| 1. |
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| 2. |
- Aguilar, Helena, et al.
(författare)
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VAV3 mediates resistance to breast cancer endocrine therapy
- 2014
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Ingår i: Breast Cancer Research. - : BioMed Central. - 1465-5411 .- 1465-542X. ; 16:3, s. R53-
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Endocrine therapies targeting cell proliferation and survival mediated by estrogen receptor alpha (ERalpha) are among the most effective systemic treatments for ERalpha-positive breast cancer. However, most tumors initially responsive to these therapies acquire resistance through mechanisms that involve ERalpha transcriptional regulatory plasticity. Here, we identify VAV3 as a critical component in this process.METHODS: A cell-based chemical compound screen was carried out to identify therapeutic strategies against resistance to endocrine therapy. Binding to ERalpha was evaluated by molecular docking analyses, an agonist fluoligand assay, and short-hairpin (sh) RNA-mediated protein depletion. Microarray analyses were performed to identify altered gene expression. Western blot of signaling and proliferation markers and shRNA-mediated protein depletion in viability and clonogenic assays were performed to delineate the role of VAV3. Genetic variation in VAV3 was assessed for association with the response to tamoxifen. Immunohistochemical analyses of VAV3 were carried out to determine the association with therapy response and different tumor markers. An analysis of gene expression association with drug sensitivity was carried out to identify a potential therapeutic approach based on differential VAV3 expression.RESULTS: The compound YC-1 was found to comparatively reduce the viability of cell models of acquired resistance. This effect was probably not due to activation of its canonical target (soluble guanylyl cyclase) but instead a result of binding to ERalpha. VAV3 was selectively reduced upon exposure to YC-1 or ERalpha depletion and, accordingly, VAV3 depletion comparatively reduced the viability of cell models of acquired resistance. In the clinical scenario, germline variation in VAV3 was associated with response to tamoxifen in Japanese breast cancer patients (rs10494071 combined P value = 8.4 x 10-4). The allele association combined with gene expression analyses indicated that low VAV3 expression predicts better clinical outcome. Conversely, high nuclear VAV3 expression in tumor cells was associated with poorer endocrine therapy response. Based on VAV3 expression levels and the response to erlotinib in cancer cell lines, targeting EGFR signaling may be a promising therapeutic strategy.CONCLUSIONS: This study proposes VAV3 as a biomarker and rationale signaling target to prevent and/or overcome resistance to endocrine therapy in breast cancer.
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| 3. |
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| 4. |
- Cruz, Raquel, et al.
(författare)
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Novel genes and sex differences in COVID-19 severity
- 2022
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 31:22, s. 3789-3806
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Tidskriftsartikel (refereegranskat)abstract
- Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.
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| 5. |
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| 6. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 7. |
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| 8. |
- Zamora, Juan Carlos, et al.
(författare)
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Considerations and consequences of allowing DNA sequence data as types of fungal taxa
- 2018
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Ingår i: IMA Fungus. - : INT MYCOLOGICAL ASSOC. - 2210-6340 .- 2210-6359. ; 9:1, s. 167-185
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Tidskriftsartikel (refereegranskat)abstract
- Nomenclatural type definitions are one of the most important concepts in biological nomenclature. Being physical objects that can be re-studied by other researchers, types permanently link taxonomy (an artificial agreement to classify biological diversity) with nomenclature (an artificial agreement to name biological diversity). Two proposals to amend the International Code of Nomenclature for algae, fungi, and plants (ICN), allowing DNA sequences alone (of any region and extent) to serve as types of taxon names for voucherless fungi (mainly putative taxa from environmental DNA sequences), have been submitted to be voted on at the 11th International Mycological Congress (Puerto Rico, July 2018). We consider various genetic processes affecting the distribution of alleles among taxa and find that alleles may not consistently and uniquely represent the species within which they are contained. Should the proposals be accepted, the meaning of nomenclatural types would change in a fundamental way from physical objects as sources of data to the data themselves. Such changes are conducive to irreproducible science, the potential typification on artefactual data, and massive creation of names with low information content, ultimately causing nomenclatural instability and unnecessary work for future researchers that would stall future explorations of fungal diversity. We conclude that the acceptance of DNA sequences alone as types of names of taxa, under the terms used in the current proposals, is unnecessary and would not solve the problem of naming putative taxa known only from DNA sequences in a scientifically defensible way. As an alternative, we highlight the use of formulas for naming putative taxa (candidate taxa) that do not require any modification of the ICN.
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| 9. |
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| 10. |
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| 11. |
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| 12. |
- Abolfathi, Bela, et al.
(författare)
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The Fourteenth Data Release of the Sloan Digital Sky Survey : First Spectroscopic Data from the Extended Baryon Oscillation Spectroscopic Survey and from the Second Phase of the Apache Point Observatory Galactic Evolution Experiment
- 2018
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Ingår i: Astrophysical Journal Supplement Series. - : IOP Publishing Ltd. - 0067-0049 .- 1538-4365. ; 235:2
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Tidskriftsartikel (refereegranskat)abstract
- The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its first two years of operation (2014-2016 July) public. Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey; the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data-driven machine-learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from the SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS web site (www.sdss.org) has been updated for this release and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020 and will be followed by SDSS-V.
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| 13. |
- Bischoff, Stephan C, et al.
