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1.	Gunnarsson, Mikael, et al. (författare) No radiation protection reasons for restrictions on C-14 urea breath tests in children. 2002 Ingår i: British Journal of Radiology. - : British Institute of Radiology. - 1748-880X .- 0007-1285. ; 75:900, s. 982-986 Tidskriftsartikel (refereegranskat)abstract Traditional 14C urea breath tests are normally not used for younger children because the radiation exposure is unknown. High sensitivity accelerator mass spectrometry and an ultra-low amount (440 Bq) of 14C urea were therefore used both to diagnose Helicobacter pylori (HP) infection in seven children, aged 3–6 years, and to make radiation dose estimates. The activity used was 125 times lower than the amount normally used for older children and 250 times lower than that used for adults. Results were compared with previously reported biokinetic and dosimetric data for adults and older children aged 7–14 years. 14C activity concentrations in urine and exhaled air per unit administered activity for younger children (3–6 years) correspond well with those for older children (7–14 years). For a child aged 3–6 years who is HP negative, the urinary bladder wall receives the highest absorbed dose, 0.3 mGy MBq-1. The effective dose is 0.1 mSv MBq-1 for the 3-year-old child and 0.07 mSv MBq-1 for the 6-year-old child. For two children, the 10 min and 20 min post-14C administration samples of exhaled air showed a significantly higher amount of 14C activity than for the rest of the children, that is 6% and 19% of administered activity exhaled per hour compared with 0.3–0.9% (mean 0.5%) of administered activity exhaled per hour indicating that these two children that is were HP positive. For a 3-year-old HP positive child, absorbed dose to the urinary bladder wall was 0.3 mGy MBq-1 and effective dose per unit of administered activity was 0.4 mSv MBq-1. Using 55 kBq, which is a normal amount for older children when liquid scintillation counters are used for measurement, the effective dose will be approximately 6 µSv to a 3-year-old HP negative child and 20 µSv to a HP positive child. Thus there is no reason for restrictions on performing a normal 14C urea breath test, even on young children.
2.	Algers, Bo, et al. (författare) Insikter om djurvälfärd svensk köttproduktions framtid 2014 Ingår i: Dagens nyheter. - 1101-2447. Tidskriftsartikel (populärvet., debatt m.m.)
3.	Altman, Daniel, et al. (författare) [Make regulation of the launching of new medical technical products more stringent!] 2008 Ingår i: Lakartidningen. - 0023-7205. ; 105:9, s. 597-8 Tidskriftsartikel (refereegranskat)
4.	Amirijoo, Mehdi, et al. (författare) On Self-Optimization of the Random Access Procedure in 3G Long Term Evolution 2009 Ingår i: Proceedings of the 11th IFIP/IEEE International Symposium on Integrated Network Management. - : IEEE. - 9781424439232 - 9781424439249 Konferensbidrag (refereegranskat)abstract Operationally efficient radio networks typically feature a high degree of self-organization. This means less planning efforts and manual intervention, and a potential for better radio resource utilization when network elements adapts its operation to the observed local conditions. The focus in this paper is selfoptimization of the random access channel (RACH) in the 3G Long Term Evolution (LTE). A comprehensive tutorial about the RACH procedure is provided to span the complexity of the selfoptimization. Moreover, the paper addresses RACH key performance metrics and appropriate modeling of the various steps and components of the procedure. Finally, some coupling between parameters and key performance metrics as well as selfoptimization examples are presented together with a feasibility discussion. The main ambition with this workshop paper is to present and define a relevant set of self-optimization problems, rather than to provide a complete solution.
5.	Amirijoo, Mehdi, et al. (författare) Towards Random Access Channel Self-Tuning in LTE 2009 Ingår i: Proceedings of the 69th IEEE Vehicular Technology Conference. - 9781424425174 ; , s. 1-5 Konferensbidrag (refereegranskat)abstract Future radio access networks are expected to show a high degree of self-organization. This paper addresses self-tuning of the random access channel (RACH) in the 3G Long Term Evolution (LTE). The feasibility of self-tuning is investigated by means of simulation, where the coupling between several parameters and the performance of RACH is provided. The conclusion of the simulations is that RACH self-tuning is indeed possible given that UE assisted measurements are available for the self-tuning mechanism.
6.	Andersson, Ing-Marie, et al. (författare) Knowledge and Experiences of Risks among Pupils in Vocational Education 2014 Ingår i: SH@W Safety and Health at Work. - : Elsevier BV. - 2093-7911 .- 2093-7997. ; 5:3, s. 140-146 Tidskriftsartikel (refereegranskat)
7.	Andersson, Ing-Marie, et al. (författare) Role of headmasters, teachers and supervisors in knowledge transfer about occupational health and safety to pupils in vocational education 2015 Ingår i: SH@W Safety and Health at Work. - : Elsevier BV. - 2093-7911 .- 2093-7997. ; 6:4, s. 317-323 Tidskriftsartikel (refereegranskat)abstract Background Young people are at an increased risk for illness in working life. The authorities stipulate certain goals for training in occupational health and safety (OHS) in vocational schools. A previous study concluded that pupils in vocational education had limited knowledge in the prevention of health risks at work. The aim of the current study, therefore, was to study how OHS training is organized in school and in workplace-based learning (WPL). Method The study design featured a qualitative approach, which included interviews with 12 headmasters, 20 teachers, and 20 supervisors at companies in which the pupils had their WPL. The study was conducted at 10 upper secondary schools, located in Central Sweden, that were graduating pupils in four vocational programs. Result The interviews with headmasters, teachers, and supervisors indicate a staggered picture of how pupils are prepared for safe work. The headmasters generally give teachers the responsibility for how goals should be reached. Teaching is very much based on risk factors that are present in the workshops and on teachers’ own experiences and knowledge. The teaching during WPL also lacks the systematic training in OHS as well as in the traditional classroom environment. Conclusion Teachers and supervisors did not plan the training in OHS in accordance with the provisions of systematic work environment management. Instead, the teachers based the training on their own experiences. Most of the supervisors did not get information from the schools as to what should be included when introducing OHS issues in WPL.
8.	Andersson, Ing-Marie, et al. (författare) What pupils in vocational schools learn about risk at work 2015 Ingår i: The Annals of Occupational Hygiene. - : Oxford University Press (OUP). - 1475-3162. Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract Negative health effects because of poor work environment is more common among young workers compared to older. One explanation might be that younger ones have a low awareness of risk, a lack of safety training, and inadequate introductions to the work. A study has been made focusing on the pupils in vocational schools knowledge and experiences about potential work environment risks in their future work. Questionnaires were distributed to 239 pupils in ten Swedish upper secondary schools’ graduating classes in four vocational programs focusing on basic knowledge about health risks at work as well as the work environment legislation. The programs were the Industrial Technology Program, the Restaurant Management and Food Program, the Transport Program, and the Handicraft Program (in which students specialize in wood). The results from the questionnaires were followed up with focus group discussions. The results showed that the pupils in general had limited knowledge that employers must, by law, conduct risk analyses and prevent risks. It was common that they mentioned themselves as the main responsible to work safe and was not clear about the employers’ duty to arrange for safe work. Pupils in all programs mentioned acute risk as the biggest risk at work. It was concluded that a systematic approach to pupils’ training in work environment is lacking. The results indicates a clear gap between what knowledge the pupils are offered and what’s intended by laws as well as state-of-the-art in occupational health risk research.
