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- 2019
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Drake, Thomas M., et al.
(författare)
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Outcomes following small bowel obstruction due to malignancy in the national audit of small bowel obstruction
- 2019
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Ingår i: European Journal of Surgical Oncology. - : Elsevier BV. - 0748-7983 .- 1532-2157. ; 45:12, s. 2319-2324
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Tidskriftsartikel (refereegranskat)abstract
- © 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology Introduction: Patients with cancer who develop small bowel obstruction are at high risk of malnutrition and morbidity following compromise of gastrointestinal tract continuity. This study aimed to characterise current management and outcomes following malignant small bowel obstruction. Methods: A prospective, multicentre cohort study of patients with small bowel obstruction who presented to UK hospitals between 16th January and 13th March 2017. Patients who presented with small bowel obstruction due to primary tumours of the intestine (excluding left-sided colonic tumours) or disseminated intra-abdominal malignancy were included. Outcomes included 30-day mortality and in-hospital complications. Cox-proportional hazards models were used to generate adjusted effects estimates, which are presented as hazard ratios (HR) alongside the corresponding 95% confidence interval (95% CI). The threshold for statistical significance was set at the level of P ≤ 0.05 a-priori. Results: 205 patients with malignant small bowel obstruction presented to emergency surgery services during the study period. Of these patients, 50 had obstruction due to right sided colon cancer, 143 due to disseminated intraabdominal malignancy, 10 had primary tumours of the small bowel and 2 patients had gastrointestinal stromal tumours. In total 100 out of 205 patients underwent a surgical intervention for obstruction. 30-day in-hospital mortality rate was 11.3% for those with primary tumours and 19.6% for those with disseminated malignancy. Severe risk of malnutrition was an independent predictor for poor mortality in this cohort (adjusted HR 16.18, 95% CI 1.86 to 140.84, p = 0.012). Patients with right-sided colon cancer had high rates of morbidity. Conclusions: Mortality rates were high in patients with disseminated malignancy and in those with right sided colon cancer. Further research should identify optimal management strategy to reduce morbidity for these patient groups.
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| 6. |
- Grey, Kathleen, et al.
(författare)
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Neoproterozoic subdivision in Australia
- 2005
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Ingår i: Central Australian Basins Symposium.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Neoproterozoic subdivision is well advanced in Australia using integrated results from lithostratigraphy, palynology, isotope chemostratigraphy and stromatolite biostratigraphy. Previously proposed Cryogenian correlations were tested by the drilling of GSWA Lancer-1 in the western Officer Basin and were found to be reliable. The consistency of the results allows the succession to be tied to limited geochronological ages from the Adelaide Rift Complex. Data are still sparse on the interval between the Sturtian and Marinoan glaciations, but good correlations exist in the Ediacaran.The base of the cap carbonate in Enorama Creek in the Adelaide Rift Complex has been ratified as the Global Stratotype Section and Point (GSSP) for the newly defined Ediacaran System and Period. The Flinders Ranges have a near-continuous section from the Marinoan glaciation to the Cambrian boundary, especially around the Brachina and Bunyeroo gorges. Lithostratigraphy, and local and regional correlations are well established, including links between the type sections, measured sections throughout the Adelaide Rift Complex and continuously cored drillhole sections on the Stuart Shelf, 80–100 km to the northeast, and to the Officer and Amadeus basins. An integrated approach, using lithostratigraphy; stratigraphic markers (glacial episodes, the time-synchronous Acraman impact ejecta layer, canyon cutting); carbon isotope chemostratigraphy; sequence stratigraphy; seismic interpretation; stromatolite biostratigraphy; and the first appearance of bilaterians and associated trace fossils, has proved successful.Acritarchs are acid-insoluble fossils of single-celled, phytoplanktonic green algae and are ideal for zonation. A rigorous