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- Andersson, Susanne, et al.
(author)
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Introduction
- 2012
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In: Promoting innovation. - Stockholm : Vinnova. - 9789186517717 ; , s. 9-19
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Book chapter (peer-reviewed)
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Commons, sustainability, democratization : Action research and the basic renewal of society
- 2016
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Editorial collection (other academic/artistic)abstract
- This book presents theoretical discussions and practical examples of Action Research from Scandinavia, Latin America and Africa, primarily dealing with how to combine nature conservation and management with local democratic community development, seeing the renewal of Commons as a way to transcend the present dichotomy between these two dimensions
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- Dahlqvist, Johanna, 1979-, et al.
(author)
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Identification and functional characterization of a novel susceptibility locus for small vessel vasculitis with MPO-ANCA
- 2022
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In: Rheumatology. - Oxford, United Kingdom : Oxford University Press (OUP). - 1462-0324 .- 1462-0332. ; 61:8, s. 3461-3470
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Journal article (peer-reviewed)abstract
- Objective To identify and characterize genetic loci associated with the risk of developing ANCA-associated vasculitides (AAV). Methods Genetic association analyses were performed after Illumina sequencing of 1853 genes and subsequent replication with genotyping of selected single nucleotide polymorphisms in a total cohort of 1110 Scandinavian cases with granulomatosis with polyangiitis or microscopic polyangiitis, and 1589 controls. A novel AAV-associated single nucleotide polymorphism was analysed for allele-specific effects on gene expression using luciferase reporter assay. Results PR3-ANCA(+) AAV was significantly associated with two independent loci in the HLA-DPB1/HLA-DPA1 region [rs1042335, P = 6.3 x 10(-61), odds ratio (OR) 0.10; rs9277341, P = 1.5 x 10(-44), OR 0.22] and with rs28929474 in the SERPINA1 gene (P = 2.7 x 10(-10), OR 2.9). MPO-ANCA(+) AAV was significantly associated with the HLA-DQB1/HLA-DQA2 locus (rs9274619, P = 5.4 x 10(-25), OR 3.7) and with a rare variant in the BACH2 gene (rs78275221, P = 7.9 x 10(-7), OR 3.0), the latter a novel susceptibility locus for MPO-ANCA(+) granulomatosis with polyangiitis/microscopic polyangiitis. The rs78275221-A risk allele reduced luciferase gene expression in endothelial cells, specifically, as compared with the non-risk allele. Conclusion We identified a novel susceptibility locus for MPO-ANCA(+) AAV and propose that the associated variant is of mechanistic importance, exerting a regulatory function on gene expression in specific cell types.
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- Dominguez, Cecilia A., et al.
(author)
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The DQB1*03:02 HLA haplotype is associated with increased risk of chronic pain after inguinal hernia surgery and lumbar disc herniation
- 2013
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In: Pain. - : Ovid Technologies (Wolters Kluwer Health). - 0304-3959 .- 1872-6623. ; 154:3, s. 427-433
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Journal article (peer-reviewed)abstract
- Neuropathic pain conditions are common after nerve injuries and are suggested to be regulated in part by genetic factors. We have previously demonstrated a strong genetic influence of the rat major histocompatibility complex on development of neuropathic pain behavior after peripheral nerve injury. In order to study if the corresponding human leukocyte antigen complex (HLA) also influences susceptibility to pain, we performed an association study in patients that had undergone surgery for inguinal hernia (n = 189). One group had developed a chronic pain state following the surgical procedure, while the control group had undergone the same type of operation, without any persistent pain. HLA DRB1genotyping revealed a significantly increased proportion of patients in the pain group carrying DRB1*04 compared to patients in the pain-free group. Additional typing of the DQB1 gene further strengthened the association; carriers of the DQB1*03:02 allele together with DRB1*04 displayed an increased risk of postsurgery pain with an odds risk of 3.16 (1.61-6.22) compared to noncarriers. This finding was subsequently replicated in the clinical material of patients with lumbar disc herniation (n = 258), where carriers of the DQB1*03:02 allele displayed a slower recovery and increased pain. In conclusion, we here for the first time demonstrate that there is an HLA-dependent risk of developing pain after surgery or lumbar disc herniation; mediated by the DRB1*04 - DQB1*03:02 haplotype. Further experimental and clinical studies are needed to fine-map the HLA effect and to address underlying mechanisms.
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- Ekman, Diana, et al.
