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- 2019
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Journal article (peer-reviewed)
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| 4. |
- Bargholtz, Chr., et al.
(author)
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The WASA detector facility at CELSIUS
- 2008
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 594:3, s. 339-350
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Journal article (peer-reviewed)abstract
- The WASA 4 pi multidetector system, aimed at investigating light meson production in light ion collisions and eta meson rare decays at the CELSIUS storage ring in Uppsala is presented. A unique feature of the system is the use of hydrogen pellets as internal targets for the first time. A detailed description of the design, together with the anticipated and achieved performance parameters are given. (C) 2008 Elsevier B.V. All rights reserved.
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| 5. |
- Kren, F., et al.
(author)
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Exclusive measurements of pp -> d pi(+)pi(0) : Double-pionic fusion without ABC effect
- 2010
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 684:2-3, s. 110-113
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Journal article (peer-reviewed)abstract
- Exclusive measurements of the reaction pp -> d pi(+)pi(0) have been carried out at T-p = 1.1 GeV at the CELSIUS storage ring using the WASA detector. The isovector pi(+)pi(0) channel exhibits no enhancement at low invariant pi pi masses, i.e. no ABC effect. Therefore this most basic isovector double-pionic fusion reaction qualifies as an ideal test case for the conventional t-channel Delta Delta excitation process. Indeed, the obtained differential distributions reveal the conventional t-channel Delta Delta mechanism as the appropriate reaction process, which also accounts for the observed energy dependence of the total cross section.
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| 6. |
- Bashkanov, M., et al.
(author)
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Exclusive measurements of pd -> He-3 pi pi : The ABC effect revisited
- 2006
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 637:4-5, s. 223-228
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Journal article (peer-reviewed)abstract
- Exclusive measurements of the reactions pd -> He-3 pi(+)7 pi(-) and pd -> He-3 pi(0)pi(0) have been carried out at T-p = 0.893 GeV at the CELSIUS storage ring using the WASA detector. The pi(+)pi(-) channel evidences a pronounced enhancement at low invariant pi pi masses-as anticipated from previous inclusive measurements of the ABC effect. This enhancement is seen to be even much larger in the isoscalar pi(0)pi(0) channel. The differential distributions prove this enhancement to be of scalar-isoscalar nature. Delta Delta calculations give a good description of the data, if a boundstate condition is imposed for the intermediate Delta Delta system.
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| 7. |
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| 8. |
- Greiff, J, et al.
(author)
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Pion production in dp -> dN pi reactions with deuteron projectiles - art. no. 064002
- 2000
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In: PHYSICAL REVIEW C. - : AMERICAN PHYSICAL SOC. - 0556-2813. ; 6206:6, s. 4002-
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Journal article (peer-reviewed)abstract
- Kinematically complete events have been studied for the reactions dp-->dp pi (0) and dp-->dn pi (+) at projectile energies between 437 and 559 MeV. The measurement covers a range of pion momenta eta =p(pi ,c.m.)(max)/m(pi)c from near the production thresh
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| 9. |
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| 10. |
- Bilger, R, et al.
(author)
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Cross sections of the pp -> pp pi(0) reaction between 310 and 425 MeV
- 2001
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In: NUCLEAR PHYSICS A. - : ELSEVIER SCIENCE BV. - 0375-9474. ; 693:3-4, s. 633-662
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Journal article (peer-reviewed)abstract
- Extensive kinematically complete measurements of the pp --> pp pi (0) reaction have been made at six beam energies: 310, 320, 340, 360, 400, and 425 MeV. Angles and energies of both final-state protons are extracted from the forward detector system of the
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| 11. |
- Bilger, R, et al.
(author)
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Spectator tagging in quasi-free pn-reactions on deuterium at PROMICE/WASA, CELSIUS
- 2000
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In: Nuclear Physics A. - : Elsevier Science B.V. Holland. ; , s. 1053c-1056c
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Conference paper (peer-reviewed)abstract
- A set of silicon detectors has been added to the PROMICE/WASA (P/W) experiment at CELSIUS. These detectors have been used for spectator-proton tagging in proton deuteron collisions to investigate proton-neutron reactions at intermediate energies. The perf
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| 12. |
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| 13. |
- Bilger, R, et al.
(author)
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Two-pion production in proton-proton collisions near threshold at Celsius
- 1998
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In: ACTA PHYSICA POLONICA B. - : ACTA PHYSICA POLONICA B, JAGELLONIAN UNIV, INST PHYSICS. ; , s. 2987-2991
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Conference paper (peer-reviewed)abstract
- Two-pion production reactions in proton-proton collisions near threshold are measured using an internal cluster-jet hydrogen target and the WASA/PROMICE detector at the CELSIUS storage ring. Four out of the five possible two-pion production reactions are
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| 14. |
- Levin, Mattias, et al.
(author)
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Persistence and evolution of allergen-specific IgE repertoires during subcutaneous specific immunotherapy.