sampling program began in 1991 to establish an acritarch biostratigraphy throughout Australian Neoproterozoic basins, based on palynological studies of continuously cored drillholes. Extensive field sampling of sections in the Flinders Ranges was unsuccessful, partly because the rift succession is too thermally mature for palynomorphs to be preserved, and partly because organic material has been leached from a deeply weathered profile. No identifiable acritarchs were recovered from this area, or from outcrops in other basins. However, Stuart Shelf drillholes contain well-preserved palynomorphs, although preservation is patchy in parts of the succession. Nevertheless, there are enough data for correlation with excellently preserved assemblages from the Officer and Amadeus basins. Georgina Basin preservation is too poor for useful analysis at present. Data from the Officer and Amadeus basins demonstrate the potential for biostratigraphic zonation in the lower and middle Ediacaran. Biostratigraphic correlation parallels correlations based on organic carbon isotope curves.Middle Ediacaran acritarch assemblages are extraordinarily diverse taxonomically, morphologically complex, and show typical patterns of secular diversity. These characteristics are ideal for the development of a zonal scheme, with levels of precision equivalent to the Phanerozoic record. The zones are independent of taphonomic and palaeoenvironmental influences, and they are demonstrably independent of lithology, lithostratigraphy, and sequence stratigraphy. Using composite sections, two palynofloras, the Ediacaran Leiosphere Palynoflora (ELP) and the Ediacaran Complex Acanthomorph Palynoflora (ECAP), have been recognised. The ECAP has been subdivided into four zones. The scheme is preliminary, but represents a significant advance in Neoproterozoic biostratigraphic studies, and should provide an important tool for future stratigraphic correlation. Additional studies are in progress to refine the correlations by examining undocumented parts of the succession, especially from Murnaroo-1 and Giles-1. The presence of certain acritarch species in probably coeval successions in Australia, Siberia, China, and northern Europe, suggests that the proposed zonation has good potential for global application, and that biostratigraphic principles and methodology can be applied to the Neoproterozoic.
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| 7. |
- Grey, Kathleen, et al.
(författare)
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Subdividing the Ediacaran of Australia using biostratigraphy
- 2005
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Ingår i: Central Australian Basins Symposium.
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Konferensbidrag (refereegranskat)abstract
- A new Global Stratotype and Section (GSSP) for the terminal Neoproterozoic, the Ediacaran Period and System, has been ratified by the International Union of Geological Sciences (IUGS), but problems of subdivision and correlation remain. Hydrocarbon and mineral exploration in the Officer, Amadeus, and Georgina basins, and the Adelaide Rift Complex has resulted in the development of palynological (mainly acritarch) correlations using range charts, based on >1000 samples from >30 drillholes sampled about every 10 m. As in the Cryogenian, biostratigraphic correlations, based on palynology and stromatolite biostratigraphy, are feasible, and results are consistent with correlations based on carbon isotope curves established using splits of palynology samples.So far, zonation is only possible for the lower and middle Ediacaran in Australia. Upper Ediacaran lithologies are generally unsuitable for palynomorph preservation and assemblages appear to be highly impoverished. However, a distinctive assemblage of large acanthomorph acritarchs, with highly complex morphologies and short stratigraphic ranges, characterises the middle Ediacaran. They are ideal candidates for biostratigraphy and this interval can be correlated with a high degree of confidence. Assemblages from Baltica and the East European Platform suggest that palynological zonation of the upper Ediacaran may be possible, despite species reduction and a return to simple morphologies. Moreover, the upper Ediacaran contains the Ediacara fauna, which may also be a suitable tool for correlation.Stromatolites indicate Australia-wide correlation at certain levels of the Ediacaran. Incipient columns of Elleria minuta, characteristic of the Amadeus Basin (Marinoan-equivalent) cap dolomite, were identified in a 50 cm-thick dolomite horizon above a diamictite, in Empress-1/1A in Western Australia. Tungussia