| 1. |
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| 2. |
- Petrie, Ruth, et al.
(författare)
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Coordinating an operational data distribution network for CMIP6 data
- 2021
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Ingår i: Geoscientific Model Development. - Goettingen, Germany : Copernicus Gesellschaft MBH. - 1991-959X .- 1991-9603. ; 14:1, s. 629-644
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Tidskriftsartikel (refereegranskat)abstract
- The distribution of data contributed to the Coupled Model Intercomparison Project Phase 6 (CMIP6) is via the Earth System Grid Federation (ESGF). The ESGF is a network of internationally distributed sites that together work as a federated data archive. Data records from climate modelling institutes are published to the ESGF and then shared around the world. It is anticipated that CMIP6 will produce approximately 20 PB of data to be published and distributed via the ESGF. In addition to this large volume of data a number of value-added CMIP6 services are required to interact with the ESGF; for example the citation and errata services both interact with the ESGF but are not a core part of its infrastructure. With a number of interacting services and a large volume of data anticipated for CMIP6, the CMIP Data Node Operations Team (CDNOT) was formed. The CDNOT coordinated and implemented a series of CMIP6 preparation data challenges to test all the interacting components in the ESGF CMIP6 software ecosystem. This ensured that when CMIP6 data were released they could be reliably distributed. No. DE-ACO2-05CH11231 and authors at Lawrence Livermore National Laboratory (LLNL) under contract DE-AC52-07NA27344 with the U.S. Department of Energy. The United States Government retains and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, world-wide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes. The Department of Energy will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-access-plan).
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| 3. |
- Abelev, Betty, et al.
(författare)
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Long-range angular correlations on the near and away side in p-Pb collisions at root S-NN=5.02 TeV
- 2013
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 719:1-3, s. 29-41
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Tidskriftsartikel (refereegranskat)abstract
- Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in high-multiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS Collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and p(T) bins, and the widths show no significant evolution with event multiplicity or p(T). These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge. (c) 2013 CERN. Published by Elsevier B.V. All rights reserved.
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| 4. |
- Abelev, Betty, et al.
(författare)
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Measurement of prompt J/psi and beauty hadron production cross sections at mid-rapidity in pp collisions at root s=7 TeV
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :11
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Tidskriftsartikel (refereegranskat)abstract
- The ALICE experiment at the LHC has studied J/psi production at mid-rapidity in pp collisions at root s = 7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L-int = 5.6 nb(-1). The fraction of J/psi from the decay of long-lived beauty hadrons was determined for J/psi candidates with transverse momentum p(t) > 1,3 GeV/c and rapidity vertical bar y vertical bar < 0.9. The cross section for prompt J/psi mesons, i.e. directly produced J/psi and prompt decays of heavier charmonium states such as the psi(2S) and chi(c) resonances, is sigma(prompt J/psi) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 8.3 +/- 0.8(stat.) +/- 1.1 (syst.)(-1.4)(+1.5) (syst. pol.) mu b. The cross section for the production of b-hadrons decaying to J/psi with p(t) > 1.3 GeV/c and vertical bar y vertical bar < 0.9 is a sigma(J/psi <- hB) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 1.46 +/- 0.38 (stat.)(-0.32)(+0.26) (syst.) mu b. The results are compared to QCD model predictions. The shape of the p(t) and y distributions of b-quarks predicted by perturbative QCD model calculations are used to extrapolate the measured cross section to derive the b (b) over bar pair total cross section and d sigma/dy at mid-rapidity.
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| 5. |
- Abelev, Betty, et al.
(författare)
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Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :7
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.
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| 6. |
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| 7. |
- Benazzi, Elisabetta, et al.
(författare)
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Acid-triggering of light-induced charge-separation in hybrid organic/inorganic molecular photoactive dyads for harnessing solar energy
- 2021
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Ingår i: Inorganic Chemistry Frontiers. - : Royal Society of Chemistry (RSC). - 2052-1553. ; 8:6, s. 1610-1618
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Tidskriftsartikel (refereegranskat)abstract
- H+ modulated charge-transfer in photoexcited covalent polyoxometalate-bodipy conjugates is described. The hybrid organic/inorganic molecular photoactive dyads are based on Keggin-type polyoxometalates (POMs, where KM = [PM11O39] and M = Mo or W) covalently grafted via an organotin linker to a bodipy (BOD) photosensitizer. The relative potentials of the photosensitizer and POM are aligned such that light-induced electron transfer from BOD to POM is permitted for the polyoxomolybdate KMoSn[BOD] but not effective for the polyoxotungstate analogue KWSn[BOD]. In both cases, the addition of acid shifts the redox potential of the POM only, to increase the driving force for electron transfer. This leads to charge-separation being switched on for KWSn[BOD] in the presence of acid. The addition of acid to KMoSn[BOD] accelerates charge-separation by an order of magnitude (from 2 ns to 200 ps) and is accompanied by a deceleration of charge recombination, leading to a charge-separated state lifetime of up to 1.3 μs. This behaviour is consistent with proton coupled electron transfer, which has previously been observed electrochemically for POMs, but this study shows, for the first time, the impact of protonation on photoinduced electron transfer. This journal is
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| 8. |
- Blanchet, Guillaume, et al.
