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Sökning: WFRF:(Gates Casey)

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1.
  • Saxena, Richa, et al. (författare)
  • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
  • 2007
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 316:5829, s. 1331-1336
  • Tidskriftsartikel (refereegranskat)abstract
    • New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
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2.
  • Yang, Dong, et al. (författare)
  • The Surface Chemistry of Metal Oxide Clusters : From Metal–Organic Frameworks to Minerals
  • 2020
  • Ingår i: ACS Central Science. - : American Chemical Society (ACS). - 2374-7943 .- 2374-7951. ; 6:9, s. 1523-1533
  • Tidskriftsartikel (refereegranskat)abstract
    • Many metal–organic frameworks (MOFs) incorporate nodes that are small metal oxide clusters. Some of these MOFs are stable at high temperatures, offering good prospects as catalysts—prospects that focus attention on their defect sites and reactivities—all part of a broader subject: the surface chemistry of metal oxide clusters, illustrated here for MOF nodes and for polyoxocations and polyoxoanions. Ligands on MOF defect sites form during synthesis and are central to the understanding and control of MOF reactivity. Reactions of alcohols are illustrative probes of Zr6O8 node defects in UiO-66, characterized by the interconversions of formate, methoxy, hydroxy, and linker carboxylate ligands and by catalysis of alcohol dehydration reactions. We posit that new reactivities of MOF nodes will emerge from incorporation of a wide range of groups on their surfaces and from targeted substitutions of metals within them.
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