| 1. |
- Achterberg, A., et al.
(författare)
-
Detection of atmospheric muon neutrinos with the IceCube 9-string detector
- 2007
-
Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998. ; 76:2, s. 027101-
-
Tidskriftsartikel (refereegranskat)abstract
- The IceCube neutrino detector is a cubic kilometer TeV to PeV neutrino detector under construction at the geographic South Pole. The dominant population of neutrinos detected in IceCube is due to meson decay in cosmic-ray air showers. These atmospheric neutrinos are relatively well understood and serve as a calibration and verification tool for the new detector. In 2006, the detector was approximately 10% completed, and we report on data acquired from the detector in this configuration. We observe an atmospheric neutrino signal consistent with expectations, demonstrating that the IceCube detector is capable of identifying neutrino events. In the first 137.4 days of live time, 234 neutrino candidates were selected with an expectation of 211 +/- 76.1(syst)+/- 14.5(stat) events from atmospheric neutrinos.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Lindström, Björn, et al.
(författare)
-
Results of UFO dynamics studies with beam in the LHC
- 2018
-
Ingår i: Journal of Physics, Conference Series. - : Institute of Physics Publishing (IOPP). - 1742-6588 .- 1742-6596. ; 1067:2
-
Tidskriftsartikel (refereegranskat)abstract
- Micrometer sized particles entering the LHC beam (the so called Unidentified Falling Objects or UFOs) are a known cause of localized beam losses since the beginning of high intensity beam operation, however the origin of these particles is not fully known. Their effect limits LHC availability by causing premature dumps due to excessive beam losses and occasionally even magnet quenches. This could become an important limitation for future accelerators such as the High Luminosity upgrade of the LHC (HL-LHC) and the Future Circular Collider (FCC). The dynamics of these UFOs was investigated in two dedicated experiments. In the first experiment, it was shown that the transverse movements of these particles can be studied by observing bunch-by-bunch losses from bunches with different horizontal and vertical emittances. In the second experiment, UFO-like events around the 16L2 interconnect in the LHC, which has seen intense UFO activity in 2017, were studied with the above method. This paper summarizes the results of both experiments.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Naldi, L., et al.
(författare)
-
Comparators, study duration, outcome measures and sponsorship in therapeutic trials of psoriasis: update of the EDEN Psoriasis Survey 2001-2006
- 2010
-
Ingår i: British Journal of Dermatology. - : Oxford University Press (OUP). - 1365-2133 .- 0007-0963. ; 162:2, s. 384-389
-
Tidskriftsartikel (refereegranskat)abstract
- Background Several new therapeutic options for psoriasis have been tested in clinical trials in recent years. Choice of comparator, study duration and outcome measures are critical for interpreting application of trial results to clinical practice. Objectives We examined whether these trial aspects have changed substantially in recent years in comparison with the past. Methods A systematic search and evaluation of all randomized controlled trials (RCTs) for psoriasis published from January 2001 up to December 2006 in 14 leading medical and dermatological journals, compared with those published from 1977 to 2000. Results There were 140 RCTs of psoriasis in the period 2001-2006 and 249 in the period 1977-2000. The proportion of placebo-controlled studies increased from 44.6% to 69.3%. The median study duration increased from 7 weeks to 12 weeks. The proportion of studies adopting the Psoriasis Area and Severity Index score as an outcome increased from 30.6% to 57.7%, while the number of studies incorporating a quality of life measure increased from only one (0.4%) to 12 studies (7.7%). The proportion of studies sponsored by pharmaceutical companies increased from 61.0% to 73.7%. Conclusions Despite the increased number of new options, the number of head-to-head comparative trials has decreased and most trials focus on short-term effects, probably reflecting the increased influence of industrial sponsorship on the research agenda.
|
|
| 10. |
- Biermann, Frank, et al.
(författare)
-
Scientific evidence on the political impact of the Sustainable Development Goals
- 2022
-
Ingår i: Nature Sustainability. - : Springer Nature. - 2398-9629. ; 5:9, s. 795-800
-
Tidskriftsartikel (refereegranskat)abstract
- In 2015, the United Nations agreed on 17 Sustainable Development Goals as the central normative framework for sustainable development worldwide. The effectiveness of governing by such broad global goals, however, remains uncertain, and we lack comprehensive meta-studies that assess the political impact of the goals across countries and globally. We present here condensed evidence from an analysis of over 3,000 scientific studies on the Sustainable Development Goals published between 2016 and April 2021. Our findings suggests that the goals have had some political impact on institutions and policies, from local to global governance. This impact has been largely discursive, affecting the way actors understand and communicate about sustainable development. More profound normative and institutional impact, from legislative action to changing resource allocation, remains rare. We conclude that the scientific evidence suggests only limited transformative political impact of the Sustainable Development Goals thus far.
