| 1. |
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| 2. |
- Sahlén, Pelin, et al.
(författare)
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Chromatin interactions in differentiating keratinocytes reveal novel atopic dermatitis– and psoriasis-associated genes
- 2020
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Ingår i: Journal of Allergy and Clinical Immunology. - : Mosby Inc.. - 0091-6749 .- 1097-6825.
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Tidskriftsartikel (refereegranskat)abstract
- Background: Hundreds of variants associated with atopic dermatitis (AD) and psoriasis, 2 common inflammatory skin disorders, have previously been discovered through genome-wide association studies (GWASs). The majority of these variants are in noncoding regions, and their target genes remain largely unclear. Objective: We sought to understand the effects of these noncoding variants on the development of AD and psoriasis by linking them to the genes that they regulate. Methods: We constructed genomic 3-dimensional maps of human keratinocytes during differentiation by using targeted chromosome conformation capture (Capture Hi-C) targeting more than 20,000 promoters and 214 GWAS variants and combined these data with transcriptome and epigenomic data sets. We validated our results with reporter assays, clustered regularly interspaced short palindromic repeats activation, and examination of patient gene expression from previous studies. Results: We identified 118 target genes of 82 AD and psoriasis GWAS variants. Differential expression of 58 of the 118 target genes (49%) occurred in either AD or psoriatic lesions, many of which were not previously linked to any skin disease. We highlighted the genes AFG1L, CLINT1, ADO, LINC00302, and RP1-140J1.1 and provided further evidence for their potential roles in AD and psoriasis. Conclusions: Our work focused on skin barrier pathology through investigation of the interaction profile of GWAS variants during keratinocyte differentiation. We have provided a catalogue of candidate genes that could modulate the risk of AD and psoriasis. Given that only 35% of the target genes are the gene nearest to the known GWAS variants, we expect that our work will contribute to the discovery of novel pathways involved in AD and psoriasis.
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| 3. |
- Santarius, T., et al.
(författare)
-
Digital sufficiency : conceptual considerations for ICTs on a finite planet
- 2022
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Ingår i: Annales des télécommunications. - : Springer Nature. - 0003-4347 .- 1958-9395.
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Tidskriftsartikel (refereegranskat)abstract
- ICT hold significant potential to increase resource and energy efficiencies and contribute to a circular economy. Yet unresolved is whether the aggregated net effect of ICT overall mitigates or aggravates environmental burdens. While the savings potentials have been explored, drivers that prevent these and possible counter measures have not been researched thoroughly. The concept digital sufficiency constitutes a basis to understand how ICT can become part of the essential environmental transformation. Digital sufficiency consists of four dimensions, each suggesting a set of strategies and policy proposals: (a) hardware sufficiency, which aims for fewer devices needing to be produced and their absolute energy demand being kept to the lowest level possible to perform the desired tasks; (b) software sufficiency, which covers ensuring that data traffic and hardware utilization during application are kept as low as possible; (c) user sufficiency, which strives for users applying digital devices frugally and using ICT in a way that promotes sustainable lifestyles; and (d) economic sufficiency, which aspires to digitalization supporting a transition to an economy characterized not by economic growth as the primary goal but by sufficient production and consumption within planetary boundaries. The policies for hardware and software sufficiency are relatively easily conceivable and executable. Policies for user and economic sufficiency are politically more difficult to implement and relate strongly to policies for environmental transformation in general. This article argues for comprehensive policies for digital sufficiency, which are indispensible if ICT are to play a beneficial role in overall environmental transformation.
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| 4. |
- Santarius, T., et al.
(författare)
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Digitalization and Sustainability : A Call for a Digital Green Deal
- 2023
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Ingår i: Environmental Science and Policy. - : Elsevier BV. - 1462-9011 .- 1873-6416. ; 147, s. 11-14
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Tidskriftsartikel (refereegranskat)abstract
- The relation between digitalization and environmental sustainability is ambiguous. There is potential of various digital technologies to slow down the transgression of planetary boundaries. Yet resource and energy demand for digital hardware production and use of data-intensive applications is of substantial size. The world over, there is no comprehensive regulation that addresses opportunities and risks of digital technology for sustainability. In this perspective article, we call for a Digital Green Deal that includes strong, cross-sectoral green digitalization policies on all levels of governance. We argue that a Digital Green Deal should first and foremost aim at greater policy coherence: Current digital policy initiatives should include measures that service environmental goals, and environmental policies must address risks and advance opportunities of digital technologies to spur sustainability transformations.