julia is widespread and appears to be facies independent. It occurs in shallow-water carbonates of the Julie Formation (Amadeus Basin), Wonoka Formation (Adelaide Rift Complex), Elkera Formation (Georgina Basin), and Wilari Dolomite Member of the Tanana Formation (eastern Officer Basin), and is present in the periglacial Egan Formation in the Kimberley area. Relative stratigraphy indicates that the Egan Formation is considerably younger than the Elatina Formation (Marinoan glaciation). The Egan glaciation took place at about 560 Ma, only a short time before the appearance of the first bilaterian trace fossils.Palynomorph assemblages are sparse during and between the Sturtian and Marinoan glaciations (~700–600 Ma) and samples immediately above the Marinoan glaciation are barren. Post-glacial benthic mats and leiospheres quickly re-established and flourished, as sea level and temperatures rose, but there is no obvious post-glacial species diversification, and no evidence of invasion by extremophiles from hot-spring refugia as envisaged in Snowball Earth predictions. Only a handful of species survived, but pre-glacial species appear to be identical to post-glacial species. Specimen numbers increased rapidly as sea-level rose, but so far, no new taxa have been identified below the Acraman impact ejecta layer.Above the Acraman impact layer, during a second sea-level rise, there is a striking change in the palynoflora, when >50 species of large acanthomorph acritarchs, belonging to several new genera, first appear and diversify rapidly. They differ significantly from older taxa and in some aspects resemble dinocysts. At least four zones have been recognised, based mainly on assemblages from continuous core in the eastern Officer Basin (Munta-1, Observatory Hill-1, Lake Maurice West-1, and Birksgate-1), the Adelaide Rift Complex succession (SCYW-1a, WWD-1 and MJ-1) and the Amadeus Basin (Wallara-1 and Rodinga-4). More detailed studies are in progress on distributions in Lake Maurice West-1, Observatory Hill-1, Murnaroo-1, and Giles-1. These drillholes are of particular significance because the precise position of the ejecta layer is known in each.Although the acanthomorph assemblage was recognised previously in Murnaroo-1, systematic sampling was not carried out and the position of the ejecta layer was not known. More refined sampling and the discovery of the ejecta layer at 279.55 m has now confirmed observations from other drillholes that the earliest appearance of the acanthomorphs is above the ejecta layer and that diversification was rapid, with 10 species already present, less than 50 m above the ejecta layer. Studies continue in an attempt to locate the earliest appearance of acanthomorphs. Preliminary examination of samples from Giles-1, where the ejecta layer was found at 554.90 m, confirms the acritarch distribution pattern. Stable isotope studies are also providing significant data about the effect of the Acraman impact on the biosphere.Several key acanthomorph species are present elsewhere in the world, including Svalbard, Norway, Siberia, and China, raising the possibility of global correlation. In particular, the Australian assemblage has several taxa in common with a succession in an area in eastern Siberia that contains one of the giant Neoproterozoic gas fields. Further work is required to define the ranges of key species outside Australia, so the scheme can be extended globally.At present, contradictions arise when correlations are attempted with the Doushantuo Formation in China. In part, this reflects the lack of methodical stratigraphic sampling in the Chinese succession and the disparity in thickness between the Chinese succession (<200 m) and the Australian succession (>2000 m). There are also discrepancies in the acritarch biostratigraphy and carbon isotope curves that raise issues about whether the Nantuo Tillite should be correlated with the type ‘Marinoan’ glaciation, the Elatina Formation, and these discrepancies have implications about how many glacial episodes happened in the Neoproterozoic. Recent dating on probable equivalents of the Elatina Formation in King Island and Tasmania suggest an age of 580 Ma. This is similar to the age of the Gaskiers and Squantum Tillites in western Canada, but considerably younger than recently obtained ages of 635 Ma on successions in southern Africa and the Nantuo Tillite in China.Prospects for subdividing and correlating the Ediacaran using biostratigraphy are excellent, provided taxonomic ranges are properly documented. Biostratigraphic subdivisions can be integrated with other means of correlation to provide a rigorous means of global correlation.
