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Sökning: WFRF:(Guo Zhiming)

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1.
  • Barimah, Alberta Osei, et al. (författare)
  • Sensitive label-free Cu2O/Ag fused chemometrics SERS sensor for rapid detection of total arsenic in tea
  • 2021
  • Ingår i: Food Control. - : Elsevier. - 0956-7135 .- 1873-7129. ; 130
  • Tidskriftsartikel (refereegranskat)abstract
    • Arsenic (As) is one of the toxic, persistent, and lethal heavy metalloids and requires rapid, less costly, and sensitive detection methods. This study proposed a label-free cuprous oxide/silver (Cu2O/Ag) surface-enhanced Raman scattering (SERS) nanoprobe to detect total As in tea. Different total As spiked tea concentrations were mixed with the Cu2O/Ag SERS nanoprobe for the SERS detection. Quantitative models were established for predicting the total As in tea by comparatively applying chemometric algorithms. Amongst the algorithms, competitive adaptive reweighted sampling partial least squares (CARS-PLS) optimized the most effective spectral variables to predict the total As in tea efficiently. The CARS-PLS gave the highest correlation coefficient value (R-p = 0.9935), very low root means square error (RMSEP = 0.0496 mu g g(-1)) in the prediction set and recorded the highest RPD value of 8.819. The proposed nanoprobe achieved a lower detection limit (0.00561 mu g g(-1)), excellent selectivity, satisfactory reproducibility, and stability. No significant difference was recorded when the performance of the Cu2O/Ag total As SERS sensor was compared with the inductively coupled plasma mass spectrometry (ICP-MS) method. Therefore, this developed Cu2O/Ag coupled chemometrics SERS sensing method could be used to efficiently determine, quantify, and predict total As in tea to promote monitoring of heavy metal contaminants.
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2.
  • Guo, Zhiming, et al. (författare)
  • Chemometrics coupled 4-Aminothiophenol labelled Ag-Au alloy SERS off-signal nanosensor for quantitative detection of mercury in black tea
  • 2020
  • Ingår i: Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy. - : Elsevier BV. - 1386-1425 .- 1873-3557. ; 242
  • Tidskriftsartikel (refereegranskat)abstract
    • Black tea like other food crops is prone to mercury ion (Hg2+) contamination right from cultivation to industrial processing. Due to the dangerous health effects posed even in trace contents, sensitive detection and quantification sensors are required. This study employed the surface-enhanced Raman scattering (SERS) enhancement property of 4-aminothiophenol (4-ATP) as a signal turn off approach functionalized on Ag-Au alloyed nanopartide to firstly detect Hg2+ in standard solutions and spiked tea samples. Different chemometric algorithms were applied on the acquired SERS and inductively coupled plasma-mass spectrometry (ICP-MS) chemical reference data to select effective wavelengths and spectral variables in order to develop models to predict the Hg2+. Results indicated that Ag-Au/4-ATP SERS sensor combined with ant colony optimization partial least squares (ACO-PLS) exhibited the best correlation efficient and minimum errors for Hg2+ standard solutions (R-c = 0.984, R-p = 0.974, RMSEC = 0.157 mu g/mL, RMSEP = 0.211 mu g/mL) and spiked tea samples (R-c = 0.979, R-p = 0.963, RMSEC = 0.181 mu g/g and RMSEP = 0210 mu g/g). The limit of detection of the proposed sensor was 4.12 x 10(-7) mu g/mL for Hg2+ standard solutions and 2.83 x 10(-5) mu g/g for Hg2+ spiked tea samples. High stability and reproducibility with relative standard deviation of 1.14% and 0.84% were detected. The potent strong relationship between the SERS sensor and the chemical reference method encourages the application of the developed chemometrics coupled SERS system for future monitoring and evaluation of Hg2+ in tea.
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3.
  • Guo, Zhiming, et al. (författare)
  • Classification for Penicillium expansum Spoilage and Defect in Apples by Electronic Nose Combined with Chemometrics
  • 2020
  • Ingår i: Sensors. - : MDPI AG. - 1424-8220. ; 20:7
  • Tidskriftsartikel (refereegranskat)abstract
    • It is crucial for the efficacy of the apple storage to apply methods like electronic nose systems for detection and prediction of spoilage or infection by Penicillium expansum. Based on the acquisition of electronic nose signals, selected sensitive feature sensors of spoilage apple and all sensors were analyzed and compared by the recognition effect. Principal component analysis (PCA), principle component analysis-discriminant analysis (PCA-DA), linear discriminant analysis (LDA), partial least squares discriminate analysis (PLS-DA) and K-nearest neighbor (KNN) were used to establish the classification model of apple with different degrees of corruption. PCA-DA has the best prediction, the accuracy of training set and prediction set was 100% and 97.22%, respectively. synergy interval (SI), genetic algorithm (GA) and competitive adaptive reweighted sampling (CARS) are three selection methods used to accurately and quickly extract appropriate feature variables, while constructing a PLS model to predict plaque area. Among them, the PLS model with unique variables was optimized by CARS method, and the best prediction result of the area of the rotten apple was obtained. The best results are as follows: Rc = 0.953, root mean square error of calibration (RMSEC) = 1.28, Rp = 0.972, root mean square error of prediction (RMSEP) = 1.01. The results demonstrated that the electronic nose has a potential application in the classification of rotten apples and the quantitative detection of spoilage area.
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4.
  • Guo, Zhiming, et al. (författare)
  • Identification of the apple spoilage causative fungi and prediction of the spoilage degree using electronic nose
  • 2021
  • Ingår i: Journal of food process engineering. - : John Wiley & Sons. - 0145-8876 .- 1745-4530. ; 44:10
  • Tidskriftsartikel (refereegranskat)abstract
    • Apple is resistant to storage, but it is susceptible to fungal infection during transportation and storage, resulting in serious losses after harvest. A convenient and nondestructive monitoring method for fungi-inoculated apples was proposed in this research. Four dominant spoilage fungi, including Aspergillus niger, Penicillium expansum, Penicillium chrysogenum, and Alternaria alternata, were inoculated on apple samples. The volatile information of samples with different degrees of spoilage was obtained by gas sensors. The pattern recognition methods were compared to classify the fungi and degrees of spoilage. Back propagation-artificial neural networks (BP-ANN) had the best identification model result with the highest recognition rates of 95.62 and 99.58% for fungi and spoilage degrees, respectively. The variable selection methods were employed, and variables of the gas sensors data for the prediction of apple spoilage area were optimized. The best prediction models of Aspergillus niger, Penicillium expansum, Penicillium chrysogenum, and Alternaria alternata were 0.854, 0.939, 0.909, and 0.918, respectively. The results show that the gas sensors can be used as a nondestructive technique in apple fungi infection evaluation. This proposed fruit spoilage detection technology is expected to provide a reference for the early detection of apple spoilage to promote food quality and safety inspection.Practical ApplicationsThis research used gas sensors to identify the four main spoilage fungi of apples and predicted the spoilage degree of apples using established prediction models. The apple spoilage detection method adopted in this research provides a reference for the early detection of fruit spoilage, which is helpful for apple storage and reduces the economic loss caused by corruption. It is an important measure to help ensure the economic benefits of apple and provide consumers with a large number of high-quality apple products.
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5.
  • Khalifa, Shaden A. M., et al. (författare)
  • Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications
  • 2021
  • Ingår i: Marine Drugs. - : MDPI AG. - 1660-3397. ; 19:5
  • Forskningsöversikt (refereegranskat)abstract
    • Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.
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6.
  • Algethami, Jari S., et al. (författare)
  • Bee Pollen : Clinical Trials and Patent Applications
  • 2022
  • Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 14:14
  • Forskningsöversikt (refereegranskat)abstract
    • Bee pollen is a natural cocktail of floral nectar, flower pollen, enzymes, and salivary secretions produced by honeybees. Bee pollen is one of the bee products most enriched in proteins, polysaccharides, polyphenols, lipids, minerals, and vitamins. It has a significant health and medicinal impact and provides protection against many diseases, including diabetes, cancer, infectious, and cardiovascular. Bee pollen is commonly promoted as a cost-effective functional food. In particular, bee pollen has been applied in clinical trials for allergies and prostate illnesses, with a few investigations on cancer and skin problems. However, it is involved in several patents and health recipes to combat chronic health problems. This review aimed to highlight the clinical trials and patents involving bee pollen for different cases and to present the role of bee pollen as a supplementary food and a potential product in cosmetic applications.
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7.
  • Barimah, Alberta Osei, et al. (författare)
  • SERS nanosensor of 3-aminobenzeneboronic acid labeled Ag for detecting total arsenic in black tea combined with chemometric algorithms
  • 2022
  • Ingår i: Journal of Food Composition and Analysis. - : Elsevier. - 0889-1575 .- 1096-0481. ; 110
  • Tidskriftsartikel (refereegranskat)abstract
    • Detrimental health effects caused by the intake of food contaminated with heavy metals have drawn concerns on effective monitoring using rapid and benign methods. This work presented a novel surface-enhanced Raman scattering (SERS)-based 3-Aminobenzeneboronic acid (ABBA) labeled silver (Ag) nanosensor combined with chemometric algorithms to detect and predict total arsenic (TAs) in acid digested spiked black tea leaves. The sensor recognizes TAs through the partial detachment of ABBA and the chemical formation of As-O-Ag linkage between the TAs and the Ag nanoparticles, which caused a SERS-on signal enhancement effect. SERS combined with competitive adaptive reweighted sampling partial least squares algorithm predicted the TAs with higher correlation coefficient (R-p) results (R-p = 0.9750) and a detection limit of 0.0273 mu g/g. Good recoveries of 83.84-109.53% and the excellent agreement with the inductively coupled plasma-mass spectrometry method (R-2 = 0.999) revealed this developed rapid method could be deployed for fast-tracking of As in food samples.