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| 5. |
- Artamonova, A., et al.
(författare)
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Time and context shaping the transition from out-of-home care to adulthood in Portugal
- 2020
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Ingår i: Children and Youth Services Review. - : Elsevier BV. - 0190-7409. ; 115
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Tidskriftsartikel (refereegranskat)abstract
- The difficulties that modern care leavers face on the way to independence are the focus of many studies. The present research illustrates how time and context - operationalised through belonging to different generations, from the previous century to today - has shaped care leavers' pathways to adulthood in Portugal. To trace these pathways, ten care leavers were selected based on purposeful sampling and snowball methods. To reveal the factors that indicate care leavers' better life outcomes, interviews with seven experts working with this vulnerable population group were organised. The pathways of male informants look "normal", even thriving, when compared with the trajectories of the general population of Portugal in the second half of the 20th century, while the experiences of female care leavers sound somewhat traumatising. The timing and sequence of the young cohorts' transition to adulthood events does not look aberrant compared to the general population. The various factors that determine a care leaver's better life outcomes emerged as access to the tangible and intangible resources needed to generate human and social capital, and personal agency. Care leavers from older cohorts were empowered by means of education and the support of former residents of out-of-home care institutions. Women from older cohorts could receive education but, due to the social context, they were not expected to build careers. The educational opportunities given to them were very basic and did not afford them the confidence to deal with adversity. Care leavers from younger cohorts seem to lose the advantage of competitive education and the sense of belonging to a large and powerful childcare institution due to the democratisation of the education system and de-institutionalisation of residential care in the country. However, they can stay in care longer, gain practical skills for independent living and benefit from the personalised support of professionals to deal with adversity.
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| 6. |
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| 7. |
- Bieser, Jan C. T., et al.
(författare)
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Impacts of telecommuting on time use and travel : A case study of a neighborhood telecommuting center in Stockholm
- 2021
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Ingår i: Travel Behaviour & Society. - : Elsevier BV. - 2214-367X .- 2214-3688. ; 23, s. 157-165
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Tidskriftsartikel (refereegranskat)abstract
- While telecommuting (TC) research heavily discusses travel impacts of home-based TC, little is known about impacts of working from a neighborhood TC center on travel and non-travel activities and their energy requirements. We conduct a case study on the impacts of the work location (employer's office, TC center, home) on time use and travel using data collected in a neighborhood TC center in Stockholm. Our results show that telecommuters more frequently replaced working from the TC center for working from the more distant employer's office than for working from home. On TC center and home office days, diarists spent less time traveling, and on home office days more time on chores and leisure than on employer office days. When working from the TC center instead of the employer's office, telecommuters frequently used the same or more energy-efficient commute modes, e.g. biking instead of the car, which was feasible because the TC center is in the local neighborhood. However, when working from home, diarists mainly used the car for private travel. Thus, energy savings of TC can be increased by providing energy-efficient transport options or local access to non-work destinations to telecommuters. TC energy impacts depend also on changes to energy requirements for nontravel activities, for space heating/cooling/lighting at all work locations, and systemic TC effects (e.g. residential relocation), which can only be observed in the long term. Thus, future TC assessments should take an even broader perspective in terms of travel and non-travel activities, their energy requirements, and systemic effects.
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| 8. |
- Bieser, Jan C. T., et al.