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| 8. |
- Hill, Andrew C., et al.
(författare)
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New records of Ediacaran Acraman ejecta in drillholes from the Stuart Shelf and Officer Basin, South Australia
- 2007
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Ingår i: Meteoritics and Planetary Science. - 1086-9379 .- 1945-5100. ; 42:11, s. 1883-1891
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Tidskriftsartikel (refereegranskat)abstract
- New occurrences of the Acraman impact ejecta layer were recently discovered in two South Australian drillholes, SCYW-79 1a (Stuart Shelf) and Munta 1 (Officer Basin) using lithostratigraphy, acritarch biostratigraphy, carbon isotope stratigraphy, and biomarker anomalies to predict the stratigraphic position. The ejecta layer is conspicuous because it consists of pink, sand-sized, angular fragments of volcanic rock distributed along the bedding plane surface of green marine siltstone. In SCYW-79 1a it forms a layer 5 mm thick; in Munta 1 the ejecta layer is thin and discontinuous because of its distance (similar to 550 km) from the impact structure. Palynological, biomarker, and carbon isotope anomalies can now be shown to coincide with the ejecta layer in SCYW-79 1a and Munta 1 suggesting the Acraman impact event may have had far reaching influences on the rapidly evolving Ediacaran biological and geochemical cycles.
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| 9. |
- Lyttkens, Carl Hampus, et al.
(författare)
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Understanding the politics of Pericles around 450 BC : The benefits of an economic perspective
- 2018
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Ingår i: Ancient History and Contemporary Social Science. - 9781474421775 ; 9, s. 269-292
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Konferensbidrag (refereegranskat)abstract
- Pericles is usually viewed as a great statesman and clever leader of the Athenians. In the mid-fifth century BC, however, he seems to have been in serious political trouble and may well have been in danger of losing a political struggle against his opponent Kimon. The fact that his incentives changed considerably at this point in time seems to have escaped attention in the literature. In contrast, we see this fierce competition as a motivation for several important policy measures that Pericles introduced at this particular time: the pay to jurors, the new law on citizenship (which has been a puzzle to many historians), and the building projects on the Acropolis and elsewhere. An economic rational-actor approach thus provides a diachronic analytical benefit by focusing on the way in which incentives change over time and a synchronic benefit by considering various decisions in a common framework.
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| 10. |
- Meijers, Andrew, et al.
(författare)
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Southern Ocean
- 2019
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Ingår i: Bulletin of The American Meteorological Society -. - : American Meteorological Society.
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 11. |
- Mondal, Arobendo, et al.
(författare)
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Large-Scale Computation of Nuclear Magnetic Resonance Shifts for Paramagnetic Solids Using CP2K
- 2018
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Ingår i: Journal of Chemical Theory and Computation. - : American Chemical Society (ACS). - 1549-9618 .- 1549-9626. ; 14:1, s. 377-394
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Tidskriftsartikel (refereegranskat)abstract
- Large-scale computations of nuclear magnetic resonance (NMR) shifts for extended paramagnetic solids (pNMR) are reported using the highly efficient Gaussian-augmented plane-wave implementation of the CP2K code. Combining hyperfine couplings obtained with hybrid functionals with g-tensors and orbital shieldings computed using gradient-corrected functionals, contact, pseudocontact, and orbital-shift contributions to pNMR shifts are accessible. Due to the efficient and highly parallel performance of CP2K, a wide variety of materials with large unit cells can be studied with extended Gaussian basis sets. Validation of various approaches for the different contributions to pNMR shifts is done first for molecules in a large supercell in comparison with typical quantum-chemical codes. This is then extended to a detailed study of g-tensors for extended solid transition-metal fluorides and for a series of complex lithium vanadium phosphates. Finally, lithium pNMR shifts are computed for Li3V2(PO4)(3), for which detailed experimental data are available. This has allowed an in-depth study of different approaches (e.g., full periodic versus incremental cluster computations of g-tensors and different functionals and basis sets for hyperfine computations) as well as a thorough analysis of the different contributions to the pNMR shifts. This study paves the way for a more-widespread computational treatment of NMR shifts for paramagnetic materials.