(författare)
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Impacts of regional climatic fluctuations on radial growth of Siberian and Scots pine at Mukhrino mire (central-western Siberia)
- 2017
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 1879-1026 .- 0048-9697. ; 574, s. 1209-1216
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Tidskriftsartikel (refereegranskat)abstract
- Ring width (TRW) chronologies from Siberian (Pinus sibirica) and Scots (Pinus sylvestris) pine trees were sampled at Mukhrino - a large mire complex in central-western Siberia - to evaluate the impacts of hydroclimatic variability on tree growth over the last three centuries. For this purpose, we compared climate-growth correlation profiles from trees growing on peat soils with those growing on adjacent mineral soils. Tree growth at both peat and mineral soils was positively correlated to air temperature during the vegetation period. This finding can be explained by (i) the positive influence of temperature on plant physiological processes (i.e. growth control) during the growing season and (ii) the indirect impact of air temperatures on water table fluctuations. We observe also a strong link between TRW and the winter Palmer Drought Severity Index (PDSI), especially in Siberian pine, reflecting the isolating effect of snow and limited freezing damage in roots. Significant negative relations were, by contrast, observed between bog TRW chronologies and hydroclimatic indices during spring and summer; they are considered an expression of the negative impacts of high water levels and moist peat soils on root development. Some unusually old bog pines - exhibiting >500 growth rings - apparently colonized the site at the beginning of the Little Ice Age, and therefore seem to confirm that (i) peat conditions may have been drier in Siberia than in most other regions of western Europe during this period. At the same time, the bog trees also point to (ii) their strong dependence on surface conditions.
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| 9. |
- Chapman, Henry N, et al.
(författare)
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Femtosecond X-ray protein nanocrystallography.
- 2011
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 470:7332, s. 73-7
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Tidskriftsartikel (refereegranskat)abstract
- X-ray crystallography provides the vast majority of macromolecular structures, but the success of the method relies on growing crystals of sufficient size. In conventional measurements, the necessary increase in X-ray dose to record data from crystals that are too small leads to extensive damage before a diffraction signal can be recorded. It is particularly challenging to obtain large, well-diffracting crystals of membrane proteins, for which fewer than 300 unique structures have been determined despite their importance in all living cells. Here we present a method for structure determination where single-crystal X-ray diffraction 'snapshots' are collected from a fully hydrated stream of nanocrystals using femtosecond pulses from a hard-X-ray free-electron laser, the Linac Coherent Light Source. We prove this concept with nanocrystals of photosystem I, one of the largest membrane protein complexes. More than 3,000,000 diffraction patterns were collected in this study, and a three-dimensional data set was assembled from individual photosystem I nanocrystals (∼200nm to 2μm in size). We mitigate the problem of radiation damage in crystallography by using pulses briefer than the timescale of most damage processes. This offers a new approach to structure determination of macromolecules that do not yield crystals of sufficient size for studies using conventional radiation sources or are particularly sensitive to radiation damage.
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| 10. |
- Deribew, Dargie, et al.
(författare)
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Crystallization-Driven Enhancement in Photovoltaic Performance through Block Copolymer Incorporation into P3HT:PCBM Blends
- 2013
-
Ingår i: Macromolecules. - : American Chemical Society (ACS). - 0024-9297 .- 1520-5835. ; 46:8, s. 3015-3024
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Tidskriftsartikel (refereegranskat)abstract
- We report the increased crystallization of poly(3-hexylthiophene)(P3HT) in the donor−acceptor mixture of [6,6]-phenyl-C61-butyric acid methylester (PCBM) with P3HT by the addition of a block copolymer, P3HT-b-PI, where PI refers to polyisoprene. The photovoltaic performance of devices created using this blendis markedly improved by the addition of the diblock copolymer. We have characterizedthe structure of thin films of the P3HT-b-PI containing mixtures using opticalmicroscopy, scanning force microscopy, UV−vis absorption spectroscopy, neutronreflectometry, and grazing incidence X-ray diffraction (GIXD). The GIXD data providethe information on the crystallinity of the films, the absorption data were used toconfirm that the addition of the diblock was responsible for the increase in crystallization, neutron reflectometry data reveal a PCBM-rich region near the hole injection layer, and the two microscopy techniques revealed the structural effect of the crystallization at the surface of the films.
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| 11. |
- Donohue, Shane, et al.
(författare)
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The Use of Geophysics for Sensitive Clay Investigations
- 2014
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Ingår i: Landslides in Sensitive Clays. - Dordrecht : Springer Netherlands. ; , s. 159-178
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Marine clay deposits in coastal, post-submarine areas of Scandinavia and North America may be subjected to quick clay landslides and hence significant efforts are being taken to map their occurrence and extent. Recently, considerable efforts by a number of researchers have been made to investigate areas of sensitive clay using a range of geophysical techniques. Although the majority of this work has focussed on measurements of electrical resistivity, other electromagnetic and seismic geophysical techniques have also received attention in the literature. The purpose of this paper is to review recent research concerning the effectiveness of a number of geophysical techniques for investigating sensitive clays. In addition to discussing a number of case studies, this review will also consider recent work showing the correlation of geophysical measurements, and in particular electrical resistivity, with a range of relevant engineering properties.
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| 12. |
- Evangelou, Evangelos, et al.
(författare)
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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
- 2018
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:10, s. 1412-1425
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Tidskriftsartikel (refereegranskat)abstract
- High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
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| 13. |
- Fallet, Manon, 1992-, et al.
(författare)
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Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection
- 2022
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Ingår i: Microbiome. - : BioMed Central (BMC). - 2049-2618. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immune system maturation — and, importantly, protection from infectious disease — is still an open question.Results: Here, we demonstrate that early life microbial exposure durably improves oyster survival when challenged with the pathogen causing Pacific oyster mortality syndrome (POMS), both in the exposed generation and in the subsequent one. Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS.Conclusions: We anticipate that this protection likely extends to additional pathogens and may prove to be an important new strategy for safeguarding oyster aquaculture efforts from infectious disease
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| 14. |
- Fantin, Nicholas J., et al.