- 2016
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In: The Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 137:5, s. 1535-1544
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Journal article (peer-reviewed)abstract
- Specific immunotherapy (SIT) is the only treatment with proved long-term curative potential in patients with allergic disease. Allergen-specific IgE is the causative agent of allergic disease, and antibodies contribute to SIT, but the effects of SIT on aeroallergen-specific B-cell repertoires are not well understood.
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| 15. |
- Malm-Erjefält, M., et al.
(author)
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Circulating eosinophils in asthma, allergic rhinitis, and atopic dermatitis lack morphological signs of degranulation
- 2005
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In: Clin Exp Allergy. ; 35:10
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Journal article (peer-reviewed)abstract
- Summary Background In allergic diseases, eosinophils in affected tissues release granule proteins with cytotoxic, immunoregulatory, and remodelling-promoting properties. From recent observations, it may be assumed that eosinophils degranulate already in circulating blood. If degranulation occurs in the circulation, this could contribute to widespread systemic effects and provide an important marker of disease. Objective To determine the degranulation status of circulating eosinophils in common allergic diseases. Methods Using a novel approach of whole blood fixation and leucocyte preparation, the granule morphology of blood eosinophils from healthy subjects, non-symptomatic patients, symptomatic patients with asthma, asthma and Churg-Strauss syndrome, allergic rhinitis, and atopic dermatitis was evaluated by transmission electron microscopy (TEM) and eosinophil peroxidase (TEM) histochemistry. Plasma and serum levels of eosinophil cationic protein were measured by fluoroenzymeimmunoassay. Selected tissue biopsies were examined by TEM. Results Regardless of symptoms, circulating eosinophils from allergic patients showed the same granule morphology as cells from healthy subjects. The majority of eosinophil-specific granules had preserved intact electron-density (96%; range: 89-98%), while the remaining granules typically exhibited marginal coarsening or mild lucency of the matrix structure. Abnormalities of the crystalline granule core were rarely detected. Furthermore, granule matrix alterations were not associated with any re-localization of intracellular EPO or increase in plasma eosinophil cationic protein. By contrast, eosinophils in diseased tissues exhibited cytolysis (granule release through membrane rupture) and piecemeal degranulation (loss of granule matrix and core structures). Conclusion In symptomatic eosinophilic diseases, circulating blood eosinophils retain their granule contents until they have reached their target organ.
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| 16. |
- Bilger, R, et al.
(author)
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THE WASA DETECTOR AT CELSIUS.
- 2000
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In: Nuclear Physics A. - : Elsevier Science B.V. Holland. ; , s. 1073-1076
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Conference paper (peer-reviewed)
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| 20. |
- Carlwig, K., et al.
(author)
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Mandibulotomy access to tumour sites : fewer complications for postoperative compared with preoperative radiotherapy
- 2021
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In: International Journal of Oral and Maxillofacial Surgery. - : Elsevier BV. - 0901-5027. ; 50:7, s. 851-856
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Journal article (peer-reviewed)abstract
- The purpose of this study was to compare complication rates at the mandibulotomy site between patients receiving preoperative radiotherapy (RT) and those receiving postoperative RT during treatment for oral and oropharyngeal cancer where the surgical procedure required a mandibular osteotomy to gain access to the tumour. Sixty-four consecutive patients treated during the period 2000–2015 were available for analysis. Their medical records were reviewed retrospectively. All patients were followed for at least 1 year postoperatively. A subgroup of patients received RT on several occasions or long before the mandibulotomy, therefore the statistical comparisons focused on the two groups of patients receiving RT on one occasion and within 6 months prior to or following surgery. Seventeen patients presented a total of 29 complications, yielding an overall complication rate of 27%. Orocutaneous fistula was the most common complication. Patients who received RT preoperatively presented a higher complication rate (9/15; 60%) when compared to those who received RT postoperatively (2/31; 6.5%) (odds ratio 21.8, P < 0.001). This study demonstrated fewer complications in the mandibulotomy area exposed to postoperative RT compared with preoperative RT. It is therefore suggested that, when possible, RT should be given postoperatively if combination treatment with RT and surgery, including a mandibulotomy, is planned.
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| 21. |
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| 22. |
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| 23. |
- Hoh, Ramona A., et al.