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| 12. |
- Pell, Andrew J., et al.
(författare)
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Paramagnetic NMR in solution and the solid state
- 2019
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Ingår i: Progress in nuclear magnetic resonance spectroscopy. - : Elsevier BV. - 0079-6565 .- 1873-3301. ; 111, s. 1-271
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Forskningsöversikt (refereegranskat)abstract
- The field of paramagnetic NMR has expanded considerably in recent years. This review addresses both the theoretical description of paramagnetic NMR, and the way in which it is currently practised. We provide a review of the theory of the NMR parameters of systems in both solution and the solid state. Here we unify the different languages used by the NMR, EPR, quantum chemistry/DFT, and magnetism communities to provide a comprehensive and coherent theoretical description. We cover the theory of the paramagnetic shift and shift anisotropy in solution both in the traditional formalism in terms of the magnetic susceptibility tensor, and using a more modern formalism employing the relevant EPR parameters, such as are used in first-principles calculations. In addition we examine the theory first in the simple non-relativistic picture, and then in the presence of spin-orbit coupling. These ideas are then extended to a description of the paramagnetic shift in periodic solids, where it is necessary to include the bulk magnetic properties, such as magnetic ordering at low temperatures. The description of the paramagnetic shift is completed by describing the current understanding of such shifts due to lanthanide and actinide ions. We then examine the paramagnetic relaxation enhancement, using a simple model employing a phenomenological picture of the electronic relaxation, and again using a more complex state-of-the-art theory which incorporates electronic relaxation explicitly. An additional important consideration in the solid state is the impact of bulk magnetic susceptibility effects on the form of the spectrum, where we include some ideas from the field of classical electrodynamics. We then continue by describing in detail the solution and solid-state NMR methods that have been deployed in the study of paramagnetic systems in chemistry, biology, and the materials sciences. Finally we describe a number of case studies in paramagnetic NMR that have been specifically chosen to highlight how the theory in part one, and the methods in part two, can be used in practice. The systems chosen include small organometallic complexes in solution, solid battery electrode materials, metalloproteins in both solution and the solid state, systems containing lanthanide ions, and multi-component materials used in pharmaceutical controlled-release formulations that have been doped with paramagnetic species to measure the component domain sizes.
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| 13. |
- Price, Nicholas, et al.
(författare)
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Combining population genomics and fitness QTLs to identify the genetics of local adaptation in Arabidopsis thaliana
- 2018
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : NATL ACAD SCIENCES. - 0027-8424 .- 1091-6490. ; 115:19, s. 5028-5033
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Tidskriftsartikel (refereegranskat)abstract
- Evidence for adaptation to different climates in the model species Arabidopsis thaliana is seen in reciprocal transplant experiments, but the genetic basis of this adaptation remains poorly understood. Field-based quantitative trait locus (QTL) studies provide direct but low-resolution evidence for the genetic basis of local adaptation. Using high-resolution population genomic approaches, we examine local adaptation along previously identified genetic trade-off (GT) and conditionally neutral (CN) QTLs for fitness between locally adapted Italian and Swedish A. thaliana populations [angstrom gren J, et al. (2013) Proc Natl Acad Sci USA 110: 21077-21082]. We find that genomic regions enriched in high F-ST SNPs colocalize with GT QTL peaks. Many of these high F-ST regions also colocalize with regions enriched for SNPs significantly correlated to climate in Eurasia and evidence of recent selective sweeps in Sweden. Examining unfolded site frequency spectra across genes containing high F-ST SNPs suggests GTs may be due to more recent adaptation in Sweden than Italy. Finally, we collapse a list of thousands of genes spanning GT QTLs to 42 genes that likely underlie the observed GTs and explore potential biological processes driving these trade-offs, from protein phosphorylation, to seed dormancy and longevity. Our analyses link population genomic analyses and field-based QTL studies of local adaptation, and emphasize that GTs play an important role in the process of local adaptation.