(författare)
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Towards a multidisciplinary approach to understand and manage obesity and related diseases
- 2017
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Ingår i: Clinical Nutrition. - : Elsevier BV. - 0261-5614 .- 1532-1983. ; 36:4, s. 917-938
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Forskningsöversikt (refereegranskat)abstract
- Overnutrition and sedentary lifestyle result in overweight or obesity defined as abnormal or excessive fat accumulation that may impair health. According to the WHO, the worldwide prevalence of obesity nearly doubled between 1980 and 2008. In 2008, over 50% of both men and women in the WHO European Region were overweight, and approximately 23% of women and 20% of men were obese. Comprehensive diagnostic and therapeutic approaches should include nutritional treatment to favor the best metabolic and nutritional outcome, as well as to induce potential disease-specific benefits from selected nutritional regimens. Obesity is usually accompanied by an increased muscle mass. This might explain why obesity, under particular circumstances such as cancer or high age, might have protective effects, a phenomenon named the 'obesity paradox'. However, loss of muscle mass or function can also occur, which is associated with poor prognosis and termed 'sarcopenic obesity'. Therefore, treatment recommendations may need to be individualized and adapted to co-morbidities. Since obesity is a chronic systemic disease it requires a multidisciplinary approach, both at the level of prevention and therapy including weight loss and maintenance. In the present personal review and position paper, authors from different disciplines including endocrinology, gastroenterology, nephrology, pediatrics, surgery, geriatrics, intensive care medicine, psychology and psychiatry, sports medicine and rheumatology, both at the basic science and clinical level, present their view on the topic and underline the necessity to provide a multidisciplinary approach, to address this epidemic.
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| 14. |
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| 15. |
- Blanton, Michael R., et al.
(författare)
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Sloan Digital Sky Survey IV : Mapping the Milky Way, Nearby Galaxies, and the Distant Universe
- 2017
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Ingår i: Astronomical Journal. - : IOP Publishing Ltd. - 0004-6256 .- 1538-3881. ; 154:1
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Tidskriftsartikel (refereegranskat)abstract
- We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and. high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median z similar to 0.03). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between z similar to 0.6 and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs. and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the. Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July.
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| 16. |
- Bott, Lukas Thomas, et al.
(författare)
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Coulomb dissociation of O-16 into He-4 and C-12
- 2023
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Ingår i: NUCLEAR PHYSICS IN ASTROPHYSICS - X, NPA-X 2022. - : EDP Sciences. - 2100-014X. ; 279
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Konferensbidrag (refereegranskat)abstract
- We measured the Coulomb dissociation of O-16 into He-4 and C-12 within the FAIR Phase-0 program at GSI Helmholtzzentrum fur Schwerionenforschung Darmstadt, Germany. From this we will extract the photon dissociation cross section O-16(alpha,gamma)C-12, which is the time reversed reaction to C-12(alpha,gamma)O-16. With this indirect method, we aim to improve on the accuracy of the experimental data at lower energies than measured so far. The expected low cross section for the Coulomb dissociation reaction and close magnetic rigidity of beam and fragments demand a high precision measurement. Hence, new detector systems were built and radical changes to the (RB)-B-3 setup were necessary to cope with the high-intensity O-16 beam. All tracking detectors were designed to let the unreacted O-16 ions pass, while detecting the C-12 and He-4.
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| 17. |
- Brito, Haissa Oliveira, et al.
(författare)
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Immune-mediated febrile response in female rats: Role of central hypothalamic mediators
- 2020
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Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Lipopolysaccharide (LPS) induces fever through cytokines like receptor-activator of nuclear factor kappa B ligand (RANKL), triggering mediators like prostaglandins (PG), endothelin-1 (ET-1), corticotrophin-releasing factor (CRF), substance P (SP) and endogenous opioids. LPS-induced fever is reduced in females compared with males except in ovariectomized (OVX) females which show increased fever mediated by PG. The present study aimed to identify the mediators involved in fever in intact and OVX female rats. Fever was induced with LPS (50 mu g/kg) intraperitoneally or CRF (2.5 mu g), ET-1 (1 pg), morphine (10 mu g) and SP (500 ng) intracerebroventricularly in sham-operated and OVX rats. The role of RANKL was evaluated with osteoprotegerin (OPG, 1 mu g, intracerebroventricularly). Expression of RANK, CRFI/II, ETB, mu-opioid (MOR) and NK1 receptors was evaluated by confocal microscopy. Besides LPS, only morphine induced fever in OVX rats while all mediators induced fever in sham-operated animals. OPG abolished LPS-induced fever in OVX but not sham-operated animals. Overall, fever involves similar central mediators in cycling females and males but only morphine induced fever in OVX females. Importantly, RANK/RANKL participates in LPS-induced fever in OVX females, as in males but not in cycling females.
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| 18. |
- Cambra, Josep M., et al.
(författare)
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Allogeneic Embryos Disregulate Leukemia Inhibitory Factor (LIF) and Its Receptor in the Porcine Endometrium During Implantation
- 2020
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Ingår i: Frontiers in Veterinary Science. - : Frontiers Media S.A.. - 2297-1769. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Despite its advantages for pig breeding, embryo transfer (ET) has a major handicap: high embryo mortality during the pre- and implantation period, probably caused by divergent phenomena of tolerance between the immunologically unrelated (i.e., allogeneic) embryos and the recipient sow. Thus, to reach a similar maternal tolerance as in conventional breeding by artificial insemination (AI) would be the key to ET-success. For this reason, we studied the expression of the leukemia inhibitory factor (LIF) cytokine and its receptor in the pig endometrium during the implantation period (days 18 and 24) in sows subjected to ET (AL group) vs. post-cervical-AI controls (Hemi-AL group). Quantification of expression was performed at both mRNA (rt-qPCR) and protein (WB) levels. The expression of endometrial LIF on day 24 was considerably lower in ET than in AI pregnancies. Correlations between endometrial mRNA levels of LIF and LIF-R showed that, contrary to early AI-pregnancies, ET-pregnancies lack an inverse relation between cytokine and receptor levels. In conclusion, ET-pregnancies lack sufficient endometrial levels of LIF to develop adequate immunotolerance mechanisms to prevent the rejection of allogeneic ET-embryos.
