both emission and detection modes. The device can be switched between modes by changing the bias direction, and it exhibits light emission with an external quantum efficiency of over 21% and a light detection limit on a subpicowatt scale. The operation speed for both functions can reach tens of megahertz. Benefiting from the small Stokes shift of perovskites, our diodes exhibit a high specific detectivity (more than 2 x 10(12) Jones) at its peak emission (~804 nm), which allows an optical signal exchange between two identical diodes. To illustrate the potential of the dual-functional diode, we show that it can be used to create a monolithic pulse sensor and a bidirectional optical communication system.
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| 26. |
- Chan, Yi-Hao, et al.
(författare)
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SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency.
- 2024
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Ingår i: The Journal of experimental medicine. - 1540-9538. ; 221:9
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Tidskriftsartikel (refereegranskat)abstract
- Inherited deficiency of the RNA lariat-debranching enzyme 1 (DBR1) is a rare etiology of brainstem viral encephalitis. The cellular basis of disease and the range of viral predisposition are unclear. We report inherited DBR1 deficiency in a 14-year-old boy who suffered from isolated SARS-CoV-2 brainstem encephalitis. The patient is homozygous for a previously reported hypomorphic and pathogenic DBR1 variant (I120T). Consistently, DBR1 I120T/I120T fibroblasts from affected individuals from this and another unrelated kindred have similarly low levels of DBR1 protein and high levels of RNA lariats. DBR1 I120T/I120T human pluripotent stem cell (hPSC)-derived hindbrain neurons are highly susceptible to SARS-CoV-2 infection. Exogenous WT DBR1 expression in DBR1 I120T/I120T fibroblasts and hindbrain neurons rescued the RNA lariat accumulation phenotype. Moreover, expression of exogenous RNA lariats, mimicking DBR1 deficiency, increased the susceptibility of WT hindbrain neurons to SARS-CoV-2 infection. Inborn errors of DBR1 impair hindbrain neuron-intrinsic antiviral immunity, predisposing to viral infections of the brainstem, including that by SARS-CoV-2.
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| 27. |
- Chen, Daru, et al.
(författare)
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Wavelength-spacing tunable multi-wavelength fiber lasers based on hybrid gain medium and Mach-Zehnder interferometer
- 2007
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Ingår i: 2007 Pacific Rim Conference on Lasers and Electro-Optics. - : IEEE. - 1424411734 - 9781424411733 ; , s. 4391428-
-
Konferensbidrag (refereegranskat)abstract
- Wavelength-spacing continuously tunable multi-wavelength fiber lasers based on a Mach-Zehnder interferometer comb filter are achieved. Stable multi-wavelength lasing based on hybrid gains of Erbium-doped fiber amplification and fiber Raman amplification (semiconductor optical amplification) is demonstrated.
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| 28. |
- Chen, K., et al.
(författare)
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Ti deficiency effect on the dielectric response of CaCu3Ti4O12 ceramics
- 2007
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Ingår i: Solid State Communications. - : Elsevier. - 0038-1098 .- 1879-2766. ; 141:8, s. 440-444
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Tidskriftsartikel (refereegranskat)abstract
- Single phase ceramics CaCu3Ti4.0O12 and CaCu3Ti3.9O12 have been prepared using the traditional solid-state reaction method. Compared with the stoichiometric ceramics CaCu3Ti4.0O12, Ti-deficient ceramics CaCu3Ti3.9O12 have the larger lattice parameter, the higher force constant, and smaller dielectric constant and the lower dissipation factor, although their fundamental characters of dielectric response are similar. Their characteristic relaxation frequencies are not well fitted with the Arrhenius Law but a tentatively supposed relation. With the Cole-Cole Law, the fitted broadened factors of dissipation peaks are 0.5433 and 0.8651 for CaCu3Ti3.9O12 and CaCu3Ti4.0O12, respectively. All facts mentioned above imply that mutually correlated motion of Ti ions or defects may be expected to be responsible for the giant dielectric constant and high dissipation factor of CaCu3T4.0O12. (c) 2006 Elsevier Ltd. All rights reserved.