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8.
  • Cai, Jianrong, et al. (författare)
  • Characterization and recognition of citrus fruit spoilage fungi using Raman scattering spectroscopic imaging
  • 2023
  • Ingår i: Vibrational Spectroscopy. - : Elsevier. - 0924-2031 .- 1873-3697. ; 124
  • Tidskriftsartikel (refereegranskat)abstract
    • Citrus fruit is cultivated globally with a high production every year. However, it is easily infected by spoilage fungi with toxic metabolites. The mechanism of changes in peel tissues of mandarins was revealed by Raman microscopic imaging. Single Raman spectra, multiple Raman spectra and microscopic images of fresh fruits and infected fruits by spoilage fungi were acquired by confocal Raman microscopy. Intensity reduction of Raman characteristic peaks at 1008 cm(-1),1154 cm(-1) and 1525 cm(-1) indicated the content of carotenoids in citrus fruit peels decreased significantly during the periods of fruit spoilage. The distribution and composition of carotenoids in the mandarins were directly illustrated on the visualized microscopic images. Classification algorithms were operated in discrimination on fresh and spoilage samples based on Raman spectra. Classification on fresh fruits and all spoiled fruits were better than that of identification on four levels (fresh samples, slight spoilage samples, medium spoilage samples and serious spoilage samples). Liner discriminant analysis (LDA) of mandarins infected by A. alternate achieved the optimal result, with correlation coefficients of calibration set and prediction set both reaching 100%. The correlation coefficients of samples infected by A. niger achieved 0.925 for calibration set and 0.900 for prediction set. Meanwhile, infected samples by P. italicum reached 0.842 and 0.800. Raman microscopic imaging was confirmed to be a powerful tool to identify compositional changes in fruits caused by spoilage fungi without chemical treatments.
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9.
  • Chen, Ping, et al. (författare)
  • Green reduction of silver nanoparticles for cadmium detection in food using surface-enhanced Raman spectroscopy coupled multivariate calibration
  • 2022
  • Ingår i: Food Chemistry. - : Elsevier. - 0308-8146 .- 1873-7072. ; 394
  • Tidskriftsartikel (refereegranskat)abstract
    • Cadmium (Cd) causes pervasive harm on human health as a poisonous heavy metal. This study proposed a surface-enhanced Raman spectroscopy (SERS) approach using sodium alginate (SA) as green reductant in combination with edge enrichment and chemometrics to build label-free Cd quantitative models. The silver nanoparticles synthesized by SA had good dispersion and enhancement factor (3.48 x 105). The optimal detection system was established by optimizing the concentration of specific molecules (trimercaptotriazine) and the droplet volume of measured liquid. Partial least squares models based on preprocessing methods and selection algorithms were compared. The results indicated that the model combined with first-order derivative preprocessing and competitive adaptive reweighted sampling algorithms achieved the best performance (R-p = 0.9989, RMSEP =1.6225) with the limit of detection of 2.36 x 10(-5) mu g L-1 in food. The SERS approach combined with edge enrichment and chemometrics holds promise for rapid and label-free determination of Cd in food.
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10.
  • El-Garawani, Islam M., et al. (författare)
  • In Vitro Induction of Apoptosis in Isolated Acute Myeloid Leukemia Cells : The Role of Anastatica hierochuntica Methanolic Extract
  • 2022
  • Ingår i: Metabolites. - : MDPI AG. - 2218-1989 .- 2218-1989. ; 12:9
  • Tidskriftsartikel (refereegranskat)abstract
    • Anastatica hierochuntica L. (Cruciferae) has been known in Egyptian folk medicine as a remedy for gastrointestinal disorders, diabetes and heart diseases. Despite the wide usage, A. hierochuntica research provides insufficient data to support its traditional practice. The cytotoxicity of A. hierochuntica methanolic extract was investigated on acute myeloid leukemia blasts (AML) and normal human peripheral leucocytes (NHPL). The phytochemical identification of bioactive compounds using 1H-NMR and LC-ESI-MS was also performed. A. hierochuntica extract caused non-significant cytotoxicity on NHPL, while the cytotoxicity on AML was significant (IC50: 0.38 ± 0.02 μg/mL). The negative expression of p53, upregulation of Caspase-3 and increase in the BAX/BCL-2 ratio were reported at the protein and mRNA levels. The results suggest that A. hierochuntica extract induced AML cell death via the p53-independent mitochondrial intrinsic pathway and further attention should be paid to this plant as a promising natural anticancer agent.
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11.
  • El-Seedi, Hesham, et al. (författare)
  • A Spotlight on the Egyptian Honeybee (Apis mellifera lamarckii)
  • 2022
  • Ingår i: Animals. - : MDPI AG. - 2076-2615. ; 12:20
  • Forskningsöversikt (refereegranskat)abstract
    • Egypt has an ongoing long history with beekeeping, which started with the ancient Egyptians making various reliefs and inscriptions of beekeeping on their tombs and temples. The Egyptian honeybee (Apis mellifera lamarckii) is an authentic Egyptian honeybee subspecies utilized in apiculture. A. m. lamarckii is a distinct honeybee subspecies that has a particular body color, size, and high levels of hygienic behavior. Additionally, it has distinctive characteristics; including the presence of the half-queens, an excessive number of swarm cells, high adaptability to climatic conditions, good resistance to specific bee diseases, including the Varro disorder, and continuous breeding during the whole year despite low productivity, using very little propolis, and tending to abscond readily. This review discusses the history of beekeeping in Egypt and its current situation in addition to its morphology, genetic analysis, and distinctive characters, and the defensive behaviors of native A. m. lamarckii subspecies.
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12.
  • El-Seedi, Hesham, et al. (författare)
  • Antimicrobial Properties of Apis mellifera's Bee Venom
  • 2020
  • Ingår i: Toxins. - : MDPI AG. - 2072-6651. ; 12:7
  • Forskningsöversikt (refereegranskat)abstract
    • Bee venom (BV) is a rich source of secondary metabolites from honeybees (Apis melliferaL.). It contains a variety of bioactive ingredients including peptides, proteins, enzymes, and volatile metabolites. The compounds contribute to the venom's observed biological functions as per its anti-inflammatory and anticancer effects. The antimicrobial action of BV has been shown in vitro and in vivo experiments against bacteria, viruses, and fungi. The synergistic therapeutic interactions of BV with antibiotics has been reported. The synergistic effect contributes to a decrease in the loading and maintenance dosage, a decrease in the side effects of chemotherapy, and a decrease in drug resistance. To our knowledge, there have been no reviews on the impact of BV and its antimicrobial constituents thus far. The purpose of this review is to address the antimicrobial properties of BV and its compounds.
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13.
  • El-Seedi, Hesham, et al. (författare)
  • Bee Stressors from an Immunological Perspective and Strategies to Improve Bee Health
  • 2022
  • Ingår i: Veterinary Sciences. - : MDPI AG. - 2306-7381. ; 9:5
  • Tidskriftsartikel (refereegranskat)abstract
    • Honeybees are the most prevalent insect pollinator species; they pollinate a wide range of crops. Colony collapse disorder (CCD), which is caused by a variety of biotic and abiotic factors, incurs high economic/ecological loss. Despite extensive research to identify and study the various ecological stressors such as microbial infections, exposure to pesticides, loss of habitat, and improper beekeeping practices that are claimed to cause these declines, the deep understanding of the observed losses of these important insects is still missing. Honeybees have an innate immune system, which includes physical barriers and cellular and humeral responses to defend against pathogens and parasites. Exposure to various stressors may affect this system and the health of individual bees and colonies. This review summarizes and discusses the composition of the honeybee immune system and the consequences of exposure to stressors, individually or in combinations, on honeybee immune competence. In addition, we discuss the relationship between bee nutrition and immunity. Nutrition and phytochemicals were highlighted as the factors with a high impact on honeybee immunity.
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14.
  • El-Seedi, Hesham, et al. (författare)
  • Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads
  • 2022
  • Ingår i: Molecules. - : MDPI AG. - 1431-5157 .- 1420-3049. ; 27:19
  • Forskningsöversikt (refereegranskat)abstract
    • Cardiotonic steroids (CTS) were first documented by ancient Egyptians more than 3000 years ago. Cardiotonic steroids are a group of steroid hormones that circulate in the blood of amphibians and toads and can also be extracted from natural products such as plants, herbs, and marines. It is well known that cardiotonic steroids reveal effects against congestive heart failure and atrial fibrillation; therefore, the term cardiotonic has been coined. Cardiotonic steroids are divided into two distinct groups: cardenolides (plant-derived) and bufadienolides (mainly of animal origin). Cardenolides have an unsaturated five-membered lactone ring attached to the steroid nucleus at position 17; bufadienolides have a doubly unsaturated six-membered lactone ring. Cancer is a leading cause of mortality in humans all over the world. In 2040, the global cancer load is expected to be 28.4 million cases, which would be a 47% increase from 2020. Moreover, viruses and inflammations also have a very nebative impact on human health and lead to mortality. In the current review, we focus on the chemistry, antiviral and anti-cancer activities of cardiotonic steroids from the naturally derived (toads) venom to combat these chronic devastating health problems. The databases of different research engines (Google Scholar, PubMed, Science Direct, and Sci-Finder) were screened using different combinations of the following terms: cardiotonic steroids, anti-inflammatory, antiviral, anticancer, toad venom, bufadienolides, and poison chemical composition. Various cardiotonic steroids were isolated from diverse toad species and exhibited superior anti-inflammatory, anticancer, and antiviral activities in in vivo and in vitro models such as marinobufagenin, gammabufotalin, resibufogenin, and bufalin. These steroids are especially difficult to identify. However, several compounds and their bioactivities were identified by using different molecular and biotechnological techniques. Biotechnology is a new tool to fully or partially generate upscaled quantities of natural products, which are otherwise only available at trace amounts in organisms.