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| 14. |
- Sanders, Kevin J., et al.
(författare)
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Broadband MAS NMR spectroscopy in the low-power limit
- 2018
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Ingår i: Chemical Physics Letters. - : Elsevier BV. - 0009-2614 .- 1873-4448. ; 697, s. 29-37
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the performance of broadband adiabatic inversion pulses in the high-power (short high-powered adiabatic pulse, SHAP) and low-power (single-sideband-selective adiabatic pulse, S(3)AP) RF regimes on a spin system subjected to large anisotropic interactions. We show by combined experimental results and spin dynamics simulations that when the magic-angle spinning rate exceeds 100 kHz S(3)APs begin outperforming SHAPs. This is especially true for low-gamma nuclei, such as Li-6 in paramagnetic Li-ion battery materials. Finally, we show how S3APs can be improved by combining multiple waveforms sweeping over multiple sidebands simultaneously, in order to produce inverted sideband profiles free from intensity biasing.
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| 15. |
- Seymour, Ieuan D., et al.
(författare)
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Characterizing Oxygen Local Environments in Paramagnetic Battery Materials via O-17 NMR and DFT Calculations
- 2016
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Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 0002-7863 .- 1520-5126. ; 138:30, s. 9405-9408
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Tidskriftsartikel (refereegranskat)abstract
- Experimental techniques that probe the local environment around O in paramagnetic Li-ion cathode materials are essential in order to understand the complex phase transformations and O redox processes that can occur during electrochemical delithiation. While Li NMR is a well-established technique for studying the local environment of Li ions in paramagnetic battery materials, the use of O-17 NMR in the same materials has not yet been reported. In this work, we present a combined O-17 NMR and hybrid density functional theory study of the local O environments in Li2MnO3, a model compound for layered Li-ion batteries. After a simple O-17 enrichment procedure, we observed five resonances with large O-17 shifts ascribed to the Fermi contact interaction with directly bonded Mn4+ ions. The five peaks were separated into two groups with shifts at 1600 to 1950 ppm and 2100 to 2450 ppm, which, -with the aid of first principles calculations, were assigned to the O-17 shifts of environments similar to the 4i and 8j sites in pristine Li2MnO3, respectively. The multiple O environments in each region were ascribed to the presence of stacking faults within the Li2MnO3 structure. From the ratio of the intensities of the different O-17 environments, the percentage of stacking faults was found to be ca. 10%. The methodology for studying (17)Oshifts in paramagnetic solids described in this work will be useful for studying the local environments of O in a range of technologically interesting transition metal oxides.
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| 16. |
- Tanentzap, Andrew J., et al.
(författare)
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Terrestrial support of lake food webs : Synthesis reveals controls over cross-ecosystem resource use
- 2017
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Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 3:3
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Tidskriftsartikel (refereegranskat)abstract
- Widespread evidence that organic matter exported from terrestrial into aquatic ecosystems supports recipient food webs remains controversial. A pressing question is not only whether high terrestrial support is possible but also what the general conditions are under which it arises. We assemble the largest data set, to date, of the isotopic composition (delta H-2, delta C-13, and delta N-15) of lake zooplankton and the resources at the base of their associated food webs. In total, our data set spans 559 observations across 147 lakes from the boreal to subtropics. By predicting terrestrial resource support from within-lake and catchment-level characteristics, we found that half of all consumer observations that is, the median were composed of at least 42% terrestrially derived material. In general, terrestrial support of zooplankton was greatest in lakes with large physical and hydrological connections to catchments that were rich in aboveground and belowground organic matter. However, some consumers responded less strongly to terrestrial resources where within-lake production was elevated. Our study shows that multiple mechanisms drive widespread cross-ecosystem support of aquatic consumers across Northern Hemisphere lakes and suggests that changes in terrestrial landscapes will influence ecosystem processes well beyond their boundaries.