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| 29. |
- Cui, Shaohua, 1995, et al.
(författare)
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Integration of UAVs with public transit for delivery: Quantifying system benefits and policy implications
- 2024
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Ingår i: Transportation Research Part A: General. - 0965-8564. ; 183
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Tidskriftsartikel (refereegranskat)abstract
- The maturation and scalability of unmanned aerial vehicle (UAV) technology offer transformative opportunities to revolutionize prompt delivery. This study explores integrating UAVs with public transportation vehicles (PTVs) to establish a novel delivery paradigm that enhances revenue for public transit operators and improves transport system efficiency without compromising passenger convenience or operational efficiency. Employing hexagonal planning technology, this study identifies and quantifies the available spatio-temporal resources of PTVs for UAV integration. This involves aligning the spatio-temporal dynamics of prompt delivery orders with PTV ridership, based on field data from Beijing's Haidian District. Utilizing these outputs, we quantitatively analyze the benefits of integrating UAVs with PTVs on increasing public transit revenue, and potentials of reducing carbon emissions and mitigating congestion. Furthermore, we quantify the long-term benefits of UAV-PTV integration by predicting future increases in delivery demand. Based on obtained quantitative results, this study discusses practical and policy implications to support the sustainable integration of UAVs with PTVs.
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| 30. |
- de Vries, Paul S., et al.
(författare)
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Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
- 2019
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Ingår i: American Journal of Epidemiology. - : Oxford University Press. - 0002-9262 .- 1476-6256. ; 188:6, s. 1033-1054
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Tidskriftsartikel (refereegranskat)abstract
- A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 x 10(-6)) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 x 10(-8) using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models.
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| 31. |
- Do, Ron, et al.
(författare)
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Common variants associated with plasma triglycerides and risk for coronary artery disease
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:11, s. 1345-
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Tidskriftsartikel (refereegranskat)abstract
- Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
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| 32. |
- Fan, Lulu, 1982, et al.
(författare)
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The Spectral Energy Distribution of the Hyperluminous, Hot Dust-obscured Galaxy W2246-0526
- 2018
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 854:2
-
Tidskriftsartikel (refereegranskat)abstract
- Hot dust-obscured galaxies (Hot DOGs) are a luminous, dust-obscured population recently discovered in the WISE All-Sky survey. Multiwavelength follow-up observations suggest that they are mainly powered by accreting supermassive black holes (SMBHs), lying in dense environments, and being in the transition phase between extreme starburst and UV-bright quasars. Therefore, they are good candidates for studying the interplay between SMBHs, star formation, and environment. W2246-0526 (hereafter, W2246), a Hot DOG at z ∼ 4.6, has been taken as the most luminous galaxy known in the universe. Revealed by the multiwavelength images, the previous Herschel SPIRE photometry of W2246 is contaminated by a foreground galaxy (W2246f), resulting in an overestimation of its total IR luminosity by a factor of about two. We perfor m the rest-frame UV/optical-to-far-IR spectral energy distribution (SED) analysis with SED3FIT and re-estimate its physical properties. The derived stellar mass M ∗ = 4.3 × 10 11 M ⊙ makes it among the most massive galaxies with spectroscopic redshift z > 4.5. Its structure is extremely compact and requires an effective mechanism to puff-up. Most of ( > 95%) its IR luminosity is from AGN torus emission, revealing the rapid growth of the central SMBH. We also predict that W2246 may have a significant molecular gas reservoir based on the dust mass estimation.
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| 33. |
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| 34. |
- Gao, Deyun, et al.
