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| 2. |
- Lindstrom, B., et al.
(författare)
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Combined multimode and singlemode fiber
- 2002
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Ingår i: Optical Fiber Communication Conference and Exhibit. ; , s. 628-629
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Konferensbidrag (refereegranskat)abstract
- A future proof combined MM- and SM-fiber is presented, which combines the advantages of both fiber types and makes upgrading and downgrading cheap and simple.
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| 16. |
- Annas, Anita, et al.
(författare)
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Basal and induced EROD activity in the chorioallantoic membrane during chicken embryo development
- 1999
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Ingår i: Environmental Toxicology and Pharmacology. - 1382-6689 .- 1872-7077. ; 8:1, s. 49-52
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The chorioallantoic membrane (CAM) is a highly vascularized tissue that takes part in the respiratory exchange of gases through the eggshell. Although the CAM may be exposed to environmental contaminants, its response to pollutants has not been studied. We examined the cytochrome P4501A (CYP1A)-catalyzed deethylation of 7-ethoxyresorufin (EROD) in the CAM during chicken embryo development. EROD was constitutively present and was inducible by the aryl hydrocarbon (Ah) receptor agonist 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126). Our results suggest the CAM as a first line of defence of the avian embryo against toxic compounds, but also as a target for CYP1A-activated chemicals.
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| 17. |
- Annas, Anita, et al.
(författare)
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Differential response of cultured human umbilical vein and artery endothelial cells to Ah receptor agonist treatment : CYP-dependent activation of food and environmental mutagens
- 2000
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Ingår i: Toxicology and Applied Pharmacology. - : Elsevier BV. - 0041-008X .- 1096-0333. ; 169:1, s. 94-101
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Tidskriftsartikel (refereegranskat)abstract
- In the present study, 7-ethoxyresorufin O-deethylase (EROD), 7,12-dimethylbenz[a]anthracene (DMBA)-hydroxylase, and covalent binding of H-3-labeled 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (H-3-Trp-P-1) and H-3-DMBA were examined in human umbilical vein endothelial cells (HUVEC) and human umbilical artery endothelial cells (HUAEC) exposed to the aryl hydrocarbon (Ah) receptor agonist beta -naphthoflavone (BNF) or vehicle only. The results revealed a marked induction of enzymatic activity in BNF-treated HUVEC compared with vehicle-treated cells, whereas no similar response was observed in BNF-treated HUAEC. EROD, DMBA hydroxylase, and covalent binding of H-3-Trp-P-1 and H-3-DMBA in BNF-treated HUVEC were reduced in the presence of the CYP1A inhibitor ellipticine. Addition of other CYP1A inhibitors ru-naphthoflavone, miconazole, 1-ethynylpyrene, 1-(1-propynyl)pyrene, or the CYP1A substrate ethoyresorufin to the incubation buffer of BNF-treated HUVEC reduced covalent binding of H-3-Trp-P-1 by 93-98%. Western blot analysis confirmed an induction of CYP1A1 in BNF-treated HUVEC, but not in BNF-treated HUAEC. CYP1A1 was, however, detected in both vehicle- and BNF-treated HUAEC. The results showed that BNF exposure induced CYP1A1 and metabolic activation of xenobiotics in HUVEC, whereas the catalytic activity remained low in BNF-treated HUAEC. Our results suggest that endothelial lining of human veins may be a target for adverse effects of xenobiotics activated into reactive metabolites by Ah receptor-regulated enzymes. Several studies have detected CYP1A1 in endothelial linings, whereas expression of CYP1A2 and CYP1B1 seems to be negligible at this site. This suggests that the metabolic activation and covalent binding of H-3-Trp-P-1 and H-3-DMBA in HUVEC are most likely mediated by CYP1A1.
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| 18. |
- Broddefalk, A, et al.
