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Numrering	Referens	Omslagsbild	Hitta
1.	Albin, Cecilia, 1962-, et al. (författare) International Negotiation : Theories and Practices 2009. - 7 Ingår i: Peace, Justice, and Security Studies. - Boulder : Lynne Rienner Publisher. - 9781588266255 ; , s. 321-327 Bokkapitel (populärvet., debatt m.m.)
2.	Almroth, Henrik, et al. (författare) Atorvastatin and persistent atrial fibrillation following cardioversion : a randomized placebo-controlled multicentre study 2009 Ingår i: European Heart Journal. - Philadelphia : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 30:7, s. 827-833 Tidskriftsartikel (refereegranskat)abstract AIMS: To evaluate the effect of atorvastatin in achieving stable sinus rhythm (SR) 30 days after electrical cardioversion (CV) in patients with persistent atrial fibrillation (AF). METHODS AND RESULTS: The study included 234 patients. The patients were randomized to treatment with atorvastatin 80 mg daily (n = 118) or placebo (n = 116) in a prospective, double-blinded fashion. Treatment was initiated 14 days before CV and was continued 30 days after CV. The two groups were well-balanced with respect to baseline characteristics. Mean age was 65 +/- 10 years, 76% of the patients were male and 4% had ischaemic heart disease. Study medication was well-tolerated in all patients but one. Before primary endpoint 12 patients were excluded. In the atorvastatin group 99 patients (89%) converted to SR at electrical CV compared with 95 (86%) in the placebo group (P = 0.42). An intention-to-treat analysis with the available data, by randomization group, showed that 57 (51%) in the atorvastatin group and 47 (42%) in the placebo group were in SR 30 days after CV (OR 1.44, 95%CI 0.85-2.44, P = 0.18). CONCLUSION: Atorvastatin was not statistically superior to placebo with regards to maintaining SR 30 days after CV in patients with persistent AF.
3.	Aminlashgari, Nina, et al. (författare) Degradation profile and preliminary clinical testing of a resorbable device for ligation of blood vessels 2013 Ingår i: Acta Biomaterialia. - : Elsevier BV. - 1742-7061 .- 1878-7568. ; 9:6, s. 6898-904 Tidskriftsartikel (refereegranskat)abstract A resorbable device for ligation of blood vessels was developed and tested in vitro to reveal the degradation profile of the device and to predict the clinical performance in terms of adequate mechanical support during a healing period of I week. In addition, preliminary clinical testing was performed that showed complete hemostasis and good tissue grip of renal arteries in five pigs. The device was made by injection molding of poly(glycolide-co-trimethylene carbonate) triblock copolymer, and it consisted of a case with a locking mechanism connected to a partly perforated flexible band. A hydrolytic degradation study was carried out for 7, 30 and 60 days in water and buffer medium, following the changes in mass, water absorption, pH and mechanical properties. A new rapid matrix-free laser desorption ionization-mass spectrometry (LDI-MS) method was developed for direct screening of degradation products released into the degradation medium. The combination of LDI-MS and electrospray ionization-mass spectrometry analyses enabled the comparison of the degradation product patterns in water and buffer medium. The identified degradation products were rich in trimethylene carbonate units, indicating preferential hydrolysis of amorphous regions where trimethylene units are located. The crystallinity of the material was doubled after 60 days of hydrolysis, additionally confirming the preferential hydrolysis of trimethylene carbonate units and the enrichment of glycolide units in the remaining solid matrix. The mechanical performance of the perforated band was followed for the first week of hydrolysis and the results suggest that sufficient strength is retained during the healing time of the blood vessels.
4.	Andersson, Jonas, et al. (författare) Markers of fibrinolysis as predictors for maintenance of sinus rhythm after electrical cardioversion 2011 Ingår i: Thrombosis Research. - : Elsevier BV. - 0049-3848 .- 1879-2472. ; 127:3, s. 189-192 Tidskriftsartikel (refereegranskat)abstract No fibrinolytic component alone was found to be a predictor of recurrence of atrial fibrillation. In multivariate models lower PAI-1 mass was associated with sinus rhythm even after adjusting for CRP, markers of the metabolic syndrome and treatment with atorvastatin. Our findings suggest a patophysiological link between AF and PAI-1 mass but the relation to inflammation remains unclear.
5.	Bertmar, Sofia, et al. (författare) Who's Most Targeted and Does My New Adblocker Really Help : A Profile-based Evaluation of Personalized Advertising 2021 Ingår i: Proc. ACM CCS Workshop on Privacy in the Electronic Society (ACM WPES @CCS). - New York, NY, USA : ACM Digital Library. - 9781450385275 Konferensbidrag (refereegranskat)abstract There is limited prior work studying how the ad personalization experienced by different users is impacted by the use of adblockers, geographic location, the user's persona, or what browser they use. To address this void, this paper presents a novel profile-based evaluation of the personalization experienced by carefully crafted user profiles. Our evaluation framework impersonates different users and captures how the personalization changes over time, how it changes when adding or removing an extension, and perhaps most importantly how the results differ depending on the profile's persona (e.g., interest, occupation, age, gender), geographic location (US East, US West, UK), what browser extension they use (none, AdBlock, AdBlock Plus, Ghostery, CatBlock), what browser they use (Chrome, Firefox), and whether they are logged in to their Google account. By comparing and contrasting observed differences we provide insights that help explain why some user groups may feel more targeted than others and why some people may feel even more targeted after having turned on their adblocker.
6.	Blomström-Lundqvist, Carina, et al. (författare) Effect of Catheter Ablation vs Antiarrhythmic Medication on Quality of Life in Patients With Atrial Fibrillation : The CAPTAF Randomized Clinical Trial 2019 Ingår i: JAMIA Journal of the American Medical Informatics Association. - Chicago : American Medical Association (AMA). - 1067-5027 .- 1527-974X .- 0098-7484 .- 1538-3598. ; 321:11, s. 1059-1068 Tidskriftsartikel (refereegranskat)abstract IMPORTANCE Quality of life is not a standard primary outcome in ablation trials, even though symptoms drive the indication. OBJECTIVE To assess quality of life with catheter ablation vs antiarrhythmic medication at 12 months in patients with atrial fibrillation. DESIGN, SETTING, AND PARTICIPANTS Randomized clinical trial at 4 university hospitals in Sweden and 1 in Finland of 155 patients aged 30-70 years with more than 6 months of atrial fibrillation and treatment failure with 1 antiarrhythmic drug or beta-blocker, with 4-year follow-up. Study dateswere July 2008-September 2017. Major exclusionswere ejection fraction <35%, left atrial diameter > 60 mm, ventricular pacing dependency, and previous ablation. INTERVENTIONS Pulmonary vein isolation ablation (n= 79) or previously untested antiarrhythmic drugs (n= 76). MAIN OUTCOMES AND MEASURES Primary outcomewas the General Health subscale score (Medical Outcomes Study 36-Item Short-Form Health Survey) at baseline and 12 months, assessed unblinded (range, 0 [worst] to 100 [best]). There were 26 secondary outcomes, including atrial fibrillation burden (% of time) from baseline to 12 months, measured by implantable cardiac monitors. The first 3 months were excluded from rhythm analysis. RESULTS Among 155 randomized patients (mean age, 56.1 years; 22.6% women), 97% completed the trial. Of 79 patients randomized to receive ablation, 75 underwent ablation, including 2 who crossed over to medication and 14 who underwent repeated ablation procedures. Of 76 patients randomized to receive antiarrhythmic medication, 74 received it, including 8 who crossed over to ablation and 43 for whom the first drug used failed. General Health score increased from 61.8 to 73.9 points in the ablation group vs 62.7 to 65.4 points in the medication group (between-group difference, 8.9 points; 95% CI, 3.1-14.7; P=.003). Of 26 secondary end points, 5 were analyzed; 2 were null and 2 were statistically significant, including decrease in atrial fibrillation burden (from 24.9% to 5.5% in the ablation group vs 23.3% to 11.5% in the medication group; difference -6.8%[95% CI, -12.9% to -0.7%]; P=.03). Of the Health Survey subscales, 5 of 7 improved significantly. Most common adverse events were urosepsis (5.1%) in the ablation group and atrial tachycardia (3.9%) in the medication group. CONCLUSIONS AND RELEVANCE Among patients with symptomatic atrial fibrillation despite use of antiarrhythmic medication, the improvement in quality of life at 12 months was greater for those treated with catheter ablation compared with antiarrhythmic medication. Although the study was limited by absence of blinding, catheter ablation may offer an advantage for quality of life.