(författare)
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PMNDN : Proxy Based Mobility Support Approach in Mobile NDN Environment
- 2017
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Ingår i: IEEE Transactions on Network and Service Management. - : IEEE. - 1932-4537. ; 14:1, s. 191-203
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper, we study the source mobility problem that exists in the current named data networking (NDN) architecture and propose a proxy-based mobility support approach named PMNDN to overcome the problem. PMNDN proposes using a proxy to efficiently manage source mobility. Besides, functionalities of the NDN access routers are extended to track the mobility status of a source and signal Proxy about a handoff event. With this design, a mobile source does not need to participate in handoff signaling which reduces the consumption of limited wireless bandwidth. PMNDN also features an ID that is structurally similar to the content name so that routing scalability of NDN architecture is maintained and addressing efficiency of Interest packets is improved. We illustrate the performance advantages of our proposed solution by comparing the handoff performance of the mobility support approaches with that in NDN architecture and current Internet architecture via analytical and simulation investigation. We show that PMNDN offers lower handoff cost, shorter handoff latency, and less packet losses during the handoff process
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| 35. |
- Gao, Kun, 1993, et al.
(författare)
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Cumulative prospect theory coupled with multi-attribute decision making for modeling travel behavior
- 2021
-
Ingår i: Transportation Research Part A: Policy and Practice. - : Elsevier BV. - 0965-8564. ; 148, s. 1-21
-
Tidskriftsartikel (refereegranskat)abstract
- This study proposes an approach for modeling travel behavior under uncertainty coupling Cumulative Prospect Theory (CPT) with Multi-attribute Decision Making (MADM) theory. CPT is utilized to depict travelers’ evaluations of each attribute, and MADM describes the process of making tradeoffs among multiple conflicting criteria. Divergent perception principles for different attributes are considered in the proposed framework. The proposed approach is utilized for an empirical analysis concerning mode shift behavior for commuting in Shanghai of China, based on data collected by stated preference surveys. Results show that the proposed approach outperforms conventional methods in terms of model performances and behavioral revelations. Empirical results demonstrate that sensitivity to gains and losses in cost and travel time are divergent in mode shift behavior. More importantly, it is found that travelers underestimate the occurrence chances of low-probability travel time and overestimate the occurrence changes of high-probability travel time in mode shift behavior, which is contrary to the findings from economics. Travelers show substantial loss aversion features as well. The heterogeneity in the value functions of CPT is investigated to shed light on differences in the evaluation process among individuals. Results reveal quite different empirical CPT parameters and behavioral mechanisms in mode shift behavior as compared to monetary experiments in economics. It highlights the importance of empirical estimations in various travel choice contexts to essentially understand travel behavior mechanisms, rather than arbitrary usage of findings from economics.
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| 36. |
- Gao, Kun, 1993, et al.
(författare)
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Data-driven interpretation on interactive and nonlinear effects of the correlated built environment on shared mobility
- 2023
-
Ingår i: Journal of Transport Geography. - 0966-6923. ; 110
-
Tidskriftsartikel (refereegranskat)abstract
- Understanding the usage demand of shared mobility systems in different areas of a city and its determinants is crucial for planning, operation and management of the systems. This study leverages an unbiased data-driven approach called accumulated effect analysis for examining the complex (nonlinear and interactive) effects of correlated built environment factors on the usage of shared mobility. Special research emphasis is given to unraveling the complex effects using an unbiased and data-driven approach that can overcome the impacts of correlations among built environment factors. Based on empirical analysis of synthetic data and a field dataset about dockless bike sharing systems (DLBS), results demonstrate that the method of partial dependency analysis prevalent in the relevant literature, will result in biases when investigating the effects of correlated built environment factors. In comparison, accumulated local effect analysis can appropriately interpret the effects of correlated built environment factors. The main effects of many built environment factors on the usage of DLBS present nonlinear and threshold patterns, quantitively revealed by accumulated local analysis. The approach can reveal complex interaction effects between different built environment factors (e.g., commercial service and education facility, and metro station coverage and living facility) on the usage of DLBS as well. The interactions among two built environment factors could even change with the values of the factors rather than invariant. The outcomes offer a new approach for revealing complex influences of different built environment factors with correlations as well as in-depth empirical understandings regarding the usage of DLBS.
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| 37. |
- Gao, Kun, 1993, et al.