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15.
  • El-Seedi, Hesham, et al. (författare)
  • Exploring natural products-based cancer therapeutics derived from egyptian flora
  • 2021
  • Ingår i: Journal of Ethnopharmacology. - : Elsevier BV. - 0378-8741 .- 1872-7573. ; 269
  • Forskningsöversikt (refereegranskat)abstract
    • Ethnopharmacological relevance: Egyptian plants are a rich source of natural molecules, representing considerable biodiversity due to climate variations between the Northern, Southern, Eastern and Western regions of the country. Sinai is considered a precious nature reserves preserving flora, fauna, marine organisms, and historical habitats with ancient origins. Here, traditional medicinal approaches have been used for hundreds of years. Healthy lifestyles, low levels of stress and microbial infections, and a dependence on flora and herbal medicine might in combination explain why the burden of cancer is lower in some regions than in others.Aim of the study: The primary aim of this review is to document the plants and natural products that are used as foods and medicines in Egypt, in general, and in Sinai, in particular, with a focus on those with demonstrated anticancer activities. The documented traditional uses of these plants are described, together with their chemical and pharmacological activities and the reported outcomes of clinical trials against cancer.Materials and methods: A literature search was performed to identify texts describing the medicinal plants that are cultivated and grown in Egypt, including information found in textbooks, published articles, the plant list website (http://www.theplantlist.org/), the medicinal plant names services website (http://mpns.kew.org/mpns-portal/), and web databases (PubMed, Science Direct, and Google Scholar).Results and discussion: We collected data for most of the plants cultivated or grown in Egypt that have been previously investigated for anticancer effects and reported their identified bioactive elements. Several plant species, belonging to different families and associated with 67 bioactive compounds, were investigated as potential anticancer agents (in vitro studies). The most potent cytotoxic activities were identified for the families Asteraceae, Lamiaceae, Chenopodiaceae, Apocynaceae, Asclepiadaceae, Euphorbiaceae, Gramineae, and Liliaceae. The anticancer activities of some species, such as Punica granatum L., Nerium oleander L., Olea europea L., Matricaria chamomilla L., Cassia acutifolia L., Nigella sativa L., Capsicum frutescens L., Withania somnifera L., and Zingiber officinale Roscoe, have been examined in clinical trials. Among the various Egyptian plant habitats, we found that most of these plants are grown in the North Sinai, New-Delta, and Giza Governorates.Conclusion: In this review, we highlight the role played by Egyptian flora in current medicinal therapies and the possibility that these plants may be examined in further studies for the development of anticancer drugs. These bioactive plant extracts form the basis for the isolation of phytochemicals with demonstrated anticancer activities. Some active components derived from these plants have been applied to preclinical and clinical settings, including resveratrol, quercetin, isoquercetin, and rutin.
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16.
  • El-Seedi, Hesham, et al. (författare)
  • Exploring the Therapeutic Potential of Royal Jelly in Metabolic Disorders and Gastrointestinal Diseases
  • 2024
  • Ingår i: Nutrients. - : MDPI. - 2072-6643. ; 16:3
  • Forskningsöversikt (refereegranskat)abstract
    • Metabolic disorders, encompassing diabetes mellitus, cardiovascular diseases, gastrointestinal disorders, etc., pose a substantial global health threat, with rising morbidity and mortality rates. Addressing these disorders is crucial, as conventional drugs often come with high costs and adverse effects. This review explores the potential of royal jelly (RJ), a natural bee product rich in bioactive components, as an alternative strategy for managing metabolic diseases. RJ exhibits diverse therapeutic properties, including antimicrobial, estrogen-like, anti-inflammatory, hypotensive, anticancer, and antioxidant effects. This review's focus is on investigating how RJ and its components impact conditions like diabetes mellitus, cardiovascular disease, and gastrointestinal illnesses. Evidence suggests that RJ serves as a complementary treatment for various health issues, notably demonstrating cholesterol- and glucose-lowering effects in diabetic rats. Specific RJ-derived metabolites, such as 10-hydroxy-2-decenoic acid (10-HDA), also known as the "Queen bee acid," show promise in reducing insulin resistance and hyperglycemia. Recent research highlights RJ's role in modulating immune responses, enhancing anti-inflammatory cytokines, and suppressing key inflammatory mediators. Despite these promising findings, further research is needed to comprehensively understand the mechanisms underlying RJ's therapeutic effects.
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17.
  • El-Seedi, Hesham, et al. (författare)
  • Gelatin nanofibers : Recent insights in synthesis, bio-medical applications and limitations
  • 2023
  • Ingår i: Heliyon. - : Elsevier. - 2405-8440. ; 9:5
  • Forskningsöversikt (refereegranskat)abstract
    • The use of gelatin and gelatin-blend polymers as environmentally safe polymers to synthesis electrospun nanofibers, has caused a revolution in the biomedical field. The development of efficient nanofibers has played a significant role in drug delivery, and for use in advanced scaffolds in regenerative medicine. Gelatin is an exceptional biopolymer, which is highly versatile, despite variations in the processing technology. The electrospinning process is an efficient technique for the manufacture of gelatin electrospun nanofibers (GNFs), as it is simple, efficient, and cost-effective. GNFs have higher porosity with large surface area and biocompatibility, despite that there are some drawbacks. These drawbacks include rapid degradation, poor mechanical strength, and complete dissolution, which limits the use of gelatin electrospun nanofibers in this form for biomedicine. Thus, these fibers need to be cross-linked, in order to control its solubility. This modification caused an improvement in the biological properties of GNFs, which made them suitable candidates for various biomedical applications, such as wound healing, drug delivery, bone regeneration, tubular scaffolding, skin, nerve, kidney, and cardiac tissue engineering. In this review an outline of electrospinning is shown with critical summary of literature evaluated with respect to the various applications of nanofibers-derived gelatin.
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18.
  • El-Seedi, Hesham, et al. (författare)
  • Insights into the Role of Natural Products in the Control of the Honey Bee Gut Parasite (Nosema spp.)
  • 2022
  • Ingår i: Animals. - : MDPI AG. - 2076-2615. ; 12:21
  • Forskningsöversikt (refereegranskat)abstract
    • The honey bee is an important economic insect due to its role in pollinating many agricultural plants. Unfortunately, bees are susceptible to many pathogens, including pests, parasites, bacteria, and viruses, most of which exert a destructive impact on thousands of colonies. The occurrence of resistance to the therapeutic substances used against these organisms is rising, and the residue from these chemicals may accumulate in honey bee products, subsequently affecting the human health. There is current advice to avoid the use of antibiotics, antifungals, antivirals, and other drugs in bees, and therefore, it is necessary to develop alternative strategies for the treatment of bee diseases. In this context, the impact of nosema diseases (nosemosis) on bee health and the negative insults of existing drugs are discussed. Moreover, attempts to combat nosema through the use of alternative compounds, including essential oils, plant extracts, and microbes in vitro and in vivo, are documented.
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19.
  • El-Seedi, Hesham R., et al. (författare)
  • Honeybee products : An updated review of neurological actions
  • 2020
  • Ingår i: Trends in Food Science & Technology. - : Elsevier BV. - 0924-2244 .- 1879-3053. ; 101, s. 17-27
  • Forskningsöversikt (refereegranskat)abstract
    • Background: According to the World Health Organization, two billion people will attain the age of 60 years or more by 2050. Ageing is a major risk factor for a number of neurodegenerative disorders, which currently possess challenge to the global health status, carrying economic and social consequences. Therefore, attention has been dedicated towards the development of neuroprotective agents derived from natural sources. Honeybee products, such as honey, bee pollen, bee bread, propolis, royal jelly, beeswax, and bee venom have been used for therapeutic purposes since ancient times in Egypt, Greece, and China. Despite the emergence of modern medicine, bee products remain clinically relevant owing to their potential as anti-inflammatory, anti-oxidant, and neuroprotective agents.Scope and approach: This review demonstrates the potential of bee products against neurological disorders in the light of the current literature.Key findings and conclusions: Bee products and individual isolated components have enormous therapeutic potential for multiple neurological disorders. The different studies show overall neuroprotective and nerve-tonic characteristics of bee products, mainly due to their anti-oxidant, anti-inflammatory and anti-apoptotic features. However, some limitations such as allergic reactions and the cytotoxic effect of some bee products warrant a special care in its development as drug leads in future studies.
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20.