(författare)
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The Canada-France Imaging Survey : Reconstructing the Milky Way Star Formation History from Its White Dwarf Population
- 2019
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 887:2
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Tidskriftsartikel (refereegranskat)abstract
- As the remnants of stars with initial masses less than or similar to 8M(circle dot), white dwarfs contain valuable information on the formation histories of stellar populations. In this paper, we use deep, high-quality, u-band photometry from the Canada-France Imaging Survey, griz photometry from Pan-STARRS1, as well as proper motions from Gaia DR2, to select 25,156 white dwarf candidates over similar to 4500 deg(2) using a reduced proper motion diagram. We develop a new white dwarf population synthesis code that returns mock observations of the Galactic field white dwarf population for a given star formation history, while simultaneously taking into account the geometry of the Milky Way (MW), survey parameters, and selection effects. We use this model to derive the star formation histories of the thin disk, thick disk, and stellar halo. Our results show that the MW disk began forming stars (11.3 +/- 0.5) Gyr ago, with a peak rate of (8.8 +/- 1.4) M-circle dot yr(-1) at (9.8 +/- 0.4) Gyr, before a slow decline to a constant rate until the present day-consistent with recent results suggesting a merging event with a satellite galaxy. Studying the residuals between the data and best-fit model shows evidence for a slight increase in star formation over the past 3 Gyr. We fit the local fraction of helium-atmosphere white dwarfs to be (21 +/- 3)%. Incorporating this methodology with data from future wide-field surveys such as the Large Synoptic Survey Telescope, Euclid, The Cosmological Advanced Survey Telescope for Optical and ultraviolet Research, and the Wide Field Infrared Survey Telescope should provide an unprecedented view into the formation of the MW at its earliest epoch through its white dwarfs.
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| 15. |
- Galimshina, Alina, 1993, et al.
(författare)
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Bio-based materials as a robust solution for building renovation: A case study
- 2022
-
Ingår i: Applied Energy. - : Elsevier BV. - 1872-9118 .- 0306-2619. ; 316
-
Tidskriftsartikel (refereegranskat)abstract
- Boosting building renovation is urgently needed to achieve carbon neutrality by 2050. Building retrofit can be achieved by energy-efficient measures such as thermal insulation or replacement of a fossil heating system. Currently, conventional materials that are mostly used for envelope insulation raising the risk of a lock-in situation where measures to mitigate climate change are actually contributing to it. Bio-based materials are a promising alternative as they can be used to not only reduce the energy consumption of a building but also temporarily store carbon. To evaluate the potential benefits of such materials, life cycle assessment (LCA) and life cycle cost analysis (LCCA) are commonly used. Such assessment allows the analysis of a building over its whole life. However, considering that buildings are very long lasting systems, many associated uncertainties can affect the outcome of LCA and LCCA. To account for all the uncertainty sources and provide a robust solution for building renovation, uncertainty quantification can be applied. In this paper, we use robust optimization under uncertainties to define the most cost-effective and climate-friendly solution. We apply bio-based materials and include carbon storage calculation in the integrated LCA and LCCA. For the robust optimization, we use a novel methodology combining a well-known non-dominated sorting genetic algorithm II (NSGA-II) with surrogate modeling to lower computational cost. The methodology is applied for a case study located in Switzerland. The results show that bio-based materials provide a robust solution for building renovation but to achieve the highest reduction potential, bio-based envelope insulation should be combined with the replacement of the existing fossil heating system.
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| 16. |
- Galimshina, Alina, 1993, et al.
(författare)
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Robust and resilient renovation solutions in different climate change scenarios
- 2020
-
Ingår i: IOP Conference Series: Earth and Environmental Science. - : IOP Publishing. - 1755-1307 .- 1755-1315. ; 588:3
-
Konferensbidrag (refereegranskat)abstract
- Building renovation is currently urgent in order to decrease the energy consumption of a building stock. In order to achieve robust renovation scenarios, uncertainty quantification is needed. Climate change scenarios are important factors and need to be included in the analysis. In this paper, three climate change scenarios are applied probabilistically for a renovation scenario using dimensionality reduction techniques and further uncertainty propagation. The results show that RCP2.6 provides more robust results and saves on average 2.10^5 CHF and 2.10^5kgCO2eq. in a building life cycle comparing to RCP 8.5. The analysis under climate change is also compared to the probabilistic calculations under current climate and the results show the underestimation of both costs and environmental impacts when climate change is not included. It can also be clearly seen that even under the best case of RCP 2.6, building renovation is urgently needed to decrease the environmental impacts and costs.
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| 17. |
- Galimshina, Alina, 1993, et al.
(författare)
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Statistical method to identify robust building renovation choices for environmental and economic performance
- 2020
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Ingår i: Building and Environment. - : Elsevier BV. - 0360-1323. ; 183
-
Tidskriftsartikel (refereegranskat)abstract
- Building renovation is urgently required to decrease the energy consumption of the existing building stock and reduce greenhouse gas emissions coming from the building sector. Selecting an appropriate renovation strategy is challenging due to the long building service life and consequent uncertainties. In this paper, we propose a new framework for the robust assessment of renovation strategies in terms of environmental and economic performance of the building's life cycle. First, we identify the possible renovation strategies and define the probability distributions for 74 uncertain parameters. Second, we create an integrated workflow for Life Cycle Assessment (LCA) and Life Cycle Cost analysis (LCC) and make use of Sobol’ indices to identify a prioritization strategy for the renovation. Finally, the selected renovation scenario is assessed by metamodeling techniques to calculate its robustness. The results of three case studies of residential buildings from different construction periods show that the priority in renovation should be given to the heating system replacement, which is followed by the exterior wall insulation and windows. This result is not in agreement with common renovation practices and this discrepancy is discussed at the end of the paper.
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| 18. |
- Galimshina, Alina, 1993, et al.
(författare)
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Strategies for robust renovation of residential buildings in Switzerland
- 2024
-
Ingår i: Nature Communications. - 2041-1723 .- 2041-1723. ; 15:1
-
Tidskriftsartikel (refereegranskat)abstract
- Building renovation is urgently required to reduce the environmental impact associated with the building stock. Typically, building renovation is performed by envelope insulation and/or changing the fossil-based heating system. The goal of this paper is to provide strategies for robust renovation considering uncertainties on the future evolution of climate, energy grid, and user behaviors, amongst others by applying life cycle assessment and life cycle cost analysis. The study includes identifying optimal renovation options for the envelope and heating systems for building representatives from all construction periods that are currently in need of renovation in Switzerland. The findings emphasize the paramount importance of heating system replacements across all construction periods. Notably, when incorporating bio-based insulation materials, a balance emerges between environmental impact reduction and low energy operation costs. This facilitates robust, equitable, and low-carbon transformations in Switzerland and similar Northern European contexts while avoiding a carbon spike due to the embodied carbon of the renovation.