(författare)
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Diverging effects of subjective prospect values of uncertain time and money
- 2021
-
Ingår i: Communications in Transportation Research. - : Elsevier BV. - 2772-4247. ; 1
-
Tidskriftsartikel (refereegranskat)abstract
- Studies from behavioral economics show that the subjective prospect value of money has diminishing sensitivity to losses/gains, represented by an S-shape, and this has been applied in representing the subjective prospect value of time in many transportation studies such as travel behavior modeling and network equilibrium. In this study, we demonstrate that the prospect value of time has an increasing sensitivity to losses/gains and can be represented by an Ϩ-shape, which contrasts that of money. We further explain the rationality of this surprising finding based on psychological and behavioral theories and discuss extensive practical implications. The correlations between sensitivities to gains and losses in terms of magnitude are revealed as well to shed light on potential underlying correlated behavioral principles. Substantial loss-aversion features are observed in the empirical analysis, supporting endowment effects. Implications of the findings on decision-making and other areas that utilize time as a key indicator have been discussed. The findings may revolutionize many research areas that utilize time as a key indicator such as transportation engineering.
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| 38. |
- Gao, Kun, 1993, et al.
(författare)
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Examining nonlinear and interaction effects of multiple determinants on airline travel satisfaction
- 2021
-
Ingår i: Transportation Research Part D: Transport and Environment. - : Elsevier BV. - 1361-9209. ; 97
-
Tidskriftsartikel (refereegranskat)abstract
- Improving passengers’ satisfaction is crucial for airline industry and requires in-depth understandings regarding the complex effects of various factors. This study investigates the importance, complex nonlinear effects and interaction effects of various factors (including passenger characteristics and service attributes) on airline travel satisfaction in data-driven manners leveraging machine-learning (ML) approaches. The results show that ML algorithms such as Random Forest have superiority in modeling airline travel satisfaction as compared to conventional logistic regressions. The quantitative importance of various factors is estimated and compared to reveal key determinants of passengers’ satisfaction using permutation-based importance and accumulated local effect analysis. More importantly, results suggest that the main effects of service attributes present piecewise nonlinear patterns. There are piecewise interaction effects between passenger characteristics and service attributes and among service attributes on airline travel satisfaction. Practical implications on efficient and cost-effective measures of promoting satisfaction are derived and discussed based on the findings.
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| 39. |
- Gao, Kun, 1993, et al.
(författare)
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Extrapolation-enhanced model for travel decision making: An ensemble machine learning approach considering behavioral theory
- 2021
-
Ingår i: Knowledge-Based Systems. - : Elsevier BV. - 0950-7051. ; 218
-
Tidskriftsartikel (refereegranskat)abstract
- Modeling individuals’ travel decision making in terms of choosing transport modes, route and departure time for daily activities is an indispensable component for transport system optimization and management. Conventional approaches of modeling travel decision making suffer from presumed model structures and parametric specifications. Emerging machine learning algorithms offer data-driven and non-parametric solutions for modeling travel decision making but encounter extrapolation issues (i.e., disability to predict scenarios beyond training samples) due to neglecting behavioral mechanisms in the framework. This study proposes an extrapolation-enhanced approach for modeling travel decision making, leveraging the complementary merits of ensemble machine learning algorithms (Random Forest in our study) and knowledge-based decision-making theory to enhance both predictive accuracy and model extrapolation. The proposed approach is examined using three datasets about travel decision making, including one estimation dataset (for cross-validation) and two test datasets (for model extrapolation tests). Especially, we use two test datasets containing extrapolated choice scenarios with features that exceed the ranges of training samples, to examine the predictive ability of proposed models in extrapolated choice scenarios, which have hardly been investigated by relevant literature. The results show that both proposed models and the direct application of Random Forest (RF) can give quite good predictive accuracy (around 80%) in the estimation dataset. However, RF has a deficient predictive ability in two test datasets with extrapolated choice scenarios. In contrast, the proposed models provide substantially superior predictive performances in the two test datasets, indicating much stronger extrapolation capacity. The model based on the proposed framework could improve the precision score by 274.93% than the direct application of RF in the first test dataset and by 21.9% in the second test dataset. The results indicate the merits of the proposed approach in terms of prediction power and extrapolation ability as compared to existing methods.
