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- Lundgren, Pia, et al.
(författare)
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High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born < 24 gestational weeks
- 2021
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Ingår i: BMJ Open Ophthalmology. - : BMJ Publishing Group Ltd. - 2397-3269. ; 6:1
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Tidskriftsartikel (refereegranskat)abstract
- Objective Prematurity is a major risk factor for retinopathy of prematurity (ROP). We aimed to elucidate ROP prevalence, treatment and retreatment in infants born before 24 gestational age (GA) weeks in a Swedish cohort. Methods and analysis Infants with completed ROP screening, born at <24 GA weeks, 2007-2018 in Sweden were included. Data of GA, birth weight (BW), sex, neonatal morbidities, maximal ROP stage, aggressive posterior ROP (APROP), ROP treatments, treatment modality and treatment centre were retrieved. Results In total, 399 infants, with a mean GA of 23.2 weeks (range 21.9-23.9) and a mean BW of 567 g (range 340-874), were included. ROP was detected in 365 (91.5%) infants, 173 (43.4%) were treated for ROP and 68 of 173 (39.3%) were treated more than once. As the first treatment, 142 (82.0%) received laser and 29 (16.1%) received intravitreal injection of antivascular endothelial growth factor (anti-VEGF). Retreatment was performed after first laser in 46 of 142 (32.4%) and in 20 of 29 (69.0%) after first anti-VEGF treatment. Retreatment rate was not associated with GA, BW or sex but with APROP, treatment method (anti-VEGF) and treatment centre where the laser was performed (p<0.001). Twenty eyes progressed to retinal detachment, and two infants developed unilateral endophthalmitis after anti-VEGF treatment. Conclusion Infants, born at <24 weeks GA, had high rates of treatment-warranting ROP and retreatments. Treatment centre highly influenced the retreatment rate after laser indicating that laser treatment could be improved in some settings.
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| 2. |
- Pivodic, Aldina, 1978, et al.
(författare)
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Development and validation of a new clinical decision support tool to optimize screening for retinopathy of prematurity
- 2022
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Ingår i: British Journal of Ophthalmology. - : BMJ Publishing Group Ltd. - 0007-1161 .- 1468-2079. ; 106:11, s. 1573-1580
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND/AIMS: Prematurely born infants undergo costly, stressful eye examinations to uncover the small fraction with retinopathy of prematurity (ROP) that needs treatment to prevent blindness. The aim was to develop a prediction tool (DIGIROP-Screen) with 100% sensitivity and high specificity to safely reduce screening of those infants not needing treatment. DIGIROP-Screen was compared with four other ROP models based on longitudinal weights.METHODS: Data, including infants born at 24-30 weeks of gestational age (GA), for DIGIROP-Screen development (DevGroup, N=6991) originate from the Swedish National Registry for ROP. Three international cohorts comprised the external validation groups (ValGroups, N=1241). Multivariable logistic regressions, over postnatal ages (PNAs) 6-14 weeks, were validated. Predictors were birth characteristics, status and age at first diagnosed ROP and essential interactions.RESULTS: ROP treatment was required in 287 (4.1%)/6991 infants in DevGroup and 49 (3.9%)/1241 in ValGroups. To allow 100% sensitivity in DevGroup, specificity at birth was 53.1% and cumulatively 60.5% at PNA 8 weeks. Applying the same cut-offs in ValGroups, specificities were similar (46.3% and 53.5%). One infant with severe malformations in ValGroups was incorrectly classified as not needing screening. For all other infants, at PNA 6-14 weeks, sensitivity was 100%. In other published models, sensitivity ranged from 88.5% to 100% and specificity ranged from 9.6% to 45.2%.CONCLUSIONS: DIGIROP-Screen, a clinical decision support tool using readily available birth and ROP screening data for infants born GA 24-30 weeks, in the European and North American populations tested can safely identify infants not needing ROP screening. DIGIROP-Screen had equal or higher sensitivity and specificity compared with other models. DIGIROP-Screen should be tested in any new cohort for validation and if not validated it can be modified using the same statistical approaches applied to a specific clinical setting.
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| 4. |
- Richter, Hans, et al.
(författare)
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Riktlinjer för synergonomi - belysning och synförhållanden på arbetsplatsen
- 2021
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Rapport (populärvet., debatt m.m.)abstract
- Belysningsområdet befinner sig i inledningen av ett omfattande teknikskifte. Ett teknikskifte som bland annat påverkar de synergonomiskaförhållandena i arbetet. Den nya LED-tekniken gör det möjligt att utformabelysningsanläggningar som minskar energibehov och kostnader, samtidigt som bättre och trivsammare arbetsmiljö som främjar hälsa ochvälbefinnande kan skapas. Men ny teknik innebär också nya utmaningar.Felaktigt utformade LED-installationer kan försämra arbetsmiljön, exempelvis till följd av bländning. För att säkerställa en god arbetsmiljö behöverde visuella miljöerna utformas med utgångspunkt från den kunskap somfinns. Dessa riktlinjer lyfter fram sådan kunskap och visar på hur arbetsplatser och organisationer med stöd av företagshälsovård och andra experter kan och bör arbeta för att skapa en god synergonomisk arbetsmiljö.
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| 5. |
- Ödman, Anders, et al.
(författare)
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Tankar kring två ringhandtag från Uppåkra
- 2003
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Ingår i: Flera fynd i Centrum - Materialstudier i och kring Uppåkra (Acta archaeologica lundensia series in 8. no.45). - 0065-0994. ; Uppåkrastudier 9, s. 89-96
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Two ring handles were found in Uppåkra by the archaeological excavations. The first one was found by metal detector survey near the church of Uppåkra and was assumed to have beonged to the medieval Church that in the 19:th cent. was replaced by the modern church. The other ring handle was found by in one of the foure large postholes in the cult house and was dated to 500-600 A.D. The ring handles comes from two shrines representing two religions. The christian ring handle has three knobs representing the Holy Trinity. The pre-Christian ring handle has four knobs. A guess is that they symbolize four gods - perhaps represented in the four big postholes of the cult house
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