| 1. |
- Aljabali, Alaa A. A., et al.
(författare)
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The viral capsid as novel nanomaterials for drug delivery
- 2021
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Ingår i: Future Science OA. - : Future Science Ltd. - 2056-5623. ; 7:9
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Forskningsöversikt (refereegranskat)abstract
- The purpose of this review is to highlight recent scientific developments and provide an overview of virus self-assembly and viral particle dynamics. Viruses are organized supramolecular structures with distinct yet related features and functions. Plant viruses are extensively used in biotechnology, and virus-like particulate matter is generated by genetic modification. Both provide a material-based means for selective distribution and delivery of drug molecules. Through surface engineering of their capsids, virus-derived nanomaterials facilitate various potential applications for selective drug delivery. Viruses have significant implications in chemotherapy, gene transfer, vaccine production, immunotherapy and molecular imaging. Lay abstract: The purpose of this review is to highlight recent scientific developments and provide an overview of virus self-assembly and viral particle dynamics. Viruses are organized supramolecular structures with distinct yet related features and functions. Plant viruses are extensively used in biotechnology, and virus-like particulate matter is generated by genetic modification. Both provide a material-based means for selective distribution and delivery of drug molecules. Through surface engineering of their capsids, virus-derived nanomaterials facilitate various potential applications for selective drug delivery. Viruses have significant implications in chemotherapy, gene transfer, vaccine production, immunotherapy and molecular imaging. Here we performed a comprehensive database search to review findings in this area, demonstrating that viral nanostructures possess unique properties that make them ideal for applications in diagnostics, cell labeling, contrasting agents and drug delivery structures.
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| 2. |
- Goyal, Rohit, et al.
(författare)
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Mind The Tracker You Wear : A Security Analysis of Wearable Health Trackers
- 2016
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Ingår i: Proceedings of the 31st Annual ACM Symposium on Applied Computing. - New York, NY, USA : Association for Computing Machinery (ACM). - 9781450337397 ; , s. 131-136
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Konferensbidrag (refereegranskat)abstract
- Wearable tracking devices have gained widespread usage and popularity because of the valuable services they offer, monitoring human's health parameters and, in general, assisting persons to take a better care of themselves. Nevertheless, the security risks associated with such devices can represent a concern among consumers, because of the sensitive information these devices deal with, like sleeping patterns, eating habits, heart rate and so on. In this paper, we analyse the key security and privacy features of two entry level health trackers from leading vendors (Jawbone and Fitbit), exploring possible attack vectors and vulnerabilities at several system levels. The results of the analysis show how these devices are vulnerable to several attacks (perpetrated with consumer-level devices equipped with just bluetooth and Wi-Fi) that can compromise users' data privacy and security, and eventually call the tracker vendors to raise the stakes against such attacks.
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| 3. |
- Goyal, Rohit, et al.
(författare)
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SafeDroid : A Distributed Malware Detection Service for Android
- 2016
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Ingår i: 2016 IEEE 9th International Conference on Service-Oriented Computing and Applications (SOCA). - New York : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 59-66
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Konferensbidrag (refereegranskat)abstract
- Android platform has become a primary target for malware. In this paper we present SafeDroid, an open source distributed service to detect malicious apps on Android by combining static analysis and machine learning techniques. It is composed by three micro-services, working together, combining static analysis and machine learning techniques. SafeDroid has been designed as a user friendly service, providing detailed feedback in case of malware detection. The detection service is optimized to be lightweight and easily updated. The feature set on which the micro-service of detection relies on on has been selected and optimized in order to focus only on the most distinguishing characteristics of the Android apps. We present a prototype to show the effectiveness of the detection mechanism service and the feasibility of the approach.
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| 4. |
- Goyal, Rohit, et al.
(författare)
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Why Hackers Love eHealth Applications
- 2016
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Konferensbidrag (refereegranskat)abstract
- The tsunami of Internet-of-Things and mobile applications for healthcare is giving hackers an easy way to burrow deeper into our lives as never before. In this paper we argue that this security disaster is mainly due to a lack of consideration by the healthcare IT industry in security and privacy issues. By means of a representative healthcare mobile app, we analyse the main vulnerabilities that eHealth applications should deal with in order to protect user data and related privacy.
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| 5. |
- Shahcheraghi, Seyed H., et al.
(författare)
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Gene Therapy for Neuropsychiatric Disorders : Potential Targets and Tools
- 2023
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Ingår i: CNS & Neurological Disorders. - : Bentham Science Publishers. - 1871-5273 .- 1996-3181. ; 22:1, s. 51-65
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Forskningsöversikt (refereegranskat)abstract
- Neuropsychiatric disorders that affect the central nervous system cause considerable pressures on the health care system and have a substantial economic burden on modern societies. The present treatments based on available drugs are mostly ineffective and often costly. The molecular process of neuropsychiatric disorders is closely connected to modifying the genetic structures inherited or caused by damage, toxic chemicals, and some current diseases. Gene therapy is presently an experimental concept for neurological disorders. Clinical applications endeavor to alleviate the symptoms, reduce disease progression, and repair defective genes. Implementing gene therapy in inherited and acquired neurological illnesses entails the integration of several scientific disciplines, including virology, neurology, neurosurgery, molecular genetics, and immunology. Genetic manipulation has the power to minimize or cure illness by inducing genetic alterations at endogenous loci. Gene therapy that involves treating the disease by deleting, silencing, or editing defective genes and delivering genetic material to produce therapeutic molecules has excellent potential as a novel approach for treating neuropsychiatric disorders. With the recent advances in gene selection and vector design quality in targeted treatments, gene therapy could be an effective approach. This review article will investigate and report the newest and the most critical molecules and factors in neuropsychiatric disorder gene therapy. Different genome editing techniques available will be evaluated, and the review will highlight preclinical research of genome editing for neuropsychiatric disorders while also evaluating current limitations and potential strategies to overcome genome editing advancements.
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| 6. |
- Shrivastava, Garima, et al.
(författare)
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Targeting LIN28 : a new hope in prostate cancer theranostics
- 2021
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Ingår i: Future Oncology. - : Future Medicine. - 1479-6694 .- 1744-8301. ; 17:29, s. 3873-3880
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Tidskriftsartikel (refereegranskat)abstract
- The mortality and morbidity rates for prostate cancer have recently increased to alarming levels, rising higher than lung cancer. Due to a lack of drug targets and molecular probes, existing theranostic techniques are limited. Human LIN28A and its paralog LIN28B overexpression are associated with a number of tumors resulting in a remarkable increase in cancer aggression and poor prognoses. The current review aims to highlight recent work identifying the key roles of LIN28A and LIN28B in prostate cancer, and to instigate further preclinical and clinical research in this important area.
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