7.	Borg, Carola, 1973-, et al. (författare) Subject- and experience-bound differences in teachers' conceptual understanding of sustainable development 2014 Ingår i: Environmental Education Research. - : Routledge. - 1350-4622 .- 1469-5871. ; 20:4, s. 526-551 Tidskriftsartikel (refereegranskat)abstract This article describe the results of a nationwide questionnaire study of 3229 Swedish upper secondary school teachers’ understanding of sustainable development in relation to their subject discipline and teaching experience. Previous research has shown that teachers have difficulties understanding the complex concept of sustainable development. According to the Swedish curriculum all teachers in all subjects should integrate a holistic perspective of sustainable development including economic, ecological and social dimensions. This study shows that teachers differ in their understanding of the concept mostly according to their subject traditions. Social science teachers emphasize social dimensions, and science teachers’ ecological dimensions, respectively. Teachers are aware of the relevance of the three dimensions to various degrees, but do not generally have a holistic understanding. The greatest uncertainty in teachers’ understanding is related to the economic dimension. Science and social science teachers are critical of incorporating economic growth into the concept of sustainable development while language, vocational and esthetical-practical teachers are not. No experience-bound differences of the teachers’ understanding could be found, but recently qualified teachers consider their understanding of sustainable development to be poorer in comparison to more experienced teachers’ self-evaluation. The study highlights the need for further training in sustainable development since more than 70 % of the questioned teachers stated that they need such training.
8.	Borg, Carola, 1973-, et al. (författare) The barriers encountered by teachers implementing education for sustainable development 2012 Ingår i: Research in Science & Technological Education. - : Informa UK Limited. - 0263-5143 .- 1470-1138. ; 30:2, s. 185-207 Tidskriftsartikel (refereegranskat)abstract Background : According to the Swedish curriculum teachers in all subjects have a responsibility to integrate a holistic perspective of sustainable development (SD) and teach according to an education for sustainable development (ESD) approach. However previous research has shown that teachers from different subjects perceive SD differently. Purpose : The study aimed at investigating if and how teachers’ subject area influences their ability to implement a holistic perspective of ESD; we investigated both the impact of teaching traditions and the barriers that teachers experienced. Sample : A stratified sample of 224 Swedish upper secondary schools participated. An online questionnaire was sent and answered by a total of 3229 teachers at these schools. In total, there were 669 science teachers, 373 social science teachers, 483 language teachers, 713 vocational and esthetical–practical teachers, and 739 teachers from other disciplines who participated in the survey. Design and methods : The questionnaire consisted of questions requiring Likert-scale responses and multiple-choice questions. The data from the questionnaire were analyzed using Pearson’s Chi-square test and one-way ANOVA. The significance level accepted was p < 0.05. Results : Teachers were influenced by their own subject traditions. Science teachers in our study were grounded in the fact-based tradition and lectures were the most common teaching method used. The teaching tradition of the social science teachers seemed to be most in line to an ESD approach. Many language teachers (41%) stated they did not include SD issues in their teaching at all. Among the barriers identified, the most common obstacles were that the teachers lacked inspiring examples of how to include SD in their teaching and that they lacked the necessary expertise about SD. Conclusion : This study highlights the need for the management within schools to create opportunities for teachers to work collaboratively when teaching ESD. It is also important to provide further training that is adjusted to the needs of different disciplines.
9.	Borg, Carola, 1973- (författare) Utbildning för hållbar utveckling ur ett lärarperspektiv : Ämnesbundna skillnader i gymnasieskolan 2011 Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract This thesis investigates how teachers from different disciplines understand and implement education for sustainable development in their teaching. A nationwide questionnaire study was conducted with 3229 upper secondary school teachers representing 224 schools in Sweden. The concept of sustainable development is complex and research has shown that teachers exhibit uncertainties in their understanding of it, and that the way they conceptualize sustainable development can have consequences for how they incorporate it into their teaching. Previous research has emphasized that Education for Sustainable Development (ESD) should promote interdisciplinary and holistic learning rather than traditional subject-based learning. This is in accordance with the Swedish curriculum, which emphasizes that all teachers in all subjects should integrate education for sustainable development. The teachers in the study were grouped into four disciplines; science-, social science-, language-, and vocational/esthetical-practical teachers. The results showed that there were many subject-bound barriers to successful implementation of ESD. Teachers were influenced by their subject tradition in: 1) how they understand sustainable development, 2) which teaching methods they use, 3) which barriers they experience, and 4) which teaching tradition they work within. Because of these differences it is important to adjust any further training of teachers according to their discipline. This study highlights the need for improved teacher education and further training of in-service teachers; more than 70% of the teachers stated that they need such training. It also highlights the issue how strong subject-bound traditions make it difficult to implement general goals of the curricula such as sustainable development.
10.	Ekman, Mattias, et al. (författare) Kostnadseffektivt att behandlakronisk hjärtsvikt med bisoprolol [Cost-effectiveness of bisoprolol in chronic heart failure] 2002 Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 14, s. 646-650 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract Kliniska prövningar har visat att betablockerare har gynnsamma effekter på dödlighet och sjuklighet vid kronisk hjärtsvikt.Hjärtsvikt är ett vanligt och allvarligt tillstånd, som dessutom orsakar samhällsekonomiska kostnader på minst 2 miljarder kronor per år.Den kliniska studien CIBIS II, som omfattade 2 647 patienter i funktionsklass III och IV, visade en signifikant minskning av mortaliteten på 32 procent när beta-blockeraren bisoprolol adderades till konventionell hjärtsviktsbehandling.Som ett led i en ekonomisk utvärdering av bisoprolol undersöktes kostnader och hälsoeffekter i samband med behandlingen. Uppgifter om läkemedelsförbrukning och sjukhusinläggningar hämtades från CIBIS II-studien. Uppgifter om patienternas överlevnad är dels hämtade från CIBIS-II-studien, dels baserade på uppgifter från tidigare studier.Den ekonomiska utvärderingen indikerar att behandling av kronisk hjärtsvikt med bisoprolol är ett kostnadseffektivt alternativ.
11.	Eriksson, Niklas, 1976-, et al. (författare) En fartygslämning vid Kapellskär : arkeologisk förundersökning, Uppland, Norrtälje kommun 2009 Rapport (övrigt vetenskapligt/konstnärligt)
12.	Eriksson, Niklas, 1976-, et al. (författare) Well Preserved or Well Recorded : Approaches to Baltic Sea Shipwrecks Exemplified by the Dalarö-Wreck Project 2012 Ingår i: Between Continents. - Istanbul : Ege Yayinlari. - 9786054701025 ; , s. 325-329 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
13.	Fang, Fang, et al. (författare) Maternal bereavement and childhood asthma-analyses in two large samples of Swedish children 2011 Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 6:11, s. e27202- Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Prenatal factors such as prenatal psychological stress might influence the development of childhood asthma. METHODOLOGY AND PRINCIPAL FINDINGS: We assessed the association between maternal bereavement shortly before and during pregnancy, as a proxy for prenatal stress, and the risk of childhood asthma in the offspring, based on two samples of children 1-4 (n = 426 334) and 7-12 (n = 493 813) years assembled from the Swedish Medical Birth Register. Exposure was maternal bereavement of a close relative from one year before pregnancy to child birth. Asthma event was defined by a hospital contact for asthma or at least two dispenses of inhaled corticosteroids or montelukast. In the younger sample we calculated hazards ratios (HRs) of a first-ever asthma event using Cox models and in the older sample odds ratio (ORs) of an asthma attack during 12 months using logistic regression. Compared to unexposed boys, exposed boys seemed to have a weakly higher risk of first-ever asthma event at 1-4 years (HR: 1.09; 95% confidence interval [CI]: 0.98, 1.22) as well as an asthma attack during 12 months at 7-12 years (OR: 1.10; 95% CI: 0.96, 1.24). No association was suggested for girls. Boys exposed during the second trimester had a significantly higher risk of asthma event at 1-4 years (HR: 1.55; 95% CI: 1.19, 2.02) and asthma attack at 7-12 years if the bereavement was an older child (OR: 1.58; 95% CI: 1.11, 2.25). The associations tended to be stronger if the bereavement was due to a traumatic death compared to natural death, but the difference was not statistically significant. CONCLUSIONS/SIGNIFICANCE: Our results showed some evidence for a positive association between prenatal stress and childhood asthma among boys but not girls.
