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- Andreasson, A., et al.
(författare)
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Fosfomycin versus Ciprofloxacin as transrectal prostatebiopsy antibiotic prophylaxis an open randomized controlled multicenter drug trial
- 2023
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Ingår i: European Urology. - : Elsevier. - 0302-2838 .- 1873-7560. ; 83:Suppl. 1, s. S180-S180
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Introduction & Objectives: Antibiotic prophylaxis are administered as a routine to decrease the risk for septic complications following transrectal prostate biopsy. Fosfomycin administered 1 h or more prior to biopsy has equal or better infectious complication rates as compared to Ciprofloxacin in both prospective and retrospective studies from countries with high rates of antibiotic resistance. The aim of this study was to investigate if Fosfomycin administered immediately prior to prostate biopsy was as effective as Ciprofloxacin in Sweden, a country with low rates of antibiotic resistance.Materials & Methods: A randomized, controlled, open, multicenter, non-inferiority-study including men of all ages undergoing transrectal prostate biopsy was performed in the urology departments of three Swedish hospitals. The total number of patients were planned for 3448, divided into low and high infection risk groups. The low-risk group was randomized to either one dose of Fosfomycin 3g or Ciprofloxacin 750mg before biopsy. The high-risk group was randomized to either two doses of Fosfomycin 3g prior to biopsy and one more 24 h after biopsy or Ciprofloxacin 500mg once prior to biopsy and then twice daily for three days. The drugs were administered orally. All patients had a rectal swab for culture before and after biopsy. The endpoint was hospitalisation due to urinary tract infection within 14 days from biopsy, follow-up was performed with a phone interview.Results: The safety board prematurely interrupted the study after 42 included patients due to an unusual high number of hospitalisations. Four out of 20 patients (20%), three in the low-risk group and one in the high-risk group, had been hospitalised due to urosepsis in the Fosfomycin group. One further patient described fever symptoms but did not seek health care. No patient in the Ciprofloxacin group (n=21) described symptoms of infection from the urinary tract. One patient was lost to follow-up. A one-sided binomial test showed a p-value of <0.001. Two of the four hospitalised patients had a positive blood culture for Pseudomonas Aeruginosa and one had a positive rectal swab culture for Pseudomonas species both before and after biopsy.Conclusions: The study does not support the use of Fosfomycin administered immediately prior to prostate biopsy. The results may have been affected by the unexpected high number of Pseudomonas infections, a bacteria where Fosfomycin often lack effect. If Fosfomycin is to be used it should be with caution if Pseudomonas has been seen in earlier cultures
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| 2. |
- Granåsen, G., et al.
(författare)
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Comparison between ultrasonic muscle strain and electromyography during an isometric ramp contraction
- 2010
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Ingår i: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. - Berlin, Heidelberg : Springer Berlin/Heidelberg. - 9783642038815 ; , s. 1565-1567
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Konferensbidrag (refereegranskat)abstract
- This study aims to explore multi modal relationships between ultrasonic muscle strain and electromyography (EMG). Canonical Correlation Analysis (CCA) is technique which can be used to explore multivariate associations between sets of variables. Multi-channel EMG and a spatial differentiated Tissue Velocity Imaging (TVI)-strain signal was compared from measurements on biceps brachii on eight subjects. A data analysis using CCA was then applied to obtain useful information of the relationship between signals.
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| 3. |
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| 4. |
- Lindberg, Frida, et al.
(författare)
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Tissue strain from Tissue Velocity Imaging (TVI) during sub-maximal isotonic muscle contractions
- 2010
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Ingår i: World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. - Berlin, Heidelberg : Springer Publishing Company. - 9783642038815 ; , s. 1554-1556
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Konferensbidrag (refereegranskat)abstract
- We have used Tissue Velocity Imaging (TVI) as a method to quantify the deformation of skeletal muscle tissue during contraction. The parameters used to describe tissue dynamics in this study were strain and strain rate, respectively. Eight subjects were evaluated performing submaximal isotonic contractions of biceps brachii before and after muscle fatigue.
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