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| 40. |
- Gao, Kun, 1993, et al.
(författare)
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Quantifying economic benefits from free-floating bike-sharing systems: A trip-level inference approach and city-scale analysis
- 2021
-
Ingår i: Transportation Research Part A: Policy and Practice. - : Elsevier BV. - 0965-8564. ; 144, s. 89-103
-
Tidskriftsartikel (refereegranskat)abstract
- Despite many qualitative discussions about the benefits of free-floating bike-sharing systems (FFBS), high-resolution and quantitative assessments about the economic benefits of FFBS for users are absent. This study proposes an innovative trip-level inference approach for quantifying the economic benefits of FFBS, leveraging massive FFBS transaction data, the emerging multimodal routing Application Programming Interface from online navigators and travel choice modeling. The proposed approach is able to analyze the economic benefit for every single bike-sharing trip and investigate the spatiotemporal heterogeneity in the economic benefits from FFBS. An empirical analysis in Shanghai is conducted using the proposed approach. The estimated saved travel time, cost, and economic benefit due to using FFBS per trip are estimated to be 9.95 min, 3.64 CNY, and 8.68 CNY-eq, respectively. The annual saved travel time, cost, and economic benefits from FFBS in Shanghai are estimated to be 17.665 billion min, 6.463 billion CNY, and 15.410 billion CNY-eq, respectively. The relationships between economic benefits from FFBS and built environment factors in different urban contexts are quantitatively examined using Multiple Linear Regression to explain the spatial heterogeneity in the economic benefits of FFBS. The outcomes provide a useful tool for evaluating the benefits of shared mobility systems, insights into the users’ economic benefit from using FFBS from per-trip, aggregated and spatial perspective, as well as its influencing factors. The results could efficiently support the scientific planning, operation and policy making concerning FFBS in different urban contexts.
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| 41. |
- Gao, Kun, 1993, et al.
(författare)
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Revealing psychological inertia in mode shift behavior and its quantitative influences on commuting trips
- 2020
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Ingår i: Transportation Research Part F: Traffic Psychology and Behaviour. - : Elsevier BV. - 1369-8478. ; 71, s. 272-287
-
Tidskriftsartikel (refereegranskat)abstract
- The inertia effects stemmed from repeated past behavior have been investigated by both psychology and transportation studies because of its bearing on explaining human mobility and forecasting travel demand. However, the existing literature from psychology does not strictly control potential endogeneity due to ignorance of detailed level-of-service (LOS) variables of alternatives and rational preference in the analysis. Quantitative transportation studies are insufficient in providing explicit behavior mechanisms. This paper aims to fill the gaps by empirically examining the effects of irrational psychological inertia in mode shift behavior with controlling potential endogeneity. A specific-designed comparison experiment is conducted to demonstrate the existence of psychological inertia in mode shift behavior. The effects of dominance in LOS variables and rational preference towards a certain transport mode are controlled to eliminate potential endogeneity in the analysis. The results demonstrate that after controlling the above-mentioned endogeneity, both car and metro users show significantly and substantially larger predilections to previously used transport mode in mode shift scenarios without overturning travel contexts than those in new context mode choice scenarios with noticeable changes in travel contexts. The results support that psychological inertia plays a significant role in mode shift behavior after controlling potential endogeneity. Moreover, this study utilizes hybrid choice modeling to quantitatively measure the effect of psychological inertia. The relationships between travelers’ characteristics and strength of psychological inertia are analyzed as well to shed light on heterogeneity in the strength of psychological inertia. The findings provide solid evidence of psychological inertia in mode shift behavior by a novel method and provide an approach to measure the quantitative effects of psychological inertia along with empirical studies.
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| 42. |
- Gao, Kun, 1993, et al.