(author)
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Clonal evolution and stereotyped sequences of human IgE lineages in aeroallergen-specific immunotherapy
- 2023
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In: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749. ; 152:1, s. 214-229
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Journal article (peer-reviewed)abstract
- Background: Allergic disease reflects specific inflammatory processes initiated by interaction between allergen and allergen-specific IgE. Specific immunotherapy (SIT) is an effective long-term treatment option, but the mechanisms by which SIT provides desensitization are not well understood. Objective: Our aim was to characterize IgE sequences expressed by allergen-specific B cells over a 3-year longitudinal study of patients with aeroallergies who were undergoing SIT. Methods: Allergen-specific IgE–expressing clones were identified by using combinatorial single-chain variable fragment libraries and tracked in PBMCs and nasal biopsy samples over a 3-year period with antibody gene repertoire sequencing. The characteristics of private IgE-expressing clones were compared with those of stereotyped or “public” IgE responses to the grass pollen allergen Phleum pratense (Phl p) 2. Result: Members of the same allergen-specific IgE lineages were observed in nasal biopsy samples and blood, and lineages detected at baseline persisted in blood and nasal biopsy samples after 3 years of SIT, including B cells that express IgE. Evidence of progressive class switch recombination to IgG subclasses was observed after 3 years of SIT. A common stereotyped Phl p 2–specific antibody heavy chain sequence was detected in multiple donors. The amino acid residues enriched in IgE-stereotyped sequences from seropositive donors were analyzed with machine learning and k-mer motif discovery. Stereotyped IgE sequences had lower overall rates of somatic hypermutation and antigen selection than did single-chain variable fragment–derived allergen-specific sequences or IgE sequences of unknown specificity. Conclusion: Longitudinal tracking of rare circulating and tissue-resident allergen-specific IgE+ clones demonstrates persistence of allergen-specific IgE+ clones, progressive class switch recombination to IgG subtypes, and distinct maturation of a stereotyped Phl p 2 clonotype.
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| 24. |
- Mao, Yuwei, et al.
(author)
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The small subunit of Rubisco and its potential as an engineering target
- 2022
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In: Journal of Experimental Botany. - : Oxford University Press. - 0022-0957 .- 1460-2431. ; 74:2, s. 543-561
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Journal article (peer-reviewed)abstract
- Rubisco catalyses the first rate-limiting step in CO2 fixation and is responsible for the vast majority of organic carbon present in the biosphere. The function and regulation of Rubisco remain an important research topic and a longstanding engineering target to enhance the efficiency of photosynthesis for agriculture and green biotechnology. The most abundant form of Rubisco (Form I) consists of eight large and eight small subunits, and is found in all plants, algae, cyanobacteria, and most phototrophic and chemolithoautotrophic proteobacteria. Although the active sites of Rubisco are located on the large subunits, expression of the small subunit regulates the size of the Rubisco pool in plants and can influence the overall catalytic efficiency of the Rubisco complex. The small subunit is now receiving increasing attention as a potential engineering target to improve the performance of Rubisco. Here we review our current understanding of the role of the small subunit and our growing capacity to explore its potential to modulate Rubisco catalysis using engineering biology approaches.
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| 25. |
- Ohlin, Mats, et al.
(author)
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Inferred Allelic Variants of Immunoglobulin Receptor Genes : A System for Their Evaluation, Documentation, and Naming
- 2019
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In: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 10
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Research review (peer-reviewed)abstract
- Immunoglobulins or antibodies are the main effector molecules of the B-cell lineage and are encoded by hundreds of variable (V), diversity (D), and joining (J) germline genes, which recombine to generate enormous IG diversity. Recently, high-throughput adaptive immune receptor repertoire sequencing (AIRR-seq) of recombined V-(D)-J genes has offered unprecedented insights into the dynamics of IG repertoires in health and disease. Faithful biological interpretation of AIRR-seq studies depends upon the annotation of raw AIRR-seq data, using reference germline gene databases to identify the germline genes within each rearrangement. Existing reference databases are incomplete, as shown by recent AIRR-seq studies that have inferred the existence of many previously unreported polymorphisms. Completing the documentation of genetic variation in germline gene databases is therefore of crucial importance. Lymphocyte receptor genes and alleles are currently assigned by the Immunoglobulins, T cell Receptors and Major Histocompatibility Nomenclature Subcommittee of the International Union of Immunological Societies (IUIS) and managed in IMGT®, the international ImMunoGeneTics information system® (IMGT). In 2017, the IMGT Group reached agreement with a group of AIRR-seq researchers on the principles of a streamlined process for identifying and naming inferred allelic sequences, for their incorporation into IMGT®. These researchers represented the AIRR Community, a network of over 300 researchers whose objective is to promote all aspects of immunoglobulin and T-cell receptor repertoire studies, including the standardization of experimental and computational aspects of AIRR-seq data generation and analysis. The Inferred Allele Review Committee (IARC) was established by the AIRR Community to devise policies, criteria, and procedures to perform this function. Formalized evaluations of novel inferred sequences have now begun and submissions are invited via a new dedicated portal (https://ogrdb.airr-community.org). Here, we summarize recommendations developed by the IARC-focusing, to begin with, on human IGHV genes-with the goal of facilitating the acceptance of inferred allelic variants of germline IGHV genes. We believe that this initiative will improve the quality of AIRR-seq studies by facilitating the description of human IG germline gene variation, and that in time, it will expand to the documentation of TR and IG genes in many vertebrate species.
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