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| 19. |
- Galimshina, Alina, 1993, et al.
(författare)
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What is the optimal robust environmental and cost-effective solution for building renovation? Not the usual one
- 2021
-
Ingår i: Energy and Buildings. - : Elsevier BV. - 0378-7788. ; 251
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Tidskriftsartikel (refereegranskat)abstract
- Buildings are responsible for a large share of CO2 emissions in the world. Building renovation is crucial to decrease the environmental impact and meet the United Nations climate action goals. However, due to buildings’ long service lives, there are many uncertainties that might cause a deviation in the results of a predicted retrofit outcome. In this paper, we determine climate-friendly and cost-effective renovation scenarios for two typical buildings with low and high energy performance in Switzerland using a methodology of robust optmization. First, we create an integrated model for life cycle assessment (LCA) and life cycle cost analysis (LCCA). Second, we define possible renovation measures and possible levels of renovation. Third, we identify and describe the uncertain parameters related to the production, replacement and dismantling of building elements as well as the operational energy use in LCCA and LCA. Afterwards, we carry out a robust multi-objective optimization to identify optimal renovation solutions. The results show that the replacement of the heating system in the building retrofit process is crucial to decrease the environmental impact. They also show that for a building with already good energy performance, the investments are not paid off by the operational savings. The optimal solution for the building with low energy performance includes the building envelope renovation in combination with the heating system replacement. For both buildings, the optimal robust cost-effective and climate-friendly solution is different from the deep renovation practice promoted to decrease the energy consumption of a building.
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| 20. |
- Galluzzi, Lorenzo, et al.
(författare)
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Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer
- 2012
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Ingår i: Cell Reports. - Cambridge : Cell press. - 2211-1247. ; 2:2, s. 257-269
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Tidskriftsartikel (refereegranskat)abstract
- Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and in vivo. By aggravating a bioenergetic catastrophe that involves the depletion of intracellular glutathione, vitamin B6 exacerbates cisplatin-mediated DNA damage, thus sensitizing a large panel of cancer cell lines to apoptosis. Moreover, vitamin B6 sensitizes cancer cells to apoptosis induction by distinct types of physical and chemical stress, including multiple chemotherapeutics. This effect requires pyridoxal kinase (PDXK), the enzyme that generates the bioactive form of vitamin B6. In line with a general role of vitamin B6 in stress responses, low PDXK expression levels were found to be associated with poor disease outcome in two independent cohorts of patients with NSCLC. These results indicate that PDXK expression levels constitute a biomarker for risk stratification among patients with NSCLC.
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| 21. |
- Hollberg, Alexander, 1985, et al.
(författare)
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Review of visualising LCA results in the design process of buildings
- 2021
-
Ingår i: Building and Environment. - : Elsevier BV. - 0360-1323. ; 190
-
Forskningsöversikt (refereegranskat)abstract
- Life Cycle Assessment (LCA) is increasingly used for decision-making in the design process of buildings and neighbourhoods. Therefore, visualisation of LCA results to support interpretation and decision-making becomes more important. The number of building LCA tools and the published literature has increased substantially in recent years. Most of them include some type of visualisation. However, there are currently no clear guidelines and no harmonised way of presenting LCA results. In this paper, we review the current state of the art in visualising LCA results to provide a structured overview. Furthermore, we discuss recent and potential future developments. The review results show a great variety in visualisation options. By matching them with common LCA goals we provide a structured basis for future developments. Case studies combining different kinds of visualisations within the design environment, interactive dashboards, and immersive technologies, such as virtual reality, show a big potential for facilitating the interpretation of LCA results and collaborative design processes. The overview and recommendations presented in this paper provide a basis for future development of intuitive and design-integrated visualisation of LCA results to support decision-making.
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| 22. |
- Jin, Shoko, et al.
(författare)
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The wide-field, multiplexed, spectroscopic facility WEAVE : Survey design, overview, and simulated implementation
- 2024
-
Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press. - 0035-8711 .- 1365-2966. ; 530:3, s. 2688-2730
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Tidskriftsartikel (refereegranskat)abstract
- WEAVE, the new wide-field, massively multiplexed spectroscopic survey facility for the William Herschel Telescope, saw first light in late 2022. WEAVE comprises a new 2-deg field-of-view prime-focus corrector system, a nearly 1000-multiplex fibre positioner, 20 individually deployable 'mini' integral field units (IFUs), and a single large IFU. These fibre systems feed a dual-beam spectrograph covering the wavelength range 366-959nm at R similar to 5000, or two shorter ranges at . After summarizing the design and implementation of WEAVE and its data systems, we present the organization, science drivers, and design of a five- to seven-year programme of eight individual surveys to: (i) study our Galaxy's origins by completing Gaia's phase-space information, providing metallicities to its limiting magnitude for similar to 3 million stars and detailed abundances for similar to 1.5 million brighter field and open-cluster stars; (ii) survey similar to 0.4 million Galactic-plane OBA stars, young stellar objects, and nearby gas to understand the evolution of young stars and their environments; (iii) perform an extensive spectral survey of white dwarfs; (iv) survey similar to 400 neutral-hydrogen-selected galaxies with the IFUs; (v) study properties and kinematics of stellar populations and ionized gas in z < 0.5 cluster galaxies; (vi) survey stellar populations and kinematics in field galaxies at 0.3 less than or similar to z less than or similar to 0.7; (vii) study the cosmic evolution of accretion and star formation using >1 million spectra of LOFAR-selected radio sources; and (viii) trace structures using intergalactic/circumgalactic gas at z > 2. Finally, we describe the WEAVE Operational Rehearsals using the WEAVE Simulator.