  • El-Seedi, Hesham R., et al. (författare)
  • Naturally Occurring Xanthones; Biological Activities, Chemical Profiles and In Silico Drug Discovery
  • 2024
  • Ingår i: Current Medicinal Chemistry. - : Bentham Science Publishers Ltd.. - 0929-8673 .- 1875-533X. ; 31:1, s. 62-101
  • Forskningsöversikt (refereegranskat)abstract
    • Xanthones are widely distributed polyphenols, present commonly in higher plants; Garcinia, Calophyllum, Hypericum, Platonia, Mangifera, Gentiana and Swertia. Xanthone tricyclic scaffold is able to interact with different biological targets, showing antibacterial and cytotoxic effects, as well as potent effects against osteoarthritis, malaria, and cardiovascular diseases. Thus, in this article we focused on pharmacological effects, applications and preclinical studies with the recent updates of xanthon & PRIME;s isolated compounds from 2017-2020. We found that only a-mangostin, gambogic acid, and mangiferin, have been subjected to preclinical studies with particular emphasis on the development of anticancer, diabetes, antimicrobial and hepatoprotective therapeutics. Molecular docking calculations were performed to predict the binding affinities of xanthone-derived compounds against SARS-CoV-2 M-pro. According to the results, cratoxanthone E and morellic acid demonstrated promising binding affinities towards SARS-CoV-2 M-pro with docking scores of -11.2 and -11.0 kcal/mol, respectively. Binding features manifested the capability of cratoxanthone E and morellic acid to exhibit nine and five hydrogen bonds, respectively, with the key amino acids of the M-pro active site. In conclusion, cratoxanthone E and morellic acid are promising anti-COVID-19 drug candidates that warrant further detailed in vivo experimental estimation and clinical assessment.
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21.
  • El-Seedi, Hesham, et al. (författare)
  • Saudi Arabian Plants : A Powerful Weapon against a Plethora of Diseases
  • 2022
  • Ingår i: PLANTS. - : MDPI AG. - 2223-7747. ; 11:24
  • Forskningsöversikt (refereegranskat)abstract
    • The kingdom of Saudi Arabia (SA) ranks fifth in Asia in terms of area. It features broad biodiversity, including interesting flora, and was the historical origin of Islam. It is endowed with a large variety of plants, including many herbs, shrubs, and trees. Many of these plants have a long history of use in traditional medicine. The aim of this review is to evaluate the present knowledge on the plants growing in SA regarding their pharmacological and biological activities and the identification of their bioactive compounds to determine which plants could be of interest for further studies. A systematic summary of the plants’ history, distribution, various pharmacological activities, bioactive compounds, and clinical trials are presented in this paper to facilitate future exploration of their therapeutic potential. The literature was obtained from several scientific search engines, including Sci-Finder, PubMed, Web of Science, Google Scholar, Scopus, MDPI, Wiley publications, and Springer Link. Plant names and their synonyms were validated by ‘The Plant List’ on 1 October 2021. SA is home to approximately 2247 plant species, including native and introduced plants that belong to 142 families and 837 genera. It shares the flora of three continents, with many unique features due to its extreme climate and geographical and geological conditions. As plants remain the leading supplier of new therapeutic agents to treat various ailments, Saudi Arabian plants may play a significant role in the fight against cancer, inflammation, and antibiotic-resistant bacteria. To date, 102 active compounds have been identified in plants from different sites in SA. Plants from the western and southwestern regions have been evaluated for various biological activities, including antioxidant, anti-cancer, antimicrobial, antimalarial, anti-inflammatory, anti-glycation, and cytotoxic activities. The aerial parts of the plants, especially the leaves, have yielded most of the bioactive compounds. Most bioactivity tests involve in vitro assessments for the inhibition of the growth of tumour cell lines, and several compounds with in vitro antitumour activity have been reported. More in-depth studies to evaluate the mode of action of the compounds are necessary to pave the way for clinical trials. Ecological and taxonomical studies are needed to evaluate the flora of SA, and a plan for the conservation of wild plants should be implemented, including the management of the protection of endemic plants.
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22.
  • Guo, Zhiming, et al. (författare)
  • Comparative study of Vis/NIR reflectance and transmittance method for on-line detection of strawberry SSC
  • 2024
  • Ingår i: Computers and Electronics in Agriculture. - : Elsevier. - 0168-1699 .- 1872-7107. ; 218
  • Tidskriftsartikel (refereegranskat)abstract
    • Strawberry, as a fragile and vulnerable fruit, the realization of automatic sorting is conducive to improve the intelligent level of strawberry industry and improve the ability of product quality management. An on-line soluble solids content (SSC) detection prototype which can protect the strawberry from mechanical damage was researched and developed. The reflectance and transmittance of visible and near infrared (Vis/NIR) spectra were acquired by the prototype respectively, and the performances of the two spectra on the SSC detection performance of strawberry were compared. Four feature selection algorithms like competitive adaptive reweighted sampling (CARS) ware used for reflectance and transmittance spectra to reduce the spectra complexity, improve the strawberry SSC detection accuracy and optimize the running time of the prototype. The comparison showed that the transmittance spectra can reflect the internal SSC information of strawberry better. Then the results of feature variable selection showed that strawberry transmittance spectra combined with CARS algorithm achieved the best result of SSC prediction, and the prediction correlation coefficient (Rp) was 0.928, the root mean square error of prediction (RMSEP) was 0.412 Brix, and the residual predictive deviation (RPD) value was 2.670. The CARS-PLS model for reflectance spectra also obtained the optimization result in the reflectance group, but its Rp, RMSEP and RPD value was 0.812, 0.587 Brix and 1.670 respectively, which still did not meet the reliability of application. The results demonstrated that the Vis/NIR transmittance spectra have great application potential in strawberry on-line internal quality detection.
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23.
  • Guo, Zhiming, et al. (författare)
  • Detection model transfer of apple soluble solids content based on NIR spectroscopy and deep learning
  • 2023
  • Ingår i: Computers and Electronics in Agriculture. - : Elsevier. - 0168-1699 .- 1872-7107. ; 212
  • Tidskriftsartikel (refereegranskat)abstract
    • Transfer and updating of near infrared (NIR) spectroscopy model of fruit internal quality has become the focus of the industrial application. Internet of Things (IoT) and deep learning (DL) were proposed to perform soluble solids content (SSC) model transfer of apple by NIR. A model transfer platform including low-power handheld internal quality terminal and interacting cloud data system had been constructed. An autoencoder (AE) neural network model was developed for the spectral correction and model transfer. The average time for transmitting detection results to the detection terminal was 1.5 to 2.0 s, with a 100% effective transmission rate. After 5000 iterations of training, the correlation coefficient of different detection terminals improved by 55%, and the root mean square error was reduced by 94%. Selected samples from the second batch of apples detected by the No. 1 detection terminal were added to the original neural network for training. After adding 30 samples, the correlation coefficient increased by 13% and the root mean square error decreased by 90%. The results demonstrated that the AE neural network for spectral correction was effective in eliminating differences between devices and significantly reducing the impact of different detection terminals on the accuracy of NIR detection of SSC in apples. Therefore, the NIR detection model transfer technique could be practically exploited for fruit quality control assessment using different detection terminals.
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24.
  • Guo, Zhiming, et al. (författare)
  • Detection of Heavy Metals in Food and Agricultural Products by Surface-enhanced Raman Spectroscopy
  • 2023
  • Ingår i: Food reviews international (Print). - : Taylor & Francis Group. - 8755-9129 .- 1525-6103. ; 39:3, s. 1440-1461
  • Forskningsöversikt (refereegranskat)abstract
    • Heavy metals accumulating in the human body produce physiological toxicity by interfering with the transport of human proteins and enzymes. Heavy metals detection is significant for food safety assurance. This review focuses on recent advances of heavy metals detection of food and agricultural products by surface-enhanced Raman spectroscopy (SERS). The article covers the SERS basic principles and advances in heavy metals detection, including mercury, arsenic, cadmium, lead, chromium among others. Insights in the potential of combining chemometrics and multivariate analysis with SERS and the exploration of novel SERS substrate platforms from both macro and micro scale are discussed. Finally, future application of SERS in heavy metal detection are prospected. SERS is a powerful and promising technique offering the advantages of simple sampling, rapid data collection and non-invasiveness. The findings of this study can allow better understanding of the heavy metals' occurrence and the possibility of its detection using SERS.
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25.
  • Guo, Zhiming, et al. (författare)
  • Determination of lead in food by surface-enhanced Raman spectroscopy with aptamer regulating gold nanoparticles reduction
  • 2022
  • Ingår i: Food Control. - : Elsevier. - 0956-7135 .- 1873-7129. ; 132
  • Tidskriftsartikel (refereegranskat)abstract
    • Lead ion (Pb2+) is a main heavy metal in food that causes heavy teratogenicity and carcinogenicity. In this study, a rapid and sensitive SERS method for detecting Pb2+ in food was established by aptamer regulating gold nanoparticles reduction. The reduction of HAuCl4 catalyzed by H2O2 is a slow process, and graphene oxide (GO) has excellent catalytic performance for the reaction, which enabled the system to generate gold nanoparticles (AuNPs) with high Raman activity. When the aptamer was introduced into the system, its binding with GO reduced the reaction speed. Upon adding Pb2+ to the system, the aptamer preferentially combined with Pb2+ and GO was released to accelerate the AuNPs production. The concentration of the AuNPs was proportional to the intensity of the added Raman signal molecule 4-MBA and the main Raman peak of Pb2+ appeared at 1595.80 cm(-1). The ability of a novel aptamer (M4-16) and traditional aptamers (T30695, TBA) for Pb2+ determination was compared, and the concentration of the aptamer, HAuCl4 and heating time were optimized to build optimal detection system. After several pretreatment of the original SERS spectroscopy, combined with the comparison of various models, the first-order derivative preprocessing combined with competitive adaptive reweighted sampling model achieved the best performance (R-c = 0.9966, R-p = 0.9972), the detection limit for Pb2+ was 0.1 mu g L-1. The combination of SERS technology and chemometrics is a promising method that could be used to achieve rapid and highly sensitive detection of Pb2+ in food.