(författare)
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Toward a method for assessing the energy impacts of telecommuting based on time-use data
- 2022
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Ingår i: Travel Behaviour & Society. - : Elsevier BV. - 2214-367X .- 2214-3688. ; 27, s. 107-116
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Tidskriftsartikel (refereegranskat)abstract
- Most telecommuting (TC) studies focus on travel impacts and do not consider changes in time spent on non-travel activities (e.g. 'leisure') and the energy impacts of these changes. We demonstrate a time-use approach to assess interrelations between changes in commuting time and time spent on travel and non-travel activities and associated energy impacts. Time-use data analysis shows that spending less time on commuting is associated with more time spent on 'sleep', 'leisure', 'personal, household and family care', 'private travel' and 'eating and drinking'. Substituting car commuting with 'sleep', 'eating and drinking', common 'leisure' and 'personal, household and family care' activities is likely to reduce energy requirements as these are associated with less energy requirements than car commuting. This is different for 'private travel', 'meal preparation at home', and energy-intensive or out-of-home 'leisure' activities, which are associated with relatively high energy requirements. The commute modal split is a key variable in energy impacts of TC, because transport modes differ in their energy requirements. While car commuters can realize high energy savings through TC, for people who usually bike or walk to work, direct energy savings through reduced commuting are zero. Thus, any additional energy impact due to substitute activities, increases net direct energy requirements. Future research should further investigate the relationship between TC and time spent on (non-)travel activities and the marginal energy requirements of these activities. If so, the time-use approach can become key for assessing energy impacts of TC and other applications which impact individual time allocation.
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| 9. |
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| 10. |
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Fieldwork Education in Social Work as One Way of Building Bridges between China and Europe : In Rajendra Baikady, Sajid S.M., Varoshini Nadesan, and M. Rezaul Islam (eds) The Routledge Handbook of Field Work Education in Social Work
- 2022
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- The Routledge Handbook of Field Work Education in Social Work is a welcome addition to the lit- erature on social work education and comparative research. It offers a wealth of contributions on field education across four continents.The book comes at a time of increased interest in international social work and in learning from others. It is also a time when educators in diverse contexts are struggling to provide quality field education for students, as field education across the globe is facing both old and new challenges. As the editors point out early in their introduction, field education is an essential part of the preparation of social workers; indeed, it is now sometimes referred to by the US Council on Social Work Education and others as the ‘signature pedagogy’ of the field. From the earliest days, educators have recognised that practical experience must accompany academic learning to prepare social work practitioners.This differentiates a profession from a purely academic subject. A review of the history of social work education bears this out. Between 1950 and 1972, the United Nations (UN) conducted five world surveys of social work education. In the very first of these, issues and variations in ‘practical training’ were dis- cussed (UN, 1950). Supervision, the need to integrate theory and practice, and the balance between observation and learning by doing were highlighted in the overview and in country summaries.The International Association of Schools of Social Work continued the global survey of educational programmes,issuing the World Guide to SocialWork Education in 1984.The crite- ria for inclusion as a social work programme were few in number and quite modest. It clearly stated, however, that ‘The course of study should include theoretical study as well as substantial continuing field practicum with an arrangement for appropriate instruction in both class and field’ (p. ix).This volume profiled social work programs in 61 countries across six continents, an expansion from the 46 countries listed in the 1950 UN publication. In 2004, the International Association of Schools of Social Work and the International Federation of Social Workers issued the first ever Global Standards for the Education and Training of the Social Work Profession. The standards were revised in 2020 (IASSW/IFSW, 2020). Both versions include lengthy sections on field education under curricula and state that field education must ‘be sufficient in duration and complexity of tasks and learning opportunities to ensure that students are prepared for professional practice’ (IASSW/IFSW, 2020, p. 13). Other standards include pro- viding qualified supervision, training for field instructors, a field manual with clear policies, and methods of evaluating students and field settings. New to the 2020 version is an aspirational stand- ard that programmes should ‘Create practice placement opportunities that correspond to at least 25% of the overall education activity within the courses (counted in either credits, days, or hours)’ (p. 14).This is