14.	Gad, Helge, et al. (författare) MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool 2014 Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221 Tidskriftsartikel (refereegranskat)abstract Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
15.	Gunnarsson, Niklas, 1986- (författare) Chronic myeloid leukemia and cancer 2017 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract Background Chronic myeloid leukemia (CML) is a relatively rare hematological malignancy with a constant incidence of approximately 90 new cases each year in Sweden (0.9 cases/100 000 inhabitants). The etiology is largely unknown but high doses of ionizing radiation are a known but rare risk factor. The treatment options were for a long time limited to chemotherapies i.e. hydroxyurea and busulfan, interferon’s and allogeneic hematopoietic stem cell transplantation and the median survival were only about four years.Since the beginning of the 21st century a new way of treating CML has been introduced, the tyrosine kinase inhibitors (TKI), leading to a rapid decrease in leukemic cells and symptoms. Due to the TKIs, the overall 5-year survival is nowadays approximately 85 % and CML patients have time to develop other diseases, including other malignancies.The aims of this thesis was to investigate the present and future prevalence of CML and the prevalence of other malignancies prior and subsequent to the diagnosis of CML, malignancies among first-degree relatives of persons with CML. In addition, the incidence of autoimmune and chronic inflammatory diseases among patients with CML was also investigated. Methods From the Swedish CML register, data over nearly all Swedish CML patients from 2002 and forward were obtained for paper II-IV.For paper I, the Swedish cancer register was used to identify all Swedish CML patients since 1970 and the Swedish cause of death register was used to identify an eventual date of death for these patients. With a constant incidence and the relative survival rates for CML patients between 2006 and 2012 as a model, the present and future prevalence was calculated.For paper II-IV, data from the Swedish cancer register was used to identify other malignancies than CML. For paper II, information about autoimmune and chronic inflammatory diseases was retrieved from the Swedish national patient register.For paper II and IV, five controls matched for year of birth, gender and county of residence were randomly selected from the Swedish register of the total population. To calculate odds ratio (OR), conditional logistic regression was used.To calculate the risk of a second malignancy for paper III, Standardized incidence ratio (SIR) was used.In paper IV, first-degree relatives (parents, siblings and offsprings) for both cases and controls were retrieved from the Swedish multi-Generation Register, where persons born later than 1932 and registered in Sweden at some time since 1961 are registered. Results Prevalence and survivalAs shown in paper I, the 5-year overall survival for CML patients increased remarkably from 0.18 to 0.82 between 1970 and 2012. The prevalence increased from 3.9 to 11.9 per 100 000 inhabitants in Sweden between 1985 and 2012. By assuming no further improvements in relative survival as compared to the survival rates between 2006 and 2012, the prevalence by 2060 is expected to increase to 22.0 per 100 000 inhabitants. This corresponds to 2 587 CML patients as compared to 1 137 CML patients in 2012. Malignancies, autoimmune and chronic inflammatory diseases prior to CMLIn study II, more than 45 000 person-years of follow-up were evaluated in 984 CML patients diagnosed between 2002 and 2012. With an OR of 1.47 (95 % CI 1.20–1.82) and 1.55 (95 % CI 1.21–1.98), respectively, the prevalence of prior malignancies and autoimmune diseases were significantly increased as compared to matched controls. On the other hand, no association between CML and chronic inflammatory diseases was shown. Second malignanciesIn 868 CML patients, diagnosed between 2002 and 2011, 52 malignancies were observed in the Swedish cancer register, as shown in paper III. When compared to expected rates in the background population, a significantly increased risk of second malignancies with a SIR of 1.52 (95 % CI 1.13–1.99) was shown. When looking at specific cancer types, gastrointestinal as well as nose and throat cancer were significantly increased. Familial aggregation of malignancies984 CML patients were identified in paper IV. However, 184 had a birth date prior to 1932, subsequently only 800 patients were analyzed. Among them, 4 287 first-degree relatives were identified, compared to 20 930 first-degree relatives of the matched controls. 611 malignancies were retrieved; no significant increase of malignancies in first-degree relatives of CML patients was shown (OR 1.06; 95 % CI: 0.96–1.16). ConclusionSince CML patients nowadays have a high survival rate, the calculations in this thesis shows that the prevalence of CML will almost double by 2060. CML patients have an increased risk of developing malignancies prior and subsequent to the diagnosis of CML, suggesting a hereditary or acquired predisposition to develop cancer. Since there is no familial aggregation of malignancies in CML patients, a hereditary predisposition to develop cancer is unlikely to be part of the pathogenesis of CML, leaving an acquired predisposition more likely.
16.	Gunnarsson, Niklas, et al. (författare) Increased Prevalence of Prior Malignancies and Autoimmune Diseases in Patients Diagnosed with Chronic Myeloid Leukemia 2015 Ingår i: Blood. - 0006-4971 .- 1528-0020. ; 126:23 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
17.	Gunnarsson, Niklas, et al. (författare) Increased prevalence of prior malignancies and autoimmune diseases in patients diagnosed with chronic myeloid leukemia 2016 Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 30:7, s. 1562-1567 Tidskriftsartikel (refereegranskat)abstract We recently reported an increased incidence of second malignancies in chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKI). To elucidate whether this increase may be linked, not to TKI but rather to a hereditary or acquired susceptibility to develop cancer, we estimated the prevalence of malignancies, autoimmune disease (AD) and chronic inflammatory disease (CID) in CML patients prior to their CML diagnosis. Nationwide population-based registers were used to identify patients diagnosed with CML in Sweden 2002-2012 and to estimate the prevalence of other malignancies, AD and CID prior to their CML diagnosis. For each patient with CML, five matched controls were selected from the general population. Conditional logistic regression was used to calculate odds ratios (OR). Nine hundred and eighty-four CML patients were assessed, representing more than 45 000 person-years of follow-up. Compared with matched controls, the prevalence of prior malignancies and AD was elevated in CML patients: OR 1.47 (95% confidence interval (CI) 1.20-1.82) and 1.55 (95% CI 1.21-1.98), respectively. No associations were detected between CML and previous CID. An increased prevalence of other malignancies and AD prior to the diagnosis of CML suggest that a hereditary or acquired predisposition to cancer and/or autoimmunity is involved in the pathogenesis of CML.
18.	Gunnarsson, Niklas, et al. (författare) No increased prevalence of malignancies among first-degree relatives of 800 patients with chronic myeloid leukemia: a population-based study in Sweden 2017 Ingår i: Leukemia. - : NATURE PUBLISHING GROUP. - 0887-6924 .- 1476-5551. ; 31:8, s. 1825-1827 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract n/a
19.	Gunnarsson, Niklas, et al. (författare) Population-based assessment of chronic myeloid leukemia in Sweden : striking increase in survival and prevalence 2016 Ingår i: European Journal of Haematology. - : Wiley. - 0902-4441 .- 1600-0609. ; 97:4, s. 387-392 Tidskriftsartikel (refereegranskat)abstract The clinical outcome for patients with chronic myeloid leukemia (CML) has improved dramatically following the introduction of tyrosine kinase inhibitors. An improved survival, combined with a constant incidence, is expected to increase the prevalence of CML. However, data on the prevalence of CML remain scarce. We examined the overall and relative (age and gender matched) survival and assessed the past, present, and projected future prevalence of CML in Sweden. Data on all patients diagnosed with CML between 1970 and 2012 were retrieved from the Swedish Cancer Register and the Swedish Cause of Death Register. The 5-year overall survival increased from 0.18 to 0.82, during the observed time period. Between 2006 and 2012, the 5-year relative survival was close to normal for 40-year-old, but considerably lower for 80-year-old CML patients. The observed prevalence tripled from 1985 to 2012, from 3.9 to 11.9 per 100 000 inhabitants. Assuming no further improvements in relative survival, the prevalence is projected to further increase by 2060 to 22.0 per 100 000 inhabitants (2587 persons in Sweden). The projected dramatic increase in CML prevalence has major medical and health economic implications and needs to be considered in planning how to organize future care of CML patients.
20.	Gunnarsson, Niklas, et al. (författare) Second malignancies following treatment of chronic myeloid leukaemia in the tyrosine kinase inhibitor era 2015 Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 169:5, s. 683-688 Tidskriftsartikel (refereegranskat)abstract Given that tyrosine kinase inhibitors (TKIs) have dramatically improved the survival of patients with chronic myeloid leukaemia (CML), we were interested in examining the possible risk of long-term adverse events, such as the emergence of other neoplasms. Therefore, we studied the development of second malignancies in 868 patients diagnosed with CML between 2002 and 2011 using the Swedish CML register, cross-linked to the Swedish Cancer register. With a median follow-up of 37 (range 0-99)years, 65 (75%) patients developed 75 second malignancies (non-haematological), 52 of which were of the invasive type. Compared to expected rates in the background population, the risk of second malignancies was higher in the CML cohort, with a standardized incidence ratio (SIR) of 152 (95% CI 113-199). The SIR before and after the second year following diagnosis of CML was 158 and 147, respectively. Among specific cancer types, gastrointestinal and nose and throat cancer were significantly increased. Founded on a population-based material, our results indicate that CML patients treated in the TKI era are at an increased risk of developing a second malignancy, with indications that this risk may more likely be linked to CML itself rather than to the TKI treatment.