9.	Andersson, Ing-Marie, et al. (författare) Young People’s Attitudes to Attractive Work, During and After Upper Secondary School 2017 Ingår i: Nordic Journal of Working Life Studies. - : Det Kgl. Bibliotek/Royal Danish Library. - 2245-0157. ; 7:1, s. 55-68 Tidskriftsartikel (refereegranskat)abstract Attractive work has been defined as a job position which an individual wants, where the employee experiences job stability and where employee identification and dedication are fostered. The present study is aimed at increasing knowledge about attitude changes to work during young people’s transition from school to work-life. A closed cohort, consisting of 225 pupils from graduating classes in 10 upper secondary schools in Sweden, was studied. The most significant result was found in the pupils’ expectations regarding work attractiveness while they were still attending school and in the subsequent year, after they had finished school. During school attendance, there were no differences between the groups, while those who did not find employment after school greatly reduced their demands regarding attractive work.Those who managed to get a job maintained the same level of expectation as during their school years, in terms of requirements for an attractive job.
10.	Andersson, Ing-Marie, et al. (författare) Young peoples’ entrance to the workplace : Introduction to occupational health and safety 2016 Rapport (övrigt vetenskapligt/konstnärligt)abstract Negative outcomes of a poor work environment are more frequent among young workers. The aim of the current study was to study former pupils’ conditions concerning occupational health and safety by investigating the workplaces’, safety climate, the degree of implementation of SWEM and the their introduction programs.Four branches were included in the study: Industrial, Restaurant, Transport and Handicraft, specialising in wood. Semi-structured dialogues were undertaken with 15 employers at companies in which former pupils were employed. They also answered a questionnaire about SWEM. Former pupils and experienced employees were upon the same occasion asked to fill in a questionnaire about safety climate at the workplace.Workplace introduction programs varied and were strongly linked to company size. Most of the former pupils and experienced employees rated the safety climate at their company as high, or good. Employers in three of the branches rated the SWEM implemented at their workplaces to be effective.The Industry companies, which had the largest workplaces, gave the most systematic and workplace introduction for new employees. There are no results from this study explaining the fact that young workers have a higher risk for workplace accidents.
11.	Balfors, Berit, et al. (författare) Strategisk miljöbedömning för hållbar samhällsplanering : Slutrapport från forskningsprogrammet SPEAK 2018 Rapport (övrigt vetenskapligt/konstnärligt)abstract Strategisk miljöbedömning är en process som myndigheter och kommuner ska genomföra när de upprättar eller ändrar vissa planer eller program som antas medföra betydande miljöpåverkan. Syftet med en miljöbedömning är att integrera miljöaspekter i planen eller programmet så att en hållbar utveckling främjas.Lagstiftningen om strategisk miljöbedömning har funnits i Sverige i snart 15 år. Men hur fungerar miljöbedömning i planeringen? Det var en av frågorna i forskningsprogrammet SPEAK. Syftet med SPEAK har varit att bidra med kunskap för att stärka miljöbedömningens roll som ett verktyg i samhällsplaneringen för att uppnå miljökvalitetsmålen och främja hållbar utveckling.I Sverige har det saknats en övergripande kartläggning över de planer och miljöbedömningar som genomförts. Därför har SPEAK utvecklat, en för Sverige unik, databas med kommunala planer och tillhörande dokument såsom samrådshandlingar, SEA-dokument och särskilda sammanställningar. Baserat på en analys av miljöbedömningspraktiken har förslag på åtgärder tagits fram för att stärka miljöbedömningen som ett verkningsfullt verktyg i planeringen för hållbar utveckling.
12.	Balfors, Berit, Professor, 1958-, et al. (författare) Strategisk miljöbedömning för nationell transportplanering med fokus på inriktningsunderlaget 2019 Rapport (övrigt vetenskapligt/konstnärligt)abstract Denna rapport utgör ett inspel till Trafikverket i en analys om hur strategisk miljöbedömning kan användas i den statliga transportplaneringens tidiga skeden med fokus på inriktningsunderlaget. Rapporten är framtaget inom projektet ”TRAMP- Är långsiktig transportplanering och miljöbedömning kompatibla processer?” som är ett forsknings- och innovationsprojekt (FoI), finansierat av Trafikverket under perioden 2017 - 2019. Deltagande forskare i projektet är Berit Balfors och Ulrika Gunnarsson-Östling, KTH, Kristina Lundberg och Tobias Robinson, Ecoloop, Karolina Isaksson och Linnea Eriksson, VTI.FoI-projektet har planerats för att successivt leverera användbart underlag till Trafikverket. Föreliggande rapport är ett underlag inför Trafikverkets arbete med att ta fram ett inriktningsunderlag.
13.	Benfalk, Christel, et al. (författare) Tillvägagångssätt för en bra djurhantering vid mobil slakt av gris 2003 Rapport (refereegranskat)
14.	Boschini, Anne, et al. (författare) Kvinnorna i toppen av den svenska inkomstfördelningen 2018 Rapport (övrigt vetenskapligt/konstnärligt)abstract Betydligt färre kvinnor än män har höga inkomster. Men sedan 1970-talet har andelen kvinnor i toppen av inkomstfördelningen tredubblats och utgör nu runt 18 procent. En internationell jämförelse visar dock att utvecklingen går snabbare i många andra länder.Sverige är vi vana vid att vara bland de bästa i världen på jämställdhet mellan kvinnor och män. Men ser man till den ekonomiska eliten är bilden en annan. De högsta positionerna i samhället innehas i betydligt större utsträckning av män än av kvinnor.Få kvinnor i toppen men andelen ökar stadigt. För att närmare förstå utvecklingen har tre nationalekonomer studerat balansen mellan könen i inkomstfördelningens topp sedan mitten av 1970-talet. Bilden som framträder är på många sätt positiv. Till exempel så har kvinnors representation i inkomsttoppen stadigt ökat och mest har det ökat i den absoluta toppen. I mitten av 1970-talet var andelen kvinnor i hundradelen av befolkningen med de högsta inkomsterna bara 6 procent. I dag är den runt 18 procent.Fler kvinnor har höga arbetsinkomster. En annan tydlig förändring är att kvinnor i högre utsträckning hamnar i toppen till följd av sin inkomst från arbete snarare än från kapital. Andelen änkor i toppen har också minskat.Kvinnorna i toppen är ofta gifta med höginkomsttagare. Forskarna har också studerat familjeförhållanden hos kvinnor och män med de högsta inkomsterna. Här finner de att de flesta män i toppen av inkomstfördelningen är gifta medan detta bara gäller ungefär hälften av kvinnorna. Dessutom är en majoritet av männen i toppen gifta med någon som inte befinner sig i inkomsttoppen, medan situationen är den omvända för kvinnorna i toppen.En anledning till att det ser ut så kan enligt författarna vara att villkoren för män och kvinnor i toppen av inkomstfördelningen ser mycket olika ut när det gäller möjligheterna att kombinera karriär med familjeliv.