clearly an effort to reduce the variability in attention paid to the field component. Organising and delivering quality field education continues to be a challenge for schools of social work. Many of the issues identified 70 years ago continue, including providing regular, xxvii Downloaded By: 10.3.98.104 At: 20:32 15 Jun 2022; For: 9781032164946, Prelims, 10.4324/9781032164946 Foreword professionally competent supervision and the need to help students integrate their classwork with field education. Over the past three decades, social work has expanded to numerous new locales,most notably to the countries of the former Soviet Union and China.The 2020 world census of social work education identified more than 3,500 programs in 159 countries (IASSW, 2021). In some places, social work is a completely new subject, and educators have had to initiate placements in areas without trained supervisors or even settings that defined them- selves as social work settings (Healy & Thomas, 2021). In other countries, including such diverse places as Jamaica and Ethiopia, expansion in the number of schools of social work and increases in the number of students enrolled has outpaced the availability of suitable field placements (Kebede, 2019). Mentoring students into the profession is less likely to occur if experienced social work supervision is missing. The Routledge Handbook of Field Work Education in Social Work includes overviews of field education and treatment of special subjects in 26 countries ranging from the United Kingdom to China, Slovenia,Turkey, Canada, and New Zealand. Several chapters provide student perspec- tives on their learning in the field. Special topics addressed include the experiences of indig- enous students in field placement and considerations for ensuring that international placements are optimally designed and supported. Reflexivity as a component of learning and way of inte- grating learning is addressed by several authors. Finally, the impact of the COVID-19 pandemic is covered in three chapters at the end of the volume. Field education faced disruptions and unusual challenges, in terms of the needs and demands of service users, threats to the health of students and field instructors, and widespread closures of in-person services. Learning from these experiences will inform education in future emergencies. In their conclusion, the editors lament that the topic of technology is not adequately addressed in the present book. Presumably, the expansion of virtual service delivery during the pandemic will offer lessons for future considera- tion of technologies in field education. In concluding the book, the editors remind readers that ‘Competency of students and graduates from a school of social work largely depends on the quality of the field education agency, availability of faculty support, competent supervisors, and expertise in introducing an innovative fieldwork practicum’. In the United States, and perhaps other contexts, increased pressures for research and publication have diminished the involvement of full-time faculty in field liaison and engagement, widening the divide between classroom instruction and field learning and severing what was, in earlier times, a close collaboration between academia and the field. At the same time, neoliberal pressures push agencies to meet higher efficiency stand- ards through increased caseloads and outputs.This leaves less time for field instruction and is resulting in fewer available placements for the growing social work student population.These trends may heighten the stresses on the dominant model of field education for social work and call out for creative solutions. Comparative study and increased sharing across borders can help in developing new models.This volume is an excellent start and a most welcome addition to the literature. Lynne M. Healy, MSW, PhD Board ofTrustees Distinguished Professor Emerita University of Connecticut School of Social Work, USA
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| 11. |
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| 12. |
- Hestbaek, A. D., et al.
(författare)
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Child welfare removal of infants: Exploring policies and principles for decision-making in Nordic countries
- 2020
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Ingår i: Children and Youth Services Review. - : Elsevier BV. - 0190-7409. ; 108
-
Tidskriftsartikel (refereegranskat)abstract
- This descriptive policy analysis examines the position of infants' rights in the family service orientated child welfare systems of Denmark, Finland, Norway and Sweden when being placed in out-of-home care. Its focus is on the contexts of, and legal procedures for, removing babies from home into public care. Children under the age of one year are taken into public care mainly through voluntary and emergency measures. Analysis of the development over a decade displays big intra-country differences in the prevalence of infant removal, varying from 2 per 1000 to 8 per 1000. The scant prevalence of public policy, practice guidelines and research indicates that infant removal is in some ways an anomaly, an unspoken leaf in the Nordic child welfare systems, whereas the Nordic welfare states otherwise extensively support families with young children through universal interventions. The findings invite to a re-examination of the rights of infants and their specific needs in the welfare states in order to establish responsive and efficient child protection systems.
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| 13. |
- Höjer Holmgren, Karin, et al.