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| 19. |
- Carraminana, Albert, et al.
(författare)
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Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)
- 2019
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Ingår i: Journal of Cardiothoracic and Vascular Anesthesia. - : W B SAUNDERS CO-ELSEVIER INC. - 1053-0770 .- 1532-8422. ; 33:9, s. 2492-2502
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design: International, multicenter, prospective, randomized controlled clinical trial. Setting: A network of university hospitals. Participants: The study comprises 1,380 patients scheduled for thoracic surgery. Interventions: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients. (C) 2019 Published by Elsevier Inc.
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| 20. |
- Chaparro, Maria, et al.
(författare)
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Surgery due to Inflammatory Bowel Disease During Pregnancy: Mothers and Offspring Outcomes From an ECCO Confer Multicentre Case Series [Scar Study]
- 2022
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Ingår i: Journal of Crohn's & Colitis. - Oxford, United Kingdom : Oxford University Press. - 1873-9946 .- 1876-4479. ; 16:9, s. 1428-1435
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Tidskriftsartikel (refereegranskat)abstract
- Aims: i] To evaluate the evolution of pregnancies and offspring after inflammatory bowel disease [IBD] surgery during pregnancy; and ii] to describe the indications, the surgical techniques, and the frequency of caesarean section concomitant with surgery.Methods: Patients operated on due to IBD during pregnancy after 1998 were included. Participating clinicians were asked to review their databases to identify cases. Data on patients demographics, IBD characteristics, medical treatments, IBD activity, pregnancy outcomes, surgery, delivery, and foetal and maternal outcomes, were recorded.Results: In all, 44 IBD patients were included, of whom 75% had Crohns disease; 18% of the surgeries were performed in the first trimester, 55% in the second, and 27% in the third trimester. One patient had complications during surgery, and 27% had postsurgical complications. No patient died. Of deliveries, 70% were carried out by caesarean section. There were 40 newborns alive. There were four miscarriages/stillbirths [one in the first, two in the second, and one in the third trimester]; two occurred during surgery, and another two occurred 2 weeks after surgery; 14% of the surgeries during the second trimester and 64% of those in the third trimester ended up with a simultaneous caesarean section or vaginal delivery. Of the 40 newborns, 61% were premature and 47% had low birth weight; 42% of newborns needed hospitalisation [25% in the intensive care unit].Conclusions: IBD surgery during pregnancy remains an extremely serious situation. Therefore, surgical management should be performed in a multidisciplinary team, involving gastroenterologists, colorectal surgeons, obstetricians, and neonatal specialists.
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| 21. |
- Costa, Joao, et al.
(författare)
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The burden of atherosclerosis in Portugal
- 2021
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Ingår i: European Heart Journal - Quality of Care and Clinical Outcomes. - : Oxford University Press. - 2058-5225 .- 2058-1742. ; 7:2, s. 154-162
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Tidskriftsartikel (refereegranskat)abstract
- Aims This article sought to estimate the burden of disease attributable to atherosclerosis in mainland Portugal in 2016.Methods and results The burden of atherosclerosis was measured in disability-adjusted life years following the latest 2010 Global Burden of Disease (GBD) methodology. Disability-adjusted life years were estimated as the sum of years of life lost (YLL) with years lived with disability (YLD). The following clinical manifestations of atherosclerosis were included: ischaemic heart disease (IHD) (including acute myocardial infarction, stable angina, and ischaemic heart failure), ischaemic cerebrovascular disease (ICVD), and peripheral arterial disease (PAD). Years of life lost were estimated based on all-cause mortality data for the Portuguese population and mortality due to IHD, ICVD, and PAD for the year 2016 sourced from national statistics. Standard life expectancy was sourced from the GBD study. Years lived with disability corresponded to the product of the number of prevalent cases by an average disability weight for all possible combinations of disease. Prevalence data for the different clinical manifestations of atherosclerosis were sourced from epidemiological studies. Disability weights were sourced from the published literature. In 2016, 15123 deaths were attributable to atherosclerosis, which corresponded to 14.3% of overall mortality in mainland Portugal. Disability-adjusted life years totalled 260943, 75% due to premature death (196438 YLL) and 25% due to disability (64505 YLD).Conclusion Atherosclerosis entails a high disease burden to society. A large part of this burden would be avoidable if evidence-based effective and cost-effective interventions targeting known risk factors, from prevention to treatment, were implemented.
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| 22. |
- Ferrando, Carlos, et al.
(författare)
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Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy : a randomised controlled trial
- 2020
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Ingår i: British Journal of Anaesthesia. - : ELSEVIER SCI LTD. - 0007-0912 .- 1471-6771. ; 124:1, s. 110-120
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Tidskriftsartikel (refereegranskat)abstract
- Background: We aimed to examine whether using a high fraction of inspired oxygen (FIO2) in the context of an individualised intra- and postoperative open-lung ventilation approach could decrease surgical site infection (SSI) in patients scheduled for abdominal surgery. Methods: We performed a multicentre, randomised controlled clinical trial in a network of 21 university hospitals from June 6, 2017 to July 19, 2018. Patients undergoing abdominal surgery were randomly assigned to receive a high (0.80) or conventional (0.3) FIO2 during the intraoperative period and during the first 3 postoperative hours. All patients were mechanically ventilated with an open-lung strategy, which included recruitment manoeuvres and individualised positive end-expiratory pressure for the best respiratory-system compliance, and individualised continuous postoperative airway pressure for adequate peripheral oxyhaemoglobin saturation. The primary outcome was the prevalence of SSI within the first 7 postoperative days. The secondary outcomes were composites of systemic complications, length of intensive care and hospital stay, and 6-month mortality. Results: We enrolled 740 subjects: 371 in the high FIO2 group and 369 in the low FIO2 group. Data from 717 subjects were available for final analysis. The rate of SSI during the first postoperative week did not differ between high (8.9%) and low (9.4%) FIO2 groups (relative risk [RR]: 0.94; 95% confidence interval [CI]: 0.59-1.50; P=0.90]). Secondary outcomes, such as atelectasis (7.7% vs 9.8%; RR: 0.77; 95% CI: 0.48-1.25; P=0.38) and myocardial ischaemia (0.6% [n=2] vs 0% [n=0]; P=0.47) did not differ between groups. Conclusions: An oxygenation strategy using high FIO2 compared with conventional FIO2 did not reduce postoperative SSIs in abdominal surgery. No differences in secondary outcomes or adverse events were found.
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| 23. |
- Flieh, Sondos M., et al.
(författare)
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Longitudinal associations between psychosomatic and emotional status and selected food portion sizes in European children and adolescents: IDEFICS/I.Family study
- 2024
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Ingår i: NUTRITION RESEARCH. - 0271-5317 .- 1879-0739. ; 127, s. 84-96
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Tidskriftsartikel (refereegranskat)abstract
- This study aims to investigate the influence of psychosomatic and emotional status on food portion sizes (PSs) consumption from high energy -dense food groups in European children and adolescents. We hypothesized that psychosomatic and emotional status would have a significant association with the PS selection of energy -dense food. The study included 7355 children aged between 2 and 9.9 years at baseline (T0) (48.8% females); 3869 after 2 years (T1) (48.2% females), and 2971 (51.8% females) after 6 years of follow-up (T3). Psychosomatic and emotional status were measured using emotional well-being during the last week score (KINDL) and Strengths and Difficulties Questionnaire. PS was calculated from daily food intake recorded in 24 -hour dietary recalls. The associations between emotional status indicators and PS from selected energy -dense food groups were assessed by multilevel linear regression models. In the cross-sectional analysis, we observed that higher KINDL scores were linked to lower PS consumption from sweet bakery products and savory snacks in both genders. Moreover, we found that adolescent females with high emotional and peer problem scores tended to consume larger PS of carbohydrate -rich and sugar -fatty food items ( P < .017). Longitudinally, higher peer problem scores were associated with increased PS from bread and rolls, margarine and lipids, and dairy products in all genders and age groups ( P < .017). In adolescents, psychosomatic and emotional status could be a trigger for consuming large PS from carbohydrate -rich and sugar -fatty energy -dense foods. Thus, nutritional interventions should consider emotional status to decrease unhealthy dietary habits in children and adolescents. (c) 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY -NC -ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
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| 24. |
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| 25. |
- Gil de la Iglesia, Didac, 1981-, et al.
(författare)
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A Self-Adaptive Multi-Agent System Approach for Collaborative Mobile Learning
- 2015
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Ingår i: IEEE Transactions on Learning Technologies. - : IEEE. - 1939-1382. ; 8:2, s. 158-172
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Tidskriftsartikel (refereegranskat)abstract
- Mobile technologies have emerged as facilitators in the learning process, extending traditional classroom activities. However, engineering mobile learning applications for outdoor usage poses severe challenges. The requirements of these applications are challenging, as many different aspects need to be catered, such as resource access and sharing, communication between peers, group management, activity flow, etc. Robustness is particularly important for learning scenarios to guarantee undisturbed and smooth user experiences, pushing the technological aspects in the background. Despite significant research in the field of mobile learning, very few efforts have focused on collaborative mobile learning requirements from a software engineering perspective. This paper focuses on aspects of the software architecture, aiming to address the challenges related to resource sharing in collaborative mobile learning activities. This includes elements such as autonomy for personal interactive learning, richness for large group collaborative learning (indoor and outdoor), as well as robustness of the learning system. Additionally, we present self-adaptation as a solution to mitigate risks of resource unavailability and organization failures that arise from environment and system dynamism. Our evaluation provides indications regarding the system correctness with respect to resource sharing and collaboration concerns, and offers qualitative evidence of self-adaptation benefits for collaborative mobile learning applications.
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| 26. |
- Gil García, Javier, et al.
(författare)
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State-Led Actions Reigniting the Financialization of Housing in Spain
- 2023
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Ingår i: Housing, Theory and Society. - : Routledge. - 1403-6096 .- 1651-2278. ; 40:1, s. 1-21
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Tidskriftsartikel (refereegranskat)abstract
- Since the 2008 economic recession, state intervention in the real estate sector has strengthened. This article explains how housing financialization was reignited in Spain following key policy reforms in 2013. We argue that Spanish authorities managed to strategically recreate a finance-friendly environment to attract global investors. They combined financial policies, other deregulatory reforms and neoliberal measures in a coordinated manner we call a policy package. Our analysis provides evidence of the legal and political arrangements at various state levels that effectively facilitated the reanimation of a new cycle of housing financialization which caused rising inflation in prices and distress in tenants’ rights. This approach contributes to the understanding of how state-led actions foster a spatial fix to overcome financial crises by granting global speculative funds extraordinary benefits. In addition, we show how this process occurred with poor democratic accountability and was also confronted by various forms of social contestation.
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| 27. |
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| 28. |
- Gil, Miguel, et al.
(författare)
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Auditing in family firms : Past trends and future research directions
- 2024
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Ingår i: Journal of small business management (Print). - : Taylor & Francis. - 0047-2778 .- 1540-627X.
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Forskningsöversikt (refereegranskat)abstract
- This systematic literature review synthesizes and maps existing research on auditing in family firms across multiple areas of study. The review includes 71 systematically selected academic articles published through to 2023. Our findings suggest that many audit-related issues, such as audit fees, audit quality, and auditor choice, differ significantly among family and nonfamily firms. Our review suggests that the positioning of the issues across different disciplines adds complexity and, to some extent, hinders the development of the field. This complexity, resulting from the intermixing of multiple concepts from different disciplines, pushes the majority of the reviewed articles toward theoretical singularity rather than a leap forward in terms of empirical relevance or theoretical plurality. By developing a field map that identifies gaps in current knowledge, our review not only suggests improvements to the status quo, but provides future research directions inspired by recent developments in family business and auditing.
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| 29. |
- Gil, Miguel, et al.
(författare)
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City Governance and Resilience During the COVID-19 Emergency : A Case Study of Mexico City
- 2021
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Ingår i: COVID-19 and Cities. - Cham : Springer. - 9783030841331 - 9783030841348 ; , s. 235-248
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Bokkapitel (refereegranskat)abstract
- During periods of social crisis, city governance and resilience become critical factors to manage the emergency. In terms of a health and economic crisis, the importance of such terms is even more meaningful. This chapter explores the case of Mexico City during the COVID-19 emergency. The study uses a multilevel framework of city governance and resilience (Lazarus JV, Binagwaho A, El-Mohandes AA, Fielding JE, Larson HJ, Plasència A, … Ratzan SC, Nat Med 26(7):1005–1008, 2020) to make sense of the empirical findings. The evidence from the case study suggests that the reactions from the largest healthcare organization in Mexico (IMSS), the federal, and the local government differed from each other in a variety of ways. Such contradictions between organizations and governments led to confusion and contradictory strategies. The findings contrast with the current understanding of city governance and resilience, which calls for communication and collaboration between government levels. This paper contributes to a better understanding of city governance and resilience during an emergency.
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| 30. |
- Gil, Miguel, et al.
(författare)
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Demand planning on small and medium-sized enterprises in Mexico : A case study of a confectionery firm
- 2020
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Ingår i: Advances in Business-Related Scientific Research Journal. - : GEA College – Faculty of Entrepreneurship. - 1855-931X. ; 11:2, s. 56-73
-
Tidskriftsartikel (refereegranskat)abstract
- Organizations that efficiently complete a demand planning process gain a competitive advantage. The current demand planning literature mostly studies relatively large organizations. However, SMEs invest a significant amount of resources into improving demand planning practices. Moreover, the context of SMEs in Latin America, and specifically Mexico, has not been explored sufficiently by the current literature. Thus, the purpose of this paper is to understand demand planning in a Mexican SME. The paper involves a case study of a confectionery firm based in Jalisco, Mexico. To make sense of the empirical findings, the Kilger and Wagner (2008) theoretical framework of demand planning was utilized. This paper concludes that Mexican SMEs have a different context compared to larger firms in developed countries. Thus, how Mexican SMEs envision and implement demand planning is unique, specifically in demand planning structures and controlling.
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| 31. |
- Gil, Miguel
(författare)
-
Digital Transformation and Corporate Sustainability Accounting
- 2021
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Ingår i: The Palgrave Handbook of Corporate Sustainability in the Digital Era. - Cham : Palgrave Macmillan. - 9783030424114 - 9783030424145 - 9783030424121 ; , s. 651-669
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Bokkapitel (refereegranskat)abstract
- This chapter seeks to understand how digital transformation (DT) affects corporate sustainability accounting (CSA). Nowadays, CSA is very topical due to policy regulations and its impact on financial performance. However, current accounting systems have fallen short in providing timely and accurate data to inform stakeholders on corporate sustainability (CS) efforts. DT provides a technological improvement in accounting that fosters the production of relevant and timely information regarding CS. This chapter explores DT and its effect on CSA in the forest exploitation industry. A case study of the industry is developed using a CS system framework. The findings of this study contribute to the understanding of DT and CS endeavors. Furthermore, practitioners and policymakers can learn from the case study presented in this chapter.
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| 32. |
- Gil, Miguel, et al.
(författare)
-
International Short-Term Trips and the Development of a Global Mindset in Business Students
- 2020
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Ingår i: Journal of Teaching in International Business. - : Taylor & Francis. - 0897-5930 .- 1528-6991. ; 31:4, s. 358-379
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Tidskriftsartikel (refereegranskat)abstract
- This paper examines whether an international short-term trip helps students to develop a global mind-set. A quantitative and qualitative analysis was carried out with students at Tecnologico de Monterrey (Mexico) who did a one-week international trip to New York. The results suggest that the international short-term trip further developed the global mind-set of business students. Furthermore, professional aspirations and networking skills, which were also developed during the short-term international trip, act as amplifiers in the development of a global mind-set.
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| 33. |
- Gil, Miguel
(författare)
-
Internationalisation of Start-Ups : An Institutional Entrepreneurship Perspective
- 2021
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Ingår i: Empirical International Entrepreneurship. - Cham : Springer. - 9783030689711 - 9783030689728 ; , s. 183-198
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Bokkapitel (refereegranskat)abstract
- How and why start-ups become international is still a relevant question in the current literature. This chapter intends to answer both questions by incorporating the notions of institutional entrepreneurship. The study uses a comparative case study of two start-up firms based in Mexico, which recently became international. The analysis of both cases revealed the importance of the role of the firms’ owners. Moreover, it became clear that both owners created and transformed organisational institutions that allowed the firms to become international. The study takes into consideration a multilevel perspective, which analyses both cases at the micro, meso, and macro institutional levels. This chapter intends to contribute to the entrepreneurial and institutional entrepreneurship bodies of literature.
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| 34. |
- Gil, Miguel, et al.
(författare)
-
Inventory Control and the Use of Technology in Businesses : A Survey Study of Micro-Companies in Mexico
- 2021
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Ingår i: Entrepreneurial Innovation for Securing Long-Term Growth in a Short-Term Economy. - Hershey, PA : IGI Global. - 9781799835684 - 9781799835691 - 9781799835707 ; , s. 1-15
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Bokkapitel (refereegranskat)abstract
- This research explores the relationship that exists between inventory control and the use of technology. A survey was conducted in the city of Guadalajara, Mexico, covering 466 micro-companies. A logit analysis was used to calculate the probability for the micro-companies to implement formal inventory controls. The study found that using technology in micro-companies fosters formal inventory control. This chapter contributes to other management control studies which claim that technology might foster the use of formal inventory controls. Furthermore, this chapter aims to advise practitioners to adopt technology in their business as a way to facilitate the implementation of formal inventory controls.
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| 35. |
- Gil, Miguel
(författare)
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La evolución de los sistemas de control administrativos : estudio de caso en un ambiente de incertidumbre
- 2013
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Ingår i: Observatorio de la Economía Latinoamericana. - 1696-8352.
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Tidskriftsartikel (refereegranskat)abstract
- Los Sistemas de Control Administrativos (SCA) son una herramienta muy importante para los gerentes de cualquier empresa, pero cuando la empresa se desarrolla en un ambiente de negocios con gran incertidumbre su aplicación se vuelve bastante compleja. El presente estudio busca encontrar los elementos claves que provocan que los SCA de una empresa con alto nivel de incertidumbre evolucionen. El estudio de caso se enfoca en una pequeña empresa de desarrollo de software que implementa un SCA y que presenta una evolución constante debido al nivel de incertidumbre presente en el ambiente de negocios. El artículo concluye con un análisis crítico sobre lo establecido actualmente en la literatura y los hallazgos empíricos del estudio de caso.
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| 36. |
- Gil, Miguel
(författare)
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La masculinidad en los negocios
- 2019
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Ingår i: Revista Atlante: Cuaderno de Educacion y Desarrollo. - 1989-4155. ; :octubre
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Tidskriftsartikel (refereegranskat)abstract
- El presente artículo analiza la conceptualización de masculinidad en los negocios. El artículo analiza el contexto en el que la masculinidad se conceptualiza desde la visión tradicional en la que se usa dominación, violencia y fuerza. Desde dicho punto de vista el artículo apunta a que en los negocios dicha conceptualización trae algunos problemas debido a que los valores de la masculinidad tradicional no son coherentes con la sociedad contemporánea. También el artículo presenta la perspectiva en la que la masculinidad se interpreta desde una perspectiva plural y no se esperan comportamientos de dominación o violencia. En este caso, el mundo de los negocios funciona de mejor manera ya que los valores de la masculinidad contemporánea son incluyentes con los miembros de la organización. Este artículo contribuya al entendimiento de la masculinidad en los negocios. Además, las conclusiones de este artículo apuntan a que la masculinidad juega un papel clave en la dinámica organizacional.
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| 37. |
- Gil, Miguel
(författare)
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Management Control Systems And Organisational Learning : A Literature Review
- 2019
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Ingår i: Journal of International Business and Economics. - : International Academy of Business and Ecomomics. - 1544-8037 .- 2378-9174. ; 19:4, s. 25-38
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Forskningsöversikt (refereegranskat)abstract
- The purpose of this article is to synthesize the current literature in Management Control Systems (MCSs) from an Organisational Learning (OL) perspective. For this literature review the 4i framework of 4i (Crossan et al., 1999) was used to analyse the current literature through a multilevel perspective and by acknowledging the feedforward and the feedback processes of learning. The findings of this literature review highlight the importance of examining how organisations use MCSs to generate new ideas (feedforward learning) rather than only focusing on implementing accounting practices (feedback learning). Theis paper has two main contributions. Firstly, this paper urges scholars about the intrinsic relationship that exist between MCSs and OL. Secondly, that the current literature does not sufficiently understand how MCSs can foster OL by producing new intuitions at the individual level.
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| 38. |
- Gil, Miguel
(författare)
-
Organizational Transformation During COVID-19
- 2020
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Ingår i: IEEE Engineering Management Review. - : IEEE. - 0360-8581 .- 1937-4178. ; 48:3, s. 31-36
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Tidskriftsartikel (refereegranskat)abstract
- Organizational transformation is an interesting topic in theory and practice. Achieving organizational transformation is seen as a huge challenge for managers as there are many aspects that the organization needs to deal with. During the COVID-19 lockdown, organizations faced an urgent need to radically transform in order to survive. Moreover, the economic and social context of the Mexican economy makes it even more important to understand how organizations can radically transform as, in theory, such a context seems to be detrimental for organizational transformation. This study analyzed 21 organizations based in Mexico and pays special attention to 5 organizations that achieved radical organizational transformation. The main takeaway point from this study is that the five organizations that achieved radical transformation had at least four things in common. First, senior managers were strongly convinced that without radical transformation the firm would perish before the end of the year. Second, these five organizations quickly reshaped their management control systems. Third, the five organizations that achieved a radical change hired specialized consultants to achieve the transformation. Finally, these organizations also outsourced to external firms to complete processes where they themselves did not have any previous experience. This article contributes to a better understanding of organizational transformation.
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| 39. |
- Gil, Miguel
(författare)
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Sistemas de Control Administrativos : el uso del Stage-Gate Process en un ambiente de innovación
- 2018
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Ingår i: Contabilidad y Negocios. - : Pontificia Universidad Catolica del Peru, Departamento de Ciencias Administrativas. - 1992-1896 .- 2221-724X. ; 13:25, s. 70-81
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Tidskriftsartikel (refereegranskat)abstract
- El objetivo de esta investigación es entender cómo funcionan los Sistemas de Control Administrativos (SCA) en un contexto de innovación. Utilizando el método de estudio de caso, se analiza la evolución de un SCA basado en las características del Stage-Gate Process (Cooper, 1990), que fue implementado en una pequeña empresa especializada en el desarrollo de aplicaciones móviles con operaciones en Guadalajara, México. El estudio concluye que, debido al tamaño de la empresa, el SCA evolucionó para utilizar controles informales que favorecieran la innovación en el desarrollo de los productos.
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| 40. |
- Gil, Miguel, et al.
(författare)
-
The impact of an incubation process on management control systems of start-ups
- 2020
-
Ingår i: Business Practices, Growth and Economic Policy in Emerging Markets. - : World Scientific. - 9789811221743 - 9789811221767 - 9789811221750 ; , s. 135-153
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Bokkapitel (refereegranskat)abstract
- Management control systems (MCSs) and business incubators (BIs) are both argued to support start-ups in their survival and growth. This research links these two increasingly relevant topics in literature and aims at answering the research question: How does an incubation process affect MCSs in start-ups? A qualitative and exploratory case study is used to answer the research question. Semi-structured interviews were conducted with three start-ups and the management of the Mexican incubator “TecLean”. The findings of this research suggest that an incubation process influences the development of MCSs in start-ups in at least two ways. First, an incubation process pushes the start-ups toward a non-traditional conceptualization of MCSs to include their stakeholders’ perspective. Second, an incubation process highlights the relevance of MCSs when aiming at obtaining venture capital (VC) and thus increases the start-ups’ awareness and initiative to implement stricter MCSs. This research suggests that practitioners in BIs should teach start-ups consciously on how to design MCSs. This may increase start-ups’ access to VC.
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| 41. |
- Gil, Miguel
(författare)
-
The Use of Excel and Its Impact on Student Performance in a Finance Course at a Mexican University
- 2022
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Ingår i: Journal of International Business Education. - : NeilsonJournals Publishing. - 1649-4946 .- 2044-4575. ; 17, s. 211-228
-
Tidskriftsartikel (refereegranskat)abstract
- This study analyses business students’ decision to use Excel or not to complete assignments in a finance course at a Mexican University, and the affect on exam performance. The study adds to current literature in that there is a lack of such research on finance students in developing nations. After quantitative data was collected, qualitative information was obtained via interviews with some of the students to understand more about their decisions. The quantitative data showed that there was no effect on student exam performance between using Excel or not in completing assignments, and completing all assignments, regardless of whether Excel was used or not, improved the students’ exam performance. The qualitative information showed that students had different responses to having a choice of using Excel, and different approaches to using it. The implications for Finance instructors in Mexico and other developing nations are discussed.
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| 42. |
- Gil-Martinez, Alejandro, et al.
(författare)
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Symmetric Tapering of Bi-Directionally Fed Leaky-Wave Antennas for Multi-Beam Synthesis
- 2023
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Ingår i: 2023 17TH EUROPEAN CONFERENCE ON ANTENNAS AND PROPAGATION, EUCAP. - : Institute of Electrical and Electronics Engineers (IEEE).
-
Konferensbidrag (refereegranskat)abstract
- We report a theoretical investigation on the possibilities and trade-offs when tapering a bi-directional fed leaky-wave antenna (LWA) to reduce the side lobes level, when operating with the two opposite antenna ports. It is demonstrated that, for high radiation efficiency designs, the directivity can be distorted due to low aperture illumination efficiency if the LWA is not symmetrically tapered with an adequate modulation function. The theory is corroborated with simulations of modulated LWAs in substrate integrated technology.
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| 43. |
- Gil-Romera, Graciela, et al.
(författare)
-
Long-term fire resilience of the Ericaceous Belt, Bale Mountains, Ethiopia
- 2019
-
Ingår i: Biology Letters. - : The Royal Society. - 1744-9561 .- 1744-957X. ; 15:7
-
Tidskriftsartikel (refereegranskat)abstract
- Fire is the most frequent disturbance in the Ericaceous Belt (ca 3000-1300 m.a.s.l.), one of the most important plant communities of tropical African mountains. Through resprouting after fire, Erica establishes a positive fire feedback under certain burning regimes. However, present-day human activity in the Bale Mountains of Ethiopia includes fire and grating systems that may have a negative impact on the resilience of the ericaceous ecosystem. Current knowledge of Erica-fire relationships is based on studies of modern vegetation, lacking a longer time perspective that can shed light on baseline conditions for the fire feedback. We hypothesite that fire has influenced Erica communities in the Bale Mountains at millennial time-scales. To test this, we (1) identity the tire history ot the Bale Mountains through a pollen and charcoal record from Garba Guracha, a lake at 3950 m.a.s.l., and (2) describe the long-term bidirectional feedback between wildfire and Erica, which may control the ecosystem's resilience. Our results support fire occurrence in the area since ca 14 000 years ago, with particularly intense burning during the early Holocene, 10.8-6.0 cal ka BP. We show that a positive feedback between Erica abundance and fire occurrence was in operation throughout the Lateglacial and Holocene, and interpret the Ericaceous Bolt of the Ethiopian mountains as a long-term fire resilient ecosystem. We propose that controlled burning should be an integral part of landscape management in the Bale Mountains National Park.
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| 44. |
- Gil-Vila, Albert, et al.
(författare)
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COVID-19 Vaccination In Autoimmune Diseases (COVAD) Study : Vaccine Safety In Idiopathic Inflammatory Myopathies
- 2022
-
Ingår i: Muscle and Nerve. - : John Wiley & Sons. - 0148-639X .- 1097-4598. ; 66:4, s. 426-437
-
Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION/AIMS: We studied COVID-19 vaccination-related adverse events (ADEs) 7-days post-vaccination in patients with idiopathic inflammatory myopathies (IIMs) and other systemic autoimmune and inflammatory disorders (SAIDs).METHODS: 7-day vaccine ADEs were collected in an international patient self-reported e-survey. Descriptive statistics and multivariable regression were performed.RESULTS: 10,900 respondents [1227 IIMs; 4640 SAIDs; 5033 healthy controls (HCs), median age 42 (IQR 30-55) years, 74% female, 45% Caucasian, 69% completely vaccinated] were analysed. 76.3% IIMs patients reported minor and 4.6% major ADEs. Patients with active IIMs reported more frequent major [OR 2.7 (1.04-7.3)] and minor [OR 1.5 (1.1-2.2)] ADEs than inactive IIMs. Rashes were more frequent in IIMs [OR-2.3(1.2-4.2)] than HCs. ADEs were not impacted by steroid dose, although hydroxychloroquine and intravenous/subcutaneous immunoglobulins were associated with a higher risk of minor ADEs [OR 1.9 (1.1-3.3), OR 2.2 (1.1-4.3)]. Overall, ADEs were less frequent in inclusion body myositis (IBM) and BNT162b2 (Pfizer) vaccine recipients DISCUSSION: 7-day post-vaccination ADEs were comparable in patients with IIMs, SAIDs, and HCs, except for a higher risk of rashes in IIMs. Patients with DM, active disease may be at higher risk, and IBM patients at lower risk of specific ADEs. Overall, the benefit of preventing severe COVID-19 through vaccination likely outweighs the risk of vaccine-related ADEs Our results may inform future guidelines regarding COVID-19 vaccination in patients with SAIDs, and specifically in IIMs. Studies to evaluate long-term outcomes and disease flares are needed to shed more light on developing future COVID-19 vaccination guidelines.
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| 45. |
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| 46. |
- González-Gil, Esther María, et al.
(författare)
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Prospective associations between dietary patterns and high sensitivity C-reactive protein in European children: the IDEFICS study.
- 2018
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Ingår i: European journal of nutrition. - : Springer Science and Business Media LLC. - 1436-6215 .- 1436-6207. ; 57:4, s. 1397-1407
-
Tidskriftsartikel (refereegranskat)abstract
- This prospective study explores high sensitivity C-reactive protein (hs-CRP) levels in relation to dietary patterns at two time points in European children.Out of the baseline sample of the IDEFICS study (n=16,228), 4020 children, aged 2-9 years at baseline, with available hs-CRP levels and valid data from a food frequency questionnaire (FFQ) at baseline (T0) and 2 years later (T1) were included. K-means clustering algorithm based on the similarities between relative food consumption frequencies of the FFQ was applied. hs-CRP was dichotomized according to sex-specific cutoff points. Multilevel logistic regression was performed to assess the relationship between dietary patterns and hs-CRP adjusting for covariates.Three consistent dietary patterns were found at T0 and T1: 'animal protein and refined carbohydrate', 'sweet and processed' and 'healthy'. Children allocated to the 'protein' and 'sweet and processed' clusters at both time points had significantly higher odds of being in the highest category of hs-CRP (OR 1.47; 95% CI 1.03-2.09 for 'animal protein and refined carbohydrate' and OR 1.44; 95% CI 1.08-1.92 for 'sweet and processed') compared to the 'healthy' cluster. The odds remained significantly higher for the 'sweet and processed' pattern (OR 1.39; 95% CI 1.05-1.84) when covariates were included.A dietary pattern characterized by frequent consumption of sugar and processed products and infrequent consumption of vegetables and fruits over time was independently related with inflammation in European children. Efforts to improve the quality of the diet in childhood may prevent future diseases related with chronic inflammation.
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| 47. |
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| 48. |
- Gutiérrez-Cueli, Inés, et al.
(författare)
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The Housing Struggle of Working-Class Migrant Women in Spain Through a Double Horizon of Political Temporality
- 2023
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Ingår i: Housing, Theory and Society. - : Routledge. - 1403-6096 .- 1651-2278.
-
Tidskriftsartikel (refereegranskat)abstract
- Impoverished and working-class migrant women have been the hardest hit and most exploited people during both the real estate-financial accumulation cycle and the aftermath of the 2008 crisis in Spain. Since 2009, these women have also been the key actors in outstanding civil disobedience to the neoliberal financial rule through their engagement in housing activism. How has this happened, and with what effects? Our research responds to these questions by focusing on the collective and contextualized strategies of extended struggles for social reproduction. This analytical framework integrates intersectional social structures, spatio-temporal dimensions of social reproduction, and the historical context of real-estate financialisation. Additionally, we argue that the notion of a “double horizon of political temporality” helps explain how the housing struggle evolved and identifies which social and political outcomes were produced. We suggest that this case reveals the mechanisms and impacts of similar grassroots movements challenging the current financialised dynamics of capitalism.
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| 49. |
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| 50. |
- Inoue, Juliana, et al.
(författare)
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Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
- 2018
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Ingår i: Emerging Infectious Diseases. - : Centers for Disease Control and Prevention. - 1080-6040 .- 1080-6059. ; 24:8, s. 1591-1593
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Tidskriftsartikel (refereegranskat)abstract
- Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.
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