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- Bethlehem, RAI, et al.
(författare)
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Brain charts for the human lifespan
- 2022
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 604:79057906, s. 525-
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Tidskriftsartikel (refereegranskat)abstract
- Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data (http://www.brainchart.io/). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes.
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- Jafari, Farzaneh, et al.
(författare)
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A new taxonomic backbone for the infrageneric classification of the species-rich genus Silene(Caryophyllaceae)
- 2020
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Ingår i: Taxon. - : Wiley. - 0040-0262 .- 1996-8175. ; 69:2, s. 337-368
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Tidskriftsartikel (refereegranskat)abstract
- The systematization of species in plant taxonomy based on the phylogenetic relationships among them are of utmost importance and also very challenging in large genera. In those, phylogenetic results often may suggest substantially different relationships than previous classifications, and call for large-scale taxonomic revisions. Delimitation of the genusSilenehas been and is still somewhat controversial, and recent molecular phylogenetic studies have settled several monophyletic groups that differ substantially from previous taxonomies. The infrageneric taxonomy ofSilenes.str. has not been updated as a whole taking the phylogenetic information into account. In this study, we review previous phylogenetic results based on multiple loci, and conducted comprehensive gene tree analyses based on the nrDNA ITS and cpDNArps16regions for 1586 and 944 samples representing 415 and 397 species, respectively, includingSileneand its allies, as well as a species tree analysis including 262 samples representing 243 species. We sampled representatives from all 44 sections recognized in the most recent global revision of the genus. The results support the recognition of three subgenera, i.e.,S.subg.Behenantha,S.subg.LychnisandS. subg.Silene, which is partly in agreement with previous molecular phylogenetic findings and contradicts all previous traditional classifications.Silenesect.Atocion, with a few annual species showing a narrow distribution range in the eastern Mediterranean, is treated as incertae sedis because of its uncertain phylogenetic position, possibly due to exceptionally high substitution rates.Silenesubg.Lychnis, weakly supported as sister to the other subgenera, splits into three main clades and includes four sections.Silenesubg.Behenantha, which forms a possible sister group in relation toS.subg.Silene, is poorly resolved basally and includes a large number of mostly small clades recognized as 18 sections. InS.subg.Silene, 11 sections are recognized, among which four are broadly circumscribed:S.sect.Auriculatae,S.sect.Sclerocalycinae,S.sect.SileneandS.sect.Siphonomorpha.Silenesect.AcutifoliaeandS.sect.Portensesare described here as new taxa, whereas new status or new combinations are proposed forS.sect.Anotites,S.sect.Muscipula,S.sect.Petrocoma,S.sect.Pulvinatae,S.sect.SclerophyllaeandS.sect.Uebelinia. Five new combinations and two new names are proposed for taxa inSileneformerly assigned toLychnisandUebelinia. The correct infrageneric nomenclature compatible with the new infrageneric system is provided along with synonymy and type citations. Shortcomings of this study, such as the lack of a morphological diagnostic key and sparse sampling of some large sections, are listed and discussed.
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- Jafari, F., et al.
(författare)
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Notes on the genus Silene (Caryophyllaceae, Sileneae) in Iran
- 2019
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Ingår i: Phytotaxa. - : Magnolia Press. - 1179-3155 .- 1179-3163. ; 425:1, s. 35-48
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Tidskriftsartikel (refereegranskat)abstract
- Two new species-Silene orientoalborzensis and S. circumcarmanica-are here described from Northeast and South Iran, respectively. They belong to Silene subg. Silene sect. Auriculatae which is the largest section of the genus in W-Asia. A specimen from center of Iran, which was identified erroneously as S. atocioides, is revised and identified as S. pendula which represents a new record for the Iranian flora. S. simsii is proposed as a nomen novum for Cucubalus multifidus.
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