21.	Gunnarsson, Niklas, et al. (författare) Second Malignancies Following Treatment of Chronic Myeloid Leukemia in the Tyrosine Kinase Inhibitor Era 2014 Ingår i: Blood. - 0006-4971 .- 1528-0020. ; 124:21 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
22.	Holmqvist, Fredrik, et al. (författare) A decade of catheter ablation of cardiac arrhythmias in Sweden : ablation practices and outcomes 2019 Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 40:10, s. 820-830 Tidskriftsartikel (refereegranskat)abstract Aims: Catheter ablation is considered the treatment of choice for many tachyarrhythmias, but convincing 'real-world' data on efficacy and safety are lacking. Using Swedish national registry data, the ablation spectrum, procedural characteristics, as well as ablation efficacy and reported adverse events are reported.Methods and Results: Consecutive patients (≥18 years of age) undergoing catheter ablation in Sweden between 01 January 2006 and 31 December 2015 were included in the study. Follow-up (repeat ablation and vital status) was collected through 31 December 2016. A total of 26 642 patients (57 ± 15 years, 62% men), undergoing a total of 34 428 ablation procedures were included in the study. In total, 4034 accessory pathway/Wolff-Parkinson-White syndrome (12%), 7358 AV-nodal re-entrant tachycardia (21%), 1813 atrial tachycardia (5.2%), 5481 typical atrial flutter (16%), 11 916 atrial fibrillation (AF, 35%), 2415 AV-nodal (7.0%), 581 premature ventricular contraction (PVC, 1.7%), and 964 ventricular tachycardia (VT) ablations (2.8%) were performed. Median follow-up time was 4.7 years (interquartile range 2.7-7.0). The spectrum of treated arrhythmias changed over time, with a gradual increase in AF, VT, and PVC ablation (P < 0.001). Decreasing procedural times and utilization of fluoroscopy with time, were seen for all arrhythmia types. The rates of repeat ablation differed between ablation types, with the highest repeat ablation seen in AF (41% within 3 years). The rate of reported adverse events was low (n = 595, 1.7%). Death in the immediate period following ablation was rare (n = 116, 0.34%).Conclusion: Catheter ablations have shifted towards more complex procedures over the past decade. Fluoroscopy time has markedly decreased and the efficacy of catheter ablation seems to improve for AF.
23.	Höglund, Johan, Professor, 1967-, et al. (författare) Climate diaspora and future food cultures in Snowpiercer(2013) and The Road (2009) 2024 Ingår i: Food, Culture, and Society. - : Taylor & Francis Group. - 1552-8014 .- 1751-7443. ; 27:2, s. 310-325 Tidskriftsartikel (refereegranskat)abstract This article takes as its starting point the realization that existing food regimes and the food systems that enable them are the main drivers of climate change. This, the article notes, is a systemic challenge, but also a profoundly cultural issue as the way that people eat is deeply connected to questions of identity and belonging. The article enters this field of inquiry by studying how the awareness that current food systems are unsustainable is being mediatized and narrated in popular fiction and film. This media often depicts humans in worlds where the current food system has collapsed, forcing also people in the Global North to move or otherwise adapt to a changing climate, and, in the process, to profoundly alter the way they eat. The article discusses two visual texts: Bong Joon-ho’s Snowpiercer (2013), and John Hillcoat’s The Road (2009). The analysis of these texts shows that they employ food, eating and migration to make life in a future transformed by climate change comprehensible to the reader. The article also investigates how the fiction studied connects food and eating to the existing world-system and thus to the material history that is driving the climate crisis.
24.	Höglund, Niklas, 1968- (författare) Atrial fibrillation : treatment, associated conditions and quantification of symptoms 2017 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia. There is a need for new pharmacological treatment strategies since the current antiarrhythmic drugs have a modest efficacy and may have severe side effects. Cardioversion (CV) of AF offers an opportunity to study related conditions in sinus rhythm (SR) and during AF. Since catheter ablation of AF is a symptomatic treatment, it is important to have tools for measurement of arrhythmia-related symptoms. Aims: To evaluate the effect of atorvastatin on maintaining SR after CV of persistent AF. To assess if highsensitivity C-reactive protein (hsCRP) predicts the recurrence of AF after CV in a population randomized to treatment with either atorvastatin or placebo. To quantify the symptomatic effect of left atrial catheter ablation of AF. To assess if the restoration of SR by CV, in a population with persistent AF, affects sleep apnea. Methods: Paper I: A total of 234 patients were randomized to treatment with either high dose atorvastatin or placebo prior to CV. Paper II: In a pre-specified substudy which included 128 of the patients in study I, hsCRP was analyzed before and after CV. Paper III: Umea 22 Arrhythmia Questions (U22) is a questionnaire that quantifies paroxysmal tachycardia symptoms. A total of 105 patients underwent first-time pulmonary vein isolation and answered U22 forms at baseline and follow-up 304 (SD 121) days after ablation. Paper IV: Polysomnography was performed before and after CV in 23 patients with persistent AF scheduled for elective CV. Results: Paper I: An intention-to-treat analysis with the available data, by randomization group, showed that 57 (51%) in the atorvastatin group and 47 (42%) in the placebo group were in SR 30 days after CV (OR 1.44, 95%CI 0.85–2.44, P=0.18). Paper II: HsCRP did not significantly predict recurrence of AF at 30 days. However, after adjusting for treatment with atorvastatin, hsCRP predicted the recurrence of AF (OR 1.14, 95% CI 1.01–1.27). Six months after CV, hsCRP at randomization predicted recurrence of AF in both univariate analysis (OR 1.30, 95% CI 1.06–1.60) and in multivariate logistic regression analysis (OR 1.33, 95% CI 1.06– 1.67). Paper III: The U22 scores for well-being, arrhythmia as cause for impaired well-being, derived timeaspect score for arrhythmia, and discomfort during attack detected relevant improvements of symptoms after the ablation. U22 showed larger improvement in patients undergoing only one procedure than in patients who later underwent repeated interventions. Paper IV: Obstructive sleep apnea occurred in 17/23 patients (74%), and central sleep apnea in 6/23 patients (26%). Five patients had both obstructive and central sleep apnea. SR at follow-up was achieved in 16 patients. The obstructive apnea-hypopnea index, central apneahypopnea index, and the number of patients with obstructive or central sleep apnea did not differ before and after restoration of SR. Conclusions: Atorvastatin is not a treatment option with regards to maintaining SR after CV in patients with persistent AF. HsCRP was associated with AF recurrence 1 and 6 months after successful CV of persistent AF. U22 quantifies the symptomatic improvement after AF ablation with adequate internal consistency and construct validity. Both obstructive and central sleep apneas are highly prevalent in patients with persistent AF. Obstructive sleep apneas are unaffected by the CV of AF to SR.
25.	Höglund, Niklas, et al. (författare) Cardioversion of atrial fibrillation does not affect obstructive sleep apnea 2017 Ingår i: Upsala Journal of Medical Sciences. - : Taylor & Francis. - 0300-9734 .- 2000-1967. ; 122:2, s. 114-118 Tidskriftsartikel (refereegranskat)abstract Background: Sleep apnea is common in patients with atrial fibrillation, but the effect of the cardioversion of atrial fibrillation to sinus rhythm on central and obstructive apneas is mainly unknown. The primary aim of the study was to analyze the association between cardioversion of atrial fibrillation and sleep apneas, to investigate whether obstructive or central sleep apneas are reduced following cardioversion. A secondary objective was to study the effect on sleep quality. Methods: Twenty-three patients with atrial fibrillation were investigated using overnight polysomnography, including esophagus pressure monitoring and ECG, before and after the cardioversion of persistent atrial fibrillation. Results: Obstructive sleep apnea occurred in 17/23 patients (74%), and central sleep apnea in 6/23 patients (26%). Five patients had both obstructive and central sleep apnea. Sinus rhythm at follow-up was achieved in 16 patients. The obstructive apnea-hypopnea index, central apnea-hypopnea index, and the number of patients with obstructive or central sleep apnea did not differ before and after restoration of sinus rhythm. Sleep time, sleep efficiency, time in different sleep stages, and subjective daytime sleepiness were normal and unaffected by cardioversion. Conclusions: Both obstructive and central sleep apneas are highly prevalent in patients with persistent atrial fibrillation. Obstructive sleep apneas are unaffected by the cardioversion of atrial fibrillation to sinus rhythm. The sleep pattern is normal and unaffected by cardioversion in patients with atrial fibrillation. Clinical Trial Registration: Trial number NCT00429884.