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
- Huls, Samare P. I., et al.
(författare)
-
Preference Variation : Where Does Health Risk Attitude Come Into the Equation?
- 2022
-
Ingår i: Value in Health. - : Elsevier. - 1098-3015 .- 1524-4733. ; 25:12, s. 2044-2052
-
Tidskriftsartikel (refereegranskat)abstract
- ObjectivesDecisions about health often involve risk, and different decision makers interpret and value risk information differently. Furthermore, an individual’s attitude toward health-specific risks can contribute to variation in health preferences and behavior. This study aimed to determine whether and how health-risk attitude and heterogeneity of health preferences are related.MethodsTo study the association between health-risk attitude and preference heterogeneity, we selected 3 discrete choice experiment case studies in the health domain that included risk attributes and accounted for preference heterogeneity. Health-risk attitude was measured using the 13-item Health-Risk Attitude Scale (HRAS-13). We analyzed 2 types of heterogeneity via panel latent class analyses, namely, how health-risk attitude relates to (1) stochastic class allocation and (2) systematic preference heterogeneity.ResultsOur study did not find evidence that health-risk attitude as measured by the HRAS-13 distinguishes people between classes. Nevertheless, we did find evidence that the HRAS-13 can distinguish people’s preferences for risk attributes within classes. This phenomenon was more pronounced in the patient samples than in the general population sample. Moreover, we found that numeracy and health literacy did distinguish people between classes.ConclusionsModeling health-risk attitude as an individual characteristic underlying preference heterogeneity has the potential to improve model fit and model interpretations. Nevertheless, the results of this study highlight the need for further research into the association between health-risk attitude and preference heterogeneity beyond class membership, a different measure of health-risk attitude, and the communication of risks.
|
|
| 14. |
- Kandolf-Sekulovic, L, et al.
(författare)
-
Which medical disciplines diagnose and treat melanoma in Europe in 2019? A survey of experts from melanoma centres in 27 European countries.
- 2021
-
Ingår i: Journal of the European Academy of Dermatology and Venereology : JEADV. - : Wiley. - 1468-3083 .- 0926-9959. ; 35:5, s. 1129-1132
-
Tidskriftsartikel (refereegranskat)abstract
- The incidence of melanoma is increasing. This places significant burden on societies to provide efficient cancer care. The European Cancer Organisation recently published the essential requirements for quality melanoma care. The present study is aimed for the first time to roughly estimate the extent to which these requirements have been met in Europe.A web-based survey of experts from melanoma centres in 27 European countries was conducted from 1 February to 1 August 2019. Data on diagnostic techniques, surgical and medical treatment, organization of cancer care and education were collected and correlated with national health and economic indicators and mortality-to-incidence ratio (MIR) as a surrogate for survival. Univariate linear regression analysis was performed to evaluate the correlations. SPSS software was used. Statistical significance was set at P<0.05.The MIR was lower in countries with a high health expenditure per capita and with a higher numbers of general practitioners (GPs) and surgeons (SURG) per million inhabitants. In these countries, GPs and dermatologists (DER) were involved in melanoma detection; high percentage of DER used dermatoscopy and were involved in the follow-up of all melanoma stages; both medical oncologists (ONC) and dermato-oncologists administered systemic treatments; and patients had better access to sentinel lymph node biopsy and were treated within multidisciplinary tumour boards.Based on these first estimates, the greater involvement of GPs in melanoma detection; the greater involvement of highly trained DER in dermatoscopy, dermatosurgery, follow-up and the systemic treatment of melanoma; and the provision of ongoing dermato-oncology training for pathologists, SURG, DER and ONC are necessary to provide an optimal melanoma care pathway. A comprehensive analysis of the melanoma care pathway based on clinical melanoma registries will be needed to more accurately evaluate these first insights.
|
|
| 15. |
|
|
| 16. |
- Lechner, A., et al.
(författare)
-
Dust-induced beam losses in the cryogenic arcs of the CERN Large Hadron Collider
- 2022
-
Ingår i: Physical Review Accelerators and Beams. - : American Physical Society. - 2469-9888. ; 25:4
-
Tidskriftsartikel (refereegranskat)abstract
- The interaction of dust particles with the LHC proton beams accounts for a major fraction of irregular beam loss events observed in LHC physics operation. The events cease after a few beam revolutions because of the expulsion of dust particles from the beam once they become ionized in the transverse beam tails. Despite the transient nature of these events, the resulting beam losses can trigger beam aborts or provoke quenches of superconducting magnets. In this paper, we study the characteristics of beam-dust particle interactions in the cryogenic arcs by reconstructing key observables like nuclear collision rates, loss durations and integral losses per event. The study is based on events recorded during 6.5 TeVoperation with stored beam intensities of up to similar to 3 x 10(14) protons per beam. We show that inelastic collision rates can reach almost 10(12) collisions per second, resulting in a loss of up to similar to 1.6 x 10(8) protons per event. We demonstrate that the experimental distributions and their dependence on beam parameters can be described quantitatively by a previously developed simulation model if dust particles are assumed to be attracted by the beam. The latter finding is consistent with recent time profile studies and yields further evidence that dust particles carry a negative charge when entering the beam. We also develop different hypotheses regarding the absence of higher-loss events in the measurements, although such events are theoretically not excluded by the simulation model. The results provide grounds for predicting dust-induced beam losses in the presence of higher-intensity beams in future runs of the High-Luminosity LHC.