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| 23. |
- Kielty, Collin L., et al.
(författare)
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The Pristine survey - XII. Gemini-GRACES chemo-dynamical study of newly discovered extremely metal-poor stars in the Galaxy
- 2021
-
Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 506:1, s. 1438-1461
-
Tidskriftsartikel (refereegranskat)abstract
- High-resolution optical spectra of 30 metal-poor stars selected from the Pristine survey are presented, based on observations taken with the Gemini Observatory GRACES spectrograph. Stellar parameters Teff and log g are determined using a Gaia DR2 colour–temperature calibration and surface gravity from the Stefan–Boltzmann equation. GRACES spectra are used to determine chemical abundances (or upper limits) for 20 elements (Li, O, Na, Mg, K, Ca, Ti, Sc, Cr, Mn, Fe, Ni, Cu, Zn, Y, Zr, Ba, La, Nd, Eu). These stars are confirmed to be metal-poor ([Fe/H] < −2.5), with higher precision than from earlier medium-resolution analyses. The chemistry for most targets is similar to other extremely metal-poor stars in the Galactic halo. Three stars near [Fe/H] = −3.0 have unusually low Ca and high Mg, suggestive of contributions from few SN II where alpha-element formation through hydrostatic nucleosynthesis was more efficient. Three new carbon-enhanced metal-poor (CEMP) stars are also identified (two CEMP-s and one potential CEMP-no star) when our chemical abundances are combined with carbon from previous medium-resolution analyses. The GRACES spectra also provide precision radial velocities (σRV ≤ 0.2 km s−1) for dynamical orbit calculations with the Gaia DR2 proper motions. Most of our targets are dynamically associated with the Galactic halo; however, five stars with [Fe/H] < −3 have planar-like orbits, including one retrograde star. Another five stars are dynamically consistent with the Gaia-Sequoia accretion event; three have typical halo [α/Fe] ratios for their metallicities, whereas two are [Mg/Fe]-deficient, and one is a new CEMP-s candidate. These results are discussed in terms of the formation and early chemical evolution of the Galaxy.
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| 24. |
- Marouli, Eirini, et al.
(författare)
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Rare and low-frequency coding variants alter human adult height
- 2017
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 542:7640, s. 186-190
-
Tidskriftsartikel (refereegranskat)abstract
- Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
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| 25. |
- Marto, João Pedro, et al.
(författare)
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Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke Registry.
- 2023
-
Ingår i: Neurology. - 1526-632X. ; 100:7
-
Tidskriftsartikel (refereegranskat)abstract
- COVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19.This was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection. With a doubly robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT).Of a total of 15,128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19; of those, 5,848 (38.7%) patients received IVT-only and 9,280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted OR 1.53; 95% CI 1.16-2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20-2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23-1.99), 24-hour mortality (OR 2.47; 95% CI 1.58-3.86), and 3-month mortality (OR 1.88; 95% CI 1.52-2.33). Patients with COVID-19 also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26-1.60).Patients with AIS and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non-COVID-19 patients receiving treatment. Current available data do not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in patients with COVID-19 or to establish different treatment recommendations in this subgroup of patients with ischemic stroke. Our findings can be taken into consideration for treatment decisions, patient monitoring, and establishing prognosis.The study was registered under ClinicalTrials.gov identifier NCT04895462.
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| 26. |
- Minelli, Caterina, et al.
(författare)
-
Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles
- 2022
-
Ingår i: Nanoscale. - : Royal Society of Chemistry (RSC). - 2040-3372 .- 2040-3364. ; 14, s. 4690-4704
-
Tidskriftsartikel (refereegranskat)abstract
- We describe the outcome of a large international interlaboratory study of the measurement of particle number concentration of colloidal nanoparticles, project 10 of the technical working area 34, "Nanoparticle Populations" of the Versailles Project on Advanced Materials and Standards (VAMAS). A total of 50 laboratories delivered results for the number concentration of 30 nm gold colloidal nanoparticles measured using particle tracking analysis (PTA), single particle inductively coupled plasma mass spectrometry (spICP-MS), ultraviolet-visible (UV-Vis) light spectroscopy, centrifugal liquid sedimentation (CLS) and small angle X-ray scattering (SAXS). The study provides quantitative data to evaluate the repeatability of these methods and their reproducibility in the measurement of number concentration of model nanoparticle systems following a common measurement protocol. We find that the population-averaging methods of SAXS, CLS and UV-Vis have high measurement repeatability and reproducibility, with between-labs variability of 2.6%, 11% and 1.4% respectively. However, results may be significantly biased for reasons including inaccurate material properties whose values are used to compute the number concentration. Particle-counting method results are less reproducibile than population-averaging methods, with measured between-labs variability of 68% and 46% for PTA and spICP-MS respectively. This study provides the stakeholder community with important comparative data to underpin measurement reproducibility and method validation for number concentration of nanoparticles.
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| 27. |
- Pham, Quoc Dat, et al.
(författare)
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Skin hydration as a tool to control the distribution and molecular effects of intermediate polarity compounds in intact stratum corneum
- 2021
-
Ingår i: Journal of Colloid and Interface Science. - : Elsevier BV. - 0021-9797. ; 603, s. 874-885
-
Tidskriftsartikel (refereegranskat)abstract
- The barrier function of the skin is mainly assured by its outermost layer, stratum corneum (SC), which consists of dead keratin-filled cells embedded in a lipid matrix. The skin is daily exposed to an environment with changing conditions in terms of hydration and different chemicals. Here we investigate how a molecule that has reasonable solubility in both hydrophobic and hydrophilic environments can be directed to certain regions in SC by changing the skin hydration. We use 1,2,3-trimethoxy propane (TMP) as a model substance and solid-state NMR on natural abundance 13C to obtain atomically resolved information on the molecular dynamics of TMP as well as SC lipid and protein components at varying hydration conditions. Upon dehydration, TMP redistributes from the hydrophilic corneocytes to the hydrophobic SC lipid regions. In this way, TMP can act to prevent the fluid–solid lipid transition in drying conditions and be present in the corneocytes in more humid conditions. Hydration can thereby be used as a switch to control the location and action of TMP or similar compounds in complex materials like SC. The general principles described here can also have impact on other applications including lipid-based formulations in food, drug delivery and cosmetics.
