| 1. |
- Björklund, Fredrik, et al.
(författare)
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Pedagogisk verksamhet - ett verktyg för framtida kompetensförsörjning?
- 2023. - 09
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Kan pedagogiska verksamheter i samhället skapa intresse hos ungdomar så att de väljer att arbeta med vattenfrågor i framtiden? Projektet undersökte utställningen Den hållbara staden på Kretseum i Malmö och Sydvattens kurs Tänk H2O! vid sjön Bolmen i Småland. Bland de positiva effekterna hos eleverna fanns ökad tilltro till den egna kompetensen på området, ökad känsla av att passa in socialt på området, och ökat intresse för vissa jobb inom VA. Rapporten avslutas med några förslag för ökade och mer beständiga effekter av pedagogisk verksamhet på den framtida kompetensförsörjningen.
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| 2. |
- Bonkhoff, Anna K, et al.
(författare)
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The relevance of rich club regions for functional outcome post-stroke is enhanced in women.
- 2023
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Ingår i: Human brain mapping. - : Wiley. - 1097-0193 .- 1065-9471. ; 44:4, s. 1579-1592
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Tidskriftsartikel (refereegranskat)abstract
- This study aimed to investigate the influence of stroke lesions in predefined highly interconnected (rich-club) brain regions on functional outcome post-stroke, determine their spatial specificity and explore the effects of biological sex on their relevance. We analyzed MRI data recorded at index stroke and ~3-months modified Rankin Scale (mRS) data from patients with acute ischemic stroke enrolled in the multisite MRI-GENIE study. Spatially normalized structural stroke lesions were parcellated into 108 atlas-defined bilateral (sub)cortical brain regions. Unfavorable outcome (mRS>2) was modeled in a Bayesian logistic regression framework. Effects of individual brain regions were captured as two compound effects for (i) six bilateral rich club and (ii) all further non-rich club regions. In spatial specificity analyses, we randomized the split into "rich club" and "non-rich club" regions and compared the effect of the actual rich club regions to the distribution of effects from 1000 combinations of six random regions. In sex-specific analyses, we introduced an additional hierarchical level in our model structure to compare male and female-specific rich club effects. A total of 822 patients (age: 64.7[15.0], 39% women) were analyzed. Rich club regions had substantial relevance in explaining unfavorable functional outcome (mean of posterior distribution: 0.08, area under the curve: 0.8). In particular, the rich club-combination had a higher relevance than 98.4% of random constellations. Rich club regions were substantially more important in explaining long-term outcome in women than in men. All in all, lesions in rich club regions were associated with increased odds of unfavorable outcome. These effects were spatially specific and more pronounced in women.
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| 3. |
- Botella Mascarell, Carmen, 1979, et al.
(författare)
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EU FP7 INFSO-ICT-247223 ARTIST4G, D1.3 Innovative scheduling and cross-layer design techniques for interference avoidance
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This document provides an overview of the proposed innovations and activities in Task 1.2 of Work Package 1 (WP1) of the ARTIST4G project, related to interference avoidance. Focus is on the technical approaches applicable at layer 2, which are grouped into five different classes of innovations related to clustering & user grouping, inter-cell interference coordination, coordinated scheduling, scheduling for joint processing and gametheory based scheduling. Descriptions of the proposed innovations are given including basic ideas, potential of performance, simulation results, realization options and possible implementation restrictions.
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| 4. |
- Bretzner, Martin, et al.
(författare)
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Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke.
- 2023
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Ingår i: Neurology. - 1526-632X .- 0028-3878. ; 100:8
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Tidskriftsartikel (refereegranskat)abstract
- While chronological age is one of the most influential determinants of poststroke outcomes, little is known of the impact of neuroimaging-derived biological "brain age." We hypothesized that radiomics analyses of T2-FLAIR images texture would provide brain age estimates and that advanced brain age of patients with stroke will be associated with cardiovascular risk factors and worse functional outcomes.We extracted radiomics from T2-FLAIR images acquired during acute stroke clinical evaluation. Brain age was determined from brain parenchyma radiomics using an ElasticNet linear regression model. Subsequently, relative brain age (RBA), which expresses brain age in comparison with chronological age-matched peers, was estimated. Finally, we built a linear regression model of RBA using clinical cardiovascular characteristics as inputs and a logistic regression model of favorable functional outcomes taking RBA as input.We reviewed 4,163 patients from a large multisite ischemic stroke cohort (mean age = 62.8 years, 42.0% female patients). T2-FLAIR radiomics predicted chronological ages (mean absolute error = 6.9 years, r = 0.81). After adjustment for covariates, RBA was higher and therefore described older-appearing brains in patients with hypertension, diabetes mellitus, a history of smoking, and a history of a prior stroke. In multivariate analyses, age, RBA, NIHSS, and a history of prior stroke were all significantly associated with functional outcome (respective adjusted odds ratios: 0.58, 0.76, 0.48, 0.55; all p-values < 0.001). Moreover, the negative effect of RBA on outcome was especially pronounced in minor strokes.T2-FLAIR radiomics can be used to predict brain age and derive RBA. Older-appearing brains, characterized by a higher RBA, reflect cardiovascular risk factor accumulation and are linked to worse outcomes after stroke.
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| 5. |
- D’Amico, Valeria, et al.