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26.
  • Guo, Zhiming, et al. (författare)
  • Determination of perchlorate in tea using SERS with a superhydrophobically treated cysteine modified silver film/polydimethylsiloxane substrate
  • 2021
  • Ingår i: Analytical Methods. - : Royal Society of Chemistry. - 1759-9660 .- 1759-9679. ; 13:13, s. 1625-1634
  • Tidskriftsartikel (refereegranskat)abstract
    • Perchlorate is a new type of persistent pollutant, which interferes with the synthesis and secretion of thyroxine and affects human health. The EU's limit for perchlorate in tea is 750 mu g kg(-1). The surface-enhanced Raman scattering (SERS) technique has the characteristics of a simple pretreatment method, rapid detection, high sensitivity, high specificity and great stability in the detection of perchlorate. This study proposed a novel superhydrophobic SERS substrate, which can be used to detect perchlorate in tea. Firstly, a chemical deposition method was used to deposit a silver film on the surface of a thin layer of polydimethylsiloxane. After drying, the substrate was immersed in 1H,1H,2H,2H-perfluorodecyltriethoxysilane aqueous solution for 15 hours to make the surface of the substrate superhydrophobic. Then cysteine molecules were deposited on the surface of the silver film/polydimethylsiloxane by incubation. The superhydrophobic surface has a unique enrichment effect on the highly diluted solution, and perchlorate has a strong affinity for the amino group of cysteine. We collected the Raman spectra of 9 gradient concentrations (1-100 mu mol L-1) of perchlorate-spiked tea samples on the hydrophobic substrate, and a linear model of the relationship between the SERS spectral intensity and the concentrations of perchlorate in tea was established. This method reached a good limit of detection of 0.0067 mu mol L-1 (0.82 mu g kg(-1)) in tea, which showed that the developed sensor has high sensitivity and could be used as a fast and simple technique for quantitative detection of perchlorate based on SERS technology.
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27.
  • Guo, Zhiming, et al. (författare)
  • Intelligent evaluation of taste constituents and polyphenols-to-amino acids ratio in matcha tea powder using near infrared spectroscopy
  • 2021
  • Ingår i: Food Chemistry. - : Elsevier. - 0308-8146 .- 1873-7072. ; 353
  • Tidskriftsartikel (refereegranskat)abstract
    • Matcha tea is rich in taste and bioactive constituents, quality evaluation of matcha tea is important to ensure flavor and efficacy. Near-infrared spectroscopy (NIR) in combination with variable selection algorithms was proposed as a fast and non-destructive method for the quality evaluation of matcha tea. Total polyphenols (TP), free amino acids (FAA), and polyphenols-to-amino acids ratio (TP/FAA) were assessed as the taste quality indicators. Successive projections algorithm (SPA), genetic algorithm (GA), and simulated annealing (SA) were subsequently developed from the synergy interval partial least squares (SiPLS). The overall results revealed that SiPLS-SPA and SiPLS-SA models combined with NIR exhibited higher predictive capabilities for the effective determination of TP, FAA and TP/FAA with correlation coefficient in the prediction set (Rp) of Rp > 0.97, Rp > 0.98 and Rp > 0.98 respectively. Therefore, this simple and efficient technique could be practically exploited for tea quality control assessment.
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28.
  • Guo, Zhiming, et al. (författare)
  • Label-free surface enhanced Raman scattering spectroscopy for discrimination and detection of dominant apple spoilage fungus
  • 2021
  • Ingår i: International Journal of Food Microbiology. - : Elsevier. - 0168-1605 .- 1879-3460. ; 338
  • Tidskriftsartikel (refereegranskat)abstract
    • Fungal infection is one of the main causes of apple corruption. The main dominant spoilage fungi in causing apple spoilage are storage mainly include Penicillium Paecilomyces paecilomyces (P. paecilomyces), penicillium chrysanthemum (P. chrysogenum), expanded Penicillium expansum (P. expansum), Aspergillus niger (Asp. niger) and Alternaria. In this study, surface-enhanced Raman spectroscopy (SERS) based on gold nanorod (AuNRs) substrate method was developed to collect and examine the Raman fingerprints of dominant apple spoilage fungus spores. Standard normal variable (SNV) was used to pretreat the obtained spectra to improve signal-tonoise ratio. Principal component analysis (PCA) was applied to extract useful spectral information. Linear discriminant analysis (LDA) and non-linear pattern recognition methods including K nearest neighbor (KNN), Support vector machine (SVM) and back propagation artificial neural networks (BPANN) were used to identify fungal species. As the comparison of modeling results shown, the BPANN model established based on the characteristic spectra variables have achieved the satisfactory result with discrimination accuracy of 98.23%; while the PCA-LDA model built using principal component variables achieved the best distinguish result with discrimination accuracy of 98.31%. It was concluded that SERS has the potential to be an inexpensive, rapid and effective method to detect and identify fungal species.
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29.
  • Guo, Zhiming, et al. (författare)
  • Nondestructive monitoring storage quality of apples at different temperatures by near-infrared transmittance spectroscopy
  • 2020
  • Ingår i: Food Science & Nutrition. - : WILEY. - 2048-7177. ; 8:7, s. 3793-3805
  • Tidskriftsartikel (refereegranskat)abstract
    • Apple is the most widely planted fruit in the world and is popular in consumers because of its rich nutritional value. In this study, the portable near-infrared (NIR) transmittance spectroscopy coupled with temperature compensation and chemometric algorithms was applied to detect the storage quality of apples. The postharvest quality of apples including soluble solids content (SSC), vitamin C (VC), titratable acid (TA), and firmness was evaluated, and the portable spectrometer was used to obtain near-infrared transmittance spectra of apples in the wavelength range of 590-1,200 nm. Mixed temperature compensation method (MTC) was used to reduce the influence of temperature on the models and to improve the adaptability of the models. Then, variable selection methods, such as uninformative variable elimination (UVE), competitive adaptive reweighted sampling (CARS), and successive projections algorithm (SPA), were developed to improve the performance of the models by determining characteristic variables and reducing redundancy. Comparing the full spectral models with the models established on variables selected by different variable selection methods, the CARS combined with partial least squares (PLS) showed the best performance with prediction correlation coefficient (R-p) and residual predictive deviation (RPD) values of 0.9236, 2.604 for SSC; 0.8684, 2.002 for TA; 0.8922, 2.087 for VC; and 0.8207, 1.992 for firmness, respectively. Results showed that NIR transmittance spectroscopy was feasible to detect postharvest quality of apples during storage.
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30.
  • Guo, Zhiming, et al. (författare)
  • Novel mesoporous silica surface loaded gold nanocomposites SERS aptasensor for sensitive detection of zearalenone
  • 2023
  • Ingår i: Food Chemistry. - : Elsevier. - 0308-8146 .- 1873-7072. ; 403
  • Tidskriftsartikel (refereegranskat)abstract
    • Mycotoxin contamination is a severe threat to global food security, thus fast and effective detection of myco-toxins is of great significance. Herein, mesoporous silica surface loaded gold nanocomposites (MSN-Rh6G-AuNPs) were prepared as surface-enhanced Raman scattering (SERS) substrate, and the SERS aptasensor (MSN-Rh6G-AuNPs@apt) was further obtained by aptamer functionalization which can realize the quantitative and sensitive detection of zearalenone (ZEN). The small nanogaps between AuNPs made MSN-Rh6G-AuNPs present strong SERS performance under excitation light irradiation, while the aptamer performed the functions of ZEN recognition and Raman signal masking. The acquired results revealed that the SERS intensity at 1508 cm-1 had a good linear relationship with ZEN concentration of 3-200 ng/mL and the limit of detection (LOD) was calculated to be 0.0064 ng/mL. In addition, the designed SERS aptasensor was successfully applied to the detection of ZEN in corn, indicating great potential in practical implications.
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31.
  • Guo, Zhiming, et al. (författare)
  • Quantitative detection of apple watercore and soluble solids content by near infrared transmittance spectroscopy
  • 2020
  • Ingår i: Journal of Food Engineering. - : ELSEVIER SCI LTD. - 0260-8774 .- 1873-5770. ; 279
  • Tidskriftsartikel (refereegranskat)abstract
    • Near-infrared (NIR) spectroscopy as an emerging analytical technique was used for the first time to quantitatively detect the watercore degree and soluble solids content (SSC) in apple. To reduce the data processing time and meet the needs of practical application, the variable selection methods including synergy interval (SI), successive projections algorithm (SPA), genetic algorithm (GA) and competitive adaptive reweighted sampling (CARS) were used to identify the characteristic variables and simplify the models. The spectral variables closely related to the apple bioactive components were used for the establishment of the partial least squares (PLS) models. The predictive correlation coefficient (R-p), root mean square error of prediction (RMSEP), and residual predictive deviation (RPD) were used to estimate the performance of the models. The CARS-PLS models displayed the best prediction performance using 600-1000 nm spectra with R-p, RMSEP, and RPD values of 0.9562, 1.340% and 3.720 for apple watercore degree; 0.9808, 0.327 (o)Bx and 4.845 for apple SSC, respectively. These results demonstrate the potential of the NIR transmittance spectroscopy technology for quantitative detection of SSC and watercore degree in apple fruit.