26.	Höglund, Niklas, 1970 (författare) Foot and ankle injuries in frontal car collisions : parametric investigations of factors influencing lower leg responses using mathematical models 2001 Licentiatavhandling (övrigt vetenskapligt/konstnärligt)
27.	Höglund, Niklas, 1970 (författare) Modelling of Factors Influencing Foot Ankle Responses and Injuries in Car Crashes 2003 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract Foot and ankle injuries in frontal car collisions are believed to be caused mainly by occupant contact with the floor and toepan, occupant interaction with the pedals, and the lower leg being deformed between the floor and knee bolster. A better understanding of the causes of foot and ankle injuries is required to design cars for improved safety of the legs. In this study, mathematical models were developed, evaluated by crash tests, and used in parametric studies to examine the factors that influence the injury outcome. The models will serve as a basis for the development of principles for countermeasures effective in a variety of crash situations. Dynamic tests with biological materials were conducted to obtain more information about injury tolerances of the human ankle in dorsiflexion loading. Mathematical vehicle-occupant models were developed in the multi body and finite element software MADYMO. The models were assessed by both crash tests and sled tests. Parametric studies were made using the mathematical models according to statistical methods. Two approaches were used in the mathematical modelling: investigation of the toepan design, and examination of the safety performance of the same car with and without safety systems. All of the toepan design parameters tested were found to have an effect on lower leg responses: the dummy responses also differed significantly depending on the foot position, occupant size and crash severity. To design cars for improved lower leg safety, efforts should be made to reduce the toepan acceleration and intrusion distance in particular. However, the simulations in this study showed that there is an important interaction between the timing of the peak acceleration and the intrusion distance: when the right foot of the driver was resting on the toepan at the time of the crash, the axial force in the right tibia increased with toepan acceleration; the intrusion magnitude was of minor importance. However, when the right foot rested initially on an accelerator that was displaced during the crash, the axial force increased with the intrusion magnitude, and toepan acceleration was of minor importance. Moreover, this study showed that the local deformation of the toepan is a likely cause of lower leg injuries and must be reduced. The interaction effects of the parameters investigated were also obvious in the examination of safety systems. Although an airbag in the toepan area might considerably reduce the tibial responses, the designers have to be aware that using a foot airbag optimized for a severe crash situation can actually increase the load on the lower leg in less severe crash situations. In this study, the foot-ankle load increased in 50% of all crash situations. Therefore, it is desirable to be able to measure the occupant size and crash severity and to adjust the airbag inflation in a crash situation. In the biological tests, lower leg specimens were struck at the plantar side of the foot and the ankle responses were measured. The average dorsiflexion angle at the time of injury was 42° and the average ankle moment in tests with fractures was 61 Nm. The mathematical modelling techniques used in this study proved to be useful tools for investigating lower leg responses in car crashes. The models developed can simulate the complex shape of toepan intrusion and the interaction between the occupant and the vehicle. The investigation of the causes of injury provided valuable information for designing vehicles with better lower leg safety.
28.	Höglund, Niklas, et al. (författare) The predictive value of C-reactive protein on recurrence of atrial fibrillation after cardioversion with or without treatment with atorvastatin 2013 Ingår i: International Journal of Cardiology. - : Elsevier. - 0167-5273 .- 1874-1754. ; 167:5, s. 2088-2091 Tidskriftsartikel (refereegranskat)abstract Background: The aim of this study was to investigate whether high-sensitivity C-reactive protein (hsCRP) levels prior to cardioversion (CV) predict recurrence of atrial fibrillation (AF) in patients randomized to treatment with either atorvastatin or placebo 30 and 180 days after CV. Methods: This was a prespecified substudy of 128 patients with persistent AF randomized to treatment with atorvastatin 80 mg/day or placebo, initiated 14 days before CV, and continued 30 days after CV. HsCRP levels were measured at randomization, at the time of CV, and 2 days and 30 days after CV. Results: In univariate analysis of those who were in sinus rhythm 2 h after CV, hsCRP did not significantly (odds ratio [OR] 1.11, 95% confidence interval [CI] 0.99-1.25) predict recurrence of AF at 30 days. However, after adjusting for treatment with atorvastatin, hsCRP predicted the recurrence of AF (OR 1.14, 95% CI 1.01-1.27). In a multivariate logistic regression analysis with gender, age, body mass index (BMI), smoking, cholesterol, and treatment with atorvastatin as covariates, the association was still significant (OR 1.14, 95% CI 1.01-1.29). Six months after CV, hsCRP at randomization predicted recurrence of AF in both univariate analysis (OR 1.30, 95% CI 1.06-1.60) and in multivariate logistic regression analysis (OR 1.33, 95% CI 1.06-1.67). Conclusion: HsCRP was associated with AF recurrence one and six months after successful CV of persistent AF. However, the association at one month was significant only after adjusting for atorvastatin treatment.
29.	Höglund, Niklas, et al. (författare) U22 protocol as measure of symptomatic improvement after catheter ablation of atrial fibrillation 2013 Ingår i: Upsala Journal of Medical Sciences. - : Informa Healthcare. - 0300-9734 .- 2000-1967. ; 118:4, s. 240-246 Tidskriftsartikel (refereegranskat)abstract Introduction. Left atrial catheter ablation is useful as symptomatic treatment in selected patients with atrial fibrillation (AF). Evaluation requires measurement of arrhythmia-related symptoms. Many of the published protocols have drawbacks and have been used in AF only, with no possible comparison to other ablations that compete for the same resources. U22 is a published protocol that quantifies paroxysmal tachycardia symptoms through scales with 11 answer alternatives, translated into discrete numerical scales 0-10. It has been shown to reflect the clinical improvement after ablation of supraventricular tachycardia. Here we report the use of U22 in measuring improvement after catheter ablation for AF. Material and methods. A total of 105 patients underwent first-time ablation for AF and answered U22 and SF-36 forms at baseline and follow-up 304 (SD 121) days after ablation. Independently, the patients underwent a clinical follow-up. All decisions regarding medication and reablation were taken without knowledge of the symptom scores. Results. The U22 scores for well-being, arrhythmia as cause for impaired well-being, derived time-aspect score for arrhythmia, and discomfort during attack detected relevant improvements of symptoms after the ablation. U22 showed larger improvement in patients undergoing only one procedure than in patients who later underwent repeated interventions, thus reflecting the independent clinical decision for reablation. Conclusion. U22 quantifies the symptomatic improvement after AF ablation with adequate internal consistency and construct validity. U22 mirrors aspects of the arrhythmia symptomatology other than SF-36.
30.	Höglund, Odd, et al. (författare) A new resorbable device for ligation of blood vessels - A pilot study 2011 Ingår i: Acta Veterinaria Scandinavica. - : Springer Science and Business Media LLC. - 0044-605X .- 1751-0147. ; 53, s. 47- Tidskriftsartikel (refereegranskat)abstract Background: During surgery, controlled haemostasis to prevent blood loss is vital for a successful outcome. It can be difficult to ligate vessels located deep in the abdomen. A device that is easy to use and enables secure ligatures could be beneficial. Cable ties made of nylon have been used for ligation but the non-resorbable material caused tissue reactions. The objective of this study was to use a resorbable material to construct a device with a self-locking mechanism and to test its mechanical strength and ligation efficiency. Methods: The device was manufactured by injection moulding of polydioxanone, a resorbable polymer used for suture materials. Polydioxanone with inherent viscosities of 1.9 dL/g and 1.3 dL/g were tested. The device consisted of a perforated flexible band which could be pulled through a case with a locking mechanism. After a first version of the device had been tested, some improvements were made. The locking case was downsized, corners were rounded off, the band was made thicker and the mould was redesigned to produce longer devices. Tensile tests were performed with the second version. The first version of the device was used to ligate the ovarian pedicle in a euthanized dog and to test echogenicity of the device with ultrasound. Compression of vessels of the ovarian pedicle was examined by histology. Both versions of the device were tested for haemostasis of and tissue grip on renal arteries in six anaesthetised pigs. Results: The tensile strength of the flexible band of the devices with inherent viscosity of 1.9 dL/g was 50.1 +/- 5.5 N (range 35.2-62.9 N, n = 11) and the devices with inherent viscosity of 1.3 dL/g had a tensile strength of 39.8 +/- 8.1 N (range 18.6-54.2 N, n = 11). Injection moulding of the polymer with lower inherent viscosity resulted in a longer flow distance. Both versions of the device had an effective tissue grip and complete haemostasis of renal arteries was verified. The device attached to the ovarian pedicle could be seen with ultrasound, and vessel compression and occlusion were verified by histology. Conclusions: Tests of functionality of the device showed complete haemostasis and good tissue grip. Devices with a band of sufficient length were easily applied and tightened in tissue.