(author)
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Stratified genetic analysis reveals sex differences in MPO-ANCA-associated vasculitis
- 2023
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In: Rheumatology. - : Oxford University Press. - 1462-0324 .- 1462-0332. ; 62:9, s. 3213-3218
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Journal article (peer-reviewed)abstract
- Objective: To identify and genetically characterize subgroups of patients with ANCA-associated vasculitides (AAV) based on sex and ANCA subtype. Methods: A previously established SNP dataset derived from DNA sequencing of 1853 genes and genotyping of 1088 Scandinavian cases with AAV and 1589 controls was stratified for sex and ANCA subtype and analysed for association with five top AAV SNPs. rs9274619, a lead variant at the HLA-DQB1/HLA-DQA2 locus previously associated with AAV positive for myeloperoxidase (MPO)-ANCA, was analysed for association with the cumulative disease involvement of ten different organ systems. Results: rs9274619 showed a significantly stronger association to MPO-ANCA-positive females than males [P = 2.0 × 10-4, OR = 2.3 (95% CI 1.5, 3.5)], whereas proteinase 3 (PR3)-ANCA-associated variants rs1042335, rs9277341 (HLA-DPB1/A1) and rs28929474 (SERPINA1) were equally associated with females and males with PR3-ANCA. In MPO-ANCA-positive cases, carriers of the rs9274619 risk allele were more prone to disease engagement of eyes [P = 0.021, OR = 11 (95% CI 2.2, 205)] but less prone to pulmonary involvement [P = 0.026, OR = 0.52 (95% CI 0.30, 0.92)]. Moreover, AAV with both MPO-ANCA and PR3-ANCA was associated with the PR3-ANCA lead SNP rs1042335 [P = 0.0015, OR = 0.091 (95% CI 0.0022, 0.55)] but not with rs9274619. Conclusions: Females and males with MPO-ANCA-positive AAV differ in genetic predisposition to disease, suggesting at least partially distinct disease mechanisms between the sexes. Double ANCA-positive AAV cases are genetically similar to PR3-ANCA-positive cases, providing clues to the clinical follow-up and treatment of these patients.
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- Forsberg, Gunnel, 1950-, et al.
(author)
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The Qvist Questions Revisited – Framing of Text and Texture
- 2012
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In: Segregationens seghet och dess föränderliga former. - Karlstad : Karlstads universitet. - 9789170634291 ; , s. 13-36
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Book chapter (peer-reviewed)abstract
- 1986 sjösattes projektet ”Qvist – Kvinnor i strukturomvandlingen” på dåvarande Arbetslivscentrum. Projektledare var docent Lena Gonäs och medarbetarna var vi, doktoranderna Gunnel Forsberg och Ewa Gunnarsson samt utredningsassistent Märit Röger (senare Borgström). Det var ett projekt som hade ambitionen att bygga en teori om triaden kön – plats – kvalifikation. Den empiriska influensen kom från två tidigare genomförda projekt som Lena lett; Strukturomvandlingsprojektet, en jämförande studie av de branscher som i början av 1980-talet genomgick omfattande strukturförändringar i form av rationaliseringar och sammanslagningar av enheter, och Utvärderingen av Kvinnokampanjen, ett projekt som analyserade effekterna av regeringens engångssatsning om 10 miljoner för att locka kvinnor att välja manligt dominerade utbildningar och yrken.
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- Gunnarsson, Ewa
(author)
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Att våga väga jämnt : om kvalifikationer och kvinnliga förhållningssätt i ett tekniskt industriarbete
- 1994
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Doctoral thesis (other academic/artistic)abstract
- The main purpose of this dissertation is to explore the meaning of gender in relation to qualifications and skills. In the dissertation two specific problem areas are explored in-depth: 1 - The meaning of gender in relation to qualifications and skills in technical industrial work. 2- The manifestations and contents of women's ways of relating interpreted as a type of non-formal skills. Empirical data were collected mainly through semi-structured indepth interviews with women (Project 40 girls) with a tailored vocational training for technical operational and maintenance work in the new coachworkshop at Saab-Scania in Trollhättan. Male work-mates as well as supervisors and key informants in the factory were also interviewed. A mainly qualitative methodological approach of grounded theory type was used for analysing the data. Theoretically the dissertation has been inspired by the Nordic feminist discussion on gender, work and rationality and the concept of responsible rationality is used to explain women's ways of relating to work. The data show that women develop an adjusted form of responsible rationality in this technical industrial work situation expressed in three care dimensions: Care for interpersonal relations at work, care for the human being in the man - machine relation and care in relation to the machine, the product and the workplace. Women's ways of relating to work also included a holistic perspective expressed in integrating both the private sphere and the work sphere in the social dialogue at work. The most conspicuous gender difference in the study is the difference in importance women and men give social skills at work. In general the women in the study emphasized the need for social skills more than the men did. The female responsible rationality is in this way reflected in the women's views on important skills at work. Another main result is that the need for social skills such as abilities to co-operate and communicate were seen as more important by both women and men the more complex technical systems they worked with. (Swedish text with summary in English)
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| 29. |
- Gunnarsson, Ewa
(author)
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Can Action Research Strengthen Democratic Dimensions in Gender Mainstreaming Processes?