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32.
  • Guo, Zhiming, et al. (författare)
  • Rapid enrichment detection of patulin and alternariol in apple using surface enhanced Raman spectroscopy with coffee-ring effect
  • 2021
  • Ingår i: Lebensmittel-Wissenschaft + Technologie. - : Elsevier. - 0023-6438 .- 1096-1127. ; 152
  • Tidskriftsartikel (refereegranskat)abstract
    • Patulin (PAT) and alternariol (AOH) are the main mycotoxin contaminants in fruits and their products, which have great toxic effects on human body due to their teratogenicity and carcinogenicity. This study proposed a surface enhanced Raman spectroscopy (SERS) technology combining chemometrics and coffee-ring effect to build high-throughput label-free detection models for PAT and AOH. A stable coffee ring structure was built by optimizing the drying temperature and droplet volume. Comparing the partial least squares (PLS) models grounded on variables selection method, the best performance was obtained by using synergy interval (Si) and genetic algorithm (GA) for PAT (R-c = 0.9905, R-p = 0.9759) and AOH (R-c = 0.9829, R-p = 0.9808), respectively. The limits of detection (LOD) for PAT and AOH were as low as 1 mu g L-1, and the recovery rates were 92.80%-114.83% with relative standard deviation (RSD) = 4.86 for PAT and 82.06%-108.13% with RSD <= 2.28% for AOH. The SERS technology combined with chemometrics and coffee-ring effect holds promise for high-throughput label-free detection of PAT and AOH in fruits and their products.
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33.
  • Guo, Zhiming, et al. (författare)
  • Sensitive determination of Patulin by aptamer functionalized magnetic surface enhanced Raman spectroscopy (SERS) sensor
  • 2023
  • Ingår i: Journal of Food Composition and Analysis. - : Elsevier BV. - 0889-1575 .- 1096-0481. ; 115
  • Tidskriftsartikel (refereegranskat)abstract
    • Food pollution caused by Patulin (PAT) seriously threatens the safety of human diets and has attracted extensive attention. Early and accurate detections of PAT are essential to prevent further toxin spreading and contamination. A surface enhanced Raman scattering (SERS) aptasensor was fabricated by combining a gold-silver core shell structure containing signal molecule (ADANRs) and chitosan modified magnetic nanoparticles (CS-Fe3O4). The modified ADANRs with the complementary chain of the aptamer (SH-cDNA-ADANRs) which were served as the signal probes and the aptamer modified CS-Fe3O4 (NH2-apt-CS-Fe3O4) were served as the capture probes. In addition to the ability to recognize the target PAT, the capture probe also showed a strong enrichment ability under the action of external magnetic force. The intraparticle plasma coupling between the inner gold core and the outer silver shell can greatly improve the SERS activity of the signal molecules. SERS aptasensor was used to collect the spectra of actual apple samples spiked with different PAT content. The minimum detection limit of SERS aptasensor for detecting PAT in actual samples was 0.0384 ng/mL and the recovery rate range was from 96.3% to 108%. In conclusion, the sensitive and specific SERS aptasensor detection of PAT based on aptamer functionalized nanoparticles exhibited great potential for practical application in mycotoxin detection and analysis.
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34.
  • Guo, Zhiming, et al. (författare)
  • Simultaneous quantification of active constituents and antioxidant capability of green tea using NIR spectroscopy coupled with swarm intelligence algorithm
  • 2020
  • Ingår i: Lebensmittel-Wissenschaft + Technologie. - : ELSEVIER. - 0023-6438 .- 1096-1127. ; 129
  • Tidskriftsartikel (refereegranskat)abstract
    • A simple, rapid and low-cost analytical method was employed for simultaneous determination of bioactive constituents and antioxidant capability of green tea. The strategy was based on swarm intelligence algorithms with partial least squares (PLS) such as simulated annealing PLS (SA-PLS), ant colony optimization PLS (ACO-PLS), genetic algorithm PLS (GA-PLS), and synergy interval PLS (Si-PLS) coupled with Near-infrared (NIR) spectroscopy. These algorithms were independently applied to select informative spectral variables and improve the prediction of green tea components. Results showed that NIR combined with SA-PLS and Si-PLS had a strong correlation coefficient with the wet-chemical methods for predicting epigallocatechin gallate (R-p(2) = 0.97); epigallocatechin (R-p(2) = 0.97); epicatechin gallate (R-p(2) = 0.96); epicatechin (R-p(2) = 0.91); catechin (R-p(2) = 0.98); caffeine (R-p(2) = 0.96); theanine (R-p(2) = 0.93); and antioxidant capability (R-p(2) = 0.80) in green tea. Our results revealed the potential utilization of NIR spectroscopy coupled with SA-PLS and Si-PLS algorithms as an effective and robust technique to simultaneously predict active constituents and antioxidant capability of green tea.
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35.
  • Huang, Chujun, et al. (författare)
  • Fusion models for detection of soluble solids content in mandarin by Vis/ NIR transmission spectroscopy combined external factors
  • 2022
  • Ingår i: Infrared physics & technology. - : Elsevier. - 1350-4495 .- 1879-0275. ; 124
  • Tidskriftsartikel (refereegranskat)abstract
    • In the process of acquiring the visible/near infrared (Vis/NIR) spectra of mandarin to predict the soluble solids content (SSC), spectra information is often influenced by the physical property of citrus. Thereupon affects the accuracy and robustness of the SSC prediction model. Calibration models were established by partial least squares (PLS) regression methods based on three spectral measurement orientations (Mandarin calyx-stem axis vertical with stem upward (A); Mandarin calyx-stem axis vertical with stem downward (B); Mandarin calyx-stem axis horizontal (C)) respectively. Novel methods that considering mandarin external factors (diameter, color and peel thickness) were established. The methods were associated with wavelength selection algorithms and their combination with alternative methods to build multivariate regression models. After evaluating the models, the model performance was improved by the external factor inclusion methods, among which the color and diameter united inclusion method combined with ACO-PLS algorithm performed the best, with Rp = 0.987 and RMSEP = 0.19 degrees Brix for its prediction model. This study serves as a reference and theoretical support for determining the influencing factors that affect fruit internal quality determination using near infrared spectroscopy.
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36.
  • Ke, Qian, et al. (författare)
  • Determination of Dicofol in Tea Using Surface-Enhanced Raman Spectroscopy Coupled Chemometrics
  • 2023
  • Ingår i: Molecules. - : MDPI AG. - 1431-5157 .- 1420-3049. ; 28:14
  • Tidskriftsartikel (refereegranskat)abstract
    • Dicofol is a highly toxic residual pesticide in tea, which seriously endangers human health. A method for detecting dicofol in tea by combining stoichiometry with surface-enhanced Raman spectroscopy (SERS) technology was proposed in this study. AuNPs were prepared, and silver shells were grown on the surface of AuNPs to obtain core-shell Au@AgNPs. Then, the core-shell Au@AgNPs were attached to the surface of a PDMS membrane by physical deposition to obtain a Au@AgNPs/PDMS substrate. The limit of detection (LOD) of this substrate for 4-ATP is as low as 0.28 x 10(-11) mol/L, and the LOD of dicofol in tea is 0.32 ng/kg, showing high sensitivity. By comparing the modeling effects of preprocessing and variable selection algorithms, it is concluded that the modeling effect of Savitzky-Golay combined with competitive adaptive reweighted sampling-partial least squares regression is the best (Rp = 0.9964, RPD = 10.6145). SERS technology combined with stoichiometry is expected to rapidly detect dicofol in tea without labels.
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37.
  • Khalifa, Shaden A. M., et al. (författare)
  • Bee Pollen : Current Status and Therapeutic Potential
  • 2021
  • Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 13:6
  • Forskningsöversikt (refereegranskat)abstract
    • Bee pollen is a combination of plant pollen and honeybee secretions and nectar. The Bible and ancient Egyptian texts are documented proof of its use in public health. It is considered a gold mine of nutrition due to its active components that have significant health and medicinal properties. Bee pollen contains bioactive compounds including proteins, amino acids, lipids, carbohydrates, minerals, vitamins, and polyphenols. The vital components of bee pollen enhance different bodily functions and offer protection against many diseases. It is generally marketed as a functional food with affordable and inexpensive prices with promising future industrial potentials. This review highlights the dietary properties of bee pollen and its influence on human health, and its applications in the food industry.
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38.
  • Khalifa, Shaden A. M., et al. (författare)
  • Comprehensive Overview on Multiple Strategies Fighting COVID-19
  • 2020
  • Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 17:16
  • Forskningsöversikt (refereegranskat)abstract
    • Lately, myriad of novel viruses have emerged causing epidemics such as SARS, MERS, and SARS-CoV-2, leading to high mortality rates worldwide. Thus, these viruses represented a challenging threat to mankind, especially considering the miniscule data available at our disposal regarding these novel viruses. The entire world established coordinative relations in research projects regarding drug and vaccine development on the external range, whereas on the internal range, all countries declared it an emergency case through imposing different restrictions related to their border control, large gatherings, school attendance, and most social activities. Pandemic combating plans prioritized all sectors including normal people, medical staff politicians, and scientists collectively shouldered the burden. Through planning and learning the previous lessons from SARS and MERS, healthcare systems could succeed in combating the viral spread and implications of these new pandemics. Different management strategies including social distance, social awareness and isolation represented successful ways to slow down the spread of the pandemic. Furthermore, pre-preparedness of some countries for emergencies is crucial to minimize the consequences of the crisis.