(författare)
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Spatial heterogeneity in distance decay of using bike sharing: An empirical large-scale analysis in Shanghai
- 2021
-
Ingår i: Transportation Research Part D: Transport and Environment. - : Elsevier BV. - 1361-9209. ; 94
-
Tidskriftsartikel (refereegranskat)abstract
- Distance decay is a vital aspect for modeling spatial interactions of human movements and an indispensable input for land use planning and travel demand prediction models. Although many studies have investigated the usage demand of bike-sharing systems in an area, research investigating the distance decay patterns of using dockless bike-sharing systems (DLBS) from a spatially heterogeneous perspective based on large-scale datasets is lacking. This study firstly utilizes massive transaction record data from DLBS in Shanghai of China and online map navigator Application Programming Interface to empirically estimate the distance decay patterns of using DLBS and reveal the spatial heterogeneity in distance decay of using DLBS across different urban contexts. Afterward, this study examines the mechanism of spatial heterogeneity in distance decay, leveraging multiple data resources including Point of Interest (POI) data, demographic data, and road network data. The associations among the distance decay of using DLBS with built environment factors are investigated by multiple linear regression. Results indicate that factors such as population density, land use entropy, branch road density, and metro station density are significantly related to larger distance decay of using DLBS, while factors such as commercial land use ratio, industrial land use ratio, and motorway density are significantly linked to smaller distance decay in Shanghai. Lastly, we further employ an adaptative geographically weighted regression to investigate the spatial divergences of the influences of built environment factors on distance decay. Results reveal notably distinct and even inverse influences of a built environment factor on the distance decay of using DLBS in different urban contexts. The findings provide insights into the distance decay patterns of using DLBS in different urban contexts and their interactions with the built environment, which can support accurate planning and management of sustainable DLBS as per specific urban characteristics.
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| 43. |
- Gao, Lingfeng, et al.
(författare)
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Emerging applications of MXenes for photodetection : Recent advances and future challenges
- 2022
-
Ingår i: Materials Today. - : Elsevier. - 1369-7021 .- 1873-4103. ; 61, s. 169-190
-
Tidskriftsartikel (refereegranskat)abstract
- The development and applications of transition metal carbides, nitrides and carbonitrides, commonly denoted as MXenes, have during the last few years rapidly expanded in various technological fields owing to their unique and controllable properties. These materials exhibit competing performance comparing with traditional materials and have created numerous opportunities for technology markets. Taking the advantage of excellent optoelectronic features, MXenes have been utilized for the construction of photodetectors with various structures and unique functionalities. While the appli-cation of MXenes in this area can be traced back to 2016, we have during the recent three years witnessed a dramatic development of MXene-based photodetectors, calling for a timely review to guideline their future direction. In this work, synthetic strategies of pristine MXenes are briefly introduced and their properties are discussed focusing on the optoelectronic aspects that are fundamental for the photoelectric conversion. Recent advances of MXene-based photodetectors are comprehensively summarized based on different types of MXenes and innovative designs of device construction. Finally, we provide perspectives for future challenges and opportunities of MXene-based photodetectors, which may enlighten their further development.
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| 44. |
- Gao, Mingming, et al.
(författare)
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Engineered 2D MXene-based materials for advanced supercapacitors and micro-supercapacitors
- 2024
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Ingår i: Materials Today. - 1369-7021 .- 1873-4103. ; 72, s. 318-358
-
Forskningsöversikt (refereegranskat)abstract
- The class of two-dimensional transition metal carbides/nitrides/oxycarbides (known as MXenes) has shown great potential in energy storage applications due to their intrinsic layered structure, outstanding electrical conductivity, tunable surface chemistry, and unique physicochemical properties. This review summarizes the latest progresses of MXene-based materials for supercapacitors and micro-supercapacitors. First, state-of-the-art structural engineering strategies for the construction of novel MXene-based electrodes are highlighted, as the electrochemical performance of MXenes is influenced by their structure, such as interlayer spacing and surface functional group density. Furthermore, the charge storage mechanisms of MXene-based electrodes in different electrolytes are discussed to stimulate further design and development of tailored materials for high-performance devices. Moreover, different device fabrication technologies are summarized and the achievements of specific device geometries (e.g., fiber-shape, planar-type, and three-dimensional devices) containing MXene-based materials are critically reviewed. Finally, perspectives and outlook for the development of high-performance MXene-based electrodes in terms of material engineering, performance improvement and device innovation are provided, clearly indicating research directions for next-generation advanced energy storage devices.