(författare)
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EU FP7 INFSO-ICT-247223 ARTIST4G, D1.1 Definitions and architecture requirements for supporting interference avoidance techniques
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- It is the main objective of the ARTIST4G Work Package 1 (WP1), to design innovative interference avoidance solutions by means of transmitter signal processing, scheduling and/or cross layer techniques. Such an approach will enable to identify optimal strategies also taking into account the practical implications on the real system. The major impacts of the WP1 innovations on the radio access network and on the mobile system interfaces, together with constraints due to practical implementations, will be analyzed in this deliverable. This deliverable will be a reference for the work in ARTIST4G Work Package 4 (WP4).A set of guiding questions used to precise the requirements for WP4 has been considered for each new cooperation/coordination functionality. Answers to these questions are provided in this deliverable by grouping the different classes of WP1 innovations into 4 categories with similar requirements on the radio access architecture. For each question, current, expected, minimum and maximum targets of the requirement will be given, helping to ensure that the range of all possible values for all the innovations are taken into account.
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| 6. |
- Giese, Laura, et al.
(författare)
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STEM by the Lake: Raising High School Women’s Engineering Self-Efficacy and Belongingness through an Educational Intervention about Water Issues and Careers
- 2022
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Ingår i: International Journal of Gender, Science and Technology. - 2040-0748. ; 14:2, s. 207-231
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Tidskriftsartikel (refereegranskat)abstract
- Women tend to have lower interest in engineering as compared to men, which previous research has shown is partly explained by gender differences in self-efficacy, social belongingness and communal career goals. Therefore, to attract more women to engineering, effective interventions are needed that target these factors. In this study, we evaluated an industry-designed intervention for high school students. The intervention consisted of a two-day interdisciplinary course on water issues and careers in the water sector, located by a lake in the Swedish countryside. The participating 722 high school students answered a survey before, immediately after, and three months after the intervention. We measured interest, self-efficacy, social belongingness, communal career goal affordance, and stereotype threat, in relation to engineering. The results showed expected gender differences in all pre-measures. A promising result was that the intervention raised women’s engineering self-efficacy and social belongingness and reduced stereotype threat levels. However, repeated exposure might be necessary for the changes to last. Engineering interest was unexpectedly not affected by the intervention, which may imply that stronger increases in self-efficacy and social belongingness are necessary to impact interest.
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| 7. |
- Levin, Johannes, et al.
(författare)
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α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden
- 2024
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Ingår i: Alzheimer's and Dementia. - 1552-5260. ; 20:6, s. 4351-4365
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains. METHODS: Using an α-synuclein seed amplification assay (SAA) in cerebrospinal fluid (CSF) from asymptomatic (n = 26) and symptomatic (n = 27) ADAD mutation carriers, including 12 with known neuropathology, we investigated the timing of occurrence and prevalence of SAA positive reactivity in ADAD in vivo. RESULTS: No asymptomatic participant and only 11% (3/27) of the symptomatic patients tested SAA positive. Neuropathology revealed LBP in 10/12 cases, primarily affecting the amygdala or the olfactory areas. In the latter group, only the individual with diffuse LBP reaching the neocortex showed α-synuclein seeding activity in CSF in vivo. DISCUSSION: Results suggest that in ADAD LBP occurs later than AD pathology and often as amygdala- or olfactory-predominant LBP, for which CSF α-synuclein SAA has low sensitivity. Highlights: Cerebrospinal fluid (CSF) real-time quaking-induced conversion (RT-QuIC) detects misfolded α-synuclein in ≈ 10% of symptomatic autosomal dominant Alzheimer's disease (ADAD) patients. CSF RT-QuIC does not detect α-synuclein seeding activity in asymptomatic mutation carriers. Lewy body pathology (LBP) in ADAD mainly occurs as olfactory only or amygdala-predominant variants. LBP develops late in the disease course in ADAD. CSF α-synuclein RT-QuIC has low sensitivity for focal, low-burden LBP.
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| 8. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 9. |
- Patalay, Praveetha, et al.
(författare)
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Mental health provision in schools: approaches and interventions in 10 European countries
- 2017
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Ingår i: Global Mental Health. - : Cambridge University Press (CUP). - 2054-4251. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- Background.The role of schools in providing community-based support for children's mental health and well-being is widely accepted and encouraged. Research has mainly focused on designing and evaluating specific interventions and there is little data available regarding what provision is available, the focus and priorities of schools and the professionals involved in providing this support. The current study presents these data from schools in 10 European countries.Methods.Online survey of 1466 schools in France, Germany, Ireland, Netherlands, Poland, Serbia, Spain, Sweden, UK and Ukraine. The participating countries were chosen based on their geographical spread, diversity of political and economic systems, and convenience in terms of access to the research group and presence of collaborators.Results.Schools reported having more universal provision than targeted provision and there was greater reported focus on children who already have difficulties compared with prevention of problems and promotion of student well-being. The most common interventions implemented related to social and emotional skills development and anti-bullying programmes. Learning and educational support professionals were present in many schools with fewer schools reporting involvement of a clinical specialist. Responses varied by country with 7.4–33.5% between-country variation across study outcomes. Secondary schools reported less support for parents and more for staff compared with primary schools, with private schools also indicating more staff support. Schools in rural locations reported less student support and professionals involved than schools in urban locations.Conclusion.The current study provides up-to-date and cross-country insight into the approaches, priorities and provision available for mental health support in schools; highlighting what schools prioritise in providing mental health support and where coverage of provision is lacking.
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| 10. |
- Wolpin, Brian M., et al.
(författare)
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Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
- 2014
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 46:9, s. 994-
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Tidskriftsartikel (refereegranskat)abstract
- We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 x 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 x 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 x 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 x 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 x 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 x 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
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