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| 17. |
- Tapia-Ruiz, Nuria, et al.
(författare)
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2021 roadmap for sodium-ion batteries
- 2021
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Ingår i: Journal of Physics. - : Institute of Physics Publishing (IOPP). - 2515-7655. ; 3:3
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Tidskriftsartikel (refereegranskat)abstract
- Increasing concerns regarding the sustainability of lithium sources, due to their limited availability and consequent expected price increase, have raised awareness of the importance of developing alternative energy-storage candidates that can sustain the ever-growing energy demand. Furthermore, limitations on the availability of the transition metals used in the manufacturing of cathode materials, together with questionable mining practices, are driving development towards more sustainable elements. Given the uniformly high abundance and cost-effectiveness of sodium, as well as its very suitable redox potential (close to that of lithium), sodium-ion battery technology offers tremendous potential to be a counterpart to lithium-ion batteries (LIBs) in different application scenarios, such as stationary energy storage and low-cost vehicles. This potential is reflected by the major investments that are being made by industry in a wide variety of markets and in diverse material combinations. Despite the associated advantages of being a drop-in replacement for LIBs, there are remarkable differences in the physicochemical properties between sodium and lithium that give rise to different behaviours, for example, different coordination preferences in compounds, desolvation energies, or solubility of the solid-electrolyte interphase inorganic salt components. This demands a more detailed study of the underlying physical and chemical processes occurring in sodium-ion batteries and allows great scope for groundbreaking advances in the field, from lab-scale to scale-up. This roadmap provides an extensive review by experts in academia and industry of the current state of the art in 2021 and the different research directions and strategies currently underway to improve the performance of sodium-ion batteries. The aim is to provide an opinion with respect to the current challenges and opportunities, from the fundamental properties to the practical applications of this technology.
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| 18. |
- Wilkinson, Jack, et al.
(författare)
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Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions
- 2024
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 14:3
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Randomised controlled trials (RCTs) inform healthcare decisions. It is now apparent that some published RCTs contain false data and some appear to have been entirely fabricated. Systematic reviews are performed to identify and synthesise all RCTs that have been conducted on a given topic. While it is usual to assess methodological features of the RCTs in the process of undertaking a systematic review, it is not usual to consider whether the RCTs contain false data. Studies containing false data therefore go unnoticed and contribute to systematic review conclusions. The INveStigating ProblEmatic Clinical Trials in Systematic Reviews (INSPECT-SR) project will develop a tool to assess the trustworthiness of RCTs in systematic reviews of healthcare-related interventions.Methods and analysis The INSPECT-SR tool will be developed using expert consensus in combination with empirical evidence, over five stages: (1) a survey of experts to assemble a comprehensive list of checks for detecting problematic RCTs, (2) an evaluation of the feasibility and impact of applying the checks to systematic reviews, (3) a Delphi survey to determine which of the checks are supported by expert consensus, culminating in, (4) a consensus meeting to select checks to be included in a draft tool and to determine its format and (5) prospective testing of the draft tool in the production of new health systematic reviews, to allow refinement based on user feedback. We anticipate that the INSPECT-SR tool will help researchers to identify problematic studies and will help patients by protecting them from the influence of false data on their healthcare.Ethics and dissemination The University of Manchester ethics decision tool was used, and this returned the result that ethical approval was not required for this project (30 September 2022), which incorporates secondary research and surveys of professionals about subjects relating to their expertise. Informed consent will be obtained from all survey participants. All results will be published as open-access articles. The final tool will be made freely available.
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