(författare)
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Structural and magnetic properties of (Fe1-xMnx)3P (x < 0.25)
- 2000
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Ingår i: PHYSICAL REVIEW B. - : AMERICAN PHYSICAL SOC. - 1098-0121. ; 61:1, s. 413-421
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Tidskriftsartikel (refereegranskat)abstract
- Structural and magnetic properties of (Fe1-xMnx)(3)P compounds have been investigated by means of x-ray and neutron diffraction experiments, magnetization measurements, Mossbauer experiments, and first principles calculations. The Curie temperature of the
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| 21. |
- Duda, LC, et al.
(författare)
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Soft-x-ray emission study of Fe/V(001) superlattices
- 1996
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Ingår i: PHYSICAL REVIEW B-CONDENSED MATTER. - : AMER INST PHYSICS. - 0163-1829. ; 54:15, s. 10393-10396
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We have studied the electronic structure of the interfaces in bet Fe/V (001) superlattices (SL's) grown on MgO(001) with soft-x-ray emission spectroscopy. Two samples with different thicknesses of Fe and V were investigated: [(V)(2)/(Fe)(5)](60) and [(V)(
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| 28. |
- Granberg, D, et al.
(författare)
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Lung and thymic carcinoids.
- 2000
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Ingår i: Surgical Endocrinology. - : Williams and Wilkins Publishers. ; , s. 413-
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 29. |
- Granberg, Lizette, et al.
(författare)
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CYP1A1 and CYP1B1 in blood-brain interfaces : CYP1A1-dependent bioactivation of 7,12-dimethylbenz(a)anthracene in endothelial cells.
- 2003
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Ingår i: Drug Metabolism And Disposition. - : American Society for Pharmacology & Experimental Therapeutics (ASPET). - 0090-9556 .- 1521-009X. ; 31:3, s. 259-265
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Tidskriftsartikel (refereegranskat)abstract
- Immunohistochemistry and autoradiography were used to identify sites of the cytochrome P450 enzymes (P450) 1A1 and 1B1 expression and activation of 7,12-dimethylbenz(a)anthracene (DMBA), in the brain of rodents pretreated with the aryl hydrocarbon receptor (AhR) agonists beta-naphthoflavone (BNF), 3,3',4,4',5-pentachlorobiphenyl or vehicle. Immunohistochemistry revealed that CYP1A1 was preferentially induced in endothelial cells (EC) in the choroid plexus, in veins in the leptomeninges, and in cerebral veins of AhR agonist-pretreated mice. No induction occurred in cerebral capillary EC. In vehicle-treated mice no localization of CYP1A1 in EC was observed. CYP1B1 was expressed in smooth muscle cells of arteries in the leptomeninges, in cerebral arteries/arterioles and to a low extent in ependymal cells of AhR agonist- and vehicle-treated mice. No CYP1B1 was detected in capillary loops of the choroid plexus or in cerebral capillaries. Following administration of [(3)H]DMBA to BNF-pretreated mice, a marked irreversible binding in EC of the choroid plexus and of veins in the leptomeninges was observed but not in cerebral capillaries. In vehicle-treated mice, there was no [(3)H]DMBA-binding at these sites. Furthermore, a high level of irreversibly bound [(3)H]DMBA occurred in EC at these sites in precision-cut mouse/rat brain slices and in excised blood-brain interfaces incubated with [(3)H]DMBA. Since [(3)H]DMBA binding sites corresponded with the sites of CYP1A1 induction, we conclude that rodents express a constitutively low but highly inducible and functional CYP1A1 in EC of some of the blood-brain interfaces. The role of CYP1A1/1B1 and environmental pollutants in the etiology of cerebrovascular disease needs further consideration.
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| 30. |
- Granberg, P, et al.
(författare)
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Anisotropic behaviour of the magnetoresistance in single crystalline iron films
- 1999
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Ingår i: JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS. - : ELSEVIER SCIENCE BV. - 0304-8853. ; 195:1, s. 1-8
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Tidskriftsartikel (refereegranskat)abstract
- Magnetoresistive properties of single crystalline Fe(0 0 1) films with thickness in the range 5-100 nm are reported. The films possess low coercive fields (similar to 100 A/m) but a weak irreversible behaviour of the magnetization remains to fields of the
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| 31. |
- Granberg, P, et al.
