| 1. |
- Adelfalk, C, et al.
(författare)
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Cohesin SMC1beta protects telomeres in meiocytes
- 2009
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Ingår i: The Journal of cell biology. - : Rockefeller University Press. - 1540-8140 .- 0021-9525. ; 187:2, s. 185-199
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Tidskriftsartikel (refereegranskat)abstract
- Meiosis-specific mammalian cohesin SMC1β is required for complete sister chromatid cohesion and proper axes/loop structure of axial elements (AEs) and synaptonemal complexes (SCs). During prophase I, telomeres attach to the nuclear envelope (NE), but in Smc1β−/− meiocytes, one fifth of their telomeres fail to attach. This study reveals that SMC1β serves a specific role at telomeres, which is independent of its role in determining AE/SC length and loop extension. SMC1β is necessary to prevent telomere shortening, and SMC3, present in all known cohesin complexes, properly localizes to telomeres only if SMC1β is present. Very prominently, telomeres in Smc1β−/− spermatocytes and oocytes loose their structural integrity and suffer a range of abnormalities. These include disconnection from SCs and formation of large telomeric protein–DNA extensions, extended telomere bridges between SCs, ring-like chromosomes, intrachromosomal telomeric repeats, and a reduction of SUN1 foci in the NE. We suggest that a telomere structure protected from DNA rearrangements depends on SMC1β.
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| 2. |
- Amombo Noa, Francoise Mystere, 1988, et al.
(författare)
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A unified topology approach to dot-, rod-, and sheet-MOFs
- 2021
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Ingår i: Chem. - : Elsevier BV. - 2451-9294 .- 2451-9308. ; 7:9, s. 2491-2512
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Tidskriftsartikel (refereegranskat)abstract
- Metal-organic frameworks made from multi-metal-ion units in the shape of clusters and rods (termed dot-MOFs and rod-MOFs) are well known. Here, we introduce MOFs with multi-metallic units in the form of sheets-sheet-MOFs. We show exemplars of all three types of units based on structures containing Y3+, Ce3+, or Gd3+ linked by benzene1,2,4,5-tetracarboxylate to give crystals of a dot-MOF in H2NMe2[Y(b-tec)(H2O)] CTH-14, a sheet-MOF in [Ce-3(btec)(Hbtec)(OAc)(HCO2)] CTH-15, and a rod-MOF in 4,4'-azopyridinium[Gd-2(btec)(2)] CTH-16. Cyclic voltammetry shows that CTH-15 stabilizes Ce(IV). Given the fact that sheet-MOFs represent an intellectual advance in the evolution of MOFs, a unified approach is proposed for the topological classification of dot-, rod-, and sheet-MOFs. It is suggested that the stability ofMOFs follow in the trend dot < rod < sheet. For CTH-14-16, the sheet- and the rod-MOF have higher thermal stability. We suggest sheet-MOFs as an additional strategy for making robust MOFs.
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