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| 28. |
- Poli, Sven, et al.
(författare)
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Penumbral Rescue by normobaric O?=?O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial
- 2024
-
Ingår i: INTERNATIONAL JOURNAL OF STROKE. - 1747-4930 .- 1747-4949. ; 19:1, s. 120-126
-
Tidskriftsartikel (refereegranskat)abstract
- Rationale: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization occurs.Aims: PROOF investigates the use of normobaric oxygen (NBO) therapy within 6 h of symptom onset/notice for brain-protective bridging until endovascular revascularization of acute intracranial anterior-circulation occlusion.Methods and design: Randomized (1:1), standard treatment-controlled, open-label, blinded endpoint, multicenter adaptive phase IIb trial.Study outcomes: Primary outcome is ischemic core growth (mL) from baseline to 24 h (intention-to-treat analysis). Secondary efficacy outcomes include change in NIHSS from baseline to 24 h, mRS at 90 days, cognitive and emotional function, and quality of life. Safety outcomes include mortality, intracranial hemorrhage, and respiratory failure. Exploratory analyses of imaging and blood biomarkers will be conducted.Sample size: Using an adaptive design with interim analysis at 80 patients per arm, up to 456 participants (228 per arm) would be needed for 80% power (one-sided alpha 0.05) to detect a mean reduction of ischemic core growth by 6.68 mL, assuming 21.4 mL standard deviation.Discussion: By enrolling endovascular thrombectomy candidates in an early time window, the trial replicates insights from preclinical studies in which NBO showed beneficial effects, namely early initiation of near 100% inspired oxygen during short temporary ischemia. Primary outcome assessment at 24 h on follow-up imaging reduces variability due to withdrawal of care and early clinical confounders such as delayed extubation and aspiration pneumonia.
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| 29. |
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| 30. |
- Reverté, Sara, et al.
(författare)
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National records of 3000 European bee and hoverfly species : A contribution to pollinator conservation
- 2023
-
Ingår i: Insect Conservation and Diversity. - 1752-458X. ; 16:6, s. 758-775
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Tidskriftsartikel (refereegranskat)abstract
- Pollinators play a crucial role in ecosystems globally, ensuring the seed production of most flowering plants. They are threatened by global changes and knowledge of their distribution at the national and continental levels is needed to implement efficient conservation actions, but this knowledge is still fragmented and/or difficult to access. As a step forward, we provide an updated list of around 3000 European bee and hoverfly species, reflecting their current distributional status at the national level (in the form of present, absent, regionally extinct, possibly extinct or non-native). This work was attainable by incorporating both published and unpublished data, as well as knowledge from a large set of taxonomists and ecologists in both groups. After providing the first National species lists for bees and hoverflies for many countries, we examine the current distributional patterns of these species and designate the countries with highest levels of species richness. We also show that many species are recorded in a single European country, highlighting the importance of articulating European and national conservation strategies. Finally, we discuss how the data provided here can be combined with future trait and Red List data to implement research that will further advance pollinator conservation.
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| 31. |
- Roselli, Carolina, et al.
(författare)
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Multi-ethnic genome-wide association study for atrial fibrillation
- 2018
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:9, s. 1225-1233
-
Tidskriftsartikel (refereegranskat)abstract
- Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
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| 32. |
- Seibert, M. Marvin, et al.
(författare)
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Single mimivirus particles intercepted and imaged with an X-ray laser
- 2011
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 470:7332, s. 78-81
-
Tidskriftsartikel (refereegranskat)abstract
- X-ray lasers offer new capabilities in understanding the structure of biological systems, complex materials and matter under extreme conditions(1-4). Very short and extremely bright, coherent X-ray pulses can be used to outrun key damage processes and obtain a single diffraction pattern from a large macromolecule, a virus or a cell before the sample explodes and turns into plasma(1). The continuous diffraction pattern of non-crystalline objects permits oversampling and direct phase retrieval(2). Here we show that high-quality diffraction data can be obtained with a single X-ray pulse from a noncrystalline biological sample, a single mimivirus particle, which was injected into the pulsed beam of a hard-X-ray free-electron laser, the Linac Coherent Light Source(5). Calculations indicate that the energy deposited into the virus by the pulse heated the particle to over 100,000 K after the pulse had left the sample. The reconstructed exit wavefront (image) yielded 32-nm full-period resolution in a single exposure and showed no measurable damage. The reconstruction indicates inhomogeneous arrangement of dense material inside the virion. We expect that significantly higher resolutions will be achieved in such experiments with shorter and brighter photon pulses focused to a smaller area. The resolution in such experiments can be further extended for samples available in multiple identical copies.
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| 33. |
- Soust-Verdaguer, B., et al.
(författare)
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Implications of using systematic decomposition structures to organize building LCA information: A comparative analysis of national standards and guidelines- IEA EBC ANNEX 72
- 2020
-
Ingår i: IOP Conference Series: Earth and Environmental Science. - : IOP Publishing. - 1755-1307 .- 1755-1315. ; 588:2
-
Konferensbidrag (refereegranskat)abstract
- Introduction: The application of the Life Cycle Assessment (LCA) technique to a building requires the collection and organization of a large amount of data over its life cycle. The systematic decomposition method can be used to classify building components, elements and materials, overcome specific difficulties that are encountered when attempting to complete the life cycle inventory and increase the reliability and transparency of results. In this paper, which was developed in the context of the research project IEA EBC Annex 72, we demonstrate the implications of taking such approach and describe the results of a comparison among different national standards/guidelines that are used to conduct LCA for building decomposition. Methods: We initially identified the main characteristics of the standards/guidelines used by Annex participant countries. The “be2226” reference office building was used as a reference to apply the different national standards/guidelines related to building decomposition. It served as a basis of comparison, allowing us to identify the implications of using different systems/standards in the LCA practice, in terms of how these differences affect the LCI structures, LCA databases and the methods used to communicate results. We also analyzed the implications of integrating these standards/guidelines into Building Information Modelling (BIM) to support LCA. Results: Twelve national classification systems/ standards/guidelines for the building decomposition were compared. Differences were identified among the levels of decomposition and grouping principles, as well as the consequences of these differences that were related to the LCI organization. In addition, differences were observed among the LCA databases and the structures of the results. Conclusions: The findings of this study summarize and provide an overview of the most relevant aspects of using a standardized building decomposition structure to conduct LCA. Recommendations are formulated on the basis of these findings.