(författare)
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Antiferromagnetic coupling and giant magnetoresistance in Fe/V(0 0 1) superlattices
- 1998
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Ingår i: JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS. - : ELSEVIER SCIENCE BV. - 0304-8853. ; 186:1-2, s. 154-160
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Tidskriftsartikel (refereegranskat)abstract
- Structural and magnetic properties of Fe/V(0 0 1) superlattices consisting of 3 monolayers Fe separated by V interlayers of thickness in the range 8-17 monolayers have been investigated. RHEED and X-ray diffraction investigations show that the samples are
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| 32. |
- Granberg, P, et al.
(författare)
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Magnetic and transport properties of epitaxial Fe/V(001) superlattice films
- 1996
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Ingår i: PHYSICAL REVIEW B-CONDENSED MATTER. - : AMER INST PHYSICS. - 0163-1829. ; 54:2, s. 1199-1204
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Tidskriftsartikel (refereegranskat)abstract
- Single-crystalline Fe(15 ML)/V (1-12 ML) superlattices, epitaxially grown in the (001) direction, have been investigated using magnetization and electrical transport measurements. For all V thicknesses the system exhibits ferromagnetic properties. Results
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| 36. |
- Isberg, P, et al.
(författare)
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Structure and magnetic properties of Fe/V (110) superlattices
- 1998
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Ingår i: PHYSICAL REVIEW B-CONDENSED MATTER. - : AMERICAN PHYSICAL SOC. - 0163-1829. ; 57:6, s. 3531-3538
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Tidskriftsartikel (refereegranskat)abstract
- Structural, magnetic, and magnetotransport properties of Fe/V (110) superlattices have been investigated. Using Al2O3 (<10(2)over bar 0>) substrates and Mo or MoxV1-x allay seed layers, the superlattices could be grown with a large in- and out-of-plane cr
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| 38. |
- Johanson, V, et al.
(författare)
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A Randomized, Cross-Over Study in Patients with Neuroendocrine Tumors (NETs) to Assess Patient Preference of Lanreotide Autogel Given by either Self/Partner or Healthcare Professional in NEUROENDOCRINOLOGY, vol 94, issue , pp 29-29
- 2011
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Ingår i: NEUROENDOCRINOLOGY. - : Karger. ; , s. 703-710
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Konferensbidrag (refereegranskat)abstract
- Background: Lanreotide Autogel® is supplied in prefilled syringes. Therefore, it is possible for patients with neuroendocrine tumors to use self-/partner-administered injections. The primary objective of this study was to assess the proportion of patients preferring self/partner injections over injections administered by health care professionals, and to describe the impact of self/partner administration on efficacy, safety, and costs. Methods: Of 62 eligible patients, 26 (42%) patients with neuroendocrine tumors treated with a stable dose of lanreotide Autogel 90 mg or 120 mg every 4 weeks agreed to participate in this Phase IV, international, open-label, crossover study, conducted at hospitals in Sweden, Norway, and Denmark. Patients were randomized to two blocks, starting with administration of lanreotide Autogel by either self/partner or a health care professional. Preference for injections administered by self/partner or health care professionals was measured, as well as efficacy, safety, and health care resource utilization (both direct and indirect costs). Results: Of 25 evaluable patients, 22 (88%) preferred self/partner injections, mainly because they experienced increased independence. Based on all patients asked to participate (n = 62), 35% preferred self/partner injections on a regular basis. There was no difference in efficacy or safety between the two administration blocks. Conclusion: Many patients with neuroendocrine tumors prefer self/partner injection of lanreotide Autogel, and are able to self/partner inject without any impact on efficacy or safety. This administration method seems to provide a good alternative for suitable patients to increase patient independence and reduce the number of clinic visits.