31.	Höglund, Richard, 1984, et al. (författare) A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan. 2012 Ingår i: Malaria journal. - : Springer Science and Business Media LLC. - 1475-2875. ; 11 Tidskriftsartikel (refereegranskat)abstract ABSTRACT: BACKGROUND: Pregnancy is associated with an increased risk of developing a malaria infection and a higher risk of developing severe malaria. The pharmacokinetic properties of many anti-malarials are also altered during pregnancy, often resulting in a decreased drug exposure. Piperaquine is a promising anti-malarial partner drug used in a fixed-dose combination with dihydroartemisinin. The aim of this study was to investigate the population pharmacokinetics of piperaquine in pregnant and non-pregnant Sudanese women with uncomplicated Plasmodium falciparum malaria. METHOD: Symptomatic patients received a standard dose regimen of the fixed dose oral piperaquine-dihydroartemisinin combination treatment. Densely sampled plasma aliquots were collected and analysed using a previously described LC-MS/MS method. Data from 12 pregnant and 12 non-pregnant women were analysed using nonlinear mixed-effects modelling. A Monte Carlo Mapped Power (MCMP) analysis was conducted based on a previously published study to evaluate the power of detecting covariates in this relatively small study. RESULTS: A three-compartment disposition model with a transit-absorption model described the observed data well. Body weight was added as an allometric function on all clearance and volume parameters. A statistically significant decrease in estimated terminal piperaquine half-life in pregnant compared with non-pregnant women was found, but there were no differences in post-hoc estimates of total piperaquine exposure. The MCMP analysis indicated a minimum of 13 pregnant and 13 non-pregnant women were required to identify pregnancy as a covariate on relevant pharmacokinetic parameters (80% power and p=0.05). Pregnancy was, therefore, evaluated as a categorical and continuous covariate (i.e. estimate gestational age) in a full covariate approach. Using this approach pregnancy was not associated with any major change in piperaquine elimination clearance. However, a trend of increasing elimination clearance with increasing gestational age could be seen. CONCLUSIONS: The population pharmacokinetic properties of piperaquine were well described by a three-compartment disposition model in pregnant and non-pregnant women with uncomplicated malaria. The modelling approach showed no major difference in piperaquine exposure between the two groups and data presented here do not warrant a dose adjustment in pregnancy in this vulnerable population.
32.	Juth, Niklas, 1973, et al. (författare) Den medicinska etiken är hotad : Medical ethics is under threat 2022 Ingår i: Dagens medicin. - 1402-1943. ; :2022-05-18 Tidskriftsartikel (populärvet., debatt m.m.)
33.	Karikari, Thomas, et al. (författare) Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. 2020 Ingår i: The Lancet. Neurology. - 1474-4465 .- 1474-4422. ; 19:5, s. 422-433 Tidskriftsartikel (refereegranskat)abstract CSF and PET biomarkers of amyloid β and tau accurately detect Alzheimer's disease pathology, but the invasiveness, high cost, and poor availability of these detection methods restrict their widespread use as clinical diagnostic tools. CSF tau phosphorylated at threonine 181 (p-tau181) is a highly specific biomarker for Alzheimer's disease pathology. We aimed to assess whether blood p-tau181 could be used as a biomarker for Alzheimer's disease and for prediction of cognitive decline and hippocampal atrophy.We developed and validated an ultrasensitive blood immunoassay for p-tau181. Assay performance was evaluated in four clinic-based prospective cohorts. The discovery cohort comprised patients with Alzheimer's disease and age-matched controls. Two validation cohorts (TRIAD and BioFINDER-2) included cognitively unimpaired older adults (mean age 63-69 years), participants with mild cognitive impairment (MCI), Alzheimer's disease, and frontotemporal dementia. In addition, TRIAD included healthy young adults (mean age 23 years) and BioFINDER-2 included patients with other neurodegenerative disorders. The primary care cohort, which recruited participants in Montreal, Canada, comprised control participants from the community without a diagnosis of a neurological condition and patients referred from primary care physicians of the Canadian National Health Service for specialist care. Concentrations of plasma p-tau181 were compared with established CSF and PET biomarkers and longitudinal measurements using Spearman correlation, area under the curve (AUC), and linear regression analyses.We studied 37 individuals in the discovery cohort, 226 in the first validation cohort (TRIAD), 763 in the second validation cohort (BioFINDER-2), and 105 in the primary care cohort (n=1131 individuals). In all cohorts, plasma p-tau181 showed gradual increases along the Alzheimer's disease continuum, from the lowest concentrations in amyloid β-negative young adults and cognitively unimpaired older adults, through higher concentrations in the amyloid β-positive cognitively unimpaired older adults and MCI groups, to the highest concentrations in the amyloid β-positive MCI and Alzheimer's disease groups (p<0·001, Alzheimer's disease vs all other groups). Plasma p-tau181 distinguished Alzheimer's disease dementia from amyloid β-negative young adults (AUC=99·40%) and cognitively unimpaired older adults (AUC=90·21-98·24% across cohorts), as well as other neurodegenerative disorders, including frontotemporal dementia (AUC=82·76-100% across cohorts), vascular dementia (AUC=92·13%), progressive supranuclear palsy or corticobasal syndrome (AUC=88·47%), and Parkinson's disease or multiple systems atrophy (AUC=81·90%). Plasma p-tau181 was associated with PET-measured cerebral tau (AUC=83·08-93·11% across cohorts) and amyloid β (AUC=76·14-88·09% across cohorts) pathologies, and 1-year cognitive decline (p=0·0015) and hippocampal atrophy (p=0·015). In the primary care cohort, plasma p-tau181 discriminated Alzheimer's disease from young adults (AUC=100%) and cognitively unimpaired older adults (AUC=84·44%), but not from MCI (AUC=55·00%).Blood p-tau181 can predict tau and amyloid β pathologies, differentiate Alzheimer's disease from other neurodegenerative disorders, and identify Alzheimer's disease across the clinical continuum. Blood p-tau181 could be used as a simple, accessible, and scalable test for screening and diagnosis of Alzheimer's disease.Alzheimer Drug Discovery Foundation, European Research Council, Swedish Research Council, Swedish Alzheimer Foundation, Swedish Dementia Foundation, Alzheimer Society Research Program.
34.	Kesek, Milos, et al. (författare) Reduction of fluoroscopy duration in radiofrequency ablation obtained by the use of a non-fluoroscopic catheter navigation system. 2006 Ingår i: Europace. - : Oxford University Press (OUP). ; 8:12, s. 1027-30 Tidskriftsartikel (refereegranskat)abstract AIMS: Radiofrequency (RF) ablation requires placement of several catheters at critical positions. The catheters are positioned with fluoroscopy, resulting in a significant radiation exposure. We have investigated to what degree an intracardiac navigation system reduces the fluoroscopy duration in different groups of routine RF ablations. METHODS AND RESULTS: The fluoroscopy time was evaluated in 365 consecutive routine RF ablations, performed between 2002 and 2005. An intracardiac navigation system (LocaLisa, Medtronic) was used from 2003. The data were prospectively entered into a database and subsequently retrieved, and the procedures classified as being performed with fluoroscopy only or with the aid of the LocaLisa system. After introduction of the LocaLisa system, the median fluoroscopy time decreased from 24 to 10 min in the 141 atrioventricular nodal re-entry tachycardia (AVNRT) ablations and from 43 to 28 min in the 71 atrial flutter (AFl) ablations (P<0.005 for both). In the 145 Wolff-Parkinson-White (WPW) ablations, a decrease from 27 to 23 min was observed (P=0.03). The decrease in AVNRT and AFl, but not in WPW was associated with the introduction of the LocaLisa system. CONCLUSION: The use of the LocaLisa system during RF ablations significantly reduced the fluoroscopy time in AVNRT and AFl ablations, by a median of 58% and 46%, respectively.
35.	Kesek, Milos, et al. (författare) Symptomatic improvement after catheter ablation of supraventricular tachycardia measured by the arrhythmia-specific questionnaire U22 2011 Ingår i: Upsala Journal of Medical Sciences. - : Uppsala Medical Society. - 0300-9734 .- 2000-1967. ; 116:1, s. 52-59 Tidskriftsartikel (refereegranskat)abstract After successful ablation of accessory pathway and atrioventricular nodal re-entrant tachycardia, the U22 protocol detected a relevant increase in arrhythmia-related well-being. Modest improvement in general well-being was detected by the SF-36 protocol.