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| 34. |
- Sroka, Ewa Maria, et al.
(författare)
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Major histocompatibility class I antigenic peptides derived from translation of pre-mRNAs generate immune tolerance
- 2023
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 120:7
-
Tidskriftsartikel (refereegranskat)abstract
- Antigenic peptides derived from introns are presented on major histocompatibility (MHC) class I molecules, but how these peptides are produced is poorly understood. Here, we show that an MHC class I epitope (SL8) sequence inserted in the second intron of the β-globin gene in a C57BL/6 mouse (HBB) generates immune tolerance. Introduction of SL8-specific CD8+ T cells derived from OT-1 transgenic mice resulted in a threefold increase in OT-1 T cell proliferation in HBB animals, as compared to wild-type animals. The growth of MCA sarcoma cells expressing the intron-derived SL8 epitope was suppressed in wild-type animals compared to HBB mice. The β-globin pre-mRNA was detected in the light polysomal fraction, and introducing stop codons identified a non-AUG initiation site between +228 and +255 nts upstream of the SL8. Isolation of ribosome footprints confirmed translation initiation within this 27 nt sequence. Furthermore, treatment with splicing inhibitor shifts the translation of the pre-mRNA to monosomal fractions and results in an increase of intron-derived peptide substrate as shown by polysome profiling and cell imaging. These results show that non-AUG-initiated translation of pre-mRNAs generates peptides for MHC class I immune tolerance and helps explain why alternative tissue-specific splicing is tolerated by the immune system.
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| 35. |
- Surendran, Praveen, et al.
(författare)
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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
- 2020
-
Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 52:12, s. 1314-1332
-
Tidskriftsartikel (refereegranskat)abstract
- Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency <= 0.01) variant BP associations (P < 5 x 10(-8)), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were similar to 8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets.
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| 36. |
- Toupalas, Georgios, et al.
(författare)
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Tuning Photoinduced Electron Transfer in POM-Bodipy Hybrids by Controlling the Environment : Experiment and Theory
- 2021
-
Ingår i: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 60:12, s. 6518-6525
-
Tidskriftsartikel (refereegranskat)abstract
- The optical and electrochemical properties of a series of polyoxometalate (POM) oxoclusters decorated with two bodipy (boron-dipyrromethene) light-harvesting units were examined. Evaluated here in this polyanionic donor-acceptor system is the effect of the solvent and associated counterions on the intramolecular photoinduced electron transfer. The results show that both solvents and counterions have a major impact upon the energy of the charge-transfer state by modifying the solvation shell around the POMs. This modification leads to a significantly shorter charge separation time in the case of smaller counterion and slower charge recombination in a less polar solvent. These results were rationalized in terms of Marcus theory and show that solvent and counterion both affect the driving force for photoinduced electron transfer and the reorganization energy. This was corroborated with theoretical investigations combining DFT and molecular dynamics simulations.
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| 37. |
- Vanderplanck, Maryse, et al.
(författare)
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Monitoring bee health in European agroecosystems using wing morphology and fat bodies
- 2021
-
Ingår i: One Ecosystem. - : Pensoft Publishers. - 2367-8194. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- Current global change substantially threatens pollinators, which directly impacts the pollination services underpinning the stability, structure and functioning of ecosystems. Amongst these threats, many synergistic drivers, such as habitat destruction and fragmentation, increasing use of agrochemicals, decreasing resource diversity, as well as climate change, are known to affect wild and managed bees. Therefore, reliable indicators for pollinator sensitivity to such threats are needed. Biological traits, such as phenotype (e.g. shape, size and asymmetry) and storage reserves (e.g. fat body size), are important pollinator traits linked to reproductive success, immunity, resilience and foraging efficiency and, therefore, could serve as valuable markers of bee health and pollination service potential.
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| 38. |
- Wagnon, Scott W., et al.
(författare)
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Experimental and modeling studies of a biofuel surrogate compound : laminar burning velocities and jet-stirred reactor measurements of anisole
- 2018
-
Ingår i: Combustion and Flame. - : Elsevier BV. - 0010-2180. ; 189, s. 325-336
-
Tidskriftsartikel (refereegranskat)abstract
- Lignocellulosic biomass is a promising alternative fuel source which can promote energy security, reduce greenhouse gas emissions, and minimize fuel consumption when paired with advanced combustion strategies. Pyrolysis is used to convert lignocellulosic biomass into a complex mixture of phenolic-rich species that can be used in a transportation fuel. Anisole (or methoxybenzene) can be used as a surrogate to represent these phenolic-rich species. Anisole also has attractive properties as a fuel component for use in advanced spark-ignition engines because of its high blending research octane number of 120. Presented in the current work are new measurements of laminar burning velocities, jet-stirred reactor (JSR) speciation of anisole/O2/N2 mixtures, and the development and validation of a detailed chemical kinetic mechanism for anisole. Homogeneous, steady state, fixed gas temperature, perfectly stirred reactor CHEMKIN simulations were used to validate the mechanism against the current JSR measurements and published JSR experiments from CNRS-Nancy. Pyrolysis and oxidation simulations were based on the experimental reactant compositions and thermodynamic state conditions including P = 1 bar and T = 675–1275 K. The oxidation compositions studied in this work span fuel-lean (ϕ = 0.5), stoichiometric, and fuel rich (ϕ = 2.0) equivalence ratios. Laminar burning velocities were measured on a heat flux stabilized burner at an unburnt T = 358 K, P = 1 bar and simulated using the CHEMKIN premixed laminar flame speed module. Ignition delay times of anisole were then simulated at conditions relevant to advanced combustion strategies. Current laminar burning velocity measurements and predicted ignition delay times were compared to gasoline components (e.g., n-heptane, iso-octane, and toluene) and gasoline surrogates to highlight differences and similarities in behavior. Reaction path analysis and sensitivity analysis were used to explain the pathways relevant to the current studies. Under pyrolysis and oxidative conditions, unimolecular decomposition of anisole to phenoxy radicals and methyl radicals was found to be important due to the relatively low bond strength between the oxygen and methyl group, ∼65 kcal/mol. Reactions of these abundant phenoxy radicals with O2 were found to be critical to accurately reproduce anisole's reactivity.