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| 42. |
- Mangeat, G., et al.
(författare)
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Machine Learning and Multiparametric Brain MRI to Differentiate Hereditary Diffuse Leukodystrophy with Spheroids from Multiple Sclerosis
- 2020
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Ingår i: Journal of Neuroimaging. - : Blackwell Publishing Inc.. - 1051-2284 .- 1552-6569. ; 30:5, s. 674-682
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND PURPOSE: Hereditary diffuse leukoencephalopathy with spheroids (HDLS) and multiple sclerosis (MS) are demyelinating and neurodegenerative disorders that can be hard to distinguish clinically and radiologically. HDLS is a rare disorder compared to MS, which has led to occurrent misdiagnosis of HDLS as MS. That is problematic since their prognosis and treatment differ. Both disorders are investigated by MRI, which could help to identify patients with high probability of having HDLS, which could guide targeted genetic testing to confirm the HDLS diagnosis. METHODS: Here, we present a machine learning method based on quantitative MRI that can achieve a robust classification of HDLS versus MS. Four HDLS and 14 age-matched MS patients underwent a quantitative brain MRI protocol (synthetic MRI) at 3 Tesla (T) (scan time '7 minutes). We also performed a repeatability analysis of the predicting features to assess their generalizability by scanning a healthy control with five scan-rescans at 3T and 1.5T. RESULTS: Our predicting features were measured with an average confidence interval of 1.7% (P =.01), at 3T and 2.3% (P =.01) at 1.5T. The model gave a 100% correct classification of the cross-validation data when using 5-11 predicting features. When the maximum measurement noise was inserted in the model, the true positive rate of HDLS was 97.2%, while the true positive rate of MS was 99.6%. CONCLUSIONS: This study suggests that computer-assistance in combination with quantitative MRI may be helpful in aiding the challenging differential diagnosis of HDLS versus MS.
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| 44. |
- Mickeviciute, G. -C, et al.
(författare)
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Neuroimaging phenotypes of CSF1R-related leukoencephalopathy : Systematic review, meta-analysis, and imaging recommendations
- 2022
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 291:3, s. 269-282
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Tidskriftsartikel (refereegranskat)abstract
- Colony-stimulating factor 1 receptor (CSF1R)-related leukoencephalopathy is a rare but fatal microgliopathy. The diagnosis is often delayed due to multifaceted symptoms that can mimic several other neurological disorders. Imaging provides diagnostic clues that help identify cases. The objective of this study was to integrate the literature on neuroimaging phenotypes of CSF1R-related leukoencephalopathy. A systematic review and meta-analysis were performed for neuroimaging findings of CSF1R-related leukoencephalopathy via PubMed, Web of Science, and Embase on 25 August 2021. The search included cases with confirmed CSF1R mutations reported under the previous terms hereditary diffuse leukoencephalopathy with spheroids, pigmentary orthochromatic leukodystrophy, and adult-onset leukoencephalopathy with axonal spheroids and pigmented glia. In 78 studies providing neuroimaging data, 195 cases were identified carrying CSF1R mutations in 14 exons and five introns. Women had a statistically significant earlier age of onset (p = 0.041, 40 vs 43 years). Mean delay between symptom onset and neuroimaging was 2.3 years. Main magnetic resonance imaging (MRI) findings were frontoparietal white matter lesions, callosal thinning, and foci of restricted diffusion. The hallmark computed tomography (CT) finding was white matter calcifications. Widespread cerebral hypometabolism and hypoperfusion were reported using positron emission tomography and single-photon emission computed tomography. In conclusion, CSF1R-related leukoencephalopathy is associated with progressive white matter lesions and brain atrophy that can resemble other neurodegenerative/-inflammatory disorders. However, long-lasting diffusion restriction and parenchymal calcifications are more specific findings that can aid the differential diagnosis. Native brain CT and brain MRI (with and without a contrast agent) are recommended with proposed protocols and pictorial examples are provided.
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