15.	Boschini, Anne, et al. (författare) Ny rapport : Näringslivet halkar efter 2018 Ingår i: Dagens industri. - 0346-640X. Tidskriftsartikel (populärvet., debatt m.m.)
16.	Burman, Joachim, et al. (författare) Autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis : the Swedish experience 2014 Ingår i: Journal of Neurology, Neurosurgery and Psychiatry. - London, United Kingdom : BMJ Publishing Group Ltd. - 0022-3050 .- 1468-330X. ; 85:10, s. 1116-1121 Tidskriftsartikel (refereegranskat)abstract Background: Autologous haematopoietic stem cell transplantation (HSCT) is a viable option for treatment of aggressive multiple sclerosis (MS). No randomised controlled trial has been performed, and thus, experiences from systematic and sustained follow-up of treated patients constitute important information about safety and efficacy. In this observational study, we describe the characteristics and outcome of the Swedish patients treated with HSCT for MS.Methods: Neurologists from the major hospitals in Sweden filled out a follow-up form with prospectively collected data. Fifty-two patients were identified in total; 48 were included in the study and evaluated for safety and side effects; 41 patients had at least 1 year of follow-up and were further analysed for clinical and radiological outcome. In this cohort, 34 patients (83%) had relapsing-remitting MS, and mean follow-up time was 47 months.Results: At 5 years, relapse-free survival was 87%; MRI event-free survival 85%; expanded disability status scale (EDSS) score progression-free survival 77%; and disease-free survival (no relapses, no new MRI lesions and no EDSS progression) 68%. Presence of gadolinium-enhancing lesions prior to HSCT was associated with a favourable outcome (disease-free survival 79% vs 46%, p=0.028). There was no mortality. The most common long-term side effects were herpes zoster reactivation (15%) and thyroid disease (8.4%).Conclusions: HSCT is a very effective treatment of inflammatory active MS and can be performed with a high degree of safety at experienced centres.
17.	Dippel, Sabine, et al. (författare) Health and welfare of organic pigs in Europe assessed with animal-based parameters 2014 Ingår i: Organic Agriculture. - : Springer Science and Business Media LLC. - 1879-4238 .- 1879-4246. ; 4:2, s. 149-161 Tidskriftsartikel (refereegranskat)abstract Organic pig farming aims at maintaining a high health and welfare state of the animals through appropriate housing, management and feeding. Better knowledge of health and welfare indicators should help to identify critical points and hence to improve health and welfare as well as performance of organic pigs. This paper describes the health and welfare of organic pigs from 101 farms across six EU countries, using selected animal-based parameters from the Welfare Quality® protocol. Parameters were collected in sows, suckling and weaned piglets in 3 to 20 farms per country. Their assessment was trained before farm visits and inter-observer agreement determined after farm visits. The most prevalent problems identified in sows were thinness (median farm prevalence 18.8 %, range 0–81.0), injuries on the anterior part of the body (15.5 %, 0–66.7), injuries on hind part of body (7.9 %, 0–50), obesity (4.9 %, 0–50.0) and vulva lesions (3.5 %, 0–42.9). In suckling piglets, the median prevalence in terms of groups affected per farm was 0 % for all parameters but ‘> 50 % dirty piglets in group’, for which it was 10 %. Farm prevalence ranged from 0 to 100 % for ‘≥ 1 lame piglet in group’, presence of diarrhoea, and ‘> 50 % dirty piglets in group’. In weaned piglets, the median prevalence in terms of groups affected per farm was 0 % with a range of 0 to 100 % for all parameters. Based on the collected data, body condition, skin and vulva lesions in sows, lameness, diarrhoea and respiratory problems in piglets could be used as management and welfare indicators, with good potential for enhancement through farm improvement schemes like herd health planning. However, some definitions could be improved, especially lameness, diarrhoea and respiratory problems in piglets.
18.	Edström, Kristina, 1963-, et al. (författare) Integrated Curriculum Design 2007 Ingår i: Rethinking Engineering Education: The CDIO Approach. - : Springer. Bokkapitel (refereegranskat)
19.	Ek, Åsa, et al. (författare) Perceived workplace safety culture among Swedish electricians 2015 Ingår i: [Host publication title missing]. Konferensbidrag (refereegranskat)abstract Accidents and injuries caused by electricity are work environment risks for electricians. About a 100 cases are reported annually to the Swedish Work Environment Authority. The safety culture at the electricians’ workplaces can affect the successfulness of safety management and the prevention of injuries. This paper presents preliminary questionnaire and interview findings on the perceived workplace safety culture of 523 male electricians who have experienced an electrical injury or accident. The results show a general need for increased safety awareness and motivation for safe work performance on different organisational levels. They also show a need for increased visibility of the management at the workplaces, increased commitment to safety, improved communication with the staff, and the need for increased reporting of incidents and experience feedback in order to achieve well-functioning learning for safety. The preliminary findings offer us a better understanding of the driving forces and barriers to efficient safety management and to safety culture improvements in this industry sector.
20.	Elolyckor i arbetet 2017 Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract I en utvidgad slutrapport från forskningsprojektet ”Elolyckor i arbetet – en undersökning om sena följder av strömgenomgång” redovisas resultat från en stor enkätstudie till elektriker och personer som anmält elolycksfall till Arbetsmiljöverket, och fördjupade kliniska undersökningar av en grupp elektriker som hade kvarstående besvär efter strömgenomgång. En tydlig strävan har varit att erfarenheter från projektet ska kunna leda till ett bättre omhändertagande av dem som drabbats av en elolycka, såväl på arbetsplatsen som inom hälso- och sjukvården och ge fördjupad förståelse för betydelsen av det förebyggande elsäkerhetsarbetet.