(författare)
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Part 1 : Tracing Russian VX to its synthetic routes by multivariate statistics of chemical attribution signatures
- 2018
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Ingår i: Talanta. - : Elsevier. - 0039-9140 .- 1873-3573. ; 186, s. 586-596
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Tidskriftsartikel (refereegranskat)abstract
- Chemical attribution signatures (CAS) associated with different synthetic routes used for the production of Russian VX (VR) were identified. The goal of the study was to retrospectively determine the production method employed for an unknown VR sample. Six different production methods were evaluated, carefully chosen to include established synthetic routes used in the past for large scale production of the agent, routes involving general phosphorus-sulfur chemistry pathways leading to the agent, and routes whose main characteristic is their innate simplicity in execution. Two laboratories worked in parallel and synthesized a total of 37 batches of VR via the six synthetic routes following predefined synthesis protocols. The chemical composition of impurities and byproducts in each route was analyzed by GC/MS-EI and 49 potential CAS were recognized as important markers in distinguishing these routes using Principal Component Analysis (PCA). The 49 potential CAS included expected species based on knowledge of reaction conditions and pathways but also several novel compounds that were fully identified and characterized by a combined analysis that included MS-CI, MS-EI and HR-MS. The CAS profiles of the calibration set were then analyzed using partial least squares discriminant analysis (PLS-DA) and a cross validated model was constructed. The model allowed the correct classification of an external test set without any misclassifications, demonstrating the utility of this methodology for attributing VR samples to a particular production method. This work is part one of a three-part series in this Forensic VSI issue of a Sweden-United States collaborative effort towards the understanding of the CAS of VR in diverse batches and matrices. This part focuses on the CAS in synthesized batches of crude VR and in the following two parts of the series the influence of food matrices on the CAS profiles are investigated.
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| 14. |
- Höjer Holmgren, Karin, et al.
(författare)
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Synthesis route attribution of sulfur mustard by multivariate data analysis of chemical signatures
- 2018
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Ingår i: Talanta. - : Elsevier BV. - 0039-9140 .- 1873-3573. ; 186, s. 615-621
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Tidskriftsartikel (refereegranskat)abstract
- A multivariate model was developed to attribute samples to a synthetic method used in the production of sulfur mustard (HD). Eleven synthetic methods were used to produce 66 samples for model construction. Three chemists working in both participating laboratories took part in the production, with the aim to introduce variability while reducing the influence of laboratory or chemist specific impurities in multivariate analysis. A gas chromatographic/mass spectrometric data set of peak areas for 103 compounds was subjected to orthogonal partial least squares - discriminant analysis to extract chemical attribution signature profiles and to construct multivariate models for classification of samples. For one- and two-step routes, model quality allowed the classification of an external test set (16/16 samples) according to synthesis conditions in the reaction yielding sulfur mustard. Classification of samples according to first-step methodology was considerably more difficult, given the high purity and uniform quality of the intermediate thiodiglycol produced in the study. Model performance in classification of aged samples was also investigated.
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| 15. |
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| 16. |
- Höjer, M., et al.
(författare)
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A noise related track maintenance tool for severe wear detection of wheel-rail contact
- 2016
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Ingår i: Civil-Comp Proceedings. - 1759-3433. ; 110
-
Tidskriftsartikel (refereegranskat)abstract
- An on-board measurement system has been developed that in real time identifies the probability for occurrence and also the exact location of severe wear in the wheelrail contact. Noise generated by the wheel-rail contact is a troublesome side effect both when railway vehicles negotiate curves and run on straight tracks. The concept behind this project is to use this noise as an indicator of the transition from the mild wear regime to the severe/catastrophic wear regime that implies high maintenance cost. At first tribometers were used in a laboratory study to investigate the relationships between wear and the emitted noise. Wear transitions from mild to severe wear were always accompanied by an increase in sound pressure of about 10 dB. The transitions also changed the sound pressure amplitude distribution from a narrow banded to a broader banded distribution. Secondly a full scale test in a small radius curve in a depot was carried out using a metro train, type C20. In agreement with the laboratory tests, the same kind of transfer from mild to severe wear was identified on the full scale tests in the depot. In addition, the sound pressure changed significantly, both in amplitude and in distribution, when transferring from mild to severe wear. By comparing the noise from the inner wheel-rail contact to noise from the outer wheel-rail contact a wear detection parameter for the outer wheel-rail contact is suggested. The third part of this project involves validation of the maintenance tool by operating the instrumented train in normal metro traffic, while at the same time collecting wear particles and making replicate casts of the rail at critical locations in the metro. Further comparison with weather data and a maintenance log has also been performed.