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39.
  • Khalifa, Shaden A. M., et al. (författare)
  • Frankincense of Boswellia sacra: Traditional and modern applied uses, pharmacological activities, and clinical trials
  • 2023
  • Ingår i: Industrial crops and products (Print). - : Elsevier. - 0926-6690 .- 1872-633X. ; 203
  • Tidskriftsartikel (refereegranskat)abstract
    • Since Boswellia sacra (Burseraceae) was studied in the 19th century, it has been known for its economic and cultural values. It is cultivated mainly in the southwest regions of Oman and some regions of Yemen, and is a natural source of frankincense, "Luban" in Arabic, around the world. Frankincense, the aromatic resin of B. sacra, is used widely both for traditional purposes and for the treatment of various ailments; e.g., dental infections, tumors, dysentery, vomiting, and fevers. Recently, many reports provided evidence for the potential biological activities of B. sacra, its synonym Boswellia carteri, and their constituent chemical compounds. These activities include cytotoxic, anti-inflammatory, antimicrobial, anti-diabetes, immunomodulatory, and anticoagulant effects. B. sacra was also tested for effects against gastric, hepatic, neurological, and skin disorders in vitro and in vivo. Clinical trials revealed good effects against carcinomas and gliomas, as well as against bladder and brain tumors. Its uses as a plant-based agent in nanotechnology displayed promising results. More efforts should be directed to further investigate these safe, plant-based bio-preservatives, and best practices should be outlined to protect these trees from extinction.
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40.
  • Khalifa, Shaden A. M., et al. (författare)
  • Screening for natural and derived bio-active compounds in preclinical and clinical studies : One of the frontlines of fighting the coronaviruses pandemic
  • 2021
  • Ingår i: Phytomedicine. - : Elsevier BV. - 0944-7113 .- 1618-095X. ; 85
  • Forskningsöversikt (refereegranskat)abstract
    • Background: Starting December 2019, mankind faced an unprecedented enemy, the COVID-19 virus. The world convened in international efforts, experiences and technologies in order to fight the emerging pandemic. Isolation, hygiene measure, diagnosis, and treatment are the most efficient ways of prevention and intervention nowadays. The health organizations and global care systems screened the available resources and offered recommendations of approved and proposed medications. However, the search for a specific selective therapy or vaccine against COVID-19 remains a challenge.Methods: A literature search was performed for the screening of natural and derived bio-active compounds which showed potent antiviral activity against coronaviruses using published articles, patents, clinical trials website (https://clinicaltrials.gov/) and web databases (PubMed, SCI Finder, Science Direct, and Google Scholar).Results: Through the screening for natural products with antiviral activities against different types of the human coronavirus, extracts of Lycoris radiata (L'Her.), Gentiana scabra Bunge, Dioscorea batatas Decne., Cassia tora L., Taxillus chinensis (DC.), Cibotium barometz L. and Echinacea purpurea L. showed a promising effect against SARSCoV. Out of the listed compound Lycorine, emetine dihydrochloride hydrate, pristimerin, harmine, conessine, berbamine, 4'-hydroxychalcone, papaverine, mycophenolic acid, mycophenolate mofetil, monensin sodium, cycloheximide, oligomycin and valinomycin show potent activity against human coronaviruses. Additionally, it is worth noting that some compounds have already moved into clinical trials for their activity against COVID-19 including fingolimod, methylprednisolone, chloroquine, tetrandrine and tocilizumab.Conclusion: Natural compounds and their derivatives could be used for developing potent therapeutics with significant activity against SARS-COV-2, providing a promising frontline in the fighting against COVID-19.
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41.
  • Salama, Suzy, et al. (författare)
  • Royal Jelly : Beneficial Properties and Synergistic Effects with Chemotherapeutic Drugs with Particular Emphasis in Anticancer Strategies
  • 2022
  • Ingår i: Nutrients. - : MDPI. - 2072-6643. ; 14:19
  • Forskningsöversikt (refereegranskat)abstract
    • Cancer is one of the major causes of death globally. Currently, various methods are used to treat cancer, including radiotherapy, surgery, and chemotherapy, all of which have serious adverse effects. A healthy lifestyle, especially a nutritional diet, plays a critical role in the treatment and prevention of many disorders, including cancer. The above notion, plus the trend in going back to nature, encourages consumers and the food industry to invest more in food products and to find potential candidates that can maintain human health. One of these agents, and a very notable food agent, is royal jelly (RJ), known to be produced by the hypopharyngeal and mandibular salivary glands of young nurse honeybees. RJ contains bioactive substances, such as carbohydrates, protein, lipids, peptides, mineral salts and polyphenols which contribute to the appreciated biological and pharmacological activities. Antioxidant, anticancer, anti-inflammatory, antidiabetic, and antibacterial impacts are among the well-recognized benefits. The combination of RJ or its constituents with anticancer drugs has synergistic effects on cancer disorders, enhancing the drug's effectiveness or reducing its side effects. The purpose of the present review is to emphasize the possible interactions between chemotherapy and RJ, or its components, in treating cancer illnesses.
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42.
  • Wang, Junyi, et al. (författare)
  • General model of multi-quality detection for apple from different origins by Vis/NIR transmittance spectroscopy
  • 2022
  • Ingår i: JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION. - : Springer Nature. - 2193-4126 .- 2193-4134. ; 16:4, s. 2582-2595
  • Tidskriftsartikel (refereegranskat)abstract
    • Visible Near-infrared (Vis/NIR) spectroscopy is widely used to evaluate fruit quality due to its fast and non-destructive advantage, but the diffuse reflectance mode only obtains information of the surface, and the traditional model is difficult to meet multi-origin detection in practical applications. A portable Vis/NIR transmittance prototype was designed and developed to acquire Vis/NIR spectra of apple samples from different origins. Soluble solids content (SSC), firmness, pH and vitamin C (VC) content were determined as the internal quality parameter. The partial least square (PLS) model was established by optimizing the best from different spectral preprocessing and feature selection algorithms. The results showed that the competitive adaptive weighted PLS (CARS-PLS) achieved the best prediction performance, with correlation coefficient of prediction (R-p), and root mean square error of prediction (RMSEP) values of 0.940, 0.542 degrees Brix for SSC, 0.789, 7.018 N for firmness, 0.698, 0.119 for pH, and 0.804, 10.363 mg kg(-1) for VC content, respectively. The general model of CARS-PLS was verified by the independent prediction sets from 7 origins. The establishment of general models expanded the prediction range, improved the prediction stability of models between different cultivars, and reduced the complexity of the models through appropriate preprocessing and feature variable selection methods. The development of the general model of different origins and cultivars for predicting the internal quality of apple has a great potential application using Vis/NIR transmittance spectroscopy.
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43.
  • Wu, Xinchen, et al. (författare)
  • Core-satellite nanoassembly system with aptamer-conjugated Au@Ag nanoparticles for SERS detection of patulin in apples
  • 2024
  • Ingår i: Food Control. - : Elsevier. - 0956-7135 .- 1873-7129. ; 159
  • Tidskriftsartikel (refereegranskat)abstract
    • Patulin (PAT), a major contaminant in apples, poses a huge threat to human health as well as the economic sector. There is an urgent need to develop a sensitive, selective, and fast-responsive method to detect PAT in apples. However, one of the main challenges is overcoming the interferences of complex food matrices. In this study, we developed a highly sensitive competitive SERS sensor based on plasmonic nanoparticles modified by aptamers. The study utilized the formation of nanocomposites through aptamer-modified Au@Ag nanoparticles (NPs) and gold nano-stars (AuNSs) to induce high-intensity Raman signals from the SERS tag. Subsequently, in the presence of PAT, the nanocomposites underwent decomposition, evident through the significant decrease in SERS intensity. According to the standard curve established in this study, the detection limit was 0.0281 ng/mL. The competitive sensor was applied to spiked apple fruit and juice samples, indicating a recovery rate ranging from 91.98% to 102.94%. The excellent analytical performances and high sensitivity observed suggest the potential of the plasmonic nanocomposite sensing strategy in detecting PAT in real matrices.
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44.
  • Xue, Shanshan, et al. (författare)
  • A film-like SERS aptasensor for sensitive detection of patulin based on GO@Au nanosheets
  • 2024
  • Ingår i: Food Chemistry. - : Elsevier. - 0308-8146 .- 1873-7072. ; 441
  • Tidskriftsartikel (refereegranskat)abstract
    • Patulin (PAT) commonly contaminates fruits, posing a significant risk to human health. Therefore, a highly effective and sensitive approach in identifying PAT is warranted. Herein, a SERS aptasensor was constructed based on a two-dimensional film -like structure. GO@Au nanosheets modified with SH-cDNA were employed as capture probes, while core -shell Au@Ag nanoparticles modified with 4 -MBA and SH-Apt were utilized as signal probes. Through the interaction between capture probes and signal probes, adjustable hotspots were formed, yielding a significant Raman signal. During sensing, the GO@Au-cDNA competitively attached to Au@AgNPs@MBA-Apt, resulting in an inverse relationship between PAT levels and SERS intensity. The acquired results exhibited linear responses to PAT within the range of 1-70 ng/mL, with a calculated limit of detection of 0.46 ng/mL. In addition, the SERS aptasensor exhibited satisfactory recoveries in apple samples, which aligned closely with HPLC. With high sensitivity and specificity, this method holds significant potential for PAT detection.