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| 45. |
- Gao, Ruo Bin, et al.
(författare)
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A Wideband Co-Linearly Polarized Composite Antenna with High Isolation
- 2024
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Ingår i: IEEE Antennas and Wireless Propagation Letters. - 1536-1225. ; 23:1, s. 419-423
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, a high-isolation two-port co-linearly polarized (co-LP) composite antenna is proposed. Dipole and W8JK array modes with co-LP omnidirectional patterns can be simultaneously supported by a plate with two etched back-to-back tapered slots. A microstrip differential and a T-divider coupling feeding networks are developed to selectively excite the dipole and W8JK modes, which results in a high isolation and low correlation between two co-LP ports without using any decoupling structures. Reflecting ground is applied to realize the directional radiation. Measurement results show that the overlapped operating band of the antenna can cover 3.4 - 4.1 GHz with low measured envelope correlation coefficients (< 2.5 × 10-3) and high isolation (> 20 dB). Dual-polarized four-port element with good performances can be easily obtained based on the proposed co-LP antenna. The simulated results of the four-port prototype indicate that the proposed antenna is a promising candidate for the future compact massive MIMO array antenna.
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| 46. |
- Gao, Shang, 1982-, et al.
(författare)
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An empirical study on the adoption of blockchain-based games from users’ perspectives
- 2021
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Ingår i: Electronic library. - : Emerald Group Publishing Limited. - 0264-0473 .- 1758-616X. ; 39:4, s. 596-614
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The purpose of the research is to investigate users’ adoption of blockchain-based games in China.Design/methodology/approach: This research applied existing technology diffusion theories to develop a research model to examine users’ adoption of blockchain-based games. As a result, a research model with nine research hypotheses was developed. The developed research model was empirically tested using data collected from a survey of 210 blockchain-based games users. Structural equation modeling was applied to analyse the collected data.Findings: The results indicated that seven of nine research hypotheses were supported. It was found that trust, perceived usefulness, perceived enjoyment and perceived ease of use were key determinants for users’ behavioural intention to use blockchain-based games. The most influential relationship in the research model appeared to be the effect of perceived usefulness on users’ behavioural intention to use blockchain-based games. However, subjective norms did not have significant positive impacts on users’ behavioural intention to use blockchain-based games.Practical implications: The regulatory support from governmental authorities is essential to provide additional legal certainty to build users’ trust in playing blockchain-based games. Blockchain-based games providers should arrange the training program targeted to the general users to enhance their understanding of the key features associated with blockchain-based games. Blockchain-based games developers should come up with good design solutions to maximize user enjoyment with blockchain-based games by considering additional entertainment elements.Originality/value: To the best of the authors’ knowledge, this study is first of its kind in investigating the adoption of blockchain-based games from users’ perspectives. This study contributes to the existing literature on the adoption of blockchain technology.
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| 47. |
- Gao, Shang, 1982-, et al.
