| 1. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 4. |
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| 5. |
- van Rheenen, W, et al.
(författare)
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Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
- 2021
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 53:12, s. 1636-
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Tidskriftsartikel (refereegranskat)abstract
- Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons.
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| 6. |
- Ansal, A., et al.
(författare)
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Seismic microzonation for earthquake risk mitigation in turkey
- 2004
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Konferensbidrag (refereegranskat)abstract
- As a tool to improve the state of land use management in Turkey and to better mitigate earthquake risk inthe future, a microzonation project was initiated after the 1999 Kocaeli earthquake. The project had twocomponents (a) drafting a microzonation manual [1], (b) conducting pilot case studies in the selected tworegions affected by the 1999 Marmara earthquakes [2]. The main purpose of the study was to test anddemonstrate the applicability of the methodology proposed in the Seismic Microzonation Manual preparedfor the project. The major contributions of the study are the probabilistic assessment of the regionalearthquake hazard, interpretation of the microtremor records, and interpretation of the available geologicaland geotechnical data based on a grid approach. All the available data was transformed to GIS format andthe results are evaluated to obtain a microzonation with respect to site amplification, liquefactionsusceptibility and landslide hazard. An attempt will be made to summarize the results of the pilot studyconducted for the Gölcük region to give an overview of the proposed methodology.
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| 7. |
- Goni, Maria Fernanda Sanchez, et al.
(författare)
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The ACER pollen and charcoal database : a global resource to document vegetation and fire response to abrupt climate changes during the last glacial period
- 2017
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Ingår i: Earth System Science Data. - : Copernicus GmbH. - 1866-3508 .- 1866-3516. ; 9:2, s. 679-695
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Tidskriftsartikel (refereegranskat)abstract
- Quaternary records provide an opportunity to examine the nature of the vegetation and fire responses to rapid past climate changes comparable in velocity and magnitude to those expected in the 21st-century. The best documented examples of rapid climate change in the past are the warming events associated with the Dansgaard-Oeschger (D-O) cycles during the last glacial period, which were sufficiently large to have had a potential feedback through changes in albedo and greenhouse gas emissions on climate. Previous reconstructions of vegetation and fire changes during the D-O cycles used independently constructed age models, making it difficult to compare the changes between different sites and regions. Here, we present the ACER (Abrupt Climate Changes and Environmental Responses) global database, which includes 93 pollen records from the last glacial period (73-15 ka) with a temporal resolution better than 1000 years, 32 of which also provide charcoal records. A harmonized and consistent chronology based on radiometric dating (C-14, U-234/Th-230, optically stimulated luminescence (OSL), Ar-40/Ar-39-dated tephra layers) has been constructed for 86 of these records, although in some cases additional information was derived using common control points based on event stratigraphy. The ACER database compiles metadata including geospatial and dating information, pollen and charcoal counts, and pollen percentages of the characteristic biomes and is archived in Microsoft Access (TM) at https://doi. org/10.1594/PANGAEA. 870867.
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| 8. |
- Danieli, B, et al.
(författare)
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Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids
- 2004
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Ingår i: Chemistry and Biodiversity. - : Wiley. - 1612-1872 .- 1612-1880. ; 1:2, s. 327-345
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Tidskriftsartikel (refereegranskat)abstract
- The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but, while 6 and 7 behaved as bifunctional tubulin binders not unlike an equimolecular mixture of taxol and thiocolchicine, 8 was surprisingly devoid of tubulin activity, acting on a distinct and yet to identify molecular target.
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| 9. |
- Dunn, Matt J, et al.
(författare)
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Minimal reporting guideline for research involving eye tracking (2023 edition)
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Ingår i: Behavior Research Methods. - 1554-3528.
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Tidskriftsartikel (refereegranskat)abstract
- A guideline is proposed that comprises the minimum items to be reported in research studies involving an eye tracker and human or non-human primate participant(s). This guideline was developed over a 3-year period using a consensus-based process via an open invitation to the international eye tracking community. This guideline will be reviewed at maximum intervals of 4 years.
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| 10. |
- Fäh, Donat, et al.
(författare)
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Coupled seismogenic geohazards in Alpine regions
- 2012
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Ingår i: Bollettino di Geofisica Teorica ed Applicata. - 0006-6729. ; 53:4, s. 485-508
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Tidskriftsartikel (refereegranskat)abstract
- COupled seismogenic GEohazards in Alpine Regions (COGEAR) is an interdisciplinary natural hazard project investigating the hazard chain induced by earthquakes. It addresses tectonic processes and the related variability of seismicity in space and time, earthquake forecasting and short-term precursors, and strong ground motion as a result of source and complex path effects. We study non-linear wave propagation phenomena, liquefaction and triggering of landslides in soil and rock, as well as earthquake-induced snow avalanches. The Valais, and in particular parts of the Rhone, Visper, and Matter valleys have been selected as study areas. Tasks include detailed field investigations, development and application of numerical modeling techniques, assessment of the susceptibility to seismically induced effects, and installation of different monitoring systems to test and validate our models. These systems are for long-term operation and include a continuous GPS and seismic networks, a test installation for observing earthquake precursors, and a system to study site-effects and non-linear phenomena in two test areas (Visp, St. Niklaus / Randa). Risk-related aspects relevant for buildings and lifelines are also considered
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| 11. |
- Romano, A., et al.
(författare)
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Reputation and socio-ecology in humans
- 2021
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Ingår i: Philosophical Transactions of the Royal Society of London. Biological Sciences. - : The Royal Society. - 0962-8436 .- 1471-2970. ; 376:1838
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Forskningsöversikt (refereegranskat)abstract
- Reputation is a fundamental feature of human sociality as it sustains cooperative relationships among unrelated individuals. Research from various disciplines provides insights on how individuals form impressions of others, condition their behaviours based on the reputation of their interacting partners and spread or learn such reputations. However, past research has often neglected the socio-ecological conditions that can shape reputation systems and their effect on cooperation. Here, we outline how social environments, cultural values and institutions come to play a crucial role in how people navigate reputation systems. Moreover, we illustrate how these socio-ecological dimensions affect the interdependence underlying social interactions (e.g. potential recipients of reputational benefits, degree of dependence) and the extent to which reputation systems promote cooperation. To do so, we review the interdisciplinary literature that illustrates how reputation systems are shaped by the variation of prominent ecological features. Finally, we discuss the implications of a socio-ecological approach to the study of reputation and outline potential avenues for future research.
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| 12. |
- Számadó, S., et al.
(författare)
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The language of cooperation: reputation and honest signalling
- 2021
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Ingår i: Philosophical Transactions of the Royal Society of London. Biological Sciences. - : ROYAL SOC. - 0962-8436 .- 1471-2970. ; 376:1838
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Tidskriftsartikel (refereegranskat)abstract
- Large-scale non-kin cooperation is a unique ingredient of human success. This type of cooperation is challenging to explain in a world of self-interested individuals. There is overwhelming empirical evidence from different disciplines that reputation and gossip promote cooperation in humans in different contexts. Despite decades of research, important details of reputation systems are still unclear. Our goal with this theme issue is to promote an interdisciplinary approach that allows us to explore and understand the evolution and maintenance of reputation systems with a special emphasis on gossip and honest signalling. The theme issue is organized around four main questions: What are the necessary conditions for reputation-based systems? What is the content and context of reputation systems? How can reputations promote cooperation? And, what is the role of gossip in maintaining reputation systems and thus cooperation?
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