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45.
  • Yin, Limei, et al. (författare)
  • Development of a Sensitive SERS Method for Label-Free Detection of Hexavalent Chromium in Tea Using Carbimazole Redox Reaction
  • 2023
  • Ingår i: Foods. - : MDPI AG. - 2304-8158. ; 12:14
  • Tidskriftsartikel (refereegranskat)abstract
    • Tea plants absorb chromium-contaminated soil and water and accumulate in tea leaves. Hexavalent chromium (Cr6+) is a very toxic heavy metal; excessive intake of tea containing Cr6+ can cause serious harm to human health. A reliable and sensitive surface-enhanced Raman spectroscopy (SERS) method was developed using Au@Ag nanoparticles as an enhanced substrate for the determination of Cr6+ in tea. The Au@AgNPs coated with carbimazole showed a highly selective reaction to Cr6+ in tea samples through a redox reaction between Cr6+ and carbimazole. The Cr6+ in the contaminated tea sample reacted with methimazole-the hydrolysate of carbimazole-to form disulfide, which led to the decrease in the Raman intensity of the peak at 595 cm(-1). The logarithm of the concentration of Cr6+ has a linear relationship with the Raman intensity at the characteristic peak and showed a limit of detection of 0.945 mg/kg for the tea sample. The carbimazole functionalized Au@AgNPs showed high selectivity in analyzing Cr6+ in tea samples, even in the presence of other metal ions. The SERS detection technique established in this study also showed comparable results with the standard ICP-MS method, indicating the applicability of the established technique in practical applications.
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46.
  • Yin, Limei, et al. (författare)
  • Dual-layers Raman reporter-tagged Au@Ag combined with core-satellite assemblies for SERS detection of Zearalenone
  • 2023
  • Ingår i: Food Chemistry. - : Elsevier BV. - 0308-8146 .- 1873-7072. ; 429
  • Tidskriftsartikel (refereegranskat)abstract
    • Zearalenone (ZEN) is a prevalent mycotoxin identified in corn. A SERS-based immunosensor by constructing core-satellite assemblies was developed for ZEN detection. ZEN monoclonal antibody modified gold nanostars (AuNSs) were fabricated as the capture probe (core). The Raman signal probes (satellites) utilized ZEN antigen linked to the core-shell structures loaded with two layers of Raman reporter molecules (AuMBA@AgMBANPs). The coupling between AuNSs and AuMBA@AgMBANPs can produce a poweful electromagnetic field, thus considerably amplifying the Raman signal. The detection range of ZEN for corn samples under the optimal conditions was 5 -400 & mu;g/kg with a LOD of 3 & mu;g/kg, which completely satisfying the requirement of maximum residual level (60 & mu;g/kg). Moreover, the proposed SERS method was consistent with the HPLC-FLD method for the detection of ZEN in naturally contaminated corn samples (90.58% -105.29%). Conclusively, fabricated immunosensor with exceptional sensitivity and specificity broaden the application of SERS in mycotoxin detection.
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47.
  • Yin, Limei, et al. (författare)
  • Rapid and sensitive detection of zearalenone in corn using SERS-based lateral flow immunosensor
  • 2022
  • Ingår i: Food Chemistry. - : Elsevier. - 0308-8146 .- 1873-7072. ; 396
  • Tidskriftsartikel (refereegranskat)abstract
    • Zearalenone (ZEN) is a universal mycotoxin contaminant in corn and its products. A surface-enhanced Raman scattering (SERS) based test strip was proposed for the detection of ZEN, which had the advantages of simplicity, rapidity, and high sensitivity. Core-shell Au@AgNPs with embedded reporter molecules (4-MBA) were synthesized as SERS nanoprobe, which exhibited excellent SERS signals and high stability. The detection range of ZEN for corn samples was 10–1000 μg/kg with the limit of detection (LOD) of 3.6 μg/kg, which is far below the recommended tolerable level (60 μg/kg). More importantly, the SERS method was verified by HPLC in the application on corn samples contaminated with ZEN, and the coincidence rates were in the range of 86.06%–111.23%, suggesting a high accuracy of the SERS assay. Therefore, the SERS-based test strip with an analysis time of less than 15 min is a promising tool for accurate and rapid detection of ZEN-field contamination.
  •  
48.
  • Yin, Limei, et al. (författare)
  • Spoilage Monitoring and Early Warning for Apples in Storage Using Gas Sensors and Chemometrics
  • 2023
  • Ingår i: Foods. - : MDPI AG. - 2304-8158. ; 12:15
  • Tidskriftsartikel (refereegranskat)abstract
    • In the process of storage and cold chain logistics, apples are prone to physical bumps or microbial infection, which easily leads to spoilage in the micro-environment, resulting in widespread infection and serious post-harvest economic losses. Thus, development of methods for monitoring apple spoilage and providing early warning of spoilage has become the focus for post-harvest loss reduction. Thus, in this study, a spoilage monitoring and early warning system was developed by measuring volatile component production during apple spoilage combined with chemometric analysis. An apple spoilage monitoring prototype was designed to include a gas monitoring array capable of measuring volatile organic compounds, such as CO2, O-2 and C2H4, integrated with the temperature and humidity sensor. The sensor information from a simulated apple warehouse was obtained by the prototype, and a multi-factor fusion early warning model of apple spoilage was established based on various modeling methods. Simulated annealing-partial least squares (SA-PLS) was the optimal model with the correlation coefficient of prediction set (R-p) and root mean square error of prediction (RMSEP) of 0.936 and 0.828, respectively. The real-time evaluation of the spoilage was successfully obtained by loading an optimal monitoring and warning model into the microcontroller. An apple remote monitoring and early warning platform was built to visualize the apple warehouse's sensors data and spoilage level. The results demonstrated that the prototype based on characteristic gas sensor array could effectively monitor and warn apple spoilage.
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49.
  • Yosri, Nermeen, et al. (författare)
  • Anti-Viral and Immunomodulatory Properties of Propolis : Chemical Diversity, Pharmacological Properties, Preclinical and Clinical Applications, and In Silico Potential against SARS-CoV-2
  • 2021
  • Ingår i: Foods. - : MDPI AG. - 2304-8158. ; 10:8
  • Forskningsöversikt (refereegranskat)abstract
    • Propolis, a resin produced by honeybees, has long been used as a dietary supplement and folk remedy, and more recent preclinical investigations have demonstrated a large spectrum of potential therapeutic bioactivities, including antioxidant, antibacterial, anti-inflammatory, neuroprotective, immunomodulatory, anticancer, and antiviral properties. As an antiviral agent, propolis and various constituents have shown promising preclinical efficacy against adenoviruses, influenza viruses, respiratory tract viruses, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), human immunodeficiency virus (HIV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 300 chemical components have been identified in propolis, including terpenes, flavonoids, and phenolic acids, with the specific constituent profile varying widely according to geographic origin and regional flora. Propolis and its constituents have demonstrated potential efficacy against SARS-CoV-2 by modulating multiple pathogenic and antiviral pathways. Molecular docking studies have demonstrated high binding affinities of propolis derivatives to multiple SARS-CoV-2 proteins, including 3C-like protease (3CL(pro)), papain-like protease (PLpro), RNA-dependent RNA polymerase (RdRp), the receptor-binding domain (RBD) of the spike protein (S-protein), and helicase (NSP13), as well as to the viral target angiotensin-converting enzyme 2 (ACE2). Among these compounds, retusapurpurin A has shown high affinity to 3CL(pro) (Delta G = -9.4 kcal/mol), RdRp (-7.5), RBD (-7.2), NSP13 (-9.4), and ACE2 (-10.4) and potent inhibition of viral entry by forming hydrogen bonds with amino acid residues within viral and human target proteins. In addition, propolis-derived baccharin demonstrated even higher binding affinity towards PLpro (-8.2 kcal/mol). Measures of drug-likeness parameters, including metabolism, distribution, absorption, excretion, and toxicity (ADMET) characteristics, also support the potential of propolis as an effective agent to combat COVID-19.
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50.
  • Yosri, Nermeen, et al. (författare)
  • Arctium lappa (Burdock) : Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine
  • 2023
  • Ingår i: Biomedicine and Pharmacotherapy. - : Elsevier. - 0753-3322 .- 1950-6007. ; 158
  • Forskningsöversikt (refereegranskat)abstract
    • Arctium lappa L. is a medicinal edible homologous plant, commonly known as burdock or bardana, which belongs to the Asteraceae family. It is widely distributed throughout Northern Asia, Europe, and North America and has been utilized for hundreds of years. The roots, fruits, seeds, and leaves of A. lappa have been extensively used in traditional Chinese Medicine (TCM). A. lappa has attracted a great deal of attention due to its possession of highly recognized bioactive metabolites with significant therapeutic potential. Numerous pharmacological effects have been demonstrated in vitro and in vivo by A. lappa and its bioactive metabolites, including antimicrobial, antiobesity, antioxidant, anticancer, anti-inflammatory, anti-diabetic, anti-allergic, antiviral, gastroprotective, hepatoprotective, and neuroprotective activities. Additionally, A. lappa has demonstrated considerable clinical efficacies and valuable applications in nanomedicine. Collectively, this review covers the properties of A. lappa and its bioactive metabolites, ethnopharmacology aspects, pharmacological effects, clinical trials, and applications in the field of nanomedicine. Hence, a significant attention should be paid to clinical trials and industrial applications of this plant with particular emphasis, on drug discovery and nanotechnology.
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