36.	Kesek, Milos, et al. (författare) U22, a protocol to quantify symptoms associated with supraventricular tachycardia. 2009 Ingår i: Pacing and Clinical Electrophysiology. - : Wiley. - 0147-8389 .- 1540-8159. ; 32:S1, s. S105-S108 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: The main indication for ablation of supraventricular tachyarrhythmias (SVTA) is symptomatic relief. Specific paroxysmal symptoms cannot be quantified with general measures of quality of life, such as with the SF-36 questionnaire. U22 is a new protocol which measures the effects of arrhythmia on well-being, the intensity of discomfort during an episode, the type and temporal characteristics of dominant symptoms, and the duration and frequency of episodes. Discrete 0-10 scales are used. Unlike SF-36, U22 can be used in individual patients. METHODS: U22 and SF-36 protocols were used in the symptomatic evaluation of 88 patients (mean age = 49.6 +/- 16.4 years; 43 men), who underwent catheter ablation of SVTA. Results: The U22 scores (SD) for (a) well-being (10 being best), (b) effects of arrhythmia on well-being (10 being worst), and (c) discomfort during arrhythmia (10 being worst) were 5.6 (2.7), 7.5 (2.8), and 8.0 (2.4), respectively. For comparison, the physical and mental component summaries of SF-36 were 45.3 (11.0) and 45.2 (12.1), respectively, slightly lower than the expected normal of 50. The intensity of dominant symptom scored by U22 was 9.7 (1.2), 10 being worst. In 29% of patients > or =4 symptoms were equally dominant. Multiple dominant symptoms in U22 were associated with a low general well-being in SF-36. CONCLUSION: We found U22 useful to quantify symptoms associated with SVTA.
37.	Klinga, Niklas, et al. (författare) Energy efficient high quality CTMP for paperboard 2007 Ingår i: International Mechanical Pulping Conference 2007, TAPPI. - 9781605602936 ; , s. 370-380 Konferensbidrag (refereegranskat)abstract This paper discusses the relationship between bulk and internal bond strength in paper sheets and their dependency on fibre length, fibre flexibility and fibre surface properties. It also discusses an interesting process concept for manufacturing of energy efficient high quality CTMP for paperboard. Post-refining pilot trials of spruce HTCTMP with an initial freeness of 740 ml were carried out at Metso Paper R&D in Sundsvall, Sweden. Both gentle high consistency and severe low consistency post-refining were performed. High consistency post-refining, at high energy input, gave freeness levels below 70 ml and still preserved the fibre length. These fibres were characterised by a very high flexibility giving sheets with a tensile index as high as 64 kNm/kg. Long fibres can however cause formation problems on a board machine which in turn can lead to poor surface properties, hence shorter fibres are from that perspective desirable. The low consistency post-refining resulted in a rapid drop in freeness due to fibre cutting. This was achieved at an extremely low specific energy input, which probably preserved most of the original fibre stiffness. In spite of this low energy input it was possible to reach the same Z-strength at a given bulk, as for the high consistency post-refined pulp. This implied that high bulk at certain internal bond strength could be,...;. achieved with stiff fibres even though the content of long fibres was low. Energy efficient low consistency postrefining of spruce HTCTMP yields high quality pulp at a total energy input of ∼800 kWh/admt and is an-interesting process concept for production of pulps intended for paperboard.
38.	Klinga, Niklas, et al. (författare) Energy efficient high quality CTMP for paperboard 2008 Ingår i: Journal of Pulp and Paper Science (JPPS). - 0826-6220. ; 34:2, s. 98-106 Tidskriftsartikel (refereegranskat)abstract This paper discusses the relationship between bulk and internal bond strength in paper sheets and their dependency on fibre length, fibre flexibility and fibre surface properties. It also discusses an interesting process concept for manufacturing of energy efficient high quality CTMP for paperboard. Post-refining pilot trials of spruce HTCTMP with an initial freeness of 740 ml were carried out at Metso Paper R&D in Sundsvall, Sweden. Both gentle high consistency and severe low consistency post-refining were performed. High consistency post-refining, at high energy input, gave freeness levels below 70 ml and still preserved the fibre length. These fibres were characterised by a very high flexibility giving sheets with a tensile index as high as 64 kNm/kg. Long fibres can however cause formation problems on a board machine which in turn can lead to poor surface properties, hence shorter fibres are from that perspective desirable. The low consistency post-refining resulted in a rapid drop in freeness due to fibre cutting. This was achieved at an extremely low specific energy input, which probably preserved most of the original fibre stiffness. In spite of this low energy input it was possible to reach the same Z-strength at a given bulk, as for the high consistency post-refined pulp. This implied that high bulk at certain internal bond strength could be achieved with stiff fibres even though the content of long fibres was low. Energy efficient low consistency post-refining of spruce HTCTMP yields high quality pulp at a total energy input of ~800 kWh/admt and is an interesting process concept for production of pulps intended for paperboard.
39.	Klinga, Niklas, et al. (författare) Paper properties of TMP and CTMP handsheets from spruce, as affected by the press load and temperature during sheet drying 2007 Ingår i: Nordic Pulp & Paper Research Journal. - 0283-2631 .- 2000-0669. ; 22:4, s. 468-474 Tidskriftsartikel (refereegranskat)abstract The objective of this investigation was to evaluate how physical properties of laboratory sheets, made from different thermomechanical and chemithermomechanical pulps, depend on the pressure and temperature levels during pressing and drying. Sheets were formed from long fibre fractions, defined as the pulp retained on a 50 mesh wire in a Britt Dynamic Drainage Jar, and pressed and dried according to a number of different pressure and temperature settings. The results showed that there were large differences in the sheet properties depending on what type of method was used for pressing and drying. High freeness pulps were more sensitive than low freeness pulps to the methods used for pressing and drying. The results indicate that the difference in sheet properties between ISO and Rapid Kothen sheets may be explained by the fact that ISO sheets are wet pressed only at room temperature, the fibres are then allowed to spring back when pressure is released whereas the fibres in Rapid Kothen sheets are locked in their positions as the sheets are pressed and dried at high temperature until dry.
40.	Klinga, Niklas, et al. (författare) Paper properties of TMP and CTMP handsheets from spruce, as affected by the solids content from pressing 2007 Ingår i: Nordic Pulp & Paper Research Journal. - 0283-2631 .- 2000-0669. ; 22:4, s. 475-480 Tidskriftsartikel (refereegranskat)abstract This paper discusses how the properties of dry handsheets from two different mechanical pulps and one chemithermomechanical pulp and their respective long fibre fractions depend on the level of dryness to which the sheets are pressed at high temperature. Sheets were pressed and dried to different dryness levels at 400 kPa and 93 degrees C in a modified Rapid Kothen dryer. Prior to testing of the physical properties, the sheets were dried without pressure at, room temperature to full dryness and kept in a conditioning room. This was performed with the aim of evaluating the consolidation and development of final strength properties with respect to dryness after a press section in a paper machine.The most interesting finding from these trials was that the increase in density and strength were far from linear with increased press dryness, especially for the long fibre fractions when looking at the Z-strength development. There was a distinct inflection of the curve when the sheets reached a press dryness level of some 50%. The most important dryness interval for internal strength development was found between 50 and 80%.The fact that most paper and board machines press the sheet to only some 50% dryness, before feeding it into the drying section, implies that much of the inherent strength potential of mechanical pulps may be unexploited. Further research on pressing to higher dryness levels will in the future be continued at FSCN at Mid Sweden University.
41.	Klinga, Niklas, et al. (författare) Sheet properties of high yield pulps related to different pressing and drying conditions - part I 2005 Ingår i: International Mechanical Pulping Conference. - Oslo : Pappersindustriens tekniske forening. ; , s. 344-348 Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract The objective of this investigation was to evaluate how physical properties of laboratory sheets, made from different thermomechanical and chemithermomechanical pulps, depend on the pressure and temperature levels during pressing and drying. Sheet were formed from long fibre fractions, defined as the pulp retained on a 50 mesh wire in a Britt Dynamic Drainage Jar, and pressed and dried according to a number of different pressure and temperature settings. The results showed that there were large differences in the sheet properties depending on what type of method that were used for pressing and drying. High freeness pulps were more sensitive to the type of method used for pressing and drying than low freeness pulps. The results indicate that the difference in sheet properties between ISO and Rapid Köthen sheets might be explained by the fact that ISO sheets are only wet pressed, the fibres are then allowed to spring back when pressure is released whereas the fibres in Rapid Köthen sheets are locked in their positions as the sheets are pressed and dried till over dry.