- 2016
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In: Action Research for Democracy. - London : Routledge Mental Health. - 9781138961227 ; , s. 165-181
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Book chapter (peer-reviewed)abstract
- Can Action Research Strengthen Democratic Dimensions in Gender Mainstreaming processes and procedures? This chapter explores how an Action Research approach and methodology can promote more democratic processes and practices in a gender mainstreaming change- and development case study. Gender and equality dimensions can on the other hand, the author argues, strengthen and extend democratic empowerment and deliberating ambitions in action research.The empirical base is the experiences from a case study in a large Swedish innovation system organized as a Triple Helix model and a Mode II science approach. The innovation system consists of 7 industrial partners and 5 technical academic divisions.The first part gives a short background to action research elements within earlier Swedish (and partly Nordic) gender and feminist research until today. The second main part draws on empirical data and findings in a ‘successful’ case study in the above mentioned innovation system. It explores embedded participative processes, learning procedures and theoretical inputs in relation to democratic dimensions relating to an action research approach. The final part scrutinizes challenges for action research with a democratic ambition when embedded in large Triple Helix systems. It discusses the concept of “robustness in science” by Novotny, Scott and Gibbons, the “governing” participatory ambition of the funding agent. It discusses the reflexivity perspective on researchers’ – participants’ dilemmas in creating a space with allows critical edge that allows for telling unwelcome truths (Kemmis,2006).
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- Gunnarsson, Ewa
(author)
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Från "byxtillägg" till likalön
- 2000
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In: Kvinnovetenskaplig tidskrift. - 0348-8365. ; 21:1, s. 79-82
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Journal article (pop. science, debate, etc.)
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| 41. |
- Gunnarsson, Ewa
(author)
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Gemensam handling för hållbar förändring - tillämpad genusforskning i ett innovationssystem
- 2011
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In: Arbetsmarknad & Arbetsliv. - Karlstad : Karlstads universitet. - 1400-9692 .- 2002-343X. ; 17:2, s. 45-57
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Journal article (peer-reviewed)abstract
- Denna artikel presenterar ett tillämpat genus- och jämställdhetsprojekt: Genus- och jämställdhetsutveckling i Fastelaboratoriet, ett innovationssystem. Genusteori kombineras här med en interaktiv forsknings- och utvecklingsansats med syftet att uppnå en hållbarare jämställdhetsintegrering. I artikeln argumenterar författaren för hur den interaktiva forskningstraditionen såväl som genusforskningen kan bidra till paradigmskiften inom samhällsvetenskapen genom att tillföra en starkare kontextualisering i kunskapsproduktionen. ”Doing gender”-traditionen som den utvecklats inom nordisk organisationsforskning utgör projektets genusteoretiska plattform.
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| 48. |
- Gunnarsson, Ewa, et al.
(author)
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Jämställdhetsintegrering som lärande förändring
- 2010
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Conference paper (other academic/artistic)abstract
- Detta bidrag presenterar ett pågående tillämpat genus- och jämställdhetsprojekt - Genus- och jämställdhetsutveckling i Fastelaboratoriet. Projektet syftar till en ökad och hållbar jämställdhetsintegrering och högre genusmedvetenhet i ett innovationssystem. I projektet deltar 8 industripartner samt 6 akademiska avdelningar och två genusforskare vid Luleå tekniska universitet. En genusteoretisk plattform “doing gender in organisations” kombineras i projektet med en interaktiv forsknings- och utvecklingsansats med syftet att öka hållbarheten i förändringsprocessen. I papret görs ett nedslag i processen hos en industriell partner. Bidraget beskriver erfarenheter från hur en grupp mellanchefer i ett tekniskt och mansdominerat industriföretag reflekterar över mötet med genusteori och lärande kopplat till nya handlingsmönster hos dem själva. Deltagande interaktiva metoder, som genusobservationer och ”concentric circles” beskrivs som ”framkallar” kulturen så att värderingar och normer som hindrar en ökad jämställdhetsintegrering och genuskompetensutveckling blir synliga. En övergripande diskussion förs om reflekterande läroprocesser och medforskning i organisationer med nyttoinriktade mål och en handlingskultur med starkt fokus på problemlösning inramat av ett naturvetenskapligt paradigm. Ett paradigm där en naturlig måttstock är den evidensbaserade forskningens. Papret problematiserar även hur förändringar i en jämställdhetsintegreringsprocess kan förstår och mätas i relation till begrepp som radikal och inkrementell förändring.
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| 49. |
- Gunnarsson, Ewa
(author)
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Kvinnor i bilindustrin
- 1990
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In: Luftföroreningar från laserskrivare. - Solna : Arbetarskyddsstyrelsen. ; , s. 15-26
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Book chapter (pop. science, debate, etc.)
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