| 1. |
- Baron, V, et al.
(författare)
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The influence of iron substitution on the magnetic properties of hausmannite, Mn2+(Fe,Mn)(2)(3+)O-4
- 1998
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Ingår i: AMERICAN MINERALOGIST. - : MINERALOGICAL SOC AMER. - 0003-004X. ; 83:7-8, s. 786-793
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The occurrence of hausmannite with an apparent Curie temperature close to 750 K, instead of 41.8 K was recently described from hydrothermally altered manganese ore from the Kalahari manganese field, South Africa. The unusual magnetic properties were relat
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| 2. |
- Chelgani, Saeed Chehreh, et al.
(författare)
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A Review of Graphite Beneficiation Techniques
- 2016
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Ingår i: Mineral Processing and Extractive Metallurgy Review. - : Taylor & Francis. - 0882-7508 .- 1547-7401. ; 37:1, s. 58-68
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Tidskriftsartikel (refereegranskat)abstract
- Graphite as the most common polymorph of naturally occurring crystalline carbon is required for many different applications such as batteries, refractories, electrical products, and pencils. Graphite resources are currently being subjected to intensive exploration to help meet rapidly growing global demand – and graphite has made it onto the list of critical raw materials as issued by the European Union. Graphite ore is mostly beneficiated using flotation separation techniques. The increasing demand for high-grade graphite products with up to 99.99% carbon has resulted in the development of various approaches to remove impurities even to parts per million range. This paper considers separation and purification techniques that are currently employed for graphite mineral beneficiation, and identifies areas in need of further research.
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| 3. |
- Kern, Marius, et al.
(författare)
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Integration of X-ray radiography and automated mineralogy data for the optimization of ore sorting routines
- 2022
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Ingår i: Minerals Engineering. - : Elsevier. - 0892-6875 .- 1872-9444. ; 186
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Tidskriftsartikel (refereegranskat)abstract
- X-ray transmission sorting is arguably the most successful ore sorting technique used in the mining industry today. In order to establish the suitability of X-ray transmission sorting for a specific ore deposit or raw material type, the current state of the art involves time-consuming and costly empirical testing. In this paper, we show how the success of X-ray transmission sorting can be reliably predicted based on X-ray radiographs that are quick and inexpensive to obtain for a large number of samples. We document this novel approach using a large suite of samples of scheelite ores from the Mittersill deposit in Austria. Using only the X-ray radiographs at a spatial resolution of 0.12 mm we quantify the volume of high-density scheelite at different spatial resolution. The results are compared to and validated by data obtained by computer tomography and scanning electron microscopy-based image analysis. The X-ray radiograph data set is then down sampled to spatial resolutions of 0.8 mm, 3.2 mm, 12 mm and 24 mm in order to gauge the optimum spatial resolution prior to any empirical testing. Upgrading curves can be calculated, and in combination with quantitative data obtained by complementary analytical methods, the mineralogical and chemical composition of concentrate and waste can be predicted. The workflow can be transferred without any problems to many other ore types with a significant density difference between ore mineral(s) and gangue minerals.
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| 4. |
- Spassova, I, et al.
(författare)
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Clinical and molecular characteristics associated with response to therapeutic PD-1/PD-L1 inhibition in advanced Merkel cell carcinoma
- 2022
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Ingår i: Journal for immunotherapy of cancer. - : BMJ. - 2051-1426. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Based on its viral-associated or UV-associated carcinogenesis, Merkel cell carcinoma (MCC) is a highly immunogenic skin cancer. Thus, clinically evident MCC occurs either in immuno-compromised patients or based on tumor-intrinsic immune escape mechanisms. This notion may explain that although advanced MCC can be effectively restrained by treatment with PD-1/PD-L1 immune checkpoint inhibitors (ICIs), a considerable percentage of patients does not benefit from ICI therapy. Biomarkers predicting ICI treatment response are currently not available.MethodsThe present multicenter retrospective study investigated clinical and molecular characteristics in 114 patients with unresectable MCC at baseline before treatment with ICI for their association with therapy response (best overall response, BOR). In a subset of 21 patients, pretreatment tumor tissue was analyzed for activation, differentiation and spatial distribution of tumor infiltrating lymphocytes (TIL).ResultsOf the 114 patients, n=74 (65%) achieved disease control (BOR=complete response/partial response/stable disease) on ICI. A Bayesian cumulative ordinal regression model revealed absence of immunosuppression and a limited number of tumor-involved organ systems was highly associated with a favorable therapy response. Unimpaired overall performance status, high age, normal serum lactate dehydrogenase and normal serum C reactive protein were moderately associated with disease control. While neither tumor Merkel cell polyomavirus nor tumor PD-L1 status showed a correlation with therapy response, treatment with anti-PD-1 antibodies was associated with a higher probability of disease control than treatment with anti-PD-L1 antibodies. Multiplexed immunohistochemistry demonstrated the predominance of CD8+ effector and central memory T cells (TCM) in close proximity to tumor cells in patients with a favorable therapy response.ConclusionsOur findings indicate the absence of immunosuppression, a limited number of tumor-affected organs, and a predominance of CD8+ TCM among TIL, as baseline parameters associated with a favorable response to PD-1/PD-L1 ICI therapy of advanced MCC. These factors should be considered when making treatment decisions in MCC patients.
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