21.	Forkby, Torbjörn, et al. (författare) Problemlösningarnas eviga nu : Om trygghetsfrämjande och brottspreventiva partnerskap 2023 Bok (övrigt vetenskapligt/konstnärligt)
22.	Grosso, Giorgia, et al. (författare) The Complex Relationship between C4b-Binding Protein, Warfarin, and Antiphospholipid Antibodies 2021 Ingår i: Thrombosis and Haemostasis. - : Georg Thieme Verlag KG. - 0340-6245 .- 2567-689X. ; 121:10, s. 1299-1309 Tidskriftsartikel (refereegranskat)abstract Background Low levels of total C4b-binding protein (C4BPt), a circulating inhibitor of the classical/lectin complement pathways, were observed in patients with antiphospholipid antibodies (aPLs) and during warfarin treatment. Objectives To investigate the associations between aPL and C4BPt in patients with persistently positive (++) aPL, with/without clinical manifestations and systemic lupus erythematosus (SLE), and in controls. Furthermore, we explored the impact of anticoagulation on C4BPt and in relation to complement activation. Methods In a cross-sectional design we investigated defined subgroups: primary (p) antiphospholipid syndrome (APS, N =67), aPL++ individuals without clinical manifestations (aPL carriers, N =15), SLE-aPL++ ( N =118, among them, secondary [s] APS, N =56), aPL negative (-) SLE (SLE-aPL-, N =291), and 322 controls. Clinical characteristics, including treatment, were tabulated. C4BPt was determined with a magnetic bead method. Complement proteins (C1q, C2, C3, C4, C3a, C3dg, sC5b-9, factor I [FI]) were measured. A mediation analysis was performed to decompose the total effect of aPL++ on C4BPt into the direct and indirect effects of aPL++ through warfarin. Results Overall, C4BPt is 20% decreased in aPL++ patients, regardless of SLE, APS, clinical manifestations, and aPL profile. C4BPt levels associate positively with complement proteins C1q, C2, C3, and C4, and negatively with complement activation product C3dg. In the SLE group, warfarin treatment contributes to approximately half of the C4BPt reduction (9%) Conclusion Both aPLs and warfarin are associated with C4BPt reduction. Complement activation in aPL++ patients may partly be explained by impaired inhibition through depressed C4BPt levels. Further studies are needed to understand the clinical implications.
23.	Gunnarsson, A Birgitta, 1958, et al. (författare) A study protocol of the photo-supported conversations about the well-being intervention (Be Well (TM)) for people with stress related disorders 2021 Ingår i: Bmc Psychology. - : Springer Science and Business Media LLC. - 2050-7283. ; 9:1 Tidskriftsartikel (refereegranskat)abstract Background: Stress-related illnesses constitute a huge problem in society. The primary care services in Sweden form the first line of care whose role is to coordinate interventions for reducing symptoms, as well as health-promoting interventions. There is lack of knowledge concerning health-promoting interventions for these illnesses. The aim of this study is to evaluate whether photo-supported conversations about well-being (Be Well (TM)) as an intervention, in addition to care as usual within the primary care services, improves health and well-being for patients with stress-related illnesses. The intervention will be compared to a control group, who receive care as usual. A further aim is to conduct a process evaluation. Methods/Design: This ongoing project has a quasi-experimental design, using quantitative and qualitative methods, and includes patients from primary care centres in two Swedish counties. Seventy patients, 20-67 years, with stress-related illnesses will be recruited. They constitute an intervention group, which receive the intervention together with care as usual, and a control group, which receive care as usual. The intervention, photo-supported conversations about well-being, involves 12 sessions. Care as usual entails medication, occupational therapy, physiotherapy and/or psychotherapy. Data collection is carried out at baseline, and outcomes are assessed directly after the intervention, as well as six months after completion of the intervention. The outcomes are evaluated based on factors related to health, well-being and everyday occupations. Furthermore, data concerning experiences of well-being and perceptions of the intervention will be collected in interviews. The therapists will also be interviewed about their experiences of performing the intervention. Data will be analysed with non-parametric statistics, and qualitative methodology. Discussion: The project is based on the concept that focusing on well-being despite living with stress-related illness may positively impact health and well-being as well as activity-related aspects, and that photo-supported conversations about well-being can contribute a complement to other treatment and rehabilitation. A strength is the use of a wide range of methods: such as quantitative measures, photographs, and qualitative interviews with participants and therapists. The results will thus provide knowledge about potential effects of this health-promoting intervention.
24.	Gunnarsson, Birgitta, 1958-, et al. (författare) An intervention using photo-supported conversations about well-being in people with stress related disorders 2022 Konferensbidrag (refereegranskat)
25.	Gunnarsson, Birgitta, et al. (författare) Be WellTM – an intervention using photo-supported conversations to promote well-being in people living with stress-related illness 2022 Ingår i: Caring in a changing world. Konferensbidrag (refereegranskat)abstract Background: Stress-related mental health illnesses are increasing in all ages. Be-WellTM is a health-promoting intervention intended for primary healthcare. Be-WellTM involves 12 sessions based on photo-supported conversations. Patients use their mobiles to photograph situations about well-being, and the photos are used as a starting point for dialogues with their therapist. Aim: The aims of this study are to evaluate the feasibility of Be-WellTM, and to compare the outcomes concerning health and well-being in the intervention group with those of a control group. Method: This ongoing study is conducted in Swedish primary healthcare. A total of 70 patients in working age, living with stress-related disorders will be recruited. The intervention group receive the intervention Be-WellTM in addition to care as usual, and the controls only receive care as usual. Prior to and directly after the intervention, and after 6 months, the participants complete questionnaires and take part in qualitative interviews about stress and well-being in their present life-situation and experiences from participating in Be-WellTM. Non-parametric and qualitative analysis will be used. Results: Twenty-nine of 35 participants have been recruited to the intervention and 28 of 35 participants to the control group. We will present the research design and preliminary outcomes from the baseline and follow-up data.Conclusion: If the intervention Be-WellTM is found to be feasible with positive outcomes, the health-promoting intervention Be-WellTM can be useful as a complementary intervention in primary healthcare for patients with stress-related illness. Implications for Caring in a changing world: Probably, photo-supported conversations may promote well-being to other patients in different life situations, but future research is warranted.
26.	Gunnarsson, Birgitta, 1958-, et al. (författare) Be-WellTM – fotostödda samtal för att främja hälsa och välbefinnande hos personer med stressrelaterad ohälsa i primärvården 2023 Konferensbidrag (refereegranskat)abstract Bakgrund/SyfteStressrelaterad ohälsa är ett stort samhällsproblem. Vi har utvecklat en hälsofrämjande behandlingsmetod med fotostödda samtal, Be-WellTM, med förhoppningen att bidra till att minska den stressrelaterade ohälsan. Metoden fokuserar på det som främjar hälsa och välbefinnande trots ohälsa och inte på symtom och problem i vardagen. Be-WellTM bygger på kunskap om betydelsen av hälsa, välbefinnande, vardagliga aktiviteter och aktivitetsbalans. Be-WellTM baserat på erfarenheter från tidigare studie i primärvården där kvinnor med stressrelaterad ohälsa fotograferade sådant som relaterade till deras välbefinnande trots stress. I intervjuerna framkom att kvinnorna blev uppmärksamma på sitt välbefinnande, vilket möjliggjorde perspektivförskjutning från det som inte fungerar i vardagen till det som fungerar.Syftet är att utvärdera Be-WellTM för personer i primärvården med diagnosticerad stressrelaterad ohälsa.Metod/TillvägagångssättBe-WellTM innebär att deltagare tar fotografier med mobil på sådant som ger välbefinnande i vardagen, för att sedan använda dem som utgångspunkt för reflekterande samtal med behandlare vid sammanlagt 12 tillfällen. I en pågående kontrollerad studie i primärvården får interventionsgruppen Be-WellTM av arbetsterapeut som tillägg till sedvanlig behandling. Inklusionskriterier är personer i yrkesverksam ålder med stressrelaterad ohälsa. Data från frågeformulär, intervjuer och fotografier samlas in före och efter intervention, samt sex månader efter intervention och behandlarna intervjuas också. Datainsamling beräknas vara avslutad början av 2023. Kvantitativa som kvalitativa analyser kommer att genomföras.Resultat/Preliminärt resultatIndikationer från intervjuer tyder på att patienter och behandlare uppskattar metoden. Vi planerar att presentera metoden Be-WellTM samt preliminära resultat i samband med Arbetsterapiforum.Slutsats/Praktisk tillämpningPresentationen ger kännedom om en möjlig behandlingsmetod som är enkel att införa i primärvården.