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| 39. |
- Wagnon, Scott W., et al.
(författare)
-
The development and validation of a chemical kinetic model for anisole, a compound to represent biomass pyrolysis fuels
- 2017
-
Konferensbidrag (refereegranskat)abstract
- Lignocellulosic biomass is a promising alternative fuel source which can promote energy security, reduce greenhouse gas emissions, and minimize fuel consumption when paired with advanced combustion strategies. Pyrolysis is used to convert lignocellulosic biomass into a complex mixture of phenolic-rich species that can be used in a transportation fuel. Anisole (or methoxybenzene) can be used as a surrogate to represent these phenolic-rich species. Anisole also has attractive properties as a fuel component for use in advanced spark-ignition engines because of its high blending research octane number of 120. Presented in the current work are new measurements of laminar burning velocities, jet-stirred reactor (JSR) speciation of anisole/O2/N2 mixtures, and the development and validation of a detailed chemical kinetic mechanism for anisole. Homogeneous, steady state, fixed temperature, perfectly stirred reactor CHEMKIN simulations were used to validate the mechanism against the current JSR measurements and published JSR experiments from CNRS-Nancy. Pyrolysis and oxidation simulations were based on the experimental reactant compositions and thermodynamic state conditions including P = 1 bar and T = 675-1275 K. The oxidation compositions studied in this work span fuel lean (φ = 0.5), stoichiometric, and fuel rich (φ = 2.0) equivalence ratios. Premixed laminar burning velocities were measured on a heat flux stabilized burner at an unburnt T = 358 K, P = 1 bar and simulated using the CHEMKIN premixed laminar flame-speed module. Under pyrolysis and oxidative conditions, unimolecular decomposition of anisole to phenoxy radicals and methyl radicals was found to be important due to the relatively low bond strength between the oxygen and methyl group, ~65 kcal-mole-1
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| 40. |
- Wain, Louise V., et al.
(författare)
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Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
- 2017
-
Ingår i: Hypertension. - 0194-911X .- 1524-4563. ; 70:3, s. e4-e19
-
Tidskriftsartikel (refereegranskat)abstract
- Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
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| 41. |
- Watson, Hunna J., et al.
(författare)
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Common Genetic Variation and Age of Onset of Anorexia Nervosa
- 2022
-
Ingår i: BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE. - : Elsevier BV. - 2667-1743. ; 2:4, s. 368-378
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Genetics and biology may influence the age of onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to age of onset of AN and to investigate the genetic associations between age of onset of AN and age at menarche.METHODS: A secondary analysis of the Psychiatric Genomics Consortium genome-wide association study (GWAS) of AN was performed, which included 9335 cases and 31,981 screened controls, all from European ancestries. We conducted GWASs of age of onset, early-onset AN (,13 years), and typical-onset AN, and genetic correlation, genetic risk score, and Mendelian randomization analyses.RESULTS: Two loci were genome-wide significant in the typical-onset AN GWAS. Heritability estimates (single nucleotide polymorphism-h2) were 0.01-0.04 for age of onset, 0.16-0.25 for early-onset AN, and 0.17-0.25 for typical-onset AN. Early-and typical-onset AN showed distinct genetic correlation patterns with putative risk factors for AN. Specifically, early-onset AN was significantly genetically correlated with younger age at menarche, and typical-onset AN was significantly negatively genetically correlated with anthropometric traits. Genetic risk scores for age of onset and early-onset AN estimated from independent GWASs significantly predicted age of onset. Mendelian randomization analysis suggested a causal link between younger age at menarche and early -onset AN.CONCLUSIONS: Our results provide evidence consistent with a common variant genetic basis for age of onset and implicate biological pathways regulating menarche and reproduction.
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| 42. |
- Weng, Lu Chen, et al.
(författare)
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Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation : The AFGen Consortium
- 2017
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1
-
Tidskriftsartikel (refereegranskat)abstract
- It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent studies (131,441 individuals, including 5,722 with AF). In the discovery analysis, the AF risk associated with the minor rs6817105 allele (at the PITX2 locus) was greater among subjects ≤ 65 years of age than among those > 65 years (interaction p-value = 4.0 × 10-5). The interaction p-value exceeded genome-wide significance in combined discovery and replication analyses (interaction p-value = 1.7 × 10-8). We observed one genome-wide significant interaction with body mass index and several suggestive interactions with age, sex, and body mass index in the discovery analysis. However, none was replicated in the independent sample. Our findings suggest that the pathogenesis of AF may differ according to age in individuals of European descent, but we did not observe evidence of statistically significant genetic interactions with sex, body mass index, or hypertension on AF risk.
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| 43. |
- Young, William J., et al.
(författare)
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Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
- 2022
-
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease. The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for cell growth and extracellular matrix interactions are significantly enriched. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlight potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization.
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- 2019
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Tidskriftsartikel (refereegranskat)
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