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| 17. |
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| 18. |
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| 19. |
- Kramers, Anna, et al.
(författare)
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Work hubs : Location considerations and opportunities for reduced travel
- 2015
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Ingår i: PROCEEDINGS OF ENVIROINFO AND ICT FOR SUSTAINABILITY 2015. - : Atlantis Press. - 9789462520929 ; , s. 126-135
-
Konferensbidrag (refereegranskat)abstract
- Cities worldwide are suffering from congestion among public transport users and motorists. Mayors have set ambitious targets to reduce traffic and improve public transportation, while at the same time reducing energy use. This paper investigates the option of using flexible workplaces in local nodes within urban regions in order to transform transportation needs. The business characteristics of this type of flexible workplace and the driving forces and potential barriers in its establishment are examined in an interview study with existing hub owners. The results provide novel information on emerging technologies related to urban transportation solutions and highlight how ICT solutions can affect the accessibility and relevance of flexible workplaces and thereby support their energy reduction potential.
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| 20. |
- Lange, Steffen, et al.
(författare)
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Digital Reset : Redirecting Technologies for the Deep Sustainability Transformation
- 2023
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Time seems out of joint. The world society has experienced a centennial pandemic, the global thermometer has displayed a sequence of hottest years on record, and Russia's war on Ukraine has shattered political order. Unsurprisingly, the economy is severely affected. Governments worldwide hope that digital technologies can provide key solutions. Yet this report shows that digitalisation, in its current and mainstream form, is rather aggravating than solving many of the pressing social and environmental crises at hand. What is needed instead is a deep sustainability transformation that fundamentally reorganises the economy and all its sectors - agriculture, mobility, energy, buildings, industry, and consumption. The Report »Digital Reset« shows how digital technologies can support the quest for such a deep sustainability transformation. The report provides a blueprint for the European Union on how to reconceptualise digitalisation so that it first and foremost contributes to achieving carbon neutrality, resource autonomy and economic resilience while supporting equity and fully respecting citizen's rights and privacy. The report is the outcome of a two-year international science-policy dialogue, »Digitalization for Sustainability« (D4S), and presents an up-to-date comprehensive analysis of opportunities, risks and governance options regarding digitalization and sustainability.
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| 21. |
- Lyu, Yezhe, et al.
(författare)
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Development of a noise related track maintenance tool
- 2015
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Ingår i: 22nd International Congress on Sound and Vibration, ICSV 2015. - : International Institute of Acoustics and Vibrations. - 9788888942483
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Konferensbidrag (refereegranskat)abstract
- The purpose of this work-package within the Quiet-track, FP7, is to develop a noise related track maintenance tool, in the form of an on-board measurement system. As a first step, lab scale tests using a pin-on-disc tribometer were used in order to distinguish how noise changes when the wear mechanism in a sliding contact shifts from normal wear to severe and catastrophic wear. Once the potential for using sound as an indication of severe wear transitions was established, full scale tests were carried out with a rapid transit (metro) train, type C20. The train was equipped with microphones that continuously measured the sound pressure near the wheel rail contact. In order to provoke severe/catastrophic wear, the test train was run in a curve with small radius, and the rails and wheels were carefully cleaned before the tests. The same kind of transfer from mild to severe/catastrophic wear was identified on the full scale test as in the laboratory scale test, confirmed by studying the surface topography and the morphology of the wear particles. Moreover, the full scale test results showed that the sound pressure changed significantly when transferring from mild to severe wear in agreement with the pin-on-disc test results. By comparing noise from the inner wheel/rail contact to noise form the outer wheel/rail contact a wear indication value for the outer wheel/rail contact is suggested in this study. This value can be seen as an advanced parameter from which the probability of severe wear, in the wheel flange/rail gauge face contact of the outer contact, can be estimated. At present, a real time condition monitoring system is set up in Stockholm (Metro line 1) in order to validate the results.
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| 22. |
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