(författare)
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Understanding the adoption of bike sharing systems By combining technology diffusion theories and perceived risk
- 2019
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Ingår i: Journal of Hospitality and Tourism Technology. - : Emerald Group Publishing Limited. - 1757-9880 .- 1757-9899. ; 10:3, s. 494-508
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: This study aims to investigate users' adoption of bike sharing systems in China.Design/methodology/approach: This research combined perceived risk factors with existing technology diffusion theories (e.g. technology acceptance model and unified theory of acceptance and use of technology) to develop a research model to examine users' adoption of bike sharing systems in China. As a result, a research model with 11 hypotheses was developed. The developed research model was empirically tested using data collected from a survey of 298 users in China. Structural equation modeling was used to analyze the collected data.Findings: The findings indicated that perceived usefulness, facilitating conditions and perceived risks were important determinants to the adoption of bike sharing systems. However, perceived ease of use and social influence did not have significant positive impacts on users' behavioral intention to use bike sharing systems.Practical implications: It is important for service providers to dedicate their time and efforts in maintaining and repairing bikes to ensure that the bikes are in a good condition to be used. System providers need to work on good solutions to better protect users' personal information and location information.Originality/value: This study is first of its kinds in investigating the adoption of bike sharing systems by combining technology diffusion theories and perceived risk theory in China.
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| 48. |
- Gao, Shang, 1982-, et al.
(författare)
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Understanding the Value of MOOCs from the Perspectives of Students : A Value-Focused Thinking Approach
- 2018
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Ingår i: Challenges and Opportunities in the Digital Era. - Cham : Springer. - 9783030021306 - 9783030021313 ; , s. 129-140
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Konferensbidrag (refereegranskat)abstract
- This study aims to identify the values of MOOCs in education from students’ perspective in China. The value of Massive Open Online Course (MOOCs) can be seen as the benefits associated with the use of MOOCs in education. To address this, we employed the Value-Focused Thinking (VFT) approach to identify the values of MOOCs with university students in China. Twenty active students of MOOCs were interviewed in China. Based on the data collected from the interviews, we developed a means-ends objective network describing the value of MOOCs in education. According to the results, efficiency in learning, effectiveness in learning, convenience of learning, learning experience of MOOCs, and usability of MOOCs were identified as the fundamental objectives to maximize values of MOOCs in education.
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| 49. |
- Gao, Shang, 1982-, et al.
(författare)
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Understanding the Value of Using Smartphones for Older Adults in China : A Value-Focused Thinking Approach
- 2019
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Ingår i: Digital Transformation for a Sustainable Society in the 21st Century. - Cham : Springer. - 9783030293734 - 9783030293741 ; , s. 533-544
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Konferensbidrag (refereegranskat)abstract
- This study aims to explore the values of using smartphones in older adults’ daily lives in China. The value of using smartphones can be seen as the benefits associated with the use of smartphones in peoples’ daily activities. By employing the Value-Focused Thinking (VFT) approach, this study investigates what fundamental objectives and means objectives are important with the daily use of smartphones for older adults in China. Based on the data collected from the interviews, we developed a means-ends objective network describing the values of using smartphones for older adults in China. According to the results, maximizing well-being, maximizing life efficiency, maximizing safety, and maximizing digital inclusion are identified as the fundamental objectives to maximize values of using smartphones for older adults in China.
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| 50. |
- Gao, Shengjun, et al.
(författare)
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Urbanization-induced warming amplifies population exposure to compound heatwaves but narrows exposure inequality between global North and South cities
- 2024
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Ingår i: NPJ CLIMATE AND ATMOSPHERIC SCIENCE. - 2397-3722. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- Urban populations face heightened extreme heat risks attributed to urban heat islands and high population densities. Although previous studies have examined global urban population exposure to heatwaves, the influence of urbanization-induced warming is still not quantified. Here, leveraging satellite-derived near-surface air temperature data, we assess the impacts of urbanization-induced warming on heat exposure in 1028 cities worldwide. Additionally, we investigate its role in shaping disparities in heat exposure between global North and South cities. Our findings reveal that urbanization-amplified compound heatwaves exacerbate heat exposure risk in more than 90% of cities, and that this amplification is stronger in high urbanization areas. Moreover, our analysis highlights the potential for overestimating disparities between global North and South cities if urbanization-induced warming is overlooked. The inequality of higher heat exposure in the global South cities than in the global North cities will be narrowed in real scenarios due to more intense urbanization-induced warming in the global North cities. We emphasize the pivotal role of urbanization-induced heatwave intensification in heat exposure assessments and call for its inclusion in future population vulnerability evaluations to extreme heat.
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