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
- Veldwijk, Jorien, et al.
(författare)
-
Exploring how individuals complete the choice tasks in a discrete choice experiment : an interview study
- 2016
-
Ingår i: BMC Medical Research Methodology. - : Springer Science and Business Media LLC. - 1471-2288. ; 16:45
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundTo be able to make valid inferences on stated preference data from a Discrete Choice Experiment (DCE) it is essential that researchers know if participants were actively involved, understood and interpreted the provided information correctly and whether they used complex decision strategies to make their choices and thereby acted in accordance with the continuity axiom.MethodsDuring structured interviews, we explored how 70 participants evaluated and completed four discrete choice tasks aloud. Hereafter, additional questions were asked to further explore if participants understood the information that was provided to them and whether they used complex decision strategies (continuity axiom) when making their choices. Two existing DCE questionnaires on rotavirus vaccination and prostate cancer-screening served as case studies.ResultsA large proportion of the participants was not able to repeat the exact definition of the risk attributes as explained to them in the introduction of the questionnaire. The majority of the participants preferred more optimal over less optimal risk attribute levels. Most participants (66 %) mentioned three or more attributes when motivating their decisions, thereby acting in accordance with the continuity axiom. However, 16 out of 70 participants continuously mentioned less than three attributes when motivating their decision. Lower educated and less literate participants tended to mention less than three attributes when motivating their decision and used trading off between attributes less often as a decision-making strategy.ConclusionThe majority of the participants seemed to have understood the provided information about the choice tasks, the attributes, and the levels. They used complex decision strategies (continuity axiom) and are therefore capable to adequately complete a DCE. However, based on the participants’ age, educational level and health literacy additional, actions should be undertaken to ensure that participants understand the choice tasks and complete the DCE as presumed.
|
|
| 21. |
- Wraith, Calvin, et al.
(författare)
-
Evolution of nuclear structure in neutron-rich odd-Zn isotopes and isomers
- 2017
-
Ingår i: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 771, s. 385-391
-
Tidskriftsartikel (refereegranskat)abstract
- Collinear laser spectroscopy was performed on Zn (Z = 30) isotopes at ISOLDE, CERN. The study of hyperfine spectra of nuclei across the Zn isotopic chain, N = 33–49, allowed the measurement of nuclear spins for the ground and isomeric states in odd-A neutron-rich nuclei up to N = 50. Exactly one longlived (>10 ms) isomeric state has been established in each 69–79Zn isotope. The nuclear magnetic dipole moments and spectroscopic quadrupole moments are well reproduced by large-scale shell–model calculations in the f5pg9 and fpg9d5 model spaces, thus establishing the dominant term in their wave function. The magnetic moment of the intruder Iπ = 1/2+ isomer in 79Zn is reproduced only if the νs1/2 orbital is added to the valence space, as realized in the recently developed PFSDG-U interaction.The spin and moments of the low-lying isomeric state in 73Zn suggest a strong onset of deformation at N = 43, while the progression towards 79Zn points to the stability of the Z = 28 and N = 50 shell gaps, supporting the magicity of 78Ni
|
|
| 22. |
- Xie, L., et al.
(författare)
-
Nuclear charge radii of Zn62-80 and their dependence on cross-shell proton excitations
- 2019
-
Ingår i: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 797
-
Tidskriftsartikel (refereegranskat)abstract
- Nuclear charge radii of Zn62-80 have been determined using collinear laser spectroscopy of bunched ion beams at CERN-ISOLDE. The subtle variations of observed charge radii, both within one isotope and along the full range of neutron numbers, are found to be well described in terms of the proton excitations across the Z = 28 shell gap, as predicted by large-scale shell model calculations. It comprehensively explains the changes in isomer-to-ground state mean square charge radii of Zn69-79, the inversion of the odd-even staggering around N = 40 and the odd-even staggering systematics of the Zn charge radii. With two protons above Z = 28, the observed charge radii of the Zn isotopic chain show a cumulative effect of different aspects of nuclear structure including single particle structure, shell closure, correlations and deformations near the proposed doubly magic nuclei, Ni-68 and Ni-78. (C) 2019 The Author(s). Published by Elsevier B.V.
|
|
