| 1. |
- Osada, H, et al.
(författare)
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LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1
- 1997
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Ingår i: Leukemia. - 0887-6924. ; 11:Suppl 3, s. 12-307
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Tidskriftsartikel (refereegranskat)abstract
- The LIM-only protein Lmo2, originally identified as an oncogenic protein in human T cell leukemia, is essential for erythropoiesis. A possible role for Lmo2 in transcription during erythropoiesis has been investigated. Direct interaction of Lmo2 was observed in vitro and in vivo with the zinc finger transcription factor GATA-1, as well as with the basic helix-loop-helix (bHLH) transcription factor Tall. By using mammalian two-hybrid analysis, E47/Tall/Lmo2/GATA-1 protein complex could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis. This data suggest that variations in amounts of complexes involving Lmo2, Tall, and GATA-1 could be important for erythroid differentiation.
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| 2. |
- Osada, H, et al.
(författare)
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Association of erythroid transcription factors : complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1
- 1995
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Ingår i: Proceedings of the National Academy of Sciences. - 0027-8424. ; 92:21, s. 9-9585
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Tidskriftsartikel (refereegranskat)abstract
- The RBTN2 LIM-domain protein, originally identified as an oncogenic protein in human T-cell leukemia, is essential for erythropoiesis. A possible role for RBTN2 in transcription during erythropoiesis has been investigated. Direct interaction of the RBTN2 protein was observed in vivo and in vitro with the GATA1 or -2 zinc-finger transcription factors, as well as with the basic helix-loop-helix protein TAL1. By using mammalian two-hybrid analysis, complexes involving RBTN2, TAL1, and GATA1, together with E47, the basic helix-loop-helix heterodimerization partner of TAL1, could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis, and the data suggest that variations in amounts of complexes involving RBTN2, TAL1, and GATA1 could be important for erythroid differentiation.
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| 3. |
- Rabbitts, T H, et al.
(författare)
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Chromosomal translocations and leukaemia : a role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis
- 1997
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Ingår i: Leukemia. - 0887-6924. ; 11:Suppl 3, s. 2-271
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Tidskriftsartikel (refereegranskat)abstract
- The LMO2 gene associated with T cell acute leukaemia has been used as an example of a gene activated by association with the T cell receptor genes after chromosomal translocations. The gene is shown to encode a LIM protein which is involved in protein interactions and during normal haematopoiesis is necessary for erythroid development. LMO2 has been shown to cause tumours when aberrantly expressed and to be able to heterodimerise with TAL1 to facilitate tumour development.
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