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- Hedenstierna, M, et al.
(författare)
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Long-term follow-up of successful hepatitis C virus therapy : waning immune responses and disappearance of liver disease are consistent with cure.
- 2015
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Ingår i: Alimentary Pharmacology and Therapeutics. - : Wiley. - 0269-2813 .- 1365-2036. ; 41:6, s. 532-543
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: A sustained viral response (SVR) after interferon-based therapy of chronic hepatitis C virus (HCV) infection is regarded to represent a cure. Previous studies have used different markers to clarify whether an SVR truly represents a cure, but no study has combined a clinical work-up with highly sensitive HCV RNA detection, and the determination of immune responses.AIM: To determine clinical, histological, virological and immunological markers 5-20 years after SVR.METHODS: In 54 patients, liver biochemistry, histology and elastography were evaluated. Liver biopsies, plasma and peripheral blood mononuclear cells (PBMCs) were tested for minute amounts of HCV RNA. HCV-specific T-cell responses were monitored by ELISpot and pentamer staining, and humoral responses by measuring HCV nonstructural (NS)3-specific antibodies and virus neutralisation.RESULTS: Liver disease regressed significantly in all patients, and 51 were HCV RNA-negative in all tissues tested. There was an inverse association between liver disease, HCV-specific T-cell responses and HCV antibody levels with time from SVR, supporting that the virus had been cleared. The three patients, who all lacked signs of liver disease, had HCV RNA in PBMCs 5-9 years after SVR. All three had HCV-specific T cells and NS3 antibodies, but no cross-neutralising antibodies.CONCLUSIONS: Our combined data confirm that a SVR corresponds to a long-term clinical cure. The waning immune responses support the disappearance of the antigenic stimulus. Transient HCV RNA traces may be detected in some patients up to 9 years after SVR, but no marker associates this with an increased risk for liver disease.
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- Isaksson, B, et al.
(författare)
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Obstructive jaundice results in increased liver expression of uncoupling protein 2 and intact skeletal muscle glucose metabolism in the rat
- 2002
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 1502-7708 .- 0036-5521. ; 37:1, s. 104-111
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Tidskriftsartikel (refereegranskat)abstract
- Background: A majority of patients with pancreatic cancer have obstructive jaundice and diabetes with skeletal muscle insulin resistance. Surgery for these patients is associated with significant morbidity. Uncoupling protein 2 (UCP2) has been proposed to regulate energy expenditure and promote liver vulnerability. The effects of obstructive jaundice on muscle glucose metabolism and expression of UCP2 in liver and muscle are unknown. Methods: Rats were operated with bile duct ligation (BDL). After 7 days, UCP2 mRNA levels were determined in liver and muscle. Simultaneously, insulin-stimulated glucose transport and glycogen synthesis in skeletal muscle were analyzed in vitro. Results: The jaundiced rats lost more weight than pair-fed controls. UCP2 mRNA levels were increased 5-fold in liver but not in muscle in jaundiced rats compared to pair-fed controls. The jaundiced rats were hypoglycemic and hypoinsulinemic but demonstrated intact or enhanced insulin action on skeletal muscle glucose transport and glycogen synthesis in vitro. Muscle glycogen content was increased in the jaundiced rats. Conclusions: Experimental obstructive jaundice in the rat is associated with increased liver expression of UCP2. rapid weight loss, and intact insulin action on skeletal Muscle glucose metabolism. Obstructive jaundice. by upregulated liver UCP2. may contribute to the cachexia and high surgical morbidity observed in these patients, but not to skeletal muscle insulin resistance in pancreatic cancer patients.
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- Svenfelt, Åsa, PhD, Docent, 1968-, et al.
(författare)
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Miljöklassning av byggnader : Inventering av metoder och intressenters behov
- 2006
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport innehåller resultatet av projektets inledningsfas, kapitel 2 är en genomgång av politiska och andra mål för hållbar utveckling inom området byggnader med syfte att sätta miljöklassningssystemet i ett sammanhang, kapitel 3 är en redovisning av hur inledningsfasen genomförts, kapitel 4 innehåller resultatet av intervjuer med företag inom bygg och fastighetsbranschen om deras inställning till ett miljöklassningsystem samt intervjuer med aktörer som potentiellt kan skapa incitament för att företag och fastighetsägare ska ansluta sig till miljöklassningssystemet, kapitel 5 behandlar översiktligt genomgången av befintliga metoder för miljöbedömning av byggnader, kapitel 6 redovisar utgångspunkter för det fortsatta arbetet med ett miljöklassningsystem, kapitel 7 innehåller diskussion och slutsatser. Befintliga metoder för miljöbedömning av byggnader redovisas som informationsblad i bilaga 7 (svenska) och bilaga 10 (utländska).
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