42.	Klinga, Niklas, et al. (författare) Sheet properties of high yield pulps related to different pressing and drying conditions - part II Annan publikation (populärvet., debatt m.m.)abstract This paper discusses how sheet properties of different mechanical pulps and chemithermomechanical pulps and their respective long fibre fractions depend on the level of dryness to which the sheets are wet pressed before being dried. This was performed with the aim of evaluating the consolidation and evolution of strength properties with respect to dryness. The results show that the development of strength, i.e. tensile strength and internal bond strength measured as Z-strength, is most pronounced in the dryness interval between 50 and 80% for the long fibre fractions.
43.	Leander, John, et al. (författare) Smart condition assessment, surveillance and management of critical bridges 2018 Konferensbidrag (refereegranskat)abstract Bridges with critical roles in heavily loaded transport infrastructures often need to be kept in service despiteknown damage and deficiencies. Closing or limiting the traffic on a bridge, leading to traffic diversions, issometimes not a feasible option. The current paper describes an approach for securing the functionalityand the safety of critical bridges by using an innovative smart system for monitoring and conditionassessment. It builds on the use of wireless sensor networks, advanced assessment methods, and cloudbased services for storage and distribution of results. This is an ongoing research project and the progressso far is presented in this paper. A case study of the Old Lidingö Bridge in Stockholm, Sweden, is used todemonstrate the approach. The monitoring system installed, devices for energy harvesting, and methodsfor condition assessment are presented. Some preliminary results on the condition of the bridge are alsopresented.
44.	Leander, John, et al. (författare) Smart condition assessment, surveillance and management of critical bridges 2019 Rapport (övrigt vetenskapligt/konstnärligt)abstract Bridges with known deficiencies often have to be kept in service as they constitute links in highly stressed transport infrastructures. Disruptions in the traffic flow are often considered unacceptable. The current project was aimed at bridges with known deficiencies in particular, with the purpose of securing the serviceability and the safety using an innovative smart system for surveillance and condition assessment.Related to measurements and collection of data, the project has focused on wireless sensor networks. In comparison to traditional wired systems, the installation demands less resources and the locations of the sensor nodes are not restricted by cabling issues. The research activities regarding sensors have been aimed at energy harvesting and energy efficient scheduling of operations. A completely wireless installation requires local power sources as batteries with limited lifetime, which restricts the time for measurements. With the purpose of extending the lifetime, systems for energy harvesting have been evaluated as, e.g., units based on vibrations and electromagnetic waves. Another aspect is when and for how long measurements and communication should be performed. By scheduling the activities of the sensor node, the results of the project shows a potential to save energy.The purpose of a monitoring system is to provide data for condition assessment and damage detection. A condition assessment involves the estimation of the present safety level and a prediction of the remaining service life. Within this field, degradation models for the interaction between corrosion and fatigue have been studied, and a probabilistic model have been developed facilitating considerations of uncertainties in the measured response and in the results from inspections. The purpose of damage detection is to find anomalies in the behaviour of the structure that might be caused by damages or a change in structural behaviour. It can involve unexpected events difficult to predict in advance, but detectable by thorough investigation of measured data. A method based on machine learning and statistical inference have been developed in the project and tested on fictitious damage cases.If the results form a condition assessment or damage detection indicates insufficient safety, a decision has to be made on interventions. A decision support model based on Bayesian decision theory have been implemented in the project and tested on data from the Old Lidingö Bridge.Cloud based services have been developed to transfer data from the sensors, to the analysis parts, and on to the decision agent. The purpose was to simplify the management of large data volumes from a monitoring system and to visualize the results in a comprehensible format. Solutions for collecting, storing and sharing of data have been developed, together with a mobile app for presentation of the results.The objective to develop an integrated system for surveillance, sharing of data, condition assessment, and decision support is partly completed. Some parts of the integration remains to be solved before a complete solution can be launched.
45.	Lingesten, Niklas, et al. (författare) Apparatus for continuous wear measurements during wet clutch durability tests 2012 Ingår i: Wear. - : Elsevier BV. - 0043-1648 .- 1873-2577. ; 288, s. 54-61 Tidskriftsartikel (refereegranskat)abstract Wet clutches are used in many applications today such as automatic transmissions and limited slip differentials in cars as well as in heavy duty equipment such as wheel loaders. The present study is concerned with the wear and engagement behavior of wet clutches in the latter type of application. A test rig is developed in which the wet clutch engagement is monitored during an arbitrary number of test cycles.This rig has many similarities with the SAE #2 test rig in that they are both inertia type test rigs. However, the test rig presented here has several original parts from heavy duty equipment in production incorporated into it. The data collection includes a continuous measurement of the position of the piston used to apply force on the clutch pack in addition to the separator disc temperatures, hydraulic actuating pressure and torque transfer characteristics. The measurements of the piston position can then be related to the clutch wear during a long test series.
46.	Lingesten, Niklas, et al. (författare) On the significance of operating temperature to the durability of a wet clutch 2013 Konferensbidrag (refereegranskat)
47.	Lingesten, Niklas, et al. (författare) Studies on wear phenomena in wet clutches 2012 Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract Wet clutches are critical components in many automatic transmissions in the automotive industry. These components handle large amounts of energy through sliding friction as they engage during machine operation, resulting in clutch disc wear. Wear experiments at high clutch engagement energies has revealed that a change in the friction material wear rate can occur at some point during the test, i.e. transitioning from a low to a high wear rate. This brings into question the conventional way of performing wear tests i.e. measuring a specimen before and after testing and the usual way of viewing wear i.e. as a constant wear rate after running in. The authors propose a two step wear model to describe the wear that can occur under some conditions exemplified in this paper.
48.	Lingesten, Niklas, et al. (författare) The influence of repeated high-energy engagements on the permeability of a paper-based wet clutch friction material 2017 Ingår i: Proceedings of the Institution of mechanical engineers. Part J, journal of engineering tribology. - : Sage Publications. - 1350-6501 .- 2041-305X. ; 231:12, s. 1574-1582 Tidskriftsartikel (refereegranskat)abstract The behavior of a wet clutch during engagement is of great importance to the durability of the clutch and the drivability of a vehicle. While many different factors influence the engagement behavior, the focus of this paper is to investigate only one factor, the permeability of the wet clutch friction material. Two test cells for measuring the permeability of friction material mounted on clutch discs have been developed. The test cells were then used to examine the effect of clutch material ageing through clutch engagement on the permeability of the material. The tests were performed on full size friction discs including the steel core prior and subsequent to testing in a wet clutch engagement test rig. The ability of the friction material to allow for oil flow both through the sliding surface layer and the bulk of the material was measured. The results indicate that repeated clutch engagements will increase the bulk permeability. However, the repeated engagements will decrease the ability to pass fluid through the friction material sliding surface. This contradictory behavior could be explained by a combination of an increase in pore size through repeated compression and the surface glaze clogging of the friction interface surface pores.
49.	Littorin, Nils, et al. (författare) Swedish Public Health Agency reporting has distorted mortality rates for the unvaccinated and the vaccinated 2022 Annan publikation (övrigt vetenskapligt/konstnärligt)
50.	Loren, Niklas, et al. (författare) Sodium reduction in foods : Challenges and strategies for technical solutions 2023 Ingår i: Journal of Food Science. - : John Wiley and Sons Inc. - 0022-1147 .- 1750-3841. ; 88:3, s. 885- Tidskriftsartikel (refereegranskat)abstract In many parts of the world, sodium consumption is higher than recommended levels, representing one of the most important food-related health challenges and leading to considerable economical costs for society. Therefore, there is a need to find technical solutions for sodium reduction that can be implemented by food producers and within food services. The aims of this review are to discuss the barriers related to sodium reduction and to highlight a variety of technical solutions. The barriers relate to consumer perception, microbiology, processing, and physicochemistry. Existing technical solutions include inhomogeneous salt distribution, coated salt particles, changing particle sizes and forms, surface coating, multisensory combinations, sodium replacements, double emulsions, adapted serum release by microstructure design, and adapted brittleness by microstructure design. These solutions, their implementation and the associated challenges, and applicable product categories are described. Some of these solutions are ready for use or are in their early development stages. Many solutions are promising, but in most cases, some form of adaptation or optimization is needed before application in specific products, and care must always be taken to ensure food safety. For instance, further research and innovation are required in the dynamic evolution of saltiness perception, consumer acceptance, the binding and migration of sodium, juiciness, microbiological safety, and the timing of salt addition during processing. Once implemented, these solutions will undoubtedly support food producers and food services in reducing sodium content and extend the application of the solutions to different foods. © 2022 Research Institutes of Sweden, Swedish Food Federation and Lyckeby Culinar AB.

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