27.	Gunnarsson, Birgitta, 1958-, et al. (författare) Be-WellTM – photo-supported conversations to promote well-being in people living with stress-related illness 2022 Konferensbidrag (refereegranskat)
28.	Gunnarsson, Britt-Louise, et al. (författare) Översättning och parallellskrivning : flerspråkig textproduktion inom ett internationellt storföretag 1999 Ingår i: Svenskans beskrivning. - Lund : Lund University Press. - 9179665918 ; , s. 134-142 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
29.	Gunnarsson, Cecilia, 1970-, et al. (författare) Amplification of HSD17B1 and ERBB2 in primary breast cancer 2003 Ingår i: Oncogene. - : Springer Science and Business Media LLC. - 0950-9232 .- 1476-5594. ; 22:1, s. 34-40 Tidskriftsartikel (refereegranskat)abstract Estrogens play a crucial role in the development of breast cancer. Estradiol can be produced in the breast tissue in situ, and one of the enzymes involved in this process is 17β-hydroxysteriod dehydrogenase (17β-HSD) type 1 that catalyzes the interconversion of estrone (E1) to the biologically more potent estradiol (E2). The gene coding for 17β-HSD type 1 (HSD17B1) is located at 17q12-21, close to the more studied ERBB2 and BRCA1. The aim of this study was to investigate if HSD17B1 shows an altered gene copy number in breast cancer. We used real-time PCR and examined 221 postmenopausal breast tumors for amplification of HSD17B1 and ERBB2. In all, 32 tumors (14.5%) showed amplification of HSD17B1 and 21% were amplified for ERBB2. Amplification of the two genes was correlated (P = 0.00078) and in 14 tumors (44%) with amplification of HSD17B1, ERBB2 was co amplified. The patients with amplification in at least one of the genes had a significantly worse outcome than patients without (P = 0.0059). For estrogen receptor (ER)-positive patients who received adjuvant tamoxifen, amplification of HSD17B1 was related to decreased breast cancer survival (P = 0.017), whereas amplification of ERRB2 was not. Amplification of HSD17B1 might be an indicator of adverse prognosis among ER-positive patients, and possibly a mechanism for decreased benefit from tamoxifen treatment.
30.	Gunnarsson, Carina, et al. (författare) Ullpellets från outnyttjad ull på Gotland – ett utvecklingsprojekt med fokus på pelleteringsprocessen 2022 Rapport (övrigt vetenskapligt/konstnärligt)abstract Wool pellets from unutilized wool on Gotland – a development project with focus on the pelleting processA large proportion of the wool produced in Sweden is discarded as it cannot be used by the textile industry. Before the wool can be used it must be collected and washed. However, a large quantity of low-quality wool is mixed in with the high-quality wool and thus enter the processing industry when the wool is collected. As it is not usable by the industry, this low-quality wool simply takes up space and lowers the processing speed as it must be separated from the high-quality wool and be discarded, lowering the economic output of the wool processing industry. However, unutilized wool has the potential to be used as a slow-acting fertilizer, soil amendment, or mulch for cultivation purposes. Pelleting is an attractive method of processing biomass into a product that is efficient and easy to handle, transport and use. Pellet presses are commercially available from small farm-scale to large-scale facilities. The aim of the project was to develop and adapt the pelleting technology to work with Swedish wool that cannot be used to produce yarns or other textiles. The goal was to develop methods and technology for pre-treating or disintegrate the wool, adapt the input and pelleting part of the pelleting process to work with low-quality wool and try to optimize the quality of the pellets. Furthermore, the goal was to analyze the plant nutrient value and strength of the pellets produced and create a packaging prototype. During the project, additional goals were added: to automate the process from pre-treatment to packaging as much as possible, and to use literature to determine if the pelletizing process is likely to be sufficient enough to hygenize the wool from weed seeds. An automated production line from wool to finished pellets has been built at Ullkontoret (Sweden’s only full-scale wool washing facility). Coarse and fine shredding, feeding and regulation of feed capacity function well, while the pelleting pressing does not work sufficiently well. Wool pelleting of only low-quality wool proved technologically challenging and neither the modified pellet presses nor the imported wool pellet press worked, despite modifications. In other European countries, this problem is solved by mixing in higher quality wool. Further technological development of wool pelleting is needed to obtain a system that can handle all types of low-quality Swedish wool. Literature studies and nutritional analyses confirm that wool pellets work well as a slow-acting fertilizer (often in mixture due to a very low phosphorus content), but the potential of wool as a soil amendment, mulch and snail repellent requires more studies. Pelleting is probably not enough to hygenize the wool from weed seeds. It is a challenge to produce a packaging that both meets the quality requirements of the product (e.g., maintain the right humidity, preventing odors) and at the same time meets the demands of the type of environmentally conscious consumer who is the main target group for a nature-based product.
31.	Gunnarsson, Fredrik, et al. (författare) Neighbor Cell Relation List and Measured Cell Identity Management in LTE 2008 Ingår i: Proceedings of the 2008 IEEE Network Operations and Management Symposium. - : IEEE. - 9781424420667 - 9781424420650 ; , s. 152-159 Konferensbidrag (refereegranskat)abstract Radio network management simplification concerns to some extent the removal, not the simplification, of tasks. In this paper we present an approach for automatic network management in 3G long term evolution (LTE), namely, methods for automatic configuration of locally-unique physical cell identities and neighbor cell relation lists. We show that these issues can be removed from the list of planning tasks and completely replaced by autonomous algorithms. These algorithms make use of mobile measurements to detect local cell identity conflicts, resolve them, and to update the neighbor cell relation lists in the cells. The performance of the approach is determined using simulations of realistically deployed macro networks. The simulations illustrate the ability of the algorithms to resolve local cell identity conflicts. In particular, the algorithms are capable of both accommodating new cells and handling a worst case scenario where all cells are initiated with the same local cell identities and where neighbor cell relation lists are empty. The contributions in this paper are meant to aid operators by allowing them to replace time consuming and costly tasks with automatic mechanisms, thus, reducing operational expenditure.
32.	Gunnarsson, Kristina, et al. (författare) Arbetsmiljö och arbetsmiljöarbete i mindre tillverkningsföretag i Dalarna : En genomgång av förutsättningar för ett systematiskt arbetsmiljöarbete på mindre arbetsplatser 2004 Rapport (övrigt vetenskapligt/konstnärligt)
33.	Gunnarsson, Kristina, 1947- (författare) Entrepreneurs and Small-Scale Enterprises : Self Reported Health, Work Conditions, Work Environment Management and Occupational Health Services 2010 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract This thesis focused on factors contributing to improved work environment in small-scale enterprises and sustainable health for the entrepreneurs. In Study I, implementation of the provision of Systematic Work Environment Management (SWEM) with and without support was investigated. Two implementation methods were used, supervised and network method. The effect of the project reached the employees faster in the enterprises with the supervised method. In general, the work environment improved in all enterprises. However, extensive support to small-scale enterprises in terms of advice and networking aimed at fulfilling SWEM regulations had limited effect – especially considering the cost of applying these methods. Studies II, III, and IV focused on entrepreneurs’ health, work conditions, strategies for maintaining good health, and utilisation of Occupational Health Service (OHS). A closed cohort of entrepreneurs in ten different trades responded to two self-administered questionnaires on health and work conditions, with five years between the surveys: at baseline, 496 entrepreneurs responded, and 251 entrepreneurs responded at follow-up. Differences were tested by Chi2-test, and associations estimated with logistic regression analyses. Qualitative interviews on entrepreneurs’ strategies for maintaining good health were included. In Study II, the most frequently reported complaints, musculoskeletal pain and mental health problems, were associated with poor job satisfaction and poor physical work environment. In Study III, consistent self-reported good health, i.e. good health both at baseline and at follow up, was associated with self-valued good social life when adjusted for physical work conditions and job satisfaction. Entrepreneurs’ strategies for maintaining good health included good planning and control over work, flexibility at work, good social contact with family, friends and other entrepreneurs, and regular physical exercise. Study IV concerned entrepreneur’s utilisation of OHS. Entrepreneurs affiliated to OHS had either better or more adverse work conditions than non-affiliated entrepreneurs. Medical care and health check-ups were the services most utilised. Affiliation to OHS correlated with use of specific information sources and active work environment management. The entrepreneurs were not consistently affiliated to OHS over the five-year-period.
34.	Gunnarsson, Kristina, et al. (författare) Entrepreneurs' Self-reported Health, Social Life, and Strategies for Maintaining Good Health 2011 Ingår i: Journal of Occupational Health. - 1341-9145 .- 1348-9585. ; 53:3, s. 205-213 Tidskriftsartikel (refereegranskat)abstract Objectives: This study investigated the association between self-reported good health and self-valued good social life. An additional aim was to examine entrepreneur's strategies for maintaining good health. Methods: The study design included a two-wave questionnaire, with five years between the surveys (2001 and 2006), and qualitative interviews. The study group consisted of 246 entrepreneurs from the central region of Sweden and represented ten different trades. Entrepreneurs reporting good health in both 2001 and 2006 were compared with entrepreneurs reporting poor health on both occasions or with inconsistent answers. Six of the entrepreneurs were strategically chosen for the interview study. Results: Consistent good health was reported by 56% of the entrepreneurs. Good social life in 2001 was associated with an increased odds ratio (OR) for consistent good health when the analyses were adjusted for physical work conditions and job satisfaction (OR 2.12, 95% CI 1.07-4.17). Findings for good leisure time, weekly moderate physical exercise, and a rating of work being less or equally important as other life areas, were similar but not statistically significant when job satisfaction was considered in the analyses. Strategies for maintaining good health included good planning and control over work, flexibility at work, good social contact with family, friends and other entrepreneurs, and regular physical exercise. Conclusion: This study demonstrated an association between self-reported good health and good social life for entrepreneurs in small-scale enterprises. In addition, the entrepreneurs emphasised strategies such as planning and control over work and physical exercise are important for maintaining good health.
35.	Gunnarsson, Kristina, et al. (författare) Return to work in small enterprises 2014 Ingår i: Small Enterprise Research. - : Informa UK Limited. - 1321-5906 .- 1175-0979. ; 21:2, s. 229-237 Tidskriftsartikel (refereegranskat)abstract The purpose of this study was to understand and identify possible areas of improvement for the return-to-work process in small enterprises. The study used a qualitative approach. Semi-structured interviews were conducted with 16 small enterprises in Sweden. The employers in the enterprise have made efforts to adapt the workplace for employees on sick leave. However, there was no set procedure for handling contacts between the employer and employee during periods of sick leave and employers indicated that they were unsure how to cooperate with the Swedish Social Insurance Agency in the return-to-work process. An area for improvement is extended professional competence and support in the return-to-work process in order to identify possibilities to enable adaption of the workplace and facilitate return to work. The occupational health service have or should have the knowledge required and could play an active role in improvement of the return-to-work process.
36.	Gunnarsson, Kristina, et al. (författare) Self rated health and working conditions of small-scale enterprisers in sweden 2007 Ingår i: Industrial Health. - : National Institute of Industrial Health. - 0019-8366 .- 1880-8026. ; 45:6, s. 775-780 Tidskriftsartikel (refereegranskat)abstract This study was an investigation of prevalence and associations between self-rated health and working conditions for small-scale enterprisers in a county in Sweden. A postal questionnaire was answered by 340 male and 153 female small-scale enterprisers in different sectors, with a response rate of 66%. For comparative purposes, data from a population study of 1,699 employees in private companies was included in the analyses. Differences were tested by Chi²-test and associations were presented as odds ratios (OR) with a 95% confidence interval (95% CI). The frequency of health problems in male enterprisers was higher than in employees in the private sector, while the frequency of health problems in female enterprisers was equal to that of the control employees. The main findings highlighted that male enterprisers reported higher rate of health problems and female enterprisers equal rate compared with employees in the private sector. Enterprisers stated musculoskeletal pain (women 59%, men 56%) and mental health problems (women 47%, men 45%) as the most frequent health problems. Poor job satisfaction, reported by 17% of the females and 20% of the male enterprisers, revealed an OR of 10.42 (95% CI 5.78-18.77) for poor general health. For the enterprisers, the most frequent complaints, musculoskeletal pain and mental health problems, were associated with poor job satisfaction and poor physical work environment. An association between poor general health and working as an enterpriser remained after adjusting for working conditions, sex and age.
37.	Gunnarsson, Kristina, et al. (författare) Swedish entrepreneurs’ use of occupational health ervices 2011 Ingår i: AAOHN Journal. - Atlanta : SLACK Inc.. - 1938-2448 .- 0891-0162. ; 59:10, s. 437-445 Tidskriftsartikel (refereegranskat)abstract Small-scale enterprises are less often covered by occupational health services and have insufficient awareness about health and risks in the work environment. This study investigated how Swedish entrepreneurs in small-scale enterprises use occupational health services. The study used a questionnaire sent in two waves, 5 years apart. At baseline, 496 entrepreneurs responded, and 251 participated 5 years later. The questionnaire included items about affiliation with and use of occupational health services, physical and psychosocial work environments, work environment management, sources of work environment information, and membership in professional networks. Only 3% of entrepreneurs without employees and 19% of entrepreneurs with employees were affiliated with an occupational health service. Entrepreneurs affiliated with occupational health services were more active in work environment management and gathering information about the work environment. The occupational health services most used were health examinations, health care, and ergonomic risk assessments. Affiliation with occupational health services was 6% at both measurements, 4% at baseline, and 10% 5 years later.
38.	Gunnarsson, Kristina, et al. (författare) Systematic Work Environment Management : Experiences from Implementation in Swedish Small-scale Enterprises 2010 Ingår i: Industrial Health. - : National Institute of Industrial Health. - 0019-8366 .- 1880-8026. ; 48:2, s. 185-196 Tidskriftsartikel (refereegranskat)abstract Small-scale enterprises face difficulties in fulfilling the regulations for organising Systematic Work Environment Management. This study compared three groups of small-scale manufacturing enterprises with and without support for implementing the provision. Two implementation methods, supervised and network method, were used. The third group worked according to their own ideas. Twenty-three enterprises participated. The effects of the implementation were evaluated after one year by semi-structured dialogue with the manager and safety representative. Each enterprise was classified on compliance with ten demands concerning the provision. The work environment was estimated by the WEST-method. Impact of the implementation on daily work was also studied. At the follow-up, the enterprises in the supervised method reported slightly more improvements in the fulfilment of the demands in the provision than the enterprises in the network method and the enterprises working on their own did. The effect of the project reached the employees faster in the enterprises with the supervised method. In general, the work environment improved to some extent in all enterprises. Extensive support to small-scale enterprises in terms of advise and networking aimed to fulfil the regulations of Systematic Work Environment Management had limited effect - especially considering the cost of applying these methods.
39.	Gunnarsson, Mikael, et al. (författare) Biokinetics and radiation dosimetry for patients undergoing a glycerol tri[1-14C]oleate fat malabsorption breath test. 2003 Ingår i: Applied Radiation and Isotopes. - 0969-8043. ; 58:4, s. 517-526 Tidskriftsartikel (refereegranskat)
40.	Gunnarsson, Mikael, et al. (författare) Long-term biokinetics and radiation exposure of patients undergoing 14C-glycocholic acid and 14C-xylose breath tests. 2007 Ingår i: Cancer Biotherapy & Radiopharmaceuticals. - : Mary Ann Liebert Inc. - 1557-8852 .- 1084-9785. ; 22:6, s. 762-771 Tidskriftsartikel (refereegranskat)abstract The (14)C-glycocholic acid and (14)C-xylose breath tests are clinically used for the diagnosis of intestinal diseases, such as bacterial overgrowth in the small intestine. The two tests have in earlier studies been thoroughly evaluated regarding their clinical value, but due to the long physical half-life of (14)C and the limited biokinetic and dosimetric data, which are available for humans, several hospitals have been restrictive in their use. The aim of this study was to investigate the long-term biokinetics and dosimetry of the two (14)C compounds in patients and volunteers, using the highly sensitive accelerator mass spectrometry (AMS) technique. Eighteen (18) subjects were included, 9 for each compound. The (14)C content in samples from exhaled air, urine, and, for some subjects, also feces were analyzed with both liquid scintillation counting (LSC) and AMS. The results from the glycocholic acid study showed that, up to 1 year after the administration, 67%+/-6% (mean+/-standard deviation) of the administered activity was recovered in exhaled air, 2.4%+/-0.4% was found in urine, and 7.6% (1 subject) in feces. In the xylose study, the major part was found in the urine (66%+/-2%). A significant part was exhaled (28%+/-5%), and the result from an initial 72-hour stool collection from 2 of the subjects showed that the excretion by feces was insignificant. The absorbed dose to various organs and tissues and the effective dose were calculated by using biokinetic models, based on a combination of experimental data from the present study and from earlier reports. In the glycocholic acid study, the highest absorbed dose was received by the colon (1.2 mGy/MBq). In the xylose study, the adipose tissue received 0.8 mGy/MBq. The effective dose was estimated to 0.5 (glycocholic acid) and 0.07 mSv/MBq (xylose). Thus, from a radiation protection point of view, we see no need for restrictions in using the two (14)C-labeled radiopharmaceuticals on adults with the activities normally administered (0.07-0.4 MBq).
41.	Gunnarsson, Mikael, et al. (författare) Principles behind Computed Tomography (CT) 2022. - 1 Ingår i: Handbook of Nuclear Medicine and Molecular Imaging for Physicists : Instrumentation and Imaging Procedures - Instrumentation and Imaging Procedures. - 9781138593268 - 9780429489556 ; 1 Bokkapitel (refereegranskat)abstract The use of Computed tomography (CT) for anatomical information in a combination with the SPECT system has in many ways added substantial information to many nuclear medicine imaging procedures. The information from the CT system can provide information on the location of lesions and can be used for attenuation correction. Modern SPECT/CT and PET/CT today have CT scanners that provide diagnostic quality. This chapter provides the principles behind the X-ray imaging and in particular CT. It describes scanner configurations and components for a typical CT system and how data are acquired. Also, a short description of dual-energy systems that provide additional information is included. Iterative reconstruction of image, and the definition of the Hounsfield unit is discussed together with how different factors affect the image quality. A part of the chapter also discusses CT dosimetry and how the absorbed doses can be measured, quantified, and possibly be reduced. A section also discusses different types of artefacts in the images caused by, for example, metals, respiratory movements, and beam hardening.
42.	Gunnarsson, Rebeqa, et al. (författare) Mutation, methylation, and gene expression profiles in dup(1q)-positive pediatric B-cell precursor acute lymphoblastic leukemia 2018 Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 32:10, s. 2117-2125 Tidskriftsartikel (refereegranskat)abstract High-throughput sequencing was applied to investigate the mutation/methylation patterns on 1q and gene expression profiles in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL) with/without (w/wo) dup(1q). Sequencing of the breakpoint regions and all exons on 1q in seven dup(1q)-positive cases revealed non-synonymous somatic single nucleotide variants (SNVs) in BLZF1, FMN2, KCNT2, LCE1C, NES, and PARP1. Deep sequencing of these in a validation cohort w (n = 17)/wo (n = 94) dup(1q) revealed similar SNV frequencies in the two groups (47% vs. 35%; P = 0.42). Only 0.6% of the 36,259 CpGs on 1q were differentially methylated between cases w (n = 14)/wo (n = 13) dup(1q). RNA sequencing of high hyperdiploid (HeH) and t(1;19)(q23;p13)-positive cases w (n = 14)/wo (n = 52) dup(1q) identified 252 and 424 differentially expressed genes, respectively; only seven overlapped. Of the overexpressed genes in the HeH and t(1;19) groups, 23 and 31%, respectively, mapped to 1q; 60-80% of these encode nucleic acid/protein binding factors or proteins with catalytic activity. We conclude that the pathogenetically important consequence of dup(1q) in BCP ALL is a gene-dosage effect, with the deregulated genes differing between genetic subtypes, but involving similar molecular functions, biological processes, and protein classes.
43.	Gunnarsson-Östling, Ulrika, 1977-, et al. (författare) What about the future? : The troubled relationship between futures and feminism 2014 Ingår i: NORA. - : Taylor & Francis Group. - 0803-8740 .- 1502-394X. ; 22:1, s. 63-69 Tidskriftsartikel (refereegranskat)abstract This position paper argues that issues related to the future are worth emphasizing and discussing with more feminist fervour and engagement than is now the case within feminist studies and futures studies. It is concluded that feminists cannot just be critical from an outside perspective, but must engage in creating alternative futures. These futures should not be common goals around which to unite, but a way to inspire feminist thinking about different futures. The authors point out the problem that the futures studies field lacks feminist perspectives, and in this position paper they discuss the gap between futures studies and feminism.
44.	Hajdu, Flora, et al. (författare) Sveriges utsläpp måste minska nu, regeringen 2023 Ingår i: Aftonbladet. - 1103-9000. Tidskriftsartikel (populärvet., debatt m.m.)
45.	Hardarson, Thorir, et al. (författare) A noninferiority, prospective, randomized, controlled trial comparing embryo development using media developed for sequential or undisturbed culture in a time-lapse setup. 2015 Ingår i: Fertility and Sterility. - : Elsevier BV. - 1556-5653 .- 0015-0282. Tidskriftsartikel (refereegranskat)abstract To study whether a culture medium that allows undisturbed culture supports human embryo development to the blastocyst stage equivalently to a well-established sequential media.
46.	Kersten, Christian, et al. (författare) Increased C-reactive protein implies a poorer stage-specific prognosis in colon cancer 2013 Ingår i: Acta Oncologica. - : Informa Plc. - 0284-186X .- 1651-226X. ; 52:8, s. 1691-1698 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: To characterize the stage-specific prognostic relevance of preoperative systemic inflammatory response, defined by C-reactive protein (CRP), in colon cancer (CC) patients.MATERIAL AND METHODS: Data from CC patients operated on from 1998 to 2007 at three hospitals from three different Nordic countries were collected retrospectively from national registries, local databases and/or patient records. Patients with emergency surgery, infection or auto-immune disease were excluded. Associations between clinical or histopathological variables and CRP were assessed. Patients were followed from the date of surgery to death or end of follow-up. Disease-specific survival (DSS) was the main endpoint.RESULTS: In total, 525 patients with age and stage distributions which were representative for CC patients were included. None of the patients was lost to follow-up. Age, TNM Stage, WHO differentiation grade and right-sided tumor location significantly associated with elevated CRP values, in contrast to postoperative morbidity, which did not. CRP levels were found to be a strong prognostic factor for DSS in CC. The risk of death due to CC was augmented with increasing levels of CRP in every stage of operated CC. Both short- and long-term DSS were impaired. The sub-hazard ratios for CRP-levels above 60 mg/L were 7.37 (CI 2.65-20.5) for stage I+ II, compared to 3.29 (CI 1.30-8.29) for stage III and 2.24 (CI 1.16-4.35) for stage IV.CONCLUSION: Increase of CRP concentrations correlate with clinically relevant poorer disease-specific survival in each stage of CC.
47.	Kontakt, variation och förändring - studier i Stockholmsspråket. Ett urval av uppsatser av Ulla-Britt Kotsinas. 2000 Samlingsverk (redaktörskap) (refereegranskat)
48.	Kontakt, variation och förändring - studier i Stockholmsspråket. Ett urval uppsatser av Ulla-Britt Kotsinas 2000 Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)
49.	Lindahl, Cecilia, et al. (författare) Inälvsparasiter i betesmark och hos grisar i ekologiska besättningar 2009 Rapport (övrigt vetenskapligt/konstnärligt)
50.	Lindelöf, Linnea, et al. (författare) 62 Acquired ficolin-3 deficiency in patients with Systemic Lupus Erythematosus 2023 Ingår i: Immunobiology. - : Elsevier. - 0171-2985 .- 1878-3279. ; 228:5, s. 152515-152515 Tidskriftsartikel (refereegranskat)abstract Background: Ficolin-3 is the main initiator of the lectin pathway in humans. Case reports of ficolin-3 deficient patients have suggested that ficolin-3 deficiency may be enriched in patients with Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease where complement plays an important role. Therefore, this study aimed to investigate the activity levels of ficolin-3 and to identify potential ficolin-3 deficient individuals in two Swedish SLE cohorts.Methods: Serum or plasma samples from SLE patients (n=810) and matched controls (n=566) were collected from the Karolinska Institute (KI) and Umeå University Hospital. The ficolin-3 activity levels were measured by an in-house developed functional ELISA with a pooled normal human serum sample as a reference. Serial samples were analyzed for ficolin-3 deficient patients when available. Sequencing data were analyzed for FCN3 frame-shift mutation +1637delC (rs532781899) and other potential loss-of-function (LoF) variants.Results: This screening revealed that the level of ficolin-3 activity varies largely in patients with SLE. The activity levels also show that SLE patients seem to generally have elevated ficolin-3 activity compared to the control group (p<0.0001). Out of 810 patients with SLE, four patients were determined to be ficolin-3 deficient. For two of these patients, the ficolin-3 activity was at normal levels at the time of diagnosis and thereafter depleted over time, indicating an acquired deficiency. For deficient patients, no or very low ficolin-3 protein levels and no lectin pathway-dependent complement activation could be detected. Autoantibodies against ficolin-3 were not detectable. No patients were homozygous for the +1637delC frameshift mutation, whereas in total 10 patients were determined to be heterozygous carriers. These heterozygous patients displayed lower levels of ficolin-3 activity but did not include the deficient patients. Additional possible LoF variants were analyzed but none were enriched in either patients or controls.Conclusions: Contrary to the classical pathway of the complement system we show that genetic ficolin-3 deficiency is not a risk factor for SLE. Instead, acquired ficolin-3 deficiency was observed in a subgroup of SLE patients, possibly due to a potent activation of the lectin pathway that depleted ficolin-3 plasma levels in these individuals.

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