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- Castro-Giner, Francesc, et al.
(författare)
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Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
- 2009
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Ingår i: Journal of Environmental Health Perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 117:12, s. 1919-1924
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. METHODS: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO(2) estimates were available. Home addresses were geocoded and linked to modeled outdoor NO(2) estimates, as a marker of local traffic-related pollution. We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor alpha (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor beta2 (ADRB2)]. RESULTS: The association between modeled NO(2) and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666 [odds ratio (OR) = 1.54; 95% confidence interval (CI), 1.10-2.24], TNFA rs2844484 (OR = 2.02; 95% CI, 1.30-3.27). For new-onset asthma, the effect of NO(2) was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52; 95% CI, 1.09-2.16). A significant interaction was found between NQO1 rs2917666 and NO(2) for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma.
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| 2. |
- Pieringer, Astrid, 1979, et al.
(författare)
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Investigation of railway curve squeal using a combination of frequency- and time-domain models
- 2016
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Ingår i: Proceedings of the 12h International Workshop on Railway Noise (IWRN12), Terrigal, Australia, September 12-16. ; , s. 444 - 451
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Konferensbidrag (refereegranskat)abstract
- Railway curve squeal arises from self-excited vibrations during curving. In this paper, a frequency- and a timedomainapproach for curve squeal are compared. In particular, the capability of the frequency-domain model topredict the onset of squeal and the squeal frequencies is studied. In the frequency-domain model, linear stabilityis investigated through complex eigenvalue analysis. The time-domain model is based on a Green's functionsapproach and uses a convolution procedure to obtain the system response. To ensure comparability, the samesubmodels are implemented in both squeal models. The structural flexibility of a rotating wheel is modelled byadopting Eulerian coordinates. To account for the moving wheel‒rail contact load, the so-called moving elementmethod is used to model the track. The local friction characteristics in the contact zone is modelled inaccordance with Coulomb's law with a constant friction coefficient. The frictional instability arises due togeometrical coupling. In the time-domain model, Kalker's non-linear, non-steady state rolling contact modelincluding the algorithms NORM and TANG for normal and tangential contact, respectively, is solved in eachtime step. In the frequency-domain model, the normal wheel/rail contact is modelled by a linearization of theforce-displacement relation obtained with NORM around the quasi-static state and full-slip conditions areconsidered in tangential direction. Conditions similar to those of a curve on the Stockholm metro exposed tosevere curve squeal are studied with both squeal models. The influence of the wheel-rail friction coefficient andthe direction of the resulting creep force on the occurrence of squeal is investigated for vanishing train speed. Results from both models are similar in terms of the instability range in the parameter